Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPGAR2)

Drug Name

Hydroxymethylpyrene Drug Info

Synonyms

1-Hydroxymethylpyrene; 1-Pyrenemethanol; KSC205I9L; MCULE-5243016090; NGDMLQSGYUCLDC-UHFFFAOYSA-N; Pyrenemethanol; RTR-011298; SCHEMBL505806; TRA0091121; ZINC2143350; pyren-1-ylmethanol; pyrenylmethan-1-ol; (1-pyrenyl)methanol; 1-(1-Hydroxymethyl)pyrene; 1-(Hydroxymethyl)pyrene; 1-Pyrenemethanol, 98%; 1-Pyrenylmethanol; 1-Pyrenylmethanol #; 24463-15-8; AC1L2XTN; AC1Q7C1N; AC1Q7CGU; ACMC-1CIST; AKOS005265175; ANW-25453; BIDD:GT0067; C76UX3EH8M; CCRIS 6510; CHEMBL1743299; CTK1A5495; DTXSID90179219; KS-00000WCR; MFCD00029252; UNII-C76UX3EH8M

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 104977
CAS Number: CAS 24463-15-8
TTD Drug ID: DMPGAR2
INTEDE Drug ID: DR2003

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Approved Drug(s)

Investigative Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Metabolized By Alcohol dehydrogenase class-I gamma (ADH1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[3]
Octanol	DMBGHPE	Discovery agent	N.A.	Investigative	[2]
Acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[2]
Pyrene-1-aldehyde	DMEF6IP	Discovery agent	N.A.	Investigative	[2]
BRN-2330710	DM87VP6	Discovery agent	N.A.	Investigative	[2]
Pyrenemethanol	DMGJ0RM	Discovery agent	N.A.	Investigative	[2]
Octanal	DMTN0OK	Discovery agent	N.A.	Investigative	[2]
------------------------------------------------------------------------------------


⏷ Show the Full List of 7 Drug(s)

Drug(s) Metabolized By Alcohol dehydrogenase class-II (ADH4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[2]
Androsterone	DMITJAK	N. A.	N. A.	Phase 3	[4]
Octanol	DMBGHPE	Discovery agent	N.A.	Investigative	[2]
Acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[2]
Pyrene-1-aldehyde	DMEF6IP	Discovery agent	N.A.	Investigative	[2]
BRN-2330710	DM87VP6	Discovery agent	N.A.	Investigative	[2]
Pyrenemethanol	DMGJ0RM	Discovery agent	N.A.	Investigative	[2]
Octanal	DMTN0OK	Discovery agent	N.A.	Investigative	[2]
------------------------------------------------------------------------------------


⏷ Show the Full List of 8 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Alcohol dehydrogenase class-II (ADH4)	DEOCWU3	ADH4_HUMAN	Substrate	[2]
Alcohol dehydrogenase class-I gamma (ADH1C)	DEM1HNL	ADH1G_HUMAN	Substrate	[2]

------------------------------------------------------------------------------------

References

1	Metabolism and excretion of 1-hydroxymethylpyrene, the proximate metabolite of the carcinogen 1-methylpyrene, in rats. Toxicology. 2016 Jul 29;366-367:43-52.
2	Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. Toxicology. 2008 Mar 12;245(1-2):65-75.
3	Natural alcohol exposure: is ethanol the main substrate for alcohol dehydrogenases in animals? Chem Biol Interact. 2011 May 30;191(1-3):14-25.
4	13-cis-retinoic acid competitively inhibits 3 alpha-hydroxysteroid oxidation by retinol dehydrogenase RoDH-4: a mechanism for its anti-androgenic effects in sebaceous glands? Biochem Biophys Res Commun. 2003 Mar 28;303(1):273-8.