General Information of Drug (ID: DMPK6YT)

Drug Name
3,4-diphenyl-1H-pyrrole-2,5-dione Drug Info
Synonyms
2,3-diphenylmaleimide; 1H-Pyrrole-2,5-dione, 3,4-diphenyl-; 31295-36-0; 3,4-diphenyl-1H-pyrrole-2,5-dione; AC1MBL6S; SCHEMBL114611; CHEMBL201949; CTK1B9880; 3,4-diphenylpyrrole-2,5-dione; DTXSID70372903; ZINC3847556
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
2752461
CAS Number
CAS 31295-36-0
TTD Drug ID
DMPK6YT

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Patented Agent(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meprobamate DMHM93Y Anxiety Approved [2]
Bryostatin-1 DM1JOXY Alzheimer disease 8A20 Phase 2 [3]
RO-320432 DMFZ1YW N. A. N. A. Terminated [4]
LY-317644 DMM20PI N. A. N. A. Terminated [5]
CDE-6960 DMA0DKI Inflammation 1A00-CA43.1 Terminated [6]
RO-316233 DMAGLPW Discovery agent N.A. Investigative [7]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione DMDO175 Discovery agent N.A. Investigative [1]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione DMGC7RY Discovery agent N.A. Investigative [1]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione DM3EV9N Discovery agent N.A. Investigative [1]
LY-326449 DMN53M4 Discovery agent N.A. Investigative [8]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PD-0183812 DMWYP86 Retinoblastoma 2D02.2 Terminated [9]
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol DMSKJ1X Discovery agent N.A. Investigative [10]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione DMDO175 Discovery agent N.A. Investigative [1]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione DMGC7RY Discovery agent N.A. Investigative [1]
BMS-536924 DMXJB4N Discovery agent N.A. Investigative [11]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione DM3EV9N Discovery agent N.A. Investigative [1]
aloisine A DM5U1LN Discovery agent N.A. Investigative [12]
3-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)phenol DMJZK40 Discovery agent N.A. Investigative [10]
(2'Z,3'E)-5-Chloro-5'-chloro-indirubin-3'-oxime DMGXRSZ Discovery agent N.A. Investigative [13]
(2'Z,3'E)-5-Chloro-5'-methyl-indirubin-3'-oxime DMZ0V6G Discovery agent N.A. Investigative [13]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ABT-263 DMNE56X Myelofibrosis 2A20.2 Phase 3 [14]
Briciclib DMK7BND Solid tumour/cancer 2A00-2F9Z Phase 1 [15]
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol DMSKJ1X Discovery agent N.A. Investigative [10]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione DMDO175 Discovery agent N.A. Investigative [1]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione DMGC7RY Discovery agent N.A. Investigative [1]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione DM3EV9N Discovery agent N.A. Investigative [1]
7-hydroxycoumarin DMTMNO7 Discovery agent N.A. Investigative [16]
⏷ Show the Full List of 7 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sodium phenylbutyrate DMXLBCQ Spinal muscular atrophy 8B61 Approved [17]
Sotrastaurin acetate DME53YS Renal transplantation NE84 Phase 2 [18]
PMID28460551-Compound-3 DMA1FRM N. A. N. A. Patented [19]
ISIS 3521 DMZFS69 N. A. N. A. Discontinued in Phase 2 [20]
BALANOL DMDLN9E N. A. N. A. Terminated [21]
RO-320432 DMFZ1YW N. A. N. A. Terminated [4]
LY-317644 DMM20PI N. A. N. A. Terminated [5]
Acteoside DM0YHKB Nephritis GB40 Terminated [22]
RO-316233 DMAGLPW Discovery agent N.A. Investigative [7]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB Discovery agent N.A. Investigative [23]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [24]
BALANOL DMDLN9E N. A. N. A. Terminated [21]
RO-320432 DMFZ1YW N. A. N. A. Terminated [4]
LY-317644 DMM20PI N. A. N. A. Terminated [5]
RO-316233 DMAGLPW Discovery agent N.A. Investigative [7]
Bisindolylmaleimide-I DMOQJZC Discovery agent N.A. Investigative [25]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione DMDO175 Discovery agent N.A. Investigative [1]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione DMGC7RY Discovery agent N.A. Investigative [1]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione DM3EV9N Discovery agent N.A. Investigative [1]
LY-326449 DMN53M4 Discovery agent N.A. Investigative [8]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
R-roscovitine DMSH108 Non-small-cell lung cancer 2C25.Y Phase 2 [26]
Ro 31-7453 DM83QCL Solid tumour/cancer 2A00-2F9Z Phase 2 [24]
P276-00 DM9DJL2 Mantle cell lymphoma 2A85.5 Phase 2 [26]
P-276 DMMJUHD Breast cancer 2C60-2C65 Phase 2 [27]
RGB-286638 DMEGOQP Haematological malignancy 2B33.Y Phase 1 [28]
AG-024322 DMY4WVK Solid tumour/cancer 2A00-2F9Z Phase 1 [26]
PHA-793887 DM2Y4FG Solid tumour/cancer 2A00-2F9Z Phase 1 [29]
Oxazolyl methylthiothiazole derivative 1 DMZM6FW N. A. N. A. Patented [30]
PMID25991433-Compound-A1 DM89LF0 N. A. N. A. Patented [31]
KENPAULLONE DMAGVXW Discovery agent N.A. Patented [32]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [33]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [34]
Gefitinib DM15F0X Colon adenocarcinoma Approved [35]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [36]
Vandetanib DMRICNP Solid tumour/cancer 2A00-2F9Z Approved [24]
Dacomitinib DMOH8VY Non-small-cell lung cancer 2C25.Y Approved [37]
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [38]
SKI-758 DMQ8E9R Ischemia 8B10-8B11 Approved [39]
Epidermal growth factor DMVONE6 Vulnerary ND56.Z Approved [37]
Merimepodib DM0HS92 Breast cancer 2C60-2C65 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
R-roscovitine DMSH108 Non-small-cell lung cancer 2C25.Y Phase 2 [26]
Ro 31-7453 DM83QCL Solid tumour/cancer 2A00-2F9Z Phase 2 [24]
PHA848125 DMS2Q9G Thymic cancer 2C27 Phase 2 [41]
TG02 DMZFIGQ Anaplastic astrocytoma 2A00.0 Phase 1/2 [42]
NUV-422 DMQJQNT Malignant glioma 2A00.0 Phase 1/2 [43]
RGB-286638 DMEGOQP Haematological malignancy 2B33.Y Phase 1 [28]
FN-1501 DM7BMD6 Solid tumour/cancer 2A00-2F9Z Phase 1 [44]
AG-024322 DMY4WVK Solid tumour/cancer 2A00-2F9Z Phase 1 [26]
PHA-793887 DM2Y4FG Solid tumour/cancer 2A00-2F9Z Phase 1 [29]
SNS-032 DMEITAS Solid tumour/cancer 2A00-2F9Z Phase 1 [45]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [46]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [47]
Regorafenib DMHSY1I Gastrointestinal stromal tumour 2B5B Approved [48]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [49]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [50]
Vandetanib DMRICNP Solid tumour/cancer 2A00-2F9Z Approved [24]
Pazopanib HCl DM6U9CQ Renal cell carcinoma 2C90 Approved [51]
Fruquintinib DMHOSCQ Colorectal cancer 2B91.Z Approved [52]
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [53]
Tivozanib DMUKC5L Renal cell carcinoma 2C90 Approved [54]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Apremilast DMTWS9E Psoriasis vulgaris EA90 Approved [55]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [56]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [57]
Ribociclib Succinate DM9CIUW Breast cancer 2C60-2C65 Approved [58]
Trilaciclib DMP5A4T Small-cell lung cancer 2C25.Y Approved [59]
LEE011 DMMX75K Breast cancer 2C60-2C65 Phase 3 [60]
Ro 31-7453 DM83QCL Solid tumour/cancer 2A00-2F9Z Phase 2 [24]
P276-00 DM9DJL2 Mantle cell lymphoma 2A85.5 Phase 2 [26]
P-276 DMMJUHD Breast cancer 2C60-2C65 Phase 2 [61]
G1T38 DMQO2IT Breast cancer 2C60-2C65 Phase 2 [14]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Apremilast DMTWS9E Psoriasis vulgaris EA90 Approved [55]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [56]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [57]
Ribociclib Succinate DM9CIUW Breast cancer 2C60-2C65 Approved [58]
Trilaciclib DMP5A4T Small-cell lung cancer 2C25.Y Approved [59]
LEE011 DMMX75K Breast cancer 2C60-2C65 Phase 3 [60]
G1T38 DMQO2IT Breast cancer 2C60-2C65 Phase 2 [14]
GLR2007 DM7DWLY Glioblastoma of brain 2A00.00 Phase 1/2 [62]
FCN-437 DMQ8VUW Breast cancer 2C60-2C65 Phase 1/2 [63]
NUV-422 DMQJQNT Malignant glioma 2A00.0 Phase 1/2 [43]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
AKB-9778 DMKNRYH Diabetic macular edema 9B71.02 Phase 2 [64]
DCC-2036 DMJKFNU Chronic myeloid leukaemia 2A20 Phase 1/2 [14]
Altiratinib DMUJCBT Solid tumour/cancer 2A00-2F9Z Phase 1 [65]
CEP-11981 DMYDTJ6 Solid tumour/cancer 2A00-2F9Z Phase 1 [66]
ARRY-614 DMXD93K Arthritis FA20 Discontinued in Phase 1 [67]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione DMDO175 Discovery agent N.A. Investigative [1]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione DMGC7RY Discovery agent N.A. Investigative [1]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione DM3EV9N Discovery agent N.A. Investigative [1]
PMID21561767C8h DMABZH6 Discovery agent N.A. Investigative [68]
(4-Phenoxy-phenyl)-quinazolin-4-yl-amine DMFO8DR Discovery agent N.A. Investigative [69]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
HKI-272 DM6QOVN Breast cancer 2C60-2C65 Phase 3 [70]
BMS-690514 DMX302C Chronic pain MG30 Phase 2 [71]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione DMDO175 Discovery agent N.A. Investigative [1]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione DMGC7RY Discovery agent N.A. Investigative [1]
BMS-536924 DMXJB4N Discovery agent N.A. Investigative [11]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione DM3EV9N Discovery agent N.A. Investigative [1]
PMID24915291C38 DMBXT9J Discovery agent N.A. Investigative [72]
Geldanamycin-estradiol hybrid DMUSJ96 Discovery agent N.A. Investigative [73]
CL-387785 DMLKFZC Discovery agent N.A. Investigative [74]
HDS-029 DMLRUVA Discovery agent N.A. Investigative [74]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
KENPAULLONE DMAGVXW Discovery agent N.A. Patented [32]
RO-316233 DMAGLPW Discovery agent N.A. Investigative [75]
Bisindolylmaleimide-I DMOQJZC Discovery agent N.A. Investigative [75]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione DMDO175 Discovery agent N.A. Investigative [1]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione DMGC7RY Discovery agent N.A. Investigative [1]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione DM3EV9N Discovery agent N.A. Investigative [1]
AZAKENPAULLONE DM61H07 Discovery agent N.A. Investigative [76]
Thieno analogue of kenpaullone DMIOTHG Discovery agent N.A. Investigative [76]
3,4-bis(indol-3-yl)maleimide derivative DMEQ1HC Discovery agent N.A. Investigative [75]
4-(Quinolin-4-yl)-N-p-tolylpyrimidin-2-amine DMDW3SX Discovery agent N.A. Investigative [77]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Angiopoietin 1 receptor (TEK) TT9VGXW TIE2_HUMAN Inhibitor [1]
Cyclin-dependent kinase 1 (CDK1) TTH6V3D CDK1_HUMAN Inhibitor [1]
Cyclin-dependent kinase 2 (CDK2) TT7HF4W CDK2_HUMAN Inhibitor [1]
Cyclin-dependent kinase 4 (CDK4) TT0PG8F CDK4_HUMAN Inhibitor [1]
Cyclin-dependent kinase 6 (CDK6) TTO0FDJ CDK6_HUMAN Inhibitor [1]
Epidermal growth factor receptor (EGFR) TTGKNB4 EGFR_HUMAN Inhibitor [1]
ERBB2 messenger RNA (HER2 mRNA) TTR5TV4 ERBB2_HUMAN Inhibitor [1]
G1/S-specific cyclin-D1 (CCND1) TTFCJ7S CCND1_HUMAN Inhibitor [1]
G1/S-specific cyclin-E1 (CCNE1) TTCEJ4F CCNE1_HUMAN Inhibitor [1]
G2/mitotic-specific cyclin B1 (CCNB1) TT9P6OW CCNB1_HUMAN Inhibitor [1]
Protein kinase C alpha (PRKCA) TTFJ8Q1 KPCA_HUMAN Inhibitor [1]
Protein kinase C epsilon (PRKCE) TTBZ7OD KPCE_HUMAN Inhibitor [1]
Protein kinase C gamma (PRKCG) TTRFOXJ KPCG_HUMAN Inhibitor [1]
Vascular endothelial growth factor receptor 2 (KDR) TTUTJGQ VGFR2_HUMAN Inhibitor [1]

References

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65 Clinical pipeline report, company report or official report of Deciphera Pharmaceuticals.
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67 Cmpany report (Arraybiopharma)
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