Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQXPA5)

• Drug Name: DNQX Drug Info
• Synonyms: dnqx; 2379-57-9; 6,7-dinitro-1,4-dihydroquinoxaline-2,3-dione; FG-9041; FG 9041; UNII-62T278S1MX; 6,7-Dinitroquinoxaline-2,3-dione (DNQX); 2,3-Quinoxalinedione, 1,4-dihydro-6,7-dinitro-; 6,7-Dinitroquinoxaline-2,3(1H,4H)-dione; 62T278S1MX; 6,7-Dinitro-1,4-dihydro-quinoxaline-2,3-dione; SR-01000075442; 1ftl; Tocris-0189; AC1MZKE9; Lopac-D-0540; Biomol-NT_000182; Oprea1_127694; Lopac0_000345; MLS000705107; SCHEMBL594575; SCHEMBL8128055; BPBio1_001176; CHEMBL155265; C8H4N4O6; CHEBI:93492; CTK8F7031; DTXSID60178476; MolPort-003-846-931

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 3899541
  ChEBI ID: CHEBI:93492
  CAS Number: CAS 2379-57-9
  TTD Drug ID: DMQXPA5

Molecule-Related Drug Atlas

Drug(s) Targeting Glutamate receptor ionotropic NMDA 2A (NMDAR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glycine	DMIOZ29	Allergic rhinitis	CA08.0	Approved	[3]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[4]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[5]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[6]
L-689560	DMCVY4U	Neurodegenerative disorder	8A20-8A23	Terminated	[7]
L-698544	DMLRBN1	Alzheimer disease	8A20	Terminated	[8]
DIZOCILPINE	DMMGYXR	Cerebrovascular ischaemia	8B1Z	Terminated	[9]
RPR-104632	DM9L50N	N. A.	N. A.	Terminated	[10]
L-698532	DMO9HM7	Neurological disorder	6B60	Terminated	[11]
L-695902	DMT1DNS	N. A.	N. A.	Terminated	[8]

Drug(s) Targeting Glutamate receptor AMPA 1 (GRIA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
E-2007	DMJDYNQ	Diabetic neuropathy	8C0Z	Approved	[12]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[13]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[14]
Farampator	DM76GRQ	Major depressive disorder	6A70.3	Discontinued in Phase 1	[15]
GYKI-52466	DM3YG5P	Alzheimer disease	8A20	Terminated	[16]
GYKI-53655	DMC0JN8	N. A.	N. A.	Terminated	[17]
Zonampanel	DM70HZD	N. A.	N. A.	Terminated	[14]
SORETOLIDE	DMTDLHG	Convulsion	8A68.Z	Terminated	[18]
[3H]kainate	DMMK7XU	Discovery agent	N.A.	Investigative	[19]
RPR-118723	DMLDWCB	Discovery agent	N.A.	Investigative	[10]

Drug(s) Targeting Glutamate receptor AMPA (GRIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[20]
E-2007	DMJDYNQ	Diabetic neuropathy	8C0Z	Approved	[21]
Zopiclone	DMPI6Z0	Insomnia	7A00-7A0Z	Approved	[22]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[23]
Enflurane	DM0YJSB	Anaesthesia	9A78.6	Approved	[24]
Isoflurane	DMY6T31	Anaesthesia	9A78.6	Approved	[25]
Bromazepam	DMY9TCW	Anxiety disorder	6B00-6B0Z	Approved	[26]
Artemisinin SP	DMFETDK	Malaria	1F40-1F45	Approved	[27]
Dihydroergotoxine	DM5D6WZ	Alzheimer disease	8A20	Approved	[28]
Barbiturate	DMJIA6T	Anaesthesia	9A78.6	Approved	[29]

Drug(s) Targeting Glutamate receptor ionotropic NMDA 1 (NMDAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cycloserine	DMT1I52	Bacterial infection	1A00-1C4Z	Approved	[30]
D-Serine	DM3YH4I	N. A.	N. A.	Phase 4	[31]
ELIPRODIL	DMIOGZM	Multiple sclerosis	8A40	Phase 2	[32]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[4]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[5]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[6]
L-689560	DMCVY4U	Neurodegenerative disorder	8A20-8A23	Terminated	[33]
L-698544	DMLRBN1	Alzheimer disease	8A20	Terminated	[8]
DIZOCILPINE	DMMGYXR	Cerebrovascular ischaemia	8B1Z	Terminated	[9]
RPR-104632	DM9L50N	N. A.	N. A.	Terminated	[10]

Drug(s) Targeting Glutamate receptor ionotropic kainate 1 (GRIK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[34]
LY293558	DM4N6EK	Pain	MG30-MG3Z	Phase 2	[35]
NS 1209	DM9EFH0	Epilepsy	8A60-8A68	Phase 2	[36]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[5]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[5]
[3H]kainate	DMMK7XU	Discovery agent	N.A.	Investigative	[37]
[3H]quisqualate	DMDQBTX	Discovery agent	N.A.	Investigative	[38]
SYM2081	DM30WDL	Discovery agent	N.A.	Investigative	[37]
dysiherbaine	DM0EBAF	Discovery agent	N.A.	Investigative	[37]
domoic acid	DMYPVO0	Discovery agent	N.A.	Investigative	[37]

Drug(s) Targeting Glutamate receptor ionotropic NMDA 2B (NMDAR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alpha 1-PI	DMXC1K9	Alpha-1 antitrypsin deficiency	5C5A	Approved	[39]
ELIPRODIL	DMIOGZM	Multiple sclerosis	8A40	Phase 2	[32]
CP-101,606	DMIU19E	Parkinson disease	8A00.0	Phase 2	[40]
CERC-301	DMSABRI	Major depressive disorder	6A70.3	Phase 2	[41]
RGH-896	DMCHZAN	Peripheral neuropathy	8C0Z	Phase 2	[42]
MIJ821	DMN45RI	Major depressive disorder	6A70.3	Phase 2	[43]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[4]
Neu-2000	DMNJTLC	Cardiac arrest	MC82	Phase 1	[44]
EVT100	DMAKWQD	Major depressive disorder	6A70.3	Phase 1	[45]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[5]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate receptor AMPA (GRIA)	TTAN6JD	NOUNIPROTAC	Inhibitor	[2]
Glutamate receptor AMPA 1 (GRIA1)	TTVPQTF	GRIA1_HUMAN	Inhibitor	[2]
Glutamate receptor ionotropic kainate 1 (GRIK1)	TT0MYE2	GRIK1_HUMAN	Inhibitor	[2]
Glutamate receptor ionotropic NMDA 1 (NMDAR1)	TTLD29N	NMDZ1_HUMAN	Inhibitor	[1]
Glutamate receptor ionotropic NMDA 2A (NMDAR2A)	TTKJEMQ	NMDE1_HUMAN	Inhibitor	[1]
Glutamate receptor ionotropic NMDA 2B (NMDAR2B)	TTN9D8E	NMDE2_HUMAN	Inhibitor	[1]

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