Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTAREC)

• Drug Name: Rimexolone Drug Info
• Synonyms: Rimexolone (sustained release intra-articular steroid suspension, Plexis, arthritis)

Indication

Disease Entry	ICD 11	Status	REF
Arthritis	FA20	Approved	[1]
Uveitis	9A96.Z	Investigative	[2]

• Cross-matching ID:
  PubChem CID: 5311412
  ChEBI ID: CHEBI:135566
  CAS Number: CAS 49697-38-3
  TTD Drug ID: DMTAREC
  INTEDE Drug ID: DR1426
  ACDINA Drug ID: D01394

Molecule-Related Drug Atlas

Drug(s) Targeting Estrogen-related receptor-alpha (ESRRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pregnenolone	DM6VFO1	Schizophrenia	6A20	Phase 4	[6]
D-5519	DM9FAJM	Asthma	CA23	Phase 3	[7]
Dexamethasone palmitate	DMCMT4V	Choroidal neovascularization	9B76	Phase 1/2	[8]
RPR-106541	DMRGC5B	Asthma	CA23	Discontinued in Phase 2	[9]
Rofleponide	DM6OSPQ	Allergic rhinitis	CA08.0	Discontinued in Phase 2	[10]
AD-121	DMB8XJM	Rheumatoid arthritis	FA20	Discontinued in Phase 1/2	[3]
GW-250495	DMWJZAP	Asthma	CA23	Discontinued in Phase 1	[3]
PLD-177	DMPHUBO	Allergic rhinitis	CA08.0	Terminated	[3]
Steroid hormone conjugates	DMOJM08	Cachexia	MG20	Terminated	[11]
daidzein	DMRFTJX	Discovery agent	N.A.	Investigative	[12]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[13]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[14]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[15]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[18]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[19]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[20]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[14]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[21]

Drug(s) Affected By T-cell surface glycoprotein CD4 (CD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[5]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[25]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[26]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[27]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[28]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[25]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[30]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[31]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[32]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[35]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[36]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[37]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Estrogen-related receptor-alpha (ESRRA)	TTPNQAC	ERR1_HUMAN	Modulator	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
NF-kappa-B inhibitor alpha (NFKBIA)	OTFT924M	IKBA_HUMAN	Gene/Protein Processing	[5]
T-cell surface glycoprotein CD4 (CD4)	OT7Z5LNF	CD4_HUMAN	Gene/Protein Processing	[5]

References

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• [2] Rimexolone FDA Label
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