Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTYBC9)

• Drug Name: OXAMATE Drug Info
• Synonyms: Oxamic acid; OXAMIC ACID; 471-47-6; 2-Amino-2-oxoacetic acid; oxamate; Acetic acid, aminooxo-; Oxalamic acid; Oxamidic acid; Oxalic acid monoamide; amino(oxo)acetic acid; Aminooxoacetic acid; Glycine, 2-oxo-; Oxamate (repellent); Glyoxylic acid, amino-; Formic acid, carbamoyl-; UNII-QU60N5OPLG; Oxamate, (aminocarbonyl)-; carbamoylformic acid; Formic acid, (aminocarbonyl)-; QU60N5OPLG; Oxamate (insect repellant); Acetic acid, 2-amino-2-oxo-; CHEBI:18058; Oxamic acid, 98%; OXM; C2H3NO3; Oxalic monoamide; Oxamate, 3; EINECS 207-443-0; NSC 47001; Oxamic Acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 974
  ChEBI ID: CHEBI:18058
  CAS Number: CAS 471-47-6
  TTD Drug ID: DMTYBC9

Molecule-Related Drug Atlas

Drug(s) Targeting GABA transaminase (ABAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Alanine	DMZDN4W	Dietary shortage	5B5K	Approved	[4]
Pyridoxal Phosphate	DMO2K0J	Malnutrition	5B50-5B71	Approved	[4]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[4]
Vigabatrin	DMYT0OG	Alcohol dependence	6C40.2	Approved	[5]
Divalproex sodium	DM4RK0G	Seizure disorder	8A6Z	Approved	[4]
CPP-115	DMK9NQI	Tourette syndrome	8A05.00	Phase 2	[6]
K-828-AB	DMJLNZQ	Dementia	6D80-6D86	Phase 2	[7]
CPP -15	DMQCHU3	Infantile spasm	8A62.0	Phase 1	[6]
T83193	DMHO29Y	Discovery agent	N.A.	Patented	[8]
4-hydroxybenzaldehyde	DM471P5	Discovery agent	N.A.	Patented	[9]

Drug(s) Targeting L-lactate dehydrogenase (LDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[1]
3,7-DIHYDROXYNAPHTHALENE-2-CARBOXYLIC ACID	DMJ0654	Discovery agent	N.A.	Investigative	[10]
4-Hydroxy-1,2,5-Oxadiazole-3-Carboxylic Acid	DM6WJ4K	Discovery agent	N.A.	Investigative	[1]
3-Hydroxyisoxazole-4-Carboxylic Acid	DMKLZXV	Discovery agent	N.A.	Investigative	[1]
Naphthalene-2,6-disulfonic acid	DMLHWNG	Discovery agent	N.A.	Investigative	[11]
4-Hydroxy-1,2,5-Thiadiazole-3-Carboxylic Acid	DME29PX	Discovery agent	N.A.	Investigative	[1]

Drug(s) Affected By L-lactate dehydrogenase A chain (LDHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[12]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[13]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[14]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[17]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[18]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[21]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA transaminase (ABAT)	TTT2LD9	GABT_HUMAN	Inhibitor	[2]
L-lactate dehydrogenase (LDH)	TTAZHU0	LDHA_HUMAN; LDHB_HUMAN; LDHC_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
L-lactate dehydrogenase A chain (LDHA)	OTN7K4XB	LDHA_HUMAN	Gene/Protein Processing	[3]

References

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• [2] Aminomethyl-1,2,4-benzothiadiazines as potential analogues of gamma-aminobutyric acid. Unexpected discovery of a taurine antagonist. J Med Chem. 1982 Feb;25(2):113-6.
• [3] Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells. J Med Chem. 2011 Mar 24;54(6):1599-612. doi: 10.1021/jm101007q. Epub 2011 Feb 18.
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• [6] Clinical pipeline report, company report or official report of Catalyst Pharma.
• [7] Phase II clinical trial of K-828-AB for treating behavioral and psychological symptoms of dementia. Kowa Co. Ltd.
• [8] Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. Bioorg Med Chem Lett. 2006 Feb;16(3):592-5.
• [9] Inactivation of GABA transaminase by 3-chloro-1-(4-hydroxyphenyl)propan-1-one. Bioorg Med Chem Lett. 2009 Feb 1;19(3):731-4.
• [10] DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
• [11] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [12] Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
• [13] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [14] Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
• [15] Quercetin acts via the G3BP1/YWHAZ axis to inhibit glycolysis and proliferation in oral squamous cell carcinoma. Toxicol Mech Methods. 2023 Feb;33(2):141-150. doi: 10.1080/15376516.2022.2103480. Epub 2022 Aug 9.
• [16] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [17] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [18] Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
• [19] 1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells. Cell Struct Funct. 2005;30(1):1-6. doi: 10.1247/csf.30.1.
• [20] Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2011 Mar;120(1):109-22.
• [21] Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.