Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMU6L4I)

• Drug Name: AZD-7545 Drug Info
• Synonyms: AZD7545; 252017-04-2; 4-[(3-Chloro-4-{[(2r)-3,3,3-Trifluoro-2-Hydroxy-2-Methylpropanoyl]amino}phenyl)sulfonyl]-N,N-Dimethylbenzamide; 4-{3-chloro-4-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamido]benzenesulfonyl}-N,N-dimethylbenzamide; DTDZLJHKVNTQGZ-GOSISDBHSA-N; AZD-7545; AZD 7545; 2q8g; C19H18ClF3N2O5S; GTPL9362; SCHEMBL6350247; AOB6866; MolPort-035-395-876; ZINC1547088; EX-A1208; AZD-7547; BCP07524; KS-00000RM2; s7517; 2244AH; AZD 7545;AZD-7545; AKOS027326647; DB07403; CS-1740; NCGC00250391-07; NCGC00250391-01; HY-16082

Indication

Disease Entry	ICD 11	Status	REF
Diabetic complication	5A2Y	Terminated	[1]

• Cross-matching ID:
  PubChem CID: 16741245
  TTD Drug ID: DMU6L4I

Molecule-Related Drug Atlas

Drug(s) Affected By Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[5]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[7]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[8]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[10]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[11]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[12]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[13]

Drug(s) Affected By kinase isozyme 3, mitochondrial (PDK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[15]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[19]
Tramadol	DMRQD04	Osteoarthritis	FA00-FA05	Approved	[20]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[13]

Drug(s) Affected By kinase isozyme 4, mitochondrial (PDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[25]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[26]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[26]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[7]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Pyruvate dehydrogenase kinase 2 (PDHK2)	TTJGCKM	PDK2_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
kinase isozyme 3, mitochondrial (PDK3)	OTCPSTID	PDK3_HUMAN	Gene/Protein Processing	[3]
kinase isozyme 4, mitochondrial (PDK4)	OTCMHMBZ	PDK4_HUMAN	Gene/Protein Processing	[3]
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1)	OTGEU8IK	ODPA_HUMAN	Post-Translational Modifications	[3]

References

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• [12] Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
• [13] Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
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• [15] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
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• [19] Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
• [20] Comparative study of the neurotoxicological effects of tramadol and tapentadol in SH-SY5Y cells. Toxicology. 2016 Jun 1;359-360:1-10. doi: 10.1016/j.tox.2016.06.010. Epub 2016 Jun 15.
• [21] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [22] Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
• [23] The PPAR gamma agonist troglitazone induces musclin mRNA expression in human myotubes. Horm Metab Res. 2006 Sep;38(9):614-6. doi: 10.1055/s-2006-951310.
• [24] Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression. Biochim Biophys Acta. 2006 Mar-Apr;1759(3-4):141-51. doi: 10.1016/j.bbaexp.2006.04.005. Epub 2006 Apr 27.
• [25] Role of sirtuin 1 in the regulation of hepatic gene expression by thyroid hormone. J Biol Chem. 2013 Jan 11;288(2):807-18. doi: 10.1074/jbc.M112.437970. Epub 2012 Dec 3.
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• [27] Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.