Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVJK9W)

Drug Name
Eicosadienoic acid Drug Info
Synonyms
Eicosadienoic acid; HOMO-GAMMA-LINOLEICACID; Homo-gamma-linoleic acid; Icosadienoic acid; SCHEMBL416181; cis-11,14-Eicosadienoic acid; cis-11,14-eicosadienoicacid; (11Z,14Z)-Eicosa-11,14-dienoic acid; (11Z,14Z)-Icosa-11,14-dienoic acid; (11Z,14Z)-icosadienoic acid; 11, 14-icosadienoate; 11, 14-icosadienoic acid; 11,14-Eicosadienoate; 11,14-Eicosadienoic acid, (Z,Z)-; 11,14-Icosadienoic acid; 11C,14C-Eicosadienoic acid; 11Z,14Z-eicosadienoic acid; 2091-39-6; 5598-38-9; AC1O5SJA; BSPBio_001326; CHEBI:73731; CHEMBL464983; FA 20:2
Cross-matching ID
PubChem CID
6439848
ChEBI ID
CHEBI:73731
CAS Number
CAS 5598-38-9
TTD Drug ID
DMVJK9W
INTEDE Drug ID
DR1989

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Prostaglandin G/H synthase 1 (COX-1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [2]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [3]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [2]
Diazepam DM08E9O Alcohol withdrawal Approved [2]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [2]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [2]
Nateglinide DMLK2QH Diabetic complication 5A2Y Approved [2]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [2]
Ketobemidone DMM3L6Z Pain MG30-MG3Z Approved [2]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [2]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Prostaglandin G/H synthase 2 (COX-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [3]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [2]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [1]
Epanova DMHEAGL Hypertriglyceridemia 5C80.1 Approved [4]
Gamma-Homolinolenic acid DMSXKYG Malnutrition 5B50-5B71 Approved [1]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [1]
Omega-6-FA DMBWY8V N. A. N. A. Phase 3 [5]
Arachidonic Acid DMUOQZD Discovery agent N.A. Investigative [6]
alpha-linolenic acid DMY64HE Discovery agent N.A. Investigative [1]
Icosapentum DMF1CM7 N. A. N. A. Investigative [1]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Prostaglandin G/H synthase 2 (COX-2) DE492CE PGH2_HUMAN Substrate [1]
Prostaglandin G/H synthase 1 (COX-1) DE073H6 PGH1_HUMAN Substrate [1]

References

1 Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J. 2006 Jun;20(8):1097-108.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 Peroxidative free radical formation and O-demethylation of etoposide(VP-16) and teniposide(VM-26). Biochem Biophys Res Commun. 1986 Feb 26;135(1):215-20.
4 Structural basis of fatty acid substrate binding to cyclooxygenase-2. J Biol Chem. 2010 Jul 16;285(29):22152-63.
5 Health implications of high dietary omega-6 polyunsaturated Fatty acids. J Nutr Metab. 2012;2012:539426.
6 PharmGKB summary: very important pharmacogene information for PTGS2. Pharmacogenet Genomics. 2011 Sep;21(9):607-13.