Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZ7N8D)

Drug Name
XCT790 Drug Info
Synonyms XCT 790; XCT-790
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
6918788
ChEBI ID
CHEBI:79999
CAS Number
CAS 725247-18-7
TTD Drug ID
DMZ7N8D

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Estrogen-related receptor-alpha (ESRRA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rimexolone DMTAREC Arthritis FA20 Approved [5]
Pregnenolone DM6VFO1 Schizophrenia 6A20 Phase 4 [6]
D-5519 DM9FAJM Asthma CA23 Phase 3 [7]
Dexamethasone palmitate DMCMT4V Choroidal neovascularization 9B76 Phase 1/2 [8]
RPR-106541 DMRGC5B Asthma CA23 Discontinued in Phase 2 [9]
Rofleponide DM6OSPQ Allergic rhinitis CA08.0 Discontinued in Phase 2 [10]
AD-121 DMB8XJM Rheumatoid arthritis FA20 Discontinued in Phase 1/2 [5]
GW-250495 DMWJZAP Asthma CA23 Discontinued in Phase 1 [5]
PLD-177 DMPHUBO Allergic rhinitis CA08.0 Terminated [5]
Steroid hormone conjugates DMOJM08 Cachexia MG20 Terminated [11]
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Drug(s) Affected By Cytochrome c oxidase subunit 8A, mitochondrial (COX8A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carfilzomib DM48K0X Multiple myeloma 2A83 Approved [3]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [12]
Bortezomib DMNO38U Leukemia Approved [3]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [13]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [14]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [15]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [16]
3R14S-OCHRATOXIN A DM2KEW6 Discovery agent N.A. Investigative [17]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [18]
Milchsaure DM462BT Pruritus EC90 Investigative [19]
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Drug(s) Affected By Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [20]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [21]
Methotrexate DM2TEOL Anterior urethra cancer Approved [22]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [23]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [12]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [24]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [25]
Mitotane DMU1GX0 Adrenocortical carcinoma 2D11.Z Approved [26]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [27]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [28]
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Drug(s) Affected By Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [29]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [30]
Panobinostat DM58WKG Chronic graft versus host disease Approved [31]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [12]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [24]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [32]
Bortezomib DMNO38U Leukemia Approved [3]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [3]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [33]
Arsenic DMTL2Y1 N. A. N. A. Approved [34]
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Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [35]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [38]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [39]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [40]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [41]
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [43]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [44]
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Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [46]
Fructose DM43AN2 Vomiting MD90 Approved [47]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [48]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [23]
Ketotifen DM74XKS Allergic conjunctivitis 9A60.02 Approved [50]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [51]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [51]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Estrogen-related receptor-alpha (ESRRA) TTPNQAC ERR1_HUMAN Antagonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) OTU0FC24 COX41_HUMAN Gene/Protein Processing [3]
Cytochrome c oxidase subunit 8A, mitochondrial (COX8A) OTU0NR39 COX8A_HUMAN Gene/Protein Processing [3]
Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A) OT5QQB5L IDH3A_HUMAN Gene/Protein Processing [3]
Peroxisome proliferator-activated receptor alpha (PPARA) OTK095PP PPARA_HUMAN Gene/Protein Processing [3]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) OTHCDQ22 PRGC1_HUMAN Gene/Protein Processing [4]

References

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22 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
23 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
24 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
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26 Mitotane alters mitochondrial respiratory chain activity by inducing cytochrome c oxidase defect in human adrenocortical cells. Endocr Relat Cancer. 2013 May 21;20(3):371-81.
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29 Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
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