Details of the Drug

General Information of Drug (ID: DMTK234)

• Drug Name: Piroxicam
• Synonyms: Akten; Artroxicam; Bruxicam; Caliment; Erazon; Felden; Feldene; Flogobene; Geldene; Improntal; Larapam; Pipoxicam; Pirkam; Piroflex; Piroftal; Piroxicamum; Pyroxycam; Reudene; Riacen; Roxicam; Roxiden; Sasulen; Solocalm; Zunden; Feldene Fast; Feldene Gel; Piroxicam usp; AK1015; CHF 1251; CP 16171; CP16171; P 5654; Apo-Piroxicam; Brexidol (TN); Brexin (TN); CP-16171; Erazon (TN); Exipan (TN); Felden (TN); Feldene (TN); Feldoral (TN); Hotemin (TN); Mobilis (TN); Pirox von ct (TN); Piroxicamum [INN-Latin]; Proponol (TN); Reumador (TN); Tracam (TN); Veral (TN); Vurdon (TN); Feldene, Roxam, Piroxicam; Piroxicam (JP15/USP/INN); Piroxicam [USAN:BAN:INN:JAN]; (3E)-3-[hydroxy-(pyridin-2-ylamino)methylidene]-2-methyl-1,1-dioxo-1; (4-Hydroxy-2-methyl-1,1-dioxobenzo[e]1,2-thiazin-3-yl)-N-(2-pyridyl)carboxamide; 2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide; 3-[hydroxy(pyridin-2-ylamino)methylidene]-2-methyl-3,4-dihydro-2H-1; 4-Hydroxy-2-methyl-3-(pyrid-2-yl-carbamoyl)-2H-1,2-benzothiazine 1,1-dioxide; 4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazin-3-caboxyamid-1,1-dioxid; 4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazin-3-caboxyamid-1,1-dioxid [German]; 4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide; 4-Hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide; 4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide; 4-hydroxy-2-methyl-N-pyridin-2-yl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide

Indication

Disease Entry	ICD 11	Status	REF
Osteoarthritis	FA00-FA05	Approved	[1]
Pain	MG30-MG3Z	Approved	[2]

• Therapeutic Class: Analgesics
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 331.3
  Logarithm of the Partition Coefficient (xlogp); 3.1
  Rotatable Bond Count (rotbonds); 2
  Hydrogen Bond Donor Count (hbonddonor); 2
  Hydrogen Bond Acceptor Count (hbondacc); 6
• ADMET Property:
  Absorption: The drug is well absorbed after oral administration []
  BDDCS Class: Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 2: low solubility and high permeability [3]
  Bioavailability: 99% of drug becomes completely available to its intended biological destination(s) [4]
  Elimination: 5% of drug is excreted from urine in the unchanged form [3]
  Half-life: The concentration or amount of drug in body reduced by one-half in 30 - 86 hours [5]
  Metabolism: The drug is metabolized via renal []
  MRTD: The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 1.51 micromolar/kg/day [6]
  Vd: The volume of distribution (Vd) of drug is 0.14 L/kg []
  Water Solubility: The ability of drug to dissolve in water is measured as 0.0073 mg/mL [3]

Adverse Drug Reaction (ADR)

ADR Term	Variation	Related DOT	DOT ID	REF
Hepatic function abnormal	Not Available	GYS1	OTJZJRWK	[7]

• Chemical Identifiers:
  Formula: C15H13N3O4S
  IUPAC Name: 4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-yl-1lambda6,2-benzothiazine-3-carboxamide
  Canonical SMILES: CN1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)NC3=CC=CC=N3
  InChI: InChI=1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20)
  InChIKey: QYSPLQLAKJAUJT-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 54676228
  ChEBI ID: CHEBI:8249
  CAS Number: 36322-90-4
  DrugBank ID: DB00554
  TTD ID: D00IBN
  VARIDT ID: DR00481
  INTEDE ID: DR1300
  ACDINA ID: D00537
• Repurposed Drugs (RPD): Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin G/H synthase 1 (COX-1)	TT8NGED	PGH1_HUMAN	Modulator	[8]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[9]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[10]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
10 kDa heat shock protein, mitochondrial (HSPE1)	OT7JSZLB	CH10_HUMAN	Gene/Protein Processing	[11]
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1)	OTO7FJA9	DHI1_HUMAN	Gene/Protein Processing	[12]
14-3-3 protein beta/alpha	OTGBS3RF	1433B_HUMAN	Gene/Protein Processing	[11]
26S proteasome non-ATPase regulatory subunit 12 (PSMD12)	OTWICA51	PSD12_HUMAN	Gene/Protein Processing	[11]
26S proteasome regulatory subunit 7 (PSMC2)	OTJ4V337	PRS7_HUMAN	Gene/Protein Processing	[11]
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP)	OTSMGKXQ	EBP_HUMAN	Gene/Protein Processing	[11]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[11]
40-kDa huntingtin-associated protein (F8A1)	OTXTQ59R	HAP40_HUMAN	Gene/Protein Processing	[11]
6-phosphogluconolactonase (PGLS)	OTO6C0IQ	6PGL_HUMAN	Gene/Protein Processing	[11]
A-kinase anchor protein 12 (AKAP12)	OTCVRDDX	AKA12_HUMAN	Gene/Protein Processing	[11]

Molecular Expression Atlas of This Drug

• The Studied Disease: Osteoarthritis
• ICD Disease Classification: FA00-FA05

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Prostaglandin G/H synthase 1 (COX-1)	DTT	PTGS1	3.97E-03	0.16	0.43
Cytochrome P450 2C8 (CYP2C8)	DME	CYP2C8	1.82E-04	-1.35E-01	-5.84E-01
Cytochrome P450 2C9 (CYP2C9)	DME	CYP2C9	1.90E-01	-9.81E-03	-5.96E-02

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Piroxicam

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Disease	REF
Aspirin	DM672AH	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Piroxicam and Aspirin.	Pain [MG30-MG3Z]	[13]

Coadministration of a Drug Treating the Disease Different from Piroxicam (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Remdesivir	DMBFZ6L	Moderate	Increased risk of hepatotoxicity by the combination of Piroxicam and Remdesivir.	1D6YCoronavirus Disease 2019 [1D6YCoronavirus Disease 2019]	[14]
Repaglinide	DM5SXUV	Moderate	Increased risk of hypoglycemia by the combination of Piroxicam and Repaglinide.	Acute diabete complication [5A2Y]	[15]
Glibenclamide	DM8JXPZ	Moderate	Increased risk of hypoglycemia by the combination of Piroxicam and Glibenclamide.	Acute diabete complication [5A2Y]	[15]
Tolazamide	DMIHRNA	Moderate	Increased risk of hypoglycemia by the combination of Piroxicam and Tolazamide.	Acute diabete complication [5A2Y]	[15]
Nateglinide	DMLK2QH	Moderate	Increased risk of hypoglycemia by the combination of Piroxicam and Nateglinide.	Acute diabete complication [5A2Y]	[15]
Glipizide	DMZA5PQ	Moderate	Increased risk of hypoglycemia by the combination of Piroxicam and Glipizide.	Acute diabete complication [5A2Y]	[15]
Arn-509	DMT81LZ	Moderate	Increased metabolism of Piroxicam caused by Arn-509 mediated induction of CYP450 enzyme.	Acute myeloid leukaemia [2A60]	[16]
Bedaquiline	DM3906J	Moderate	Increased risk of hepatotoxicity by the combination of Piroxicam and Bedaquiline.	Antimicrobial drug resistance [MG50-MG52]	[17]
Cilostazol	DMZMSCT	Moderate	Increased risk of bleeding by the combination of Piroxicam and Cilostazol.	Arterial occlusive disease [BD40]	[18]
Voriconazole	DMAOL2S	Moderate	Decreased metabolism of Piroxicam caused by Voriconazole mediated inhibition of CYP450 enzyme.	Aspergillosis [1F20]	[14]
Budesonide	DMJIBAW	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Piroxicam and Budesonide.	Asthma [CA23]	[19]
Ofloxacin	DM0VQN3	Moderate	Additive CNS stimulant effects by the combination of Piroxicam and Ofloxacin.	Bacterial infection [1A00-1C4Z]	[20]
Kanamycin	DM2DMPO	Moderate	Increased risk of nephrotoxicity by the combination of Piroxicam and Kanamycin.	Bacterial infection [1A00-1C4Z]	[21]
Trovafloxacin	DM6AN32	Moderate	Additive CNS stimulant effects by the combination of Piroxicam and Trovafloxacin.	Bacterial infection [1A00-1C4Z]	[20]
Streptomycin	DME1LQN	Moderate	Increased risk of nephrotoxicity by the combination of Piroxicam and Streptomycin.	Bacterial infection [1A00-1C4Z]	[21]
Gemifloxacin	DMHT34O	Moderate	Additive CNS depression effects by the combination of Piroxicam and Gemifloxacin.	Bacterial infection [1A00-1C4Z]	[20]
Norfloxacin	DMIZ6W2	Moderate	Additive CNS stimulant effects by the combination of Piroxicam and Norfloxacin.	Bacterial infection [1A00-1C4Z]	[20]
ABT-492	DMJFD2I	Moderate	Additive CNS depression effects by the combination of Piroxicam and ABT-492.	Bacterial infection [1A00-1C4Z]	[20]
Gentamicin	DMKINJO	Moderate	Increased risk of nephrotoxicity by the combination of Piroxicam and Gentamicin.	Bacterial infection [1A00-1C4Z]	[21]
Netilmicin	DMRD1QK	Moderate	Increased risk of nephrotoxicity by the combination of Piroxicam and Netilmicin.	Bacterial infection [1A00-1C4Z]	[21]
Levofloxacin	DMS60RB	Moderate	Additive CNS stimulant effects by the combination of Piroxicam and Levofloxacin.	Bacterial infection [1A00-1C4Z]	[20]
Tobramycin	DMUI0CH	Moderate	Increased risk of nephrotoxicity by the combination of Piroxicam and Tobramycin.	Bacterial infection [1A00-1C4Z]	[21]
Lomefloxacin	DMVRH9C	Moderate	Additive CNS stimulant effects by the combination of Piroxicam and Lomefloxacin.	Bacterial infection [1A00-1C4Z]	[20]
Etidronic acid	DM1XHYJ	Moderate	Increased risk of nephrotoxicity by the combination of Piroxicam and Etidronic acid.	Bone paget disease [FB85]	[22]
Risedronate	DM5FLTY	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Piroxicam and Risedronate.	Bone paget disease [FB85]	[22]
Alendronate	DMY2KX9	Moderate	Increased risk of nephrotoxicity by the combination of Piroxicam and Alendronate.	Bone paget disease [FB85]	[22]
Pexidartinib	DMS2J0Z	Major	Increased risk of hepatotoxicity by the combination of Piroxicam and Pexidartinib.	Bone/articular cartilage neoplasm [2F7B]	[23]
Alpelisib	DMEXMYK	Moderate	Increased metabolism of Piroxicam caused by Alpelisib mediated induction of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[24]
Trastuzumab Emtansine	DMU1LXS	Moderate	Increased risk of bleeding by the combination of Piroxicam and Trastuzumab Emtansine.	Breast cancer [2C60-2C6Y]	[18]
Iodipamide	DMXIQYS	Major	Increased risk of nephrotoxicity by the combination of Piroxicam and Iodipamide.	Cholelithiasis [DC11]	[25]
Regorafenib	DMHSY1I	Major	Increased risk of bleeding by the combination of Piroxicam and Regorafenib.	Colorectal cancer [2B91]	[16]
Drospirenone	DM1A9W3	Moderate	Increased risk of hyperkalemia by the combination of Piroxicam and Drospirenone.	Contraceptive management [QA21]	[26]
Methoxyflurane	DML0RAE	Moderate	Increased risk of nephrotoxicity by the combination of Piroxicam and Methoxyflurane.	Corneal disease [9A76-9A78]	[16]
Ardeparin	DMYRX8B	Major	Increased risk of bleeding by the combination of Piroxicam and Ardeparin.	Coronary thrombosis [BA43]	[27]
Mifepristone	DMGZQEF	Moderate	Decreased metabolism of Piroxicam caused by Mifepristone mediated inhibition of CYP450 enzyme.	Cushing syndrome [5A70]	[28]
Ivacaftor	DMZC1HS	Moderate	Decreased metabolism of Piroxicam caused by Ivacaftor mediated inhibition of CYP450 enzyme.	Cystic fibrosis [CA25]	[29]
MK-8228	DMOB58Q	Moderate	Increased metabolism of Piroxicam caused by MK-8228 mediated induction of CYP450 enzyme.	Cytomegaloviral disease [1D82]	[30]
Danaparoid	DM6CLBN	Major	Increased risk of bleeding by the combination of Piroxicam and Danaparoid.	Deep vein thrombosis [BD71]	[27]
Rivaroxaban	DMQMBZ1	Major	Increased risk of bleeding by the combination of Piroxicam and Rivaroxaban.	Deep vein thrombosis [BD71]	[31]
Aprepitant	DM053KT	Moderate	Increased metabolism of Piroxicam caused by Aprepitant mediated induction of CYP450 enzyme.	Depression [6A70-6A7Z]	[32]
Sertraline	DM0FB1J	Moderate	Increased risk of bleeding by the combination of Piroxicam and Sertraline.	Depression [6A70-6A7Z]	[33]
Vilazodone	DM4LECQ	Moderate	Increased risk of bleeding by the combination of Piroxicam and Vilazodone.	Depression [6A70-6A7Z]	[33]
Paroxetine	DM5PVQE	Moderate	Increased risk of bleeding by the combination of Piroxicam and Paroxetine.	Depression [6A70-6A7Z]	[33]
Vortioxetine	DM6F1PU	Moderate	Increased risk of bleeding by the combination of Piroxicam and Vortioxetine.	Depression [6A70-6A7Z]	[33]
Milnacipran	DMBFE74	Moderate	Increased risk of bleeding by the combination of Piroxicam and Milnacipran.	Depression [6A70-6A7Z]	[33]
Escitalopram	DMFK9HG	Moderate	Increased risk of bleeding by the combination of Piroxicam and Escitalopram.	Depression [6A70-6A7Z]	[33]
Desvenlafaxine	DMHD4PE	Moderate	Increased risk of bleeding by the combination of Piroxicam and Desvenlafaxine.	Depression [6A70-6A7Z]	[33]
Clomipramine	DMINRKW	Moderate	Increased risk of bleeding by the combination of Piroxicam and Clomipramine.	Depression [6A70-6A7Z]	[33]
PMID28870136-Compound-49	DMTUC9E	Moderate	Increased risk of bleeding by the combination of Piroxicam and PMID28870136-Compound-49.	Discovery agent [N.A.]	[34]
Fenfluramine	DM0762O	Moderate	Increased risk of bleeding by the combination of Piroxicam and Fenfluramine.	Epilepsy/seizure [8A61-8A6Z]	[33]
Cannabidiol	DM0659E	Moderate	Increased risk of hepatotoxicity by the combination of Piroxicam and Cannabidiol.	Epileptic encephalopathy [8A62]	[16]
Benzthiazide	DMQWZ0H	Moderate	Antagonize the effect of Piroxicam when combined with Benzthiazide.	Essential hypertension [BA00]	[35]
Tazemetostat	DMWP1BH	Moderate	Increased risk of bleeding by the combination of Piroxicam and Tazemetostat.	Follicular lymphoma [2A80]	[18]
Avapritinib	DMK2GZX	Major	Increased risk of bleeding by the combination of Piroxicam and Avapritinib.	Gastrointestinal stromal tumour [2B5B]	[16]
Sulfinpyrazone	DMEV954	Moderate	Increased risk of bleeding by the combination of Piroxicam and Sulfinpyrazone.	Gout [FA25]	[18]
Eplerenone	DMF0NQR	Moderate	Increased risk of hyperkalemia by the combination of Piroxicam and Eplerenone.	Heart failure [BD10-BD1Z]	[36]
Chlorothiazide	DMLHESP	Moderate	Antagonize the effect of Piroxicam when combined with Chlorothiazide.	Heart failure [BD10-BD1Z]	[35]
Furosemide	DMMQ8ZG	Moderate	Antagonize the effect of Piroxicam when combined with Furosemide.	Heart failure [BD10-BD1Z]	[35]
Amiloride	DMRTSGP	Moderate	Antagonize the effect of Piroxicam when combined with Amiloride.	Heart failure [BD10-BD1Z]	[35]
Bumetanide	DMRV7H0	Moderate	Antagonize the effect of Piroxicam when combined with Bumetanide.	Heart failure [BD10-BD1Z]	[35]
Hydroflumethiazide	DMVPUQI	Moderate	Antagonize the effect of Piroxicam when combined with Hydroflumethiazide.	Heart failure [BD10-BD1Z]	[35]
Rifapentine	DMCHV4I	Moderate	Increased metabolism of Piroxicam caused by Rifapentine mediated induction of CYP450 enzyme.	HIV-infected patients with tuberculosis [1B10-1B14]	[37]
Brentuximab vedotin	DMWLC57	Moderate	Increased risk of hepatotoxicity by the combination of Piroxicam and Brentuximab vedotin.	Hodgkin lymphoma [2B30]	[38]
Efavirenz	DMC0GSJ	Moderate	Increased risk of hepatotoxicity by the combination of Piroxicam and Efavirenz.	Human immunodeficiency virus disease [1C60-1C62]	[39]
Etravirine	DMGV8QU	Moderate	Decreased metabolism of Piroxicam caused by Etravirine mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[40]
Fenofibrate	DMFKXDY	Moderate	Decreased metabolism of Piroxicam caused by Fenofibrate mediated inhibition of CYP450 enzyme.	Hyper-lipoproteinaemia [5C80]	[14]
Mipomersen	DMGSRN1	Major	Increased risk of hepatotoxicity by the combination of Piroxicam and Mipomersen.	Hyper-lipoproteinaemia [5C80]	[41]
Teriflunomide	DMQ2FKJ	Major	Increased risk of hepatotoxicity by the combination of Piroxicam and Teriflunomide.	Hyper-lipoproteinaemia [5C80]	[42]
BMS-201038	DMQTAGO	Major	Increased risk of hepatotoxicity by the combination of Piroxicam and BMS-201038.	Hyper-lipoproteinaemia [5C80]	[43]
Indapamide	DMGN1PW	Moderate	Antagonize the effect of Piroxicam when combined with Indapamide.	Hypertension [BA00-BA04]	[35]
Trichlormethiazide	DMHAQCO	Moderate	Antagonize the effect of Piroxicam when combined with Trichlormethiazide.	Hypertension [BA00-BA04]	[35]
Hydrochlorothiazide	DMUSZHD	Moderate	Antagonize the effect of Piroxicam when combined with Hydrochlorothiazide.	Hypertension [BA00-BA04]	[44]
Dipyridamole	DMXY30O	Moderate	Increased risk of bleeding by the combination of Piroxicam and Dipyridamole.	Hypertension [BA00-BA04]	[18]
Potassium chloride	DMMTAJC	Moderate	Increased risk of hyperkalemia by the combination of Piroxicam and Potassium chloride.	Hypo-kalaemia [5C77]	[45]
Fludrocortisone	DMUDIR8	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Piroxicam and Fludrocortisone.	Hypo-osmolality/hyponatraemia [5C72]	[19]
Balsalazide	DM7I1T9	Moderate	Increased risk of nephrotoxicity by the combination of Piroxicam and Balsalazide.	Indeterminate colitis [DD72]	[46]
Methotrexate	DM2TEOL	Major	Increased risk of nephrotoxicity by the combination of Piroxicam and Methotrexate.	Leukaemia [2A60-2B33]	[47]
Porfimer Sodium	DM7ZWNY	Moderate	Increased risk of photosensitivity reactions by the combination of Piroxicam and Porfimer Sodium.	Lung cancer [2C25]	[48]
PF-06463922	DMKM7EW	Moderate	Increased metabolism of Piroxicam caused by PF-06463922 mediated induction of CYP450 enzyme.	Lung cancer [2C25]	[14]
Calaspargase pegol	DMQZBXI	Moderate	Increased risk of bleeding by the combination of Piroxicam and Calaspargase pegol.	Malignant haematopoietic neoplasm [2B33]	[49]
Idelalisib	DM602WT	Moderate	Increased risk of hepatotoxicity by the combination of Piroxicam and Idelalisib.	Mature B-cell leukaemia [2A82]	[50]
Acalabrutinib	DM7GCVW	Major	Increased risk of bleeding by the combination of Piroxicam and Acalabrutinib.	Mature B-cell lymphoma [2A85]	[51]
Clofarabine	DMCVJ86	Moderate	Increased risk of hepatotoxicity by the combination of Piroxicam and Clofarabine.	Mature B-cell lymphoma [2A85]	[16]
Ibrutinib	DMHZCPO	Major	Increased risk of bleeding by the combination of Piroxicam and Ibrutinib.	Mature B-cell lymphoma [2A85]	[52]
Ponatinib	DMYGJQO	Major	Increased risk of bleeding by the combination of Piroxicam and Ponatinib.	Mature B-cell lymphoma [2A85]	[53]
Dabrafenib	DMX6OE3	Moderate	Increased metabolism of Piroxicam caused by Dabrafenib mediated induction of CYP450 enzyme.	Melanoma [2C30]	[16]
Exjade	DMHPRWG	Major	Increased risk of nephrotoxicity by the combination of Piroxicam and Exjade.	Mineral absorption/transport disorder [5C64]	[54]
Panobinostat	DM58WKG	Major	Increased risk of bleeding by the combination of Piroxicam and Panobinostat.	Multiple myeloma [2A83]	[14]
Ruxolitinib	DM7Q98D	Moderate	Increased risk of bleeding by the combination of Piroxicam and Ruxolitinib.	Myeloproliferative neoplasm [2A20]	[18]
Dasatinib	DMJV2EK	Major	Increased risk of bleeding by the combination of Piroxicam and Dasatinib.	Myeloproliferative neoplasm [2A20]	[55]
Omacetaxine mepesuccinate	DMPU2WX	Major	Increased risk of bleeding by the combination of Piroxicam and Omacetaxine mepesuccinate.	Myeloproliferative neoplasm [2A20]	[56]
Prasugrel	DM7MT6E	Major	Increased risk of bleeding by the combination of Piroxicam and Prasugrel.	Myocardial infarction [BA41-BA43]	[16]
Vorapaxar	DMA16BR	Major	Increased risk of bleeding by the combination of Piroxicam and Vorapaxar.	Myocardial infarction [BA41-BA43]	[57]
Tirofiban	DMQG17S	Moderate	Increased risk of bleeding by the combination of Piroxicam and Tirofiban.	Myocardial infarction [BA41-BA43]	[58]
Sibutramine	DMFJTDI	Moderate	Increased risk of bleeding by the combination of Piroxicam and Sibutramine.	Obesity [5B80-5B81]	[33]
Dexfenfluramine	DMJ7YDS	Moderate	Increased risk of bleeding by the combination of Piroxicam and Dexfenfluramine.	Obesity [5B80-5B81]	[33]
Polythiazide	DMCH80F	Moderate	Antagonize the effect of Piroxicam when combined with Polythiazide.	Oedema [MG29]	[35]
Diclofenac	DMPIHLS	Moderate	Increased risk of hepatotoxicity by the combination of Piroxicam and Diclofenac.	Osteoarthritis [FA00-FA05]	[59]
Rucaparib	DM9PVX8	Moderate	Decreased metabolism of Piroxicam caused by Rucaparib mediated inhibition of CYP450 enzyme.	Ovarian cancer [2C73]	[60]
MK-4827	DMLYGH4	Moderate	Increased risk of bleeding by the combination of Piroxicam and MK-4827.	Ovarian cancer [2C73]	[16]
Prednisone	DM2HG4X	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Piroxicam and Prednisone.	Postoperative inflammation [1A00-CA43]	[19]
Hydrocortisone	DMGEMB7	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Piroxicam and Hydrocortisone.	Postoperative inflammation [1A00-CA43]	[19]
Enzalutamide	DMGL19D	Moderate	Increased metabolism of Piroxicam caused by Enzalutamide mediated induction of CYP450 enzyme.	Prostate cancer [2C82]	[61]
Bosentan	DMIOGBU	Moderate	Increased metabolism of Piroxicam caused by Bosentan mediated induction of CYP450 enzyme.	Pulmonary hypertension [BB01]	[62]
Epoprostenol	DMUTYR2	Moderate	Increased risk of bleeding by the combination of Piroxicam and Epoprostenol.	Pulmonary hypertension [BB01]	[63]
Iloprost	DMVPZBE	Moderate	Increased risk of bleeding by the combination of Piroxicam and Iloprost.	Pulmonary hypertension [BB01]	[63]
Temsirolimus	DMS104F	Major	Increased risk of nephrotoxicity by the combination of Piroxicam and Temsirolimus.	Renal cell carcinoma [2C90]	[64]
Gatifloxacin	DMSL679	Moderate	Additive CNS stimulant effects by the combination of Piroxicam and Gatifloxacin.	Respiratory infection [CA07-CA4Z]	[20]
Sulfasalazine	DMICA9H	Moderate	Increased risk of nephrotoxicity by the combination of Piroxicam and Sulfasalazine.	Rheumatoid arthritis [FA20]	[46]
Leflunomide	DMR8ONJ	Major	Increased risk of hepatotoxicity by the combination of Piroxicam and Leflunomide.	Rheumatoid arthritis [FA20]	[42]
Trabectedin	DMG3Y89	Moderate	Increased risk of hepatotoxicity by the combination of Piroxicam and Trabectedin.	Solid tumour/cancer [2A00-2F9Z]	[16]
Prednisolone	DMQ8FR2	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Piroxicam and Prednisolone.	Solid tumour/cancer [2A00-2F9Z]	[19]
Pitolisant	DM8RFNJ	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Piroxicam and Pitolisant.	Somnolence [MG42]	[16]
Naltrexone	DMUL45H	Moderate	Increased risk of hepatotoxicity by the combination of Piroxicam and Naltrexone.	Substance abuse [6C40]	[65]
Caplacizumab	DMPUKA7	Moderate	Increased risk of bleeding by the combination of Piroxicam and Caplacizumab.	Thrombocytopenia [3B64]	[18]
Apixaban	DM89JLN	Major	Increased risk of bleeding by the combination of Piroxicam and Apixaban.	Thrombosis [DB61-GB90]	[16]
Cangrelor	DM8JRH0	Moderate	Increased risk of bleeding by the combination of Piroxicam and Cangrelor.	Thrombosis [DB61-GB90]	[18]
Brilinta	DMBR01X	Moderate	Increased risk of bleeding by the combination of Piroxicam and Brilinta.	Thrombosis [DB61-GB90]	[16]
Cabozantinib	DMIYDT4	Major	Increased risk of bleeding by the combination of Piroxicam and Cabozantinib.	Thyroid cancer [2D10]	[66]
Sirolimus	DMGW1ID	Major	Increased risk of nephrotoxicity by the combination of Piroxicam and Sirolimus.	Transplant rejection [NE84]	[64]
Tacrolimus	DMZ7XNQ	Major	Increased risk of nephrotoxicity by the combination of Piroxicam and Tacrolimus.	Transplant rejection [NE84]	[64]
Tolbutamide	DM02AWV	Moderate	Increased risk of hypoglycemia by the combination of Piroxicam and Tolbutamide.	Type 2 diabetes mellitus [5A11]	[15]
Chlorpropamide	DMPHZQE	Moderate	Increased risk of hypoglycemia by the combination of Piroxicam and Chlorpropamide.	Type 2 diabetes mellitus [5A11]	[15]
Olsalazine	DMZW9HA	Moderate	Increased risk of nephrotoxicity by the combination of Piroxicam and Olsalazine.	Ulcerative colitis [DD71]	[46]
Cinoxacin	DM4EWNS	Moderate	Additive CNS stimulant effects by the combination of Piroxicam and Cinoxacin.	Urinary tract infection [GC08]	[20]
Plazomicin	DMKMBES	Moderate	Increased risk of nephrotoxicity by the combination of Piroxicam and Plazomicin.	Urinary tract infection [GC08]	[21]
Nalidixic acid	DMRM0JV	Moderate	Additive CNS stimulant effects by the combination of Piroxicam and Nalidixic acid.	Urinary tract infection [GC08]	[20]
Triamcinolone	DM98IXF	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Piroxicam and Triamcinolone.	Vasomotor/allergic rhinitis [CA08]	[19]
Betrixaban	DM2C4RF	Major	Increased risk of bleeding by the combination of Piroxicam and Betrixaban.	Venous thromboembolism [BD72]	[67]

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Allura red AC dye	E00338	33258	Colorant
D&C red no. 28	E00491	6097185	Colorant
D&C red no. 33	E00261	19116	Colorant
FD&C blue no. 1	E00263	19700	Colorant
FD&C blue no. 2	E00446	2723854	Colorant
Quinoline yellow WS	E00309	24671	Colorant
Sodium lauryl sulfate	E00464	3423265	Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Sunset yellow FCF	E00255	17730	Colorant
Beta-D-lactose	E00099	6134	Diluent; Dry powder inhaler carrier; Lyophilization aid
Ethylene glycol ethyl ether	E00164	8076	Solubilizing agent; Solvent
FD&C red no. 3	E00629	Not Available	Colorant
Ferric hydroxide oxide yellow	E00539	23320441	Colorant
Ferrosoferric oxide	E00231	14789	Colorant
Lactose monohydrate	E00393	104938	Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate	E00208	11177	lubricant
Povidone	E00667	Not Available	Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Propylene glycol	E00040	1030	Antimicrobial preservative; Humectant; Plasticizing agent; Solvent
Silicon dioxide	E00670	Not Available	Anticaking agent; Opacifying agent; Viscosity-controlling agent
Sodium hydroxide	E00234	14798	Alkalizing agent
Soybean lecithin	E00637	Not Available	Other agent
Titanium dioxide	E00322	26042	Coating agent; Colorant; Opacifying agent
Vinylpyrrolidone	E00668	Not Available	Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent

Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Piroxicam 10 mg capsule	10 mg	Oral Capsule	Oral
Piroxicam 20 mg capsule	20 mg	Oral Capsule	Oral

Jump to Detail Pharmaceutical Formulation Page of This Drug

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