Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZDN4W)

Drug Name

L-alanine Drug Info

Synonyms

ALA; Alaninum; LPG; Polyalanine; A-Alanine; A-Aminopropionic acid; Alanina [DCIT,Spanish]; Alanine (USP); L-A-Aminopropionicacid; L-Alanine (9CI); L-Alanine (JAN); L-Alanine, homopolymer; L-Alanine, labeled with tritium; L-a-Alanine; L-a-Aminopropionic acid; Poly-DL-alanine; L-Alanine, labeled with carbon-14; Alanine, L-(7CI,8CI); F4F207FF-8FF8-4789-99A1-147AE0A36673; L-Alanine, N-coco alkyl derivs.; Propanoic acid, 2-amino-, (S); (C14)L-Alanine; (S)-2-Aminopropionic acid; 14C-L-Alanine

Indication

Disease Entry	ICD 11	Status	REF
Dietary shortage	5B5K	Approved	[1] , [2] , [3]
Glioma	2A00.0	Approved	[1] , [2] , [3]

Therapeutic Class

Dietary supplement

Cross-matching ID

PubChem CID: 5950
ChEBI ID: CHEBI:16977
CAS Number: CAS 56-41-7
TTD Drug ID: DMZDN4W
VARIDT Drug ID: DR00142

Molecule-Related Drug Atlas

Molecule Type:

DTT

DTP

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Transported By Alanine/serine/cysteine/threonine transporter 1 (SLC1A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
D-Serine	DM3YH4I	N. A.	N. A.	Phase 4	[7]
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Drug(s) Transported By Sodium-coupled neutral amino acid transporter 1 (SLC38A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-glutamine	DM69G8X	Short bowel syndrome	KB89.1	Approved	[5]
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Drug(s) Transported By Sodium-coupled neutral amino acid transporter 2 (SLC38A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-glutamine	DM69G8X	Short bowel syndrome	KB89.1	Approved	[5]
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Drug(s) Transported By Sodium-coupled neutral amino acid transporter 3 (SLC38A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic acid	DMEMBJC	Folate-deficiency anemia	3A02.Y	Approved	[8]
L-glutamine	DM69G8X	Short bowel syndrome	KB89.1	Approved	[5]
Aminosalicylic acid	DMENSL5	Inflammatory bowel disease	DD72	Approved	[9]
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Drug(s) Transported By Sodium-coupled neutral amino acid transporter 4 (SLC38A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-glutamine	DM69G8X	Short bowel syndrome	KB89.1	Approved	[5]
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Drug(s) Transported By Sodium-coupled neutral amino acid transporter 5 (SLC38A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-glutamine	DM69G8X	Short bowel syndrome	KB89.1	Approved	[5]
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Drug(s) Transported By L-type amino acid transporter 2 (SLC7A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-tryptophan	DMIBH7M	Depression	6A70-6A7Z	Approved	[6]
Glycine	DMIOZ29	Malnutrition	5B50-5B71	Approved	[6]
L-Proline	DMKSTWR	Malnutrition	5B50-5B71	Approved	[6]
L-Phenylalanine	DMQXI9F	Malnutrition	5B50-5B71	Approved	[10]
L-tyrosine	DM9O8DT	Malnutrition	5B50-5B71	Approved	[6]
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Drug(s) Targeting GABA transaminase (ABAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pyridoxal Phosphate	DMO2K0J	Malnutrition	5B50-5B71	Approved	[4]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[4]
Vigabatrin	DMYT0OG	Complex partial seizure	8A68.0	Approved	[11]
Divalproex sodium	DM4RK0G	Seizure disorder	8A6Z	Approved	[4]
CPP-115	DMK9NQI	Tourette syndrome	8A05.00	Phase 2	[12]
K-828-AB	DMJLNZQ	Dementia	6D80-6D86	Phase 2	[13]
CPP -15	DMQCHU3	Infantile spasm	8A62.0	Phase 1	[12]
T83193	DMHO29Y	Discovery agent	N.A.	Patented	[14]
4-hydroxybenzaldehyde	DM471P5	Discovery agent	N.A.	Patented	[15]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[16]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA transaminase (ABAT)	TTT2LD9	GABT_HUMAN	Inhibitor	[4]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Sodium-coupled neutral amino acid transporter 3 (SLC38A3)	DTKWJH3	S38A3_HUMAN	Substrate	[5]
Sodium-coupled neutral amino acid transporter 5 (SLC38A5)	DTLX28N	S38A5_HUMAN	Substrate	[5]
Sodium-coupled neutral amino acid transporter 4 (SLC38A4)	DTPJBD5	S38A4_HUMAN	Substrate	[5]
Sodium-coupled neutral amino acid transporter 2 (SLC38A2)	DTTWL58	S38A2_HUMAN	Substrate	[5]
Sodium-coupled neutral amino acid transporter 1 (SLC38A1)	DTD815L	S38A1_HUMAN	Substrate	[5]
L-type amino acid transporter 2 (SLC7A8)	DTJF3DX	LAT2_HUMAN	Substrate	[6]
Alanine/serine/cysteine/threonine transporter 1 (SLC1A4)	DTC54PX	SATT_HUMAN	Substrate	[7]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 720).
2	Drug information of L-Alanine, Health Canada, 2008. (drugid: 7638)
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4	DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6.
5	Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11.
6	The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.3.8.20)
7	D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures. PLoS One. 2016 Jun 7;11(6):e0156551.
8	Purification of recombinant human N-acetyltransferase type 1 (NAT1) expressed in E. coli and characterization of its potential role in folate metabolism. Biochem Pharmacol. 1995 Jun 16;49(12):1759-67.
9	Identification of amino acids imparting acceptor substrate selectivity to human arylamine acetyltransferases NAT1 and NAT2. Biochem J. 2000 May 15;348 Pt 1:159-66.
10	Quantifying the relative contributions of different solute carriers to aggregate substrate transport. Sci Rep. 2017 Jan 16;7:40628.
11	Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
12	Clinical pipeline report, company report or official report of Catalyst Pharma.
13	Phase II clinical trial of K-828-AB for treating behavioral and psychological symptoms of dementia. Kowa Co. Ltd.
14	Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. Bioorg Med Chem Lett. 2006 Feb;16(3):592-5.
15	Inactivation of GABA transaminase by 3-chloro-1-(4-hydroxyphenyl)propan-1-one. Bioorg Med Chem Lett. 2009 Feb 1;19(3):731-4.
16	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.