Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTP (ID: DT8QKNP)

• DTP Name: Peptide transporter 2 (SLC15A2) DTP Info
• Gene Name: PEPT2

Molecule-Related Drug & Molecule List

23 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aminolevulinic acid hci	DMS4BLQ	Acne vulgaris	ED80	Approved	[1]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[2]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[3]
Benazepril	DMH1M9B	Hypertension	BA00-BA04	Approved	[4]
Bestatin	DM8L9D4	Acute myeloid leukaemia	2A60	Approved	[5]
Cefaclor	DMJXDGC	Bacterial infection	1A00-1C4Z	Approved	[2]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[6]
Cefixime	DMY60I8	Acute gonococcal cervicitis		Approved	[3]
Cefradine	DMUNSWV	Acute otitis media	AB00	Approved	[3]
Ceftibuten	DMWV2AG	Acute otitis media	AB00	Approved	[3]
Cephalexin	DMD5JU8	Acute otitis media	AB00	Approved	[3]
Cyclacillin	DMHSJB4	Bacterial infection	1A00-1C4Z	Approved	[3]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[3]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[7]
Entecavir	DM7VTQO	Hepatitis B virus infection	1E51.0	Approved	[8]
Fosinopril	DM9NJ52	Chronic heart failure	BD1Z	Approved	[9]
Latamoxef	DMANL0D	Bacterial infection	1A00-1C4Z	Approved	[3]
Moexipril	DM26E4B	Hypertension	BA00-BA04	Approved	[4]
Perindopril	DMOPZDT	Hypertension	BA00-BA04	Approved	[4]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[4]
Spirapril	DM5XLTY	Hypertension	BA00-BA04	Approved	[4]
Trandolapril	DM4L6EU	Chronic heart failure	BD1Z	Approved	[4]
Valaciclovir	DMHKS94	Genital herpes	1A94	Approved	[10]

1 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metampicillin	DMQW5MH	N. A.	N. A.	Preclinical	[3]

References

• [1] PEPT2-mediated transport of 5-aminolevulinic acid and carnosine in astrocytes. Brain Res. 2006 Nov 29;1122(1):18-23.
• [2] Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55.
• [3] Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60.
• [4] Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41.
• [5] Molecular mechanism of dipeptide and drug transport by the human renal H+/oligopeptide cotransporter hPEPT2. Am J Physiol Renal Physiol. 2008 Jun;294(6):F1422-32.
• [6] Species Differences in Human and Rodent PEPT2-Mediated Transport of Glycylsarcosine and Cefadroxil in Pichia Pastoris Transformants. Drug Metab Dispos. 2017 Feb;45(2):130-136.
• [7] Ethanol inhibits functional activity of the human intestinal dipeptide transporter hPepT1 expressed in Xenopus oocytes. Alcohol Clin Exp Res. 2008 May;32(5):777-84.
• [8] The oligopeptide transporter 2-mediated reabsorption of entecavir in rat kidney. Eur J Pharm Sci. 2014 Feb 14;52:41-7.
• [9] Mechanism of intestinal absorption and renal reabsorption of an orally active ace inhibitor: uptake and transport of fosinopril in cell cultures. Drug Metab Dispos. 2001 Oct;29(10):1307-15.
• [10] Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2. Biochem Biophys Res Commun. 1998 May 19;246(2):470-5.