Details of Disease

General Information of Disease (ID: DISJQHVN)

Disease Name	Periodontal disease
Synonyms	periodontium disorder; periodontium disease or disorder; periodontium disease; periodontal disorder; periodontal disease; disorder of periodontium; disease or disorder of periodontium; disease of supporting structures of teeth; disease of periodontium
Disease Class	DA0C: Periodontal disease
Definition	An inflammatory process of the gingival tissues and/or periodontal membrane of the teeth, resulting in an abnormally deep gingival sulcus, possibly producing periodontal pockets and loss of alveolar bone support.
Disease Hierarchy	DISWD40R: Disease DISBXWAX: Tooth disorder DISJQHVN: Periodontal disease
ICD Code	ICD-11 ICD-11: DA0C Expand ICD-11 'DA0C Expand ICD-10 'K05.3; 'K05.5; 'K05.6
Disease Identifiers	MONDO ID MONDO_0002635 MESH ID D010510 UMLS CUI C0031090 MedGen ID 10658 SNOMED CT ID 2556008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
AlloDerm	DM60JLD	Approved	NA	[1]
------------------------------------------------------------------------------------

This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
PerioPatch	DMFM6OU	Phase 2	NA	[2]
RhGDF-5	DMN1EFR	Phase 2	NA	[3]
------------------------------------------------------------------------------------

This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
MSI-469	DMHMQYL	Terminated	NA	[4]
------------------------------------------------------------------------------------

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
BT-301	DMT5VPL	Investigative	NA	[5]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 41 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
IL17A	TTG0MT6	Limited	Biomarker	[6]
MAP3K11	TTETX6Q	Limited	Altered Expression	[7]
MRGPRX2	TT3YV20	Limited	Altered Expression	[8]
PON1	TT9LX82	Limited	Biomarker	[9]
TNFSF11	TT9E8HR	Limited	Altered Expression	[10]
VDR	TTK59TV	Limited	Genetic Variation	[11]
CAMP	TTULOB6	Disputed	Altered Expression	[12]
TREM1	TTHZQP0	Disputed	Biomarker	[13]
ADRB3	TTMXGCW	moderate	Genetic Variation	[14]
F2RL1	TTQR74A	moderate	Biomarker	[15]
IL12RB2	TT4SWR8	moderate	Genetic Variation	[16]
PLTP	TTZF6SN	moderate	Altered Expression	[17]
SLAMF7	TT7ILZ1	moderate	Biomarker	[18]
TNFRSF11B	TT2CJ75	moderate	Altered Expression	[19]
CD14	TT6I7DC	Strong	Biomarker	[20]
CD40LG	TTIJP3Q	Strong	Biomarker	[21]
CD80	TT89Z17	Strong	Altered Expression	[22]
CTSC	TT4H0V2	Strong	Genetic Variation	[23]
DLK1	TTF4AVB	Strong	Biomarker	[24]
DPP7	TTOYT5L	Strong	Altered Expression	[25]
IFNL1	TTM624L	Strong	Biomarker	[26]
IL15	TTJFA35	Strong	Biomarker	[27]
IL16	TTW4R0B	Strong	Biomarker	[21]
IL19	TT87RWS	Strong	Biomarker	[21]
IL21	TT9QEJ6	Strong	Biomarker	[21]
IL24	TT1EPXZ	Strong	Biomarker	[21]
IL7	TT8FRMO	Strong	Biomarker	[21]
MMP8	TTGA1IV	Strong	Biomarker	[28]
MTNR1B	TT32JK8	Strong	Altered Expression	[29]
OTC	TT5KIO9	Strong	Biomarker	[30]
PKN3	TTW3P4R	Strong	Biomarker	[31]
SLC52A2	TT6TKEN	Strong	Biomarker	[32]
SMPD1	TTJTM88	Strong	Genetic Variation	[33]
TLR6	TTWRI8V	Strong	Genetic Variation	[34]
TMPRSS6	TTL9KE7	Strong	Altered Expression	[29]
TREM2	TTQRMSJ	Strong	Biomarker	[35]
ALPL	TTMR5UV	Definitive	Biomarker	[36]
BPI	TTXCSDR	Definitive	Genetic Variation	[37]
GOT1	TTU507L	Definitive	Biomarker	[36]
TRB	TT84HCW	Definitive	Altered Expression	[38]
TRBC1	TT1DHW2	Definitive	Altered Expression	[38]
------------------------------------------------------------------------------------


⏷ Show the Full List of 41 DTT(s)

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC7A9	DTP7AEQ	Strong	Biomarker	[39]
------------------------------------------------------------------------------------

This Disease Is Related to 45 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
AZU1	OTHXU264	Limited	Biomarker	[40]
CRACR2A	OTJUGSVE	Limited	Genetic Variation	[41]
DRAM1	OTIJTXEN	Limited	Biomarker	[42]
NLRC4	OTAIA3NA	Limited	Biomarker	[43]
ODAM	OTT666SJ	Limited	Biomarker	[44]
PLPPR4	OTBOWTC5	Limited	Biomarker	[7]
RTL1	OTOT33IM	Limited	Altered Expression	[45]
SETMAR	OTE2MIMZ	Limited	Altered Expression	[45]
SH3BP2	OT90JNBS	Limited	Biomarker	[46]
SLIT3	OTU8MKEU	Limited	Biomarker	[47]
DHX40	OTOL02QN	moderate	Altered Expression	[48]
FGB	OT6RKLI9	moderate	Genetic Variation	[49]
LRWD1	OTHRVJQC	moderate	Biomarker	[50]
RARRES2	OT1BJE8K	moderate	Biomarker	[51]
S100A2	OTTGHJ1H	moderate	Altered Expression	[52]
AMY1A	OT6G4B8O	Strong	Biomarker	[53]
ARPC5	OTFNMMDL	Strong	Biomarker	[54]
BRINP3	OT4VFHWN	Strong	Altered Expression	[55]
CAMTA1	OTAN1S5B	Strong	Genetic Variation	[56]
CRTAP	OT53H5U6	Strong	Genetic Variation	[57]
CST2	OTRKRW50	Strong	Biomarker	[58]
CTDSP2	OTT2BOJG	Strong	Biomarker	[59]
CTDSPL	OTZJ0CZK	Strong	Biomarker	[59]
CYTIP	OTRJ3ZC5	Strong	Genetic Variation	[57]
DDX39A	OT0Z6E1K	Strong	Biomarker	[39]
DDX39B	OTEVCFVU	Strong	Biomarker	[39]
DEFA1	OT5N1B9B	Strong	Biomarker	[60]
EDIL3	OTDVVNS0	Strong	Altered Expression	[61]
ESCO2	OTJEMAQU	Strong	Altered Expression	[62]
FAM20A	OT5Z5IW8	Strong	Genetic Variation	[63]
FDCSP	OT8KGE9M	Strong	Biomarker	[64]
GCFC2	OTC7FRXL	Strong	Genetic Variation	[65]
IBSP	OT29944Y	Strong	Genetic Variation	[66]
IFI16	OT4SPU0U	Strong	Altered Expression	[67]
JMJD6	OTILR7E4	Strong	Genetic Variation	[59]
KDM4B	OT5P1UPY	Strong	Biomarker	[68]
MAPK8IP2	OTDUHLN0	Strong	Genetic Variation	[69]
NFKBIL1	OTYFTPS0	Strong	Biomarker	[39]
PADI2	OTT40K94	Strong	Biomarker	[70]
PES1	OTMZK7XE	Strong	Genetic Variation	[71]
SMIM10L2B	OT04IG2N	Strong	Biomarker	[72]
TLX2	OTPFAUM8	Strong	Biomarker	[73]
TRAT1	OTMPUNPD	Strong	Biomarker	[74]
TRIM25	OT35SG1R	Strong	Biomarker	[50]
DEFB1	OT5SV0E4	Definitive	Genetic Variation	[75]
------------------------------------------------------------------------------------


⏷ Show the Full List of 45 DOT(s)

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Clinical pipeline report, company report or official report of Izun Pharmaceuticals Corp.
3	ClinicalTrials.gov (NCT01124006) A Multicenter, Randomized, Double-blind, Placebo Controlled, Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of 2 Doses of Intradiscal rhGDF-5 (Single Administration) for the Treatment of Early Stage Lumbar Disc Degeneration. U.S. National Institutes of Health.
4	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006076)
5	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
6	The use of crevicular fluid to assess markers of inflammation and angiogenesis, IL-17 and VEGF, in patients with solid tumors receiving zoledronic acid and/or bevacizumab.Support Care Cancer. 2020 Jan;28(1):177-184. doi: 10.1007/s00520-019-04793-2. Epub 2019 Apr 17.
7	Porphyromonas gingivalis Tyrosine Phosphatase Php1 Promotes Community Development and Pathogenicity.mBio. 2019 Sep 24;10(5):e02004-19. doi: 10.1128/mBio.02004-19.
8	Differential Regulation of Mas-Related G Protein-Coupled Receptor X2-Mediated Mast Cell Degranulation by Antimicrobial Host Defense Peptides and Porphyromonas gingivalis Lipopolysaccharide.Infect Immun. 2017 Sep 20;85(10):e00246-17. doi: 10.1128/IAI.00246-17. Print 2017 Oct.
9	The relationship of oral disturbances of diabetes mellitus patients with paraoxonase gene polymorphisms.Cell Biochem Funct. 2008 Dec;26(8):870-3. doi: 10.1002/cbf.1519.
10	Innate lymphoid cells are present in gingivitis and periodontitis.J Periodontol. 2019 Feb;90(2):200-207. doi: 10.1002/JPER.17-0750. Epub 2018 Aug 29.
11	Relationship between vitamin D receptor gene polymorphism and susceptibility to chronic kidney disease and periodontal disease in community-dwelling elderly.J Clin Periodontol. 2018 Jun;45(6):672-679. doi: 10.1111/jcpe.12896. Epub 2018 May 16.
12	Antimicrobial peptide hCAP-18/LL-37 protein and mRNA expressions in different periodontal diseases.Oral Dis. 2011 Jan;17(1):60-7. doi: 10.1111/j.1601-0825.2010.01704.x.
13	Effects of Porphyromonasgingivalis LPS and LR12 peptide on TREM-1 expression by monocytes.J Clin Periodontol. 2018 Jul;45(7):799-805. doi: 10.1111/jcpe.12925. Epub 2018 Jun 8.
14	Interaction between beta-3 adrenergic receptor genotype and environmental factors on periodontal progression.J Clin Periodontol. 2019 Jun;46(6):623-630. doi: 10.1111/jcpe.13115. Epub 2019 May 8.
15	Keratinocyte-specific ablation of protease-activated receptor 2 prevents gingival inflammation and bone loss in a mouse model of periodontal disease.Cell Microbiol. 2018 Nov;20(11):e12891. doi: 10.1111/cmi.12891. Epub 2018 Jul 31.
16	Polymorphisms in the 5' flanking region of IL12RB2 are associated with susceptibility to periodontal diseases in the Japanese population.J Clin Periodontol. 2008 Apr;35(4):317-23. doi: 10.1111/j.1600-051X.2008.01208.x.
17	SAA and PLTP activity in plasma of periodontal patients before and after full-mouth tooth extraction.Oral Dis. 2008 Sep;14(6):514-9. doi: 10.1111/j.1601-0825.2007.01411.x.
18	Role of the NK cell-activating receptor CRACC in periodontitis.Infect Immun. 2013 Mar;81(3):690-6. doi: 10.1128/IAI.00895-12. Epub 2012 Dec 17.
19	Severe magnesium deficiency compromises systemic bone mineral density and aggravates inflammatory bone resorption.J Nutr Biochem. 2020 Mar;77:108301. doi: 10.1016/j.jnutbio.2019.108301. Epub 2019 Nov 26.
20	Estimation of sCD14 levels in saliva obtained from patients with various periodontal conditions.Oral Dis. 2008 Jul;14(5):450-6. doi: 10.1111/j.1601-0825.2007.01400.x.
21	Adaptive immune response in osteoclastic bone resorption induced by orally administered Aggregatibacter actinomycetemcomitans in a rat model of periodontal disease.Mol Oral Microbiol. 2010 Aug;25(4):275-92. doi: 10.1111/j.2041-1014.2010.00576.x.
22	Expression of major histocompatibility complex class II and CD80 by gingival epithelial cells induces activation of CD4+ T cells in response to bacterial challenge.Infect Immun. 2005 Feb;73(2):1044-51. doi: 10.1128/IAI.73.2.1044-1051.2005.
23	Cathepsin C gene: First compound heterozygous patient with Papillon-Lefvre syndrome and a novel symptomless mutation.Hum Mutat. 2001 Feb;17(2):152-3. doi: 10.1002/1098-1004(200102)17:2<152::AID-HUMU10>3.0.CO;2-#.
24	Genetic variation of a fimbrial protein from Porphyromonas gingivalis and its distribution in patients with periodontal diseases.Microbiol Res. 2005;160(3):257-63. doi: 10.1016/j.micres.2004.11.004.
25	Distribution of dipeptidyl peptidase (DPP) 4, DPP5, DPP7 and DPP11 in human oral microbiota-potent biomarkers indicating presence of periodontopathic bacteria.FEMS Microbiol Lett. 2018 Nov 1;365(22). doi: 10.1093/femsle/fny221.
26	IL-29 Enhances CXCL10 Production in TNF--stimulated Human Oral Epithelial Cells.Immunol Invest. 2017 Aug;46(6):615-624. doi: 10.1080/08820139.2017.1336176.
27	IL-15 and RANKL Play a Synergistically Important Role in Osteoclastogenesis.J Cell Biochem. 2017 Apr;118(4):739-747. doi: 10.1002/jcb.25726. Epub 2016 Dec 20.
28	Diagnostic sensitivity and specificity of host-derived salivary biomarkers in periodontal disease amongst adults: Systematic review.J Clin Periodontol. 2020 Mar;47(3):289-308. doi: 10.1111/jcpe.13218. Epub 2019 Dec 26.
29	Metallothioneins in Failure of Dental Implants and Periodontitis Down Syndrome Patients.Genes (Basel). 2019 Sep 14;10(9):711. doi: 10.3390/genes10090711.
30	Polycaprolactone nanofibers loaded oxytetracycline hydrochloride and zinc oxide for treatment of periodontal disease.Mater Sci Eng C Mater Biol Appl. 2019 Oct;103:109798. doi: 10.1016/j.msec.2019.109798. Epub 2019 May 27.
31	Protein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling.Sci Signal. 2017 Aug 29;10(494):eaan0023. doi: 10.1126/scisignal.aan0023.
32	Activation of calcium signaling in human gingival fibroblasts by recombinant Porphyromonas gingivalis RgpB protein.Eur J Oral Sci. 2019 Aug;127(4):287-293. doi: 10.1111/eos.12622. Epub 2019 Jun 8.
33	Acute periodontal lesions (periodontal abscesses and necrotizing periodontal diseases) and endo-periodontal lesions.J Clin Periodontol. 2018 Jun;45 Suppl 20:S78-S94. doi: 10.1111/jcpe.12941.
34	Associations of Toll-Like Receptor and -Defensin Polymorphisms with Measures of Periodontal Disease (PD) in HIV+ North American Adults: An Exploratory Study.PLoS One. 2016 Oct 11;11(10):e0164075. doi: 10.1371/journal.pone.0164075. eCollection 2016.
35	Increased expression of triggering receptor expressed on myeloid cells 1 and 2 in inflamed human gingiva.J Periodontal Res. 2017 Jun;52(3):512-521. doi: 10.1111/jre.12417. Epub 2016 Sep 14.
36	Salivary aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase: possible markers in periodontal diseases?.Clin Chem Lab Med. 2006;44(5):612-5. doi: 10.1515/CCLM.2006.096.
37	A645G (Lys216Glu) polymorphism of the bactericidal/permeability-increasing protein gene in periodontal disease.Int J Immunogenet. 2006 Aug;33(4):255-60. doi: 10.1111/j.1744-313X.2006.00608.x.
38	Expression of T-cell receptor Vbeta2, 6 and 8 gene families in chronic adult periodontal disease.Eur J Oral Sci. 1997 Oct;105(5 Pt 1):397-404. doi: 10.1111/j.1600-0722.1997.tb02136.x.
39	Salivary biomarkers in association with periodontal parameters and the periodontitis risk haplotype.Innate Immun. 2018 Oct;24(7):439-447. doi: 10.1177/1753425918796207. Epub 2018 Sep 3.
40	Azurocidin in gingival crevicular fluid as a potential biomarker of chronic periodontitis.J Periodontal Res. 2020 Apr;55(2):209-214. doi: 10.1111/jre.12703. Epub 2019 Oct 14.
41	A genome-wide association study identifies an association between variants in EFCAB4B gene and periodontal disease in an Italian isolated population.J Periodontal Res. 2018 Dec;53(6):992-998. doi: 10.1111/jre.12598. Epub 2018 Oct 4.
42	Damage-regulated autophagy modulator 1 in oral inflammation and infection.Clin Oral Investig. 2018 Nov;22(8):2933-2941. doi: 10.1007/s00784-018-2381-6. Epub 2018 Feb 13.
43	NLRC4 inflammasome has a protective role on inflammatory bone resorption in a murine model of periodontal disease.Immunobiology. 2020 Jan;225(1):151855. doi: 10.1016/j.imbio.2019.10.004. Epub 2019 Nov 30.
44	The sensitive detection of ODAM by using sandwich-type biosensors with a cognate pair of aptamers for the early diagnosis of periodontal disease.Biosens Bioelectron. 2019 Feb 1;126:122-128. doi: 10.1016/j.bios.2018.10.040. Epub 2018 Oct 23.
45	Salivary levels of specialized pro-resolving lipid mediators as indicators of periodontal health/disease status.J Clin Periodontol. 2019 Oct;46(10):978-990. doi: 10.1111/jcpe.13173. Epub 2019 Aug 20.
46	Alveolar Bone Protection by Targeting the SH3BP2-SYK Axis in Osteoclasts.J Bone Miner Res. 2020 Feb;35(2):382-395. doi: 10.1002/jbmr.3882. Epub 2019 Oct 24.
47	Gingival crevicular fluid levels of SLIT3 are increased in periodontal disease.Oral Dis. 2020 Jan;26(1):182-192. doi: 10.1111/odi.13227. Epub 2019 Nov 26.
48	The peptidylarginine deiminase gene is a conserved feature of Porphyromonas gingivalis.Sci Rep. 2015 Sep 25;5:13936. doi: 10.1038/srep13936.
49	Association of increased levels of fibrinogen and the -455G/A fibrinogen gene polymorphism with chronic periodontitis.J Periodontol. 2003 Mar;74(3):329-37. doi: 10.1902/jop.2003.74.3.329.
50	Role of microbial biofilms in the maintenance of oral health and in the development of dental caries and periodontal diseases. Consensus report of group 1 of the Joint EFP/ORCA workshop on the boundaries between caries and periodontal disease.J Clin Periodontol. 2017 Mar;44 Suppl 18:S5-S11. doi: 10.1111/jcpe.12682.
51	Antimicrobial and Attractant Roles for Chemerin in the Oral Cavity during Inflammatory Gum Disease.Front Immunol. 2017 Mar 29;8:353. doi: 10.3389/fimmu.2017.00353. eCollection 2017.
52	S100A2 level changes are related to human periodontitis.Mol Cells. 2011 Nov;32(5):445-50. doi: 10.1007/s10059-011-0132-5. Epub 2011 Sep 9.
53	Batch injection analysis towards auxiliary diagnosis of periodontal diseases based on indirect amperometric detection of salivary -amylase on a cupric oxide electrode.Anal Chim Acta. 2018 Dec 24;1041:50-57. doi: 10.1016/j.aca.2018.08.039. Epub 2018 Aug 29.
54	Targeted Proteomics Guided by Label-free Quantitative Proteome Analysis in Saliva Reveal Transition Signatures from Health to Periodontal Disease.Mol Cell Proteomics. 2018 Jul;17(7):1392-1409. doi: 10.1074/mcp.RA118.000718. Epub 2018 Apr 2.
55	FAM5C contributes to aggressive periodontitis.PLoS One. 2010 Apr 7;5(4):e10053. doi: 10.1371/journal.pone.0010053.
56	Genetic Susceptibility Contributing to Periodontal and Cardiovascular Disease.J Dent Res. 2017 Jun;96(6):610-617. doi: 10.1177/0022034517699786. Epub 2017 Mar 22.
57	Assessment of CASP gene polymorphisms in periodontal disease.Genet Mol Res. 2015 Dec 22;14(4):18069-77. doi: 10.4238/2015.December.22.33.
58	Salivary and serum cystatin SA levels in patients with type 2 diabetes mellitus or diabetic nephropathy.Arch Oral Biol. 2019 Aug;104:67-75. doi: 10.1016/j.archoralbio.2019.05.020. Epub 2019 May 22.
59	Effects of smoking and genotype on the PSR index of periodontal disease in adults aged 18-49.Int J Environ Res Public Health. 2012 Aug;9(8):2839-50. doi: 10.3390/ijerph9082839. Epub 2012 Aug 10.
60	The Human Salivary Antimicrobial Peptide Profile according to the Oral Microbiota in Health, Periodontitis and Smoking.J Innate Immun. 2019;11(5):432-444. doi: 10.1159/000494146. Epub 2018 Nov 28.
61	Clinical association between chronic periodontitis and the leukocyte extravasation inhibitors developmental endothelial locus-1 and pentraxin-3.Eur J Oral Sci. 2017 Aug;125(4):258-264. doi: 10.1111/eos.12357. Epub 2017 Jun 23.
62	Evaluation and comparison of serum vitamin D and calcium levels in periodontally healthy, chronic gingivitis and chronic periodontitis in patients with and without diabetes mellitus - a cross-sectional study.Acta Odontol Scand. 2019 Nov;77(8):592-599. doi: 10.1080/00016357.2019.1623910. Epub 2019 Jun 14.
63	Periodontal disease and FAM20A mutations.J Hum Genet. 2017 Jul;62(7):679-686. doi: 10.1038/jhg.2017.26. Epub 2017 Mar 16.
64	C4orf7 modulates osteogenesis and adipogenesis of human periodontal ligament cells.Am J Transl Res. 2017 Dec 15;9(12):5708-5718. eCollection 2017.
65	The effect of periodontal therapy on neopterin and vascular cell adhesion molecule-1 levels in chronic periodontitis patients with and without acute myocardial infarction: a case-control study.J Appl Oral Sci. 2018 Apr 5;26:e20170199. doi: 10.1590/1678-7757-2017-0199.
66	Periodontal diagnosis in the context of the BSP implementation plan for the 2017 classification system of periodontal diseases and conditions: presentation of a patient with a history of periodontal treatment.Br Dent J. 2019 Feb;226(4):265-267. doi: 10.1038/s41415-019-0015-2.
67	Common Polymorphisms in IFI16 and AIM2 Genes Are Associated With Periodontal Disease.J Periodontol. 2017 Jul;88(7):663-672. doi: 10.1902/jop.2017.160553. Epub 2017 Apr 7.
68	Inhibition of the histone demethylase KDM4B leads to activation of KDM1A, attenuates bacterial-induced pro-inflammatory cytokine release, and reduces osteoclastogenesis.Epigenetics. 2018;13(5):557-572. doi: 10.1080/15592294.2018.1481703. Epub 2018 Aug 7.
69	Prevalence of Porphyromonas gingivalis fimA genotypes in Japanese children.J Oral Sci. 2012 Mar;54(1):77-83. doi: 10.2334/josnusd.54.77.
70	Gingival crevicular fluid semaphorin 4D and peptidylarginine deiminase-2 levels in periodontal health and disease.J Periodontol. 2019 Sep;90(9):973-981. doi: 10.1002/JPER.18-0608. Epub 2019 May 13.
71	Esthetic Assessment of Implants Placed into Fresh Extraction Sockets for Single-Tooth Replacements Using a Flapless Approach.Clin Implant Dent Relat Res. 2017 Apr;19(2):351-364. doi: 10.1111/cid.12458. Epub 2016 Nov 2.
72	In- vitro-activity of additive application of hydrogen peroxide in antimicrobial photodynamic therapy using LED in the blue spectrum against bacteria and biofilm associated with periodontal disease.Photodiagnosis Photodyn Ther. 2019 Jun;26:306-312. doi: 10.1016/j.pdpdt.2019.04.015. Epub 2019 Apr 16.
73	Effect of nitric oxide-releasing derivative of indomethacin on Prevotella intermedia lipopolysaccharide-induced production of proinflammatory mediators in murine macrophages.Biochem Biophys Res Commun. 2017 Oct 14;492(2):224-230. doi: 10.1016/j.bbrc.2017.08.055. Epub 2017 Aug 16.
74	Differential expression of inflammasome regulatory transcripts in periodontal disease.J Periodontol. 2020 May;91(5):606-616. doi: 10.1002/JPER.19-0222. Epub 2019 Oct 17.
75	LTF and DEFB1 polymorphisms are associated with susceptibility toward chronic periodontitis development.Oral Dis. 2017 Oct;23(7):1001-1008. doi: 10.1111/odi.12689. Epub 2017 Jun 5.