Details of the Drug Combination

General Information of Drug Combination (ID: DC6TUBF)

Drug Combination Name
Mitoxantrone Azacitidine
Indication
Disease Entry Status REF
Adult Acute Megakaryoblastic Leukemia (M7) Phase 1 [1]
Component Drugs Mitoxantrone   DMM39BF Azacitidine   DMTA5OE
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Mitoxantrone
Disease Entry ICD 11 Status REF
Acute myelogenous leukaemia 2A41 Approved [2]
Adult acute monocytic leukemia N.A. Approved [2]
Leukemia N.A. Approved [2]
Solid tumour/cancer 2A00-2F9Z Approved [3]
Non-hodgkin lymphoma 2B33.5 Phase 1/2 [4]
Metastatic prostate carcinoma N.A. Investigative [2]
Mitoxantrone Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
DNA topoisomerase II (TOP2) TT0IHXV TOP2A_HUMAN; TOP2B_HUMAN Modulator [10]
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Mitoxantrone Interacts with 5 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [11]
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [12]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [12]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [13]
ATP-binding cassette sub-family A member 3 (ABCA3) DT2T6VQ ABCA3_HUMAN Substrate [14]
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Mitoxantrone Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Metabolism [15]
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Mitoxantrone Interacts with 230 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Increases Expression [16]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [16]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [17]
Voltage-dependent T-type calcium channel subunit alpha-1G (CACNA1G) OTGKBRE4 CAC1G_HUMAN Decreases Expression [7]
Tyrosine-protein kinase JAK2 (JAK2) OTBIDOOR JAK2_HUMAN Decreases Expression [7]
Sodium channel subunit beta-2 (SCN2B) OTFAHJ38 SCN2B_HUMAN Decreases Expression [7]
LIM domain-binding protein 3 (LDB3) OTGQL1AM LDB3_HUMAN Decreases Expression [7]
Creatine kinase M-type (CKM) OTME0KO7 KCRM_HUMAN Decreases Expression [7]
Glutathione peroxidase 1 (GPX1) OTE2O72Q GPX1_HUMAN Increases Expression [7]
Glycogen phosphorylase, muscle form (PYGM) OTWLVWTV PYGM_HUMAN Decreases Expression [7]
Dystrophin (DMD) OTD21T5J DMD_HUMAN Decreases Expression [7]
Myosin-7 (MYH7) OT4Z9T8N MYH7_HUMAN Decreases Expression [7]
Myosin-6 (MYH6) OT3YNCH1 MYH6_HUMAN Decreases Expression [7]
Troponin T, slow skeletal muscle (TNNT1) OT8PBOAR TNNT1_HUMAN Decreases Expression [7]
Receptor tyrosine-protein kinase erbB-3 (ERBB3) OTRSST0A ERBB3_HUMAN Decreases Expression [7]
Sarcoplasmic reticulum histidine-rich calcium-binding protein (HRC) OTDLEJ4T SRCH_HUMAN Decreases Expression [7]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [7]
Sodium/potassium-transporting ATPase subunit alpha-2 (ATP1A2) OTCF8OWW AT1A2_HUMAN Decreases Expression [7]
Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1) OT8SPJNX KCNQ1_HUMAN Decreases Expression [7]
cAMP-dependent protein kinase catalytic subunit PRKX (PRKX) OTDAC6Z0 PRKX_HUMAN Increases Expression [7]
Myomesin-2 (MYOM2) OTD2UOXW MYOM2_HUMAN Decreases Expression [7]
Inward rectifier potassium channel 2 (KCNJ2) OT2OQEZS KCNJ2_HUMAN Increases Expression [7]
Actin, alpha skeletal muscle (ACTA1) OTOVGLPG ACTS_HUMAN Decreases Expression [7]
Iroquois-class homeodomain protein IRX-4 (IRX4) OT0TV6WK IRX4_HUMAN Decreases Expression [7]
Ankyrin-2 (ANK2) OTWB4R1Y ANK2_HUMAN Decreases Expression [7]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [7]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Decreases Expression [7]
Dual specificity protein phosphatase 4 (DUSP4) OT6WAO12 DUS4_HUMAN Increases Expression [7]
Sodium channel protein type 5 subunit alpha (SCN5A) OTGYZWR6 SCN5A_HUMAN Decreases Expression [7]
Protein phosphatase 1 regulatory subunit 3A (PPP1R3A) OTJL9VYP PPR3A_HUMAN Decreases Expression [7]
Caveolae-associated protein 4 (CAVIN4) OTB1DM2C CAVN4_HUMAN Decreases Expression [7]
Nebulin-related-anchoring protein (NRAP) OTO6H3YF NRAP_HUMAN Decreases Expression [7]
Ryanodine receptor 2 (RYR2) OT0PF19E RYR2_HUMAN Decreases Expression [7]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [7]
Histone-lysine N-methyltransferase PRDM16 (PRDM16) OT0BGA27 PRD16_HUMAN Decreases Expression [7]
Voltage-dependent calcium channel subunit alpha-2/delta-2 (CACNA2D2) OTFJXVQQ CA2D2_HUMAN Decreases Expression [7]
Atrial natriuretic peptide-converting enzyme (CORIN) OT4SK7DK CORIN_HUMAN Decreases Expression [7]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Increases Expression [18]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [17]
Glucocorticoid receptor (NR3C1) OTCI2YDI GCR_HUMAN Decreases Activity [19]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Affects Activity [20]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Decreases Activity [21]
Retinoic acid receptor alpha (RARA) OT192V9V RARA_HUMAN Affects Mutagenesis [22]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [17]
Retinoic acid receptor beta (RARB) OT367U3E RARB_HUMAN Increases Expression [23]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [24]
Protein PML (PML) OT6SM2GD PML_HUMAN Affects Mutagenesis [22]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [25]
Caspase-2 (CASP2) OTUDYSPP CASP2_HUMAN Increases Expression [26]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Activity [25]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Activity [25]
Caspase-6 (CASP6) OTXLD3EC CASP6_HUMAN Increases Activity [25]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Decreases Expression [27]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Decreases Expression [8]
Sequestosome-1 (SQSTM1) OTGY5D5J SQSTM_HUMAN Decreases Expression [28]
Beclin-1 (BECN1) OT4X293M BECN1_HUMAN Decreases Expression [28]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Activity [25]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Decreases Activity [21]
Autophagy protein 5 (ATG5) OT4T5SMS ATG5_HUMAN Decreases Expression [28]
Regulator of G-protein signaling 2 (RGS2) OT0FSRW7 RGS2_HUMAN Affects Response To Substance [9]
Mitochondrial pyruvate carrier 2 (MPC2) OT0GHXGG MPC2_HUMAN Affects Response To Substance [9]
Molybdenum cofactor sulfurase (MOCOS) OT0TL3Q5 MOCOS_HUMAN Affects Response To Substance [9]
Tripartite motif-containing protein 2 (TRIM2) OT0V1YVC TRIM2_HUMAN Affects Response To Substance [9]
LEM domain-containing protein 2 (LEMD2) OT0YLT7L LEMD2_HUMAN Affects Response To Substance [29]
Iroquois-class homeodomain protein IRX-1 (IRX1) OT0ZN9EJ IRX1_HUMAN Affects Response To Substance [29]
Insulin-like growth factor-binding protein 7 (IGFBP7) OT1D416P IBP7_HUMAN Affects Response To Substance [9]
Methylosome subunit pICln (CLNS1A) OT1HL9L1 ICLN_HUMAN Affects Response To Substance [9]
D-3-phosphoglycerate dehydrogenase (PHGDH) OT1LMRTG SERA_HUMAN Affects Response To Substance [9]
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2) OT1LQSGX MTDC_HUMAN Affects Response To Substance [9]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D) OT1RWFV0 PDE4D_HUMAN Affects Response To Substance [9]
TBC1 domain family member 8 (TBC1D8) OT2011SS TBCD8_HUMAN Affects Response To Substance [9]
Protein FAM117A (FAM117A) OT2FBGGV F117A_HUMAN Affects Response To Substance [9]
Protein transport protein Sec31A (SEC31A) OT2U42AC SC31A_HUMAN Affects Response To Substance [9]
DNA-binding protein SATB2 (SATB2) OT2W80XC SATB2_HUMAN Affects Response To Substance [9]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Affects Response To Substance [9]
Very long chain fatty acid elongase 5 (ELOVL5) OT375W1Z ELOV5_HUMAN Affects Response To Substance [29]
Nuclear receptor subfamily 4 group A member 2 (NR4A2) OT3F9IR2 NR4A2_HUMAN Affects Response To Substance [9]
Solute carrier organic anion transporter family member 4A1 (SLCO4A1) OT3J1G7H SO4A1_HUMAN Affects Response To Substance [9]
Fatty acid CoA ligase Acsl3 (ACSL3) OT3MWER1 ACSL3_HUMAN Affects Response To Substance [9]
Leucine-rich repeat transmembrane protein FLRT3 (FLRT3) OT3XMZU3 FLRT3_HUMAN Affects Response To Substance [9]
ELAV-like protein 4 (ELAVL4) OT3YH6J6 ELAV4_HUMAN Affects Response To Substance [29]
Angiomotin-like protein 1 (AMOTL1) OT40G45S AMOL1_HUMAN Affects Response To Substance [29]
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A) OT4RF9Z4 PDE8A_HUMAN Affects Response To Substance [9]
PRELI domain containing protein 3B (PRELID3B) OT4TRT4K PLD3B_HUMAN Affects Response To Substance [9]
Argininosuccinate synthase (ASS1) OT4ZMG0Q ASSY_HUMAN Affects Response To Substance [9]
DNA topoisomerase 1 (TOP1) OT51O0CF TOP1_HUMAN Increases ADR [30]
Centrosomal protein 15 (CEP15) OT52961J CEP15_HUMAN Affects Response To Substance [9]
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (OXCT1) OT536PE7 SCOT1_HUMAN Affects Response To Substance [9]
Ubiquitin-like protein ISG15 (ISG15) OT53QQ7N ISG15_HUMAN Affects Response To Substance [9]
cAMP-responsive element-binding protein-like 2 (CREBL2) OT58JBNU CRBL2_HUMAN Affects Response To Substance [9]
PACRG-like protein (PACRGL) OT5DEP0X PACRL_HUMAN Affects Response To Substance [29]
Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A) OT5QQB5L IDH3A_HUMAN Affects Response To Substance [9]
G antigen 6 (GAGE6) OT5WRC1N GAGE6_HUMAN Affects Response To Substance [9]
Melanoma-associated antigen D1 (MAGED1) OT6EOLFC MAGD1_HUMAN Affects Response To Substance [9]
Laminin subunit beta-1 (LAMB1) OT6J9LJR LAMB1_HUMAN Affects Response To Substance [9]
Glutathione peroxidase 3 (GPX3) OT6PK94R GPX3_HUMAN Affects Response To Substance [9]
Band 4.1-like protein 2 (EPB41L2) OT6UABPM E41L2_HUMAN Affects Response To Substance [29]
Monocarboxylate transporter 7 (SLC16A6) OT7BIIZX MOT7_HUMAN Affects Response To Substance [9]
Homeobox protein engrailed-2 (EN2) OT7EZCM2 HME2_HUMAN Affects Response To Substance [9]
Exosome complex exonuclease RRP44 (DIS3) OT7UPHJS RRP44_HUMAN Affects Response To Substance [9]
Protein LBH (LBH) OT87AT1X LBH_HUMAN Affects Response To Substance [9]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Increases ADR [30]
Secreted frizzled-related protein 4 (SFRP4) OT8PQUVB SFRP4_HUMAN Affects Response To Substance [29]
Mesoderm-specific transcript homolog protein (MEST) OT8Q4U8Y MEST_HUMAN Affects Response To Substance [9]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Affects Response To Substance [9]
Exostosin-like 2 (EXTL2) OT8U672K EXTL2_HUMAN Affects Response To Substance [9]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Affects Response To Substance [9]
Frizzled-2 (FZD2) OT952ML1 FZD2_HUMAN Affects Response To Substance [9]
Transcription factor MafF (MAFF) OT9B7MX0 MAFF_HUMAN Affects Response To Substance [29]
Pyridoxal phosphate homeostasis protein (PLPBP) OT9DZ8P6 PLPHP_HUMAN Affects Response To Substance [9]
Splicing factor 45 (RBM17) OT9ROJCL SPF45_HUMAN Decreases Response To Substance [31]
Coxsackievirus and adenovirus receptor (CXADR) OT9ZP02A CXAR_HUMAN Affects Response To Substance [9]
RING finger and CHY zinc finger domain-containing protein 1 (RCHY1) OTAE7504 ZN363_HUMAN Affects Response To Substance [9]
Transgelin (TAGLN) OTAEZ0KP TAGL_HUMAN Affects Response To Substance [9]
POM121 and ZP3 fusion protein (POMZP3) OTAH2JOK POZP3_HUMAN Affects Response To Substance [9]
Transmembrane protein 47 (TMEM47) OTAJ4CPX TMM47_HUMAN Affects Response To Substance [9]
RCC1 and BTB domain-containing protein 1 (RCBTB1) OTAYELI8 RCBT1_HUMAN Affects Response To Substance [9]
Collagen alpha-1(XI) chain (COL11A1) OTB0DRMS COBA1_HUMAN Affects Response To Substance [9]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Affects Response To Substance [9]
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) OTB97VIK IF2B3_HUMAN Affects Response To Substance [9]
Cochlin (COCH) OTBEHD89 COCH_HUMAN Affects Response To Substance [9]
Epoxide hydrolase 1 (EPHX1) OTBKWQER HYEP_HUMAN Increases ADR [30]
Spondin-1 (SPON1) OTC06MY4 SPON1_HUMAN Affects Response To Substance [9]
Interferon regulatory factor 7 (IRF7) OTC1A2PQ IRF7_HUMAN Affects Response To Substance [9]
Cocaine esterase (CES2) OTC647SQ EST2_HUMAN Affects Response To Substance [9]
Mothers against decapentaplegic homolog 2 (SMAD2) OTC6VB4K SMAD2_HUMAN Affects Response To Substance [9]
Cystathionine gamma-lyase (CTH) OTC90LA0 CGL_HUMAN Affects Response To Substance [9]
KRR1 small subunit processome component homolog (KRR1) OTCMJ3K3 KRR1_HUMAN Affects Response To Substance [9]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Affects Response To Substance [9]
Interferon-stimulated gene 20 kDa protein (ISG20) OTCWRJJW ISG20_HUMAN Affects Response To Substance [9]
Tropomyosin alpha-1 chain (TPM1) OTD73X6R TPM1_HUMAN Affects Response To Substance [9]
Spondin-2 (SPON2) OTE7JLNM SPON2_HUMAN Affects Response To Substance [9]
Interferon-induced transmembrane protein 1 (IFITM1) OTECO1G8 IFM1_HUMAN Affects Response To Substance [9]
Syndecan-2 (SDC2) OTEEHY1D SDC2_HUMAN Affects Response To Substance [9]
Schwannomin-interacting protein 1 (SCHIP1) OTF3FR4A SCHI1_HUMAN Affects Response To Substance [9]
NADH dehydrogenase iron-sulfur protein 5 (NDUFS5) OTF40UYJ NDUS5_HUMAN Affects Response To Substance [9]
G antigen 7 (GAGE7) OTF8BTR9 GAGE7_HUMAN Affects Response To Substance [9]
Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2) OTFHWIY8 DHRS2_HUMAN Affects Response To Substance [9]
Fatty acid synthase (FASN) OTFII9KG FAS_HUMAN Decreases Response To Substance [32]
Laminin subunit alpha-2 (LAMA2) OTFROQWE LAMA2_HUMAN Affects Response To Substance [29]
Squalene synthase (FDFT1) OTGDISIT FDFT_HUMAN Affects Response To Substance [9]
Double-stranded RNA-specific editase 1 (ADARB1) OTGKSZEV RED1_HUMAN Affects Response To Substance [9]
Chordin-like protein 1 (CHRDL1) OTGMWVVA CRDL1_HUMAN Affects Response To Substance [9]
Cytotoxic granule associated RNA binding protein TIA1 (TIA1) OTGPN3P8 TIA1_HUMAN Affects Response To Substance [9]
Voltage-gated potassium channel subunit beta-2 (KCNAB2) OTH115IE KCAB2_HUMAN Affects Response To Substance [9]
Nidogen-2 (NID2) OTHC33FF NID2_HUMAN Affects Response To Substance [9]
Endothelial lipase (LIPG) OTHEE942 LIPG_HUMAN Affects Response To Substance [9]
Chemokine-like factor (CKLF) OTHLPHA0 CKLF_HUMAN Affects Response To Substance [9]
E3 ubiquitin-protein ligase MYCBP2 (MYCBP2) OTHODA1F MYCB2_HUMAN Affects Response To Substance [9]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Affects Response To Substance [9]
Basal cell adhesion molecule (BCAM) OTHZOPSD BCAM_HUMAN Affects Response To Substance [9]
Melanoma-associated antigen 6 (MAGEA6) OTI8S0O2 MAGA6_HUMAN Affects Response To Substance [9]
Laminin subunit gamma-1 (LAMC1) OTIG527N LAMC1_HUMAN Affects Response To Substance [9]
Leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4) OTIMWEK5 LGR4_HUMAN Affects Response To Substance [9]
Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA) OTIOLNHE LICH_HUMAN Affects Response To Substance [9]
Runt-related transcription factor 3 (RUNX3) OTITK1XD RUNX3_HUMAN Affects Response To Substance [9]
Lymphocyte function-associated antigen 3 (CD58) OTIUGMGS LFA3_HUMAN Affects Response To Substance [9]
Insulin-like growth factor-binding protein 3 (IGFBP3) OTIX63TX IBP3_HUMAN Affects Response To Substance [9]
Nuclear receptor-interacting protein 1 (NRIP1) OTIZOJQV NRIP1_HUMAN Affects Response To Substance [9]
Protein S100-P (S100P) OTJCXNJG S100P_HUMAN Affects Response To Substance [9]
Ectoderm-neural cortex protein 1 (ENC1) OTJEUB6U ENC1_HUMAN Affects Response To Substance [9]
Transcriptional activator Myb (MYB) OTJH64IV MYB_HUMAN Increases ADR [30]
Trefoil factor 3 (TFF3) OTJJDRTU TFF3_HUMAN Affects Response To Substance [9]
Antigen peptide transporter 1 (TAP1) OTJL27PW TAP1_HUMAN Affects Response To Substance [33]
Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1) OTKCR5XL CK2N1_HUMAN Affects Response To Substance [9]
Aldehyde dehydrogenase, mitochondrial (ALDH2) OTKJ9I3N ALDH2_HUMAN Affects Response To Substance [9]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Affects Response To Substance [9]
CUGBP Elav-like family member 2 (CELF2) OTLJJ4VT CELF2_HUMAN Affects Response To Substance [9]
Protein CASC3 (CASC3) OTLK3K4U CASC3_HUMAN Affects Response To Substance [29]
Tyrosine-protein kinase Fyn (FYN) OTLSLVZS FYN_HUMAN Affects Response To Substance [9]
Peroxiredoxin-2 (PRDX2) OTLWCY9T PRDX2_HUMAN Affects Response To Substance [9]
Homeobox protein Hox-A5 (HOXA5) OTLWGPQD HXA5_HUMAN Affects Response To Substance [9]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Affects Response To Substance [9]
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) OTMDVWPS DYRK2_HUMAN Affects Response To Substance [9]
Copper-transporting ATPase 1 (ATP7A) OTMR3GXP ATP7A_HUMAN Decreases Response To Substance [34]
Neurofilament heavy polypeptide (NEFH) OTMSCW5I NFH_HUMAN Affects Response To Substance [9]
Death-associated protein kinase 1 (DAPK1) OTNCNUCO DAPK1_HUMAN Affects Response To Substance [9]
Protein phosphatase inhibitor 2 (PPP1R2) OTNLOUQR IPP2_HUMAN Affects Response To Substance [9]
HMG box transcription factor BBX (BBX) OTNQ3QUC BBX_HUMAN Affects Response To Substance [9]
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5) OTNY3VMD PLCE_HUMAN Affects Response To Substance [9]
Melanoma-associated antigen D4 (MAGED4B) OTO37U7W MAGD4_HUMAN Affects Response To Substance [9]
Beta-secretase 2 (BACE2) OTO5YQVK BACE2_HUMAN Affects Response To Substance [9]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Decreases Response To Substance [35]
Receptor-type tyrosine-protein phosphatase epsilon (PTPRE) OTOD5NID PTPRE_HUMAN Affects Response To Substance [9]
Probable serine carboxypeptidase CPVL (CPVL) OTOJL31C CPVL_HUMAN Affects Response To Substance [9]
Caveolae-associated protein 3 (CAVIN3) OTOLBK79 CAVN3_HUMAN Affects Response To Substance [9]
Ecotropic viral integration site 5 protein homolog (EVI5) OTOPAP55 EVI5_HUMAN Affects Response To Substance [9]
Pre-B-cell leukemia transcription factor 1 (PBX1) OTORABGO PBX1_HUMAN Affects Response To Substance [9]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Decreases Response To Substance [36]
GTP cyclohydrolase 1 (GCH1) OTOZ6NSL GCH1_HUMAN Affects Response To Substance [9]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (PLCB4) OTPA0QHW PLCB4_HUMAN Affects Response To Substance [9]
G antigen 4 (GAGE4) OTPB5C0O GAGE4_HUMAN Affects Response To Substance [9]
Interleukin-13 receptor subunit alpha-2 (IL13RA2) OTPC2G0X I13R2_HUMAN Affects Response To Substance [9]
Tribbles homolog 1 (TRIB1) OTPEO17G TRIB1_HUMAN Affects Response To Substance [9]
Tumor protein D52 (TPD52) OTPKSK43 TPD52_HUMAN Affects Response To Substance [9]
DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) OTPL0AI1 ABC3C_HUMAN Affects Response To Substance [9]
Eukaryotic translation initiation factor 5A-1 (EIF5A) OTQ8DJX5 IF5A1_HUMAN Affects Response To Substance [9]
Clusterin (CLU) OTQGG0JM CLUS_HUMAN Affects Response To Substance [9]
Histone deacetylase 4 (HDAC4) OTQNGD32 HDAC4_HUMAN Affects Response To Substance [9]
Tissue-type plasminogen activator (PLAT) OTQPDNAB TPA_HUMAN Affects Response To Substance [9]
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1) OTQRET2B S5A1_HUMAN Affects Response To Substance [9]
Sal-like protein 2 (SALL2) OTQWI68Q SALL2_HUMAN Affects Response To Substance [9]
G antigen 2A (GAGE2A) OTRAJ80C GAG2A_HUMAN Affects Response To Substance [9]
Actin, gamma-enteric smooth muscle (ACTG2) OTRDWUO0 ACTH_HUMAN Affects Response To Substance [9]
DNA endonuclease RBBP8 (RBBP8) OTRHJ3GI CTIP_HUMAN Affects Response To Substance [9]
Cysteine/serine-rich nuclear protein 2 (CSRNP2) OTRZNC1C CSRN2_HUMAN Affects Response To Substance [29]
Heat shock-related 70 kDa protein 2 (HSPA2) OTSDET7B HSP72_HUMAN Affects Response To Substance [9]
Guanylate cyclase soluble subunit beta-1 (GUCY1B1) OTSHPHVB GCYB1_HUMAN Affects Response To Substance [9]
Bone marrow stromal antigen 2 (BST2) OTU4LCJV BST2_HUMAN Affects Response To Substance [9]
Synaptotagmin-like protein 2 (SYTL2) OTUIOWKL SYTL2_HUMAN Affects Response To Substance [29]
Max-interacting protein 1 (MXI1) OTUQ9E0D MXI1_HUMAN Affects Response To Substance [9]
Fibronectin type-III domain-containing protein 3A (FNDC3A) OTUX3S2I FND3A_HUMAN Affects Response To Substance [9]
HLA class II histocompatibility antigen, DR beta 5 chain (HLA-DRB5) OTUX5TWM DRB5_HUMAN Affects Response To Substance [9]
Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) OTV04QE5 P4HA1_HUMAN Affects Response To Substance [9]
Forkhead box protein F2 (FOXF2) OTV20NGX FOXF2_HUMAN Affects Response To Substance [9]
Nicotinamide phosphoribosyltransferase (NAMPT) OTVJR3GL NAMPT_HUMAN Affects Response To Substance [9]
Poly polymerase tankyrase-1 (TNKS) OTVOUTPX TNKS1_HUMAN Affects Response To Substance [9]
ADP-ribose glycohydrolase MACROD1 (MACROD1) OTWFEVRW MACD1_HUMAN Affects Response To Substance [9]
Sorbin and SH3 domain-containing protein 1 (SORBS1) OTWH8762 SRBS1_HUMAN Affects Response To Substance [9]
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) OTX8L3M5 SAHH2_HUMAN Affects Response To Substance [9]
Insulin-like growth factor 1 receptor (IGF1R) OTXJIF13 IGF1R_HUMAN Affects Response To Substance [37]
Ras-related GTP-binding protein D (RRAGD) OTXLVWAH RRAGD_HUMAN Affects Response To Substance [29]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B) OTY94WRA HM20B_HUMAN Affects Response To Substance [9]
Bone morphogenetic protein 7 (BMP7) OTYATP2K BMP7_HUMAN Affects Response To Substance [9]
Glutamine synthetase (GLUL) OTYGTCGF GLNA_HUMAN Affects Response To Substance [9]
Complement decay-accelerating factor (CD55) OTZ3HWTO DAF_HUMAN Affects Response To Substance [9]
BTB/POZ domain-containing protein 3 (BTBD3) OTZ607YT BTBD3_HUMAN Affects Response To Substance [9]
Zinc finger protein PLAGL1 (PLAGL1) OTZAO900 PLAL1_HUMAN Affects Response To Substance [9]
Ras GTPase-activating protein 1 (RASA1) OTZJ3LP4 RASA1_HUMAN Affects Response To Substance [29]
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) OTZRWTGA IQGA1_HUMAN Affects Response To Substance [9]
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⏷ Show the Full List of 230 DOT(s)
Indication(s) of Azacitidine
Disease Entry ICD 11 Status REF
Acute myelogenous leukaemia 2A41 Approved [5]
Chronic myelomonocytic leukemia N.A. Approved [5]
Leukemia N.A. Approved [5]
Myelodysplastic syndrome 2A37 Approved [6]
Myeloproliferative neoplasm 2A20 Approved [5]
Plasma cell myeloma 2A83.1 Approved [5]
Azacitidine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
DNA [cytosine-5]-methyltransferase (DNMT) TTHVCUP NOUNIPROTAC Inhibitor [42]
------------------------------------------------------------------------------------
Azacitidine Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytidine aminohydrolase (CDA) DEKEDRC CDD_HUMAN Metabolism [43]
Cytidine deaminase (cdd) DEYILK4 E0TLJ6_MYCHH Metabolism [44]
------------------------------------------------------------------------------------
Azacitidine Interacts with 275 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Affects Expression [45]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Increases Expression [46]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Increases Expression [46]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Increases Expression [46]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Increases Expression [46]
Sulfotransferase 1C2 (SULT1C2) OT07MMZS ST1C2_HUMAN Increases Expression [38]
Phospholipid phosphatase 1 (PLPP1) OT0IIMI5 PLPP1_HUMAN Increases Expression [38]
Tectonin beta-propeller repeat-containing protein 2 (TECPR2) OT1UFECZ TCPR2_HUMAN Increases Expression [38]
TBC1 domain family member 4 (TBC1D4) OTK66C40 TBCD4_HUMAN Decreases Expression [38]
Multiple epidermal growth factor-like domains protein 6 (MEGF6) OTEUYTP1 MEGF6_HUMAN Decreases Expression [38]
Stanniocalcin-2 (STC2) OT86YP8G STC2_HUMAN Decreases Expression [38]
Integrin beta-2 (ITGB2) OTEKPEPR ITB2_HUMAN Decreases Expression [38]
Protein S100-A9 (S100A9) OTOARHCS S10A9_HUMAN Increases Expression [38]
Receptor-type tyrosine-protein phosphatase C (PTPRC) OT6KOR77 PTPRC_HUMAN Increases Expression [38]
Delta-aminolevulinic acid dehydratase (ALAD) OTHM9GSH HEM2_HUMAN Decreases Expression [38]
Hepatocyte growth factor (HGF) OTGHUA23 HGF_HUMAN Increases Expression [38]
Heat shock 70 kDa protein 6 (HSPA6) OTH4S7WB HSP76_HUMAN Increases Expression [38]
Gamma-aminobutyric acid receptor subunit beta-1 (GABRB1) OT4L2SSB GBRB1_HUMAN Increases Expression [38]
Transcription factor E3 (TFE3) OTM99ZWH TFE3_HUMAN Increases Expression [38]
Pro-thyrotropin-releasing hormone (TRH) OT02UY2V TRH_HUMAN Decreases Expression [38]
Protein S100-P (S100P) OTJCXNJG S100P_HUMAN Increases Expression [38]
Protein PML (PML) OT6SM2GD PML_HUMAN Increases Expression [38]
DNA-binding protein inhibitor ID-1 (ID1) OTKGNZN5 ID1_HUMAN Increases Expression [38]
Cyclin-dependent kinase 4 inhibitor B (CDKN2B) OTAG24N1 CDN2B_HUMAN Decreases Methylation [38]
LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1) OT729S0T LIMS1_HUMAN Increases Expression [38]
E3 SUMO-protein ligase RanBP2 (RANBP2) OTFG5CVF RBP2_HUMAN Increases Expression [38]
Cyclin-dependent kinase inhibitor 1C (CDKN1C) OTASTJ3Q CDN1C_HUMAN Increases Expression [38]
Ras-related protein Rab-13 (RAB13) OTIQ484I RAB13_HUMAN Decreases Methylation [38]
Lysozyme C (LYZ) OTD7H0G6 LYSC_HUMAN Increases Expression [38]
Claudin-10 (CLDN10) OT2CVAKY CLD10_HUMAN Decreases Expression [38]
Sushi repeat-containing protein SRPX (SRPX) OT5B9LXS SRPX_HUMAN Decreases Expression [38]
Protein delta homolog 1 (DLK1) OTE1VLNB DLK1_HUMAN Decreases Methylation [38]
DNA-binding protein inhibitor ID-3 (ID3) OTUULW5Z ID3_HUMAN Increases Expression [38]
Collagen alpha-1(XIV) chain (COL14A1) OTLNJ13O COEA1_HUMAN Increases Expression [38]
Equilibrative nucleoside transporter 2 (SLC29A2) OTUAOB8T S29A2_HUMAN Decreases Expression [38]
Cytohesin-1 (CYTH1) OTYH9NRJ CYH1_HUMAN Increases Expression [38]
C3a anaphylatoxin chemotactic receptor (C3AR1) OT8J0TF8 C3AR_HUMAN Increases Expression [38]
DNA dC->dU-editing enzyme APOBEC-3F (APOBEC3F) OT750IJM ABC3F_HUMAN Increases Expression [38]
Angiogenic factor with G patch and FHA domains 1 (AGGF1) OTA7U2T8 AGGF1_HUMAN Increases Expression [38]
E3 ubiquitin-protein ligase Praja-1 (PJA1) OTFKTMEI PJA1_HUMAN Increases Expression [38]
Caspase-10 (CASP10) OTE6J88E CASPA_HUMAN Increases Expression [38]
Tetraspanin-32 (TSPAN32) OTSXW7EW TSN32_HUMAN Decreases Expression [38]
Tribbles homolog 1 (TRIB1) OTPEO17G TRIB1_HUMAN Decreases Expression [38]
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) OTT5JX1F LITAF_HUMAN Decreases Expression [38]
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1A) OTVTB5R5 PI51A_HUMAN Decreases Expression [38]
Centromere protein O (CENPO) OTXAH83Y CENPO_HUMAN Increases Expression [38]
Iron-sulfur cluster assembly 1 homolog, mitochondrial (ISCA1) OTU230MC ISCA1_HUMAN Increases Expression [38]
E3 ubiquitin-protein ligase TRIM8 (TRIM8) OTS6JFR0 TRIM8_HUMAN Increases Expression [38]
Uncharacterized protein C6orf62 (C6ORF62) OTGK4G35 CF062_HUMAN Increases Expression [38]
Metal transporter CNNM2 (CNNM2) OTZHO8WU CNNM2_HUMAN Decreases Expression [38]
Pantothenate kinase 3 (PANK3) OT77CFJ6 PANK3_HUMAN Decreases Expression [38]
DNA dC->dU-editing enzyme APOBEC-3G (APOBEC3G) OT410VP5 ABC3G_HUMAN Increases Expression [38]
Neuritin (NRN1) OTWJG0SO NRN1_HUMAN Decreases Expression [38]
NTF2-related export protein 2 (NXT2) OTK82YVT NXT2_HUMAN Increases Expression [38]
THUMP domain-containing protein 1 (THUMPD1) OTKU8KWH THUM1_HUMAN Increases Expression [38]
Protein FAM8A1 (FAM8A1) OT1QVTGS FA8A1_HUMAN Increases Expression [38]
Type 2 lactosamine alpha-2,3-sialyltransferase (ST3GAL6) OTB17Q43 SIA10_HUMAN Increases Expression [38]
Methionine-R-sulfoxide reductase B2, mitochondrial (MSRB2) OTURGRA8 MSRB2_HUMAN Increases Expression [38]
Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1) OTJCX8K9 MD1L1_HUMAN Decreases Expression [38]
Signal-regulatory protein beta-1 (SIRPB1) OTGHALWJ SIRB1_HUMAN Decreases Expression [39]
Syntenin-1 (SDCBP) OTS3NCC5 SDCB1_HUMAN Decreases Expression [39]
Complexin-1 (CPLX1) OT7UIGTP CPLX1_HUMAN Increases Expression [39]
Nephrocystin-1 (NPHP1) OTZHCFFQ NPHP1_HUMAN Increases Expression [39]
Phosphatase and actin regulator 2 (PHACTR2) OTWMX2A8 PHAR2_HUMAN Increases Expression [39]
Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) OT4TMERS NFAC1_HUMAN Increases Expression [39]
Acyl-CoA 6-desaturase (FADS2) OTUX531P FADS2_HUMAN Decreases Expression [39]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Increases Expression [39]
Cystatin-C (CST3) OTNZ6AO4 CYTC_HUMAN Increases Expression [39]
Cystatin-S (CST4) OTXXM8EH CYTS_HUMAN Increases Expression [39]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Increases Expression [39]
Integrin beta-1 (ITGB1) OT6G1IAR ITB1_HUMAN Decreases Expression [39]
Keratin, type II cytoskeletal 8 (KRT8) OTTM4X11 K2C8_HUMAN Increases Expression [39]
Neurofilament light polypeptide (NEFL) OTQESJV4 NFL_HUMAN Increases Expression [39]
Protein disulfide-isomerase (P4HB) OTTYNYPF PDIA1_HUMAN Increases Expression [39]
Decorin (DCN) OTWLJL7K PGS2_HUMAN Decreases Expression [39]
Profilin-1 (PFN1) OTHTGA1H PROF1_HUMAN Increases Expression [39]
Proto-oncogene tyrosine-protein kinase receptor Ret (RET) OTLU040A RET_HUMAN Decreases Expression [39]
Tropomyosin beta chain (TPM2) OTA1L0P8 TPM2_HUMAN Increases Expression [39]
Transcription factor Sp1 (SP1) OTISPT4X SP1_HUMAN Decreases Expression [39]
Keratin, type I cytoskeletal 19 (KRT19) OTDGDQ75 K1C19_HUMAN Increases Expression [39]
Insulin-like growth factor-binding protein 1 (IGFBP1) OT6UQV2K IBP1_HUMAN Increases Expression [39]
Small ribosomal subunit protein uS2 (RPSA) OTJZHEGT RSSA_HUMAN Decreases Expression [39]
Glycodelin (PAEP) OTQA0NV4 PAEP_HUMAN Decreases Expression [39]
E3 SUMO-protein ligase EGR2 (EGR2) OTAVQ78J EGR2_HUMAN Increases Expression [39]
Pregnancy-specific beta-1-glycoprotein 1 (PSG1) OT1U4ZZW PSG1_HUMAN Increases Expression [39]
Collagen alpha-3(VI) chain (COL6A3) OTAS6R6I CO6A3_HUMAN Decreases Expression [39]
Parathyroid hormone-related protein (PTHLH) OTI1JF13 PTHR_HUMAN Decreases Expression [39]
Plastin-3 (PLS3) OTYBM4PK PLST_HUMAN Decreases Expression [39]
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2) OT1LQSGX MTDC_HUMAN Decreases Expression [39]
Pyruvate kinase PKM (PKM) OTLHHMC2 KPYM_HUMAN Increases Expression [39]
Carboxypeptidase E (CPE) OTXNTV79 CBPE_HUMAN Increases Expression [39]
High mobility group protein HMG-I/HMG-Y (HMGA1) OTQUSHPX HMGA1_HUMAN Increases Expression [39]
Gap junction alpha-1 protein (GJA1) OTT94MKL CXA1_HUMAN Decreases Expression [39]
Desmin (DES) OTI09KBW DESM_HUMAN Increases Expression [39]
Plasma membrane calcium-transporting ATPase 1 (ATP2B1) OT5MXG9W AT2B1_HUMAN Decreases Expression [39]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [39]
5'-nucleotidase (NT5E) OT7J5LT6 5NTD_HUMAN Increases Expression [39]
Fibroblast growth factor 7 (FGF7) OTGK6ANL FGF7_HUMAN Decreases Expression [39]
Insulin-like growth factor-binding protein 4 (IGFBP4) OT2HZRBD IBP4_HUMAN Increases Expression [39]
Transcription elongation factor A protein 1 (TCEA1) OTBFO594 TCEA1_HUMAN Decreases Expression [39]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Increases Expression [39]
Tenascin (TNC) OTK4FSHR TENA_HUMAN Decreases Expression [39]
V-type proton ATPase 16 kDa proteolipid subunit c (ATP6V0C) OTKPL09B VATL_HUMAN Increases Expression [39]
Protein ITPRID2 (ITPRID2) OTO3JDX5 ITPI2_HUMAN Increases Expression [39]
Dual specificity protein phosphatase 1 (DUSP1) OTN6BR75 DUS1_HUMAN Increases Expression [39]
Interleukin-12 subunit beta (IL12B) OT0JF8A3 IL12B_HUMAN Increases Expression [39]
Neurotensin/neuromedin N (NTS) OTPGDNQS NEUT_HUMAN Decreases Expression [39]
Guanylate-binding protein 2 (GBP2) OTVU4G07 GBP2_HUMAN Decreases Expression [39]
MHC class II transactivator (CIITA) OTRJNZFO C2TA_HUMAN Increases Expression [39]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [39]
Exosome RNA helicase MTR4 (MTREX) OTSQY30V MTREX_HUMAN Increases Expression [39]
Alpha-S1-casein (CSN1S1) OTXOW6XJ CASA1_HUMAN Increases Expression [39]
Nuclear receptor-interacting protein 1 (NRIP1) OTIZOJQV NRIP1_HUMAN Decreases Expression [39]
Homeobox protein Hox-A1 (HOXA1) OTMSOJ7D HXA1_HUMAN Increases Expression [39]
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) OT6E2OW6 ENTP1_HUMAN Increases Expression [39]
Ephrin-A3 (EFNA3) OTJGOUMZ EFNA3_HUMAN Increases Expression [39]
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 (ART1) OT7FBG5W NAR1_HUMAN Increases Expression [39]
Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1) OTYHXLWZ BCAT1_HUMAN Decreases Expression [39]
Microfibrillar-associated protein 2 (MFAP2) OTMHVBTV MFAP2_HUMAN Decreases Expression [39]
Laminin subunit beta-2 (LAMB2) OT71OI2Y LAMB2_HUMAN Increases Expression [39]
NHP2-like protein 1 (SNU13) OTH56TIH NH2L1_HUMAN Increases Expression [39]
Homeobox protein DLX-6 (DLX6) OT0FIJHY DLX6_HUMAN Increases Expression [39]
Neurotrypsin (PRSS12) OT1MYL3L NETR_HUMAN Decreases Expression [39]
Elongation factor 1-alpha 1 (EEF1A1) OT00THXS EF1A1_HUMAN Decreases Expression [39]
Microtubule-associated protein 1A (MAP1A) OTHO8K43 MAP1A_HUMAN Decreases Expression [39]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Expression [39]
Cytochrome c oxidase subunit 6A2, mitochondrial (COX6A2) OTQR5SXD CX6A2_HUMAN Increases Expression [39]
cAMP-responsive element modulator (CREM) OTJIJ5AL CREM_HUMAN Decreases Expression [39]
Caldesmon (CALD1) OTNJKJ6Q CALD1_HUMAN Increases Expression [39]
ATP-dependent RNA helicase A (DHX9) OT5AAOQI DHX9_HUMAN Decreases Expression [39]
Serine/threonine-protein kinase PAK 1 (PAK1) OT17LZNZ PAK1_HUMAN Increases Expression [39]
Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5) OT6T408U MP2K5_HUMAN Decreases Expression [39]
Chitotriosidase-1 (CHIT1) OTPQR0A6 CHIT1_HUMAN Increases Expression [39]
Ras and Rab interactor 1 (RIN1) OTPBROUD RIN1_HUMAN Increases Expression [39]
Keratin, type I cuticular Ha2 (KRT32) OTZCGZYT K1H2_HUMAN Increases Expression [39]
Semaphorin-3A (SEMA3A) OTQJSV7W SEM3A_HUMAN Increases Expression [39]
Ras GTPase-activating protein 3 (RASA3) OT9C54MN RASA3_HUMAN Increases Expression [39]
Mediator of DNA damage checkpoint protein 1 (MDC1) OTEUQH4J MDC1_HUMAN Increases Expression [39]
Transmembrane glycoprotein NMB (GPNMB) OTB7KQKV GPNMB_HUMAN Decreases Expression [39]
Mortality factor 4-like protein 2 (MORF4L2) OT8OI3EC MO4L2_HUMAN Decreases Expression [39]
kinase isozyme 1, mitochondrial (PDK1) OTMABK9Z PDK1_HUMAN Increases Expression [39]
Serine/threonine-protein kinase 38 (STK38) OTKMYCYR STK38_HUMAN Decreases Expression [39]
Serine/threonine-protein phosphatase 2A activator (PTPA) OTRGFOI7 PTPA_HUMAN Increases Expression [39]
Reticulocalbin-1 (RCN1) OT3JBGAG RCN1_HUMAN Decreases Expression [39]
Olfactory receptor 8B8 (OR8B8) OTCISNYV OR8B8_HUMAN Increases Expression [39]
Leukotriene B4 receptor 1 (LTB4R) OT3SRH4H LT4R1_HUMAN Decreases Expression [39]
Serine/arginine-rich splicing factor 7 (SRSF7) OTRS4W4S SRSF7_HUMAN Decreases Expression [39]
Guanylate kinase (GUK1) OTLI0HRU KGUA_HUMAN Increases Expression [39]
Filamin A-interacting protein 1-like (FILIP1L) OTPY8IMS FIL1L_HUMAN Decreases Expression [39]
Nucleolar MIF4G domain-containing protein 1 (NOM1) OTWZSJJC NOM1_HUMAN Decreases Expression [39]
Opioid growth factor receptor-like protein 1 (OGFRL1) OT6QGBYE OGRL1_HUMAN Increases Expression [39]
Serine/threonine-protein kinase MRCK alpha (CDC42BPA) OTCPFOSA MRCKA_HUMAN Decreases Expression [39]
Extracellular sulfatase Sulf-1 (SULF1) OTJCNCO0 SULF1_HUMAN Decreases Expression [39]
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (GCNT2) OTRUIMC4 GNT2A_HUMAN Decreases Expression [39]
Oxidation resistance protein 1 (OXR1) OTPIDMT3 OXR1_HUMAN Increases Expression [39]
Alpha-2,8-sialyltransferase 8B (ST8SIA2) OTRBBBD8 SIA8B_HUMAN Decreases Expression [39]
Type II iodothyronine deiodinase (DIO2) OTGPNSLH IOD2_HUMAN Decreases Expression [39]
G-patch domain and KOW motifs-containing protein (GPKOW) OTGS3H0M GPKOW_HUMAN Increases Expression [39]
Rho guanine nucleotide exchange factor 2 (ARHGEF2) OTBQTFRT ARHG2_HUMAN Decreases Expression [39]
Homogentisate 1,2-dioxygenase (HGD) OTTKLQOO HGD_HUMAN Increases Expression [39]
Secretory carrier-associated membrane protein 4 (SCAMP4) OTSCZTJ5 SCAM4_HUMAN Increases Expression [39]
Protein bicaudal D homolog 1 (BICD1) OT78IYPF BICD1_HUMAN Decreases Expression [39]
Ankyrin repeat and SOCS box protein 2 (ASB2) OTF9LV7L ASB2_HUMAN Increases Expression [39]
Eyes absent homolog 1 (EYA1) OTHU807A EYA1_HUMAN Decreases Expression [39]
Bcl-2-like protein 13 (BCL2L13) OT2VRFTM B2L13_HUMAN Increases Expression [39]
RNA helicase Mov10l1 (MOV10L1) OTP978LK M10L1_HUMAN Increases Expression [39]
Rac GTPase-activating protein 1 (RACGAP1) OTQE8IEH RGAP1_HUMAN Increases Expression [39]
Ras-related protein Rab-1B (RAB1B) OTAFCUAS RAB1B_HUMAN Increases Expression [39]
Semaphorin-6C (SEMA6C) OT1N59T5 SEM6C_HUMAN Increases Expression [39]
Sentrin-specific protease 3 (SENP3) OTFQDOMC SENP3_HUMAN Increases Expression [39]
Ribonuclease P protein subunit p21 (RPP21) OT53MDNE RPP21_HUMAN Increases Expression [39]
Protocadherin-18 (PCDH18) OTTLQWRN PCD18_HUMAN Decreases Expression [39]
Protein S100-A14 (S100A14) OTVFJJ91 S10AE_HUMAN Decreases Expression [39]
Tryptase gamma (TPSG1) OTDESHKT TRYG1_HUMAN Decreases Expression [39]
Rho GTPase-activating protein 35 (ARHGAP35) OTJ8POG0 RHG35_HUMAN Increases Expression [39]
Neuroligin-3 (NLGN3) OTKDEC1Q NLGN3_HUMAN Increases Expression [39]
Polycystin-2-like protein 1 (PKD2L1) OT1KJDAT PK2L1_HUMAN Increases Expression [39]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) OTTLJH8W ATS1_HUMAN Decreases Expression [39]
Cytoplasmic phosphatidylinositol transfer protein 1 (PITPNC1) OT64TTGC PITC1_HUMAN Decreases Expression [39]
Transcription factor SOX-13 (SOX13) OTCIF6KC SOX13_HUMAN Decreases Expression [39]
Afadin- and alpha-actinin-binding protein (SSX2IP) OTEIZ7N1 ADIP_HUMAN Increases Expression [39]
Transmembrane emp24 domain-containing protein 3 (TMED3) OTNOPHHC TMED3_HUMAN Increases Expression [39]
Protocadherin beta-4 (PCDHB4) OTF665E0 PCDB4_HUMAN Decreases Expression [39]
Protocadherin beta-14 (PCDHB14) OTFZF1ST PCDBE_HUMAN Decreases Expression [39]
Adenylate kinase isoenzyme 5 (AK5) OTTGXLOT KAD5_HUMAN Increases Expression [39]
Albumin (ALB) OTVMM513 ALBU_HUMAN Increases Expression [47]
Alpha-fetoprotein (AFP) OT9GG3ZI FETA_HUMAN Increases Expression [47]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases Expression [47]
Tyrosine aminotransferase (TAT) OT2CJ91O ATTY_HUMAN Increases Expression [47]
Hepatocyte nuclear factor 4-alpha (HNF4A) OTY1TOAB HNF4A_HUMAN Increases Expression [47]
CCAAT/enhancer-binding protein alpha (CEBPA) OTOM9OE4 CEBPA_HUMAN Increases Expression [47]
Hematopoietically-expressed homeobox protein HHEX (HHEX) OTLIUVYX HHEX_HUMAN Increases Expression [47]
Suppressor of cytokine signaling 3 (SOCS3) OTY183WJ SOCS3_HUMAN Affects Expression [45]
Telomerase reverse transcriptase (TERT) OT085VVA TERT_HUMAN Decreases Expression [48]
Aquaporin-9 (AQP9) OTLGH5ZY AQP9_HUMAN Increases Expression [49]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 (GNG7) OTHS1L0E GBG7_HUMAN Affects Methylation [50]
Claudin-7 (CLDN7) OTNE0XHQ CLD7_HUMAN Decreases Expression [51]
Claudin-9 (CLDN9) OTCKI2IZ CLD9_HUMAN Increases Expression [52]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [48]
Calcitonin (CALCA) OTZ11LHB CALC_HUMAN Decreases Methylation [53]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Response To Substance [54]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Increases Expression [55]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Affects Activity [20]
Interleukin-4 (IL4) OTOXBWAU IL4_HUMAN Affects Methylation [56]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Affects Methylation [56]
Tyrosine-protein kinase Fyn (FYN) OTLSLVZS FYN_HUMAN Increases Expression [57]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Increases Expression [58]
L-lactate dehydrogenase B chain (LDHB) OT9B1CT3 LDHB_HUMAN Increases Expression [59]
Thyroid peroxidase (TPO) OTJJLL20 PERT_HUMAN Increases Expression [60]
Prostate-specific antigen (KLK3) OTFGSBFJ KLK3_HUMAN Increases Expression [58]
Histone H1.0 (H1-0) OTRLJK4Z H10_HUMAN Increases Expression [61]
Interleukin-6 receptor subunit alpha (IL6R) OTCQL07Z IL6RA_HUMAN Affects Expression [45]
Gamma-enolase (ENO2) OTRODL0T ENOG_HUMAN Decreases Expression [62]
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Increases Expression [58]
Microtubule-associated protein tau (MAPT) OTMTP2Z7 TAU_HUMAN Decreases Expression [63]
Chromogranin-A (CHGA) OTXYX5JH CMGA_HUMAN Decreases Expression [62]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Decreases Expression [58]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Increases Expression [64]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Increases Expression [62]
15-hydroxyprostaglandin dehydrogenase (HPGD) OTYZI6JB PGDH_HUMAN Decreases Methylation [65]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [66]
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Increases Expression [67]
Thyrotropin receptor (TSHR) OT0BC8LB TSHR_HUMAN Increases Expression [60]
Hepatocyte nuclear factor 1-alpha (HNF1A) OT9DOUKL HNF1A_HUMAN Increases Expression [49]
Fibulin-1 (FBLN1) OT5MHHOP FBLN1_HUMAN Increases Expression [57]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [68]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Decreases Expression [58]
DNA cytosine-5)-methyltransferase 1 (DNMT1) OTM2DGTK DNMT1_HUMAN Decreases Expression [69]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Affects Methylation [70]
Oxytocin receptor (OXTR) OT7WFW4U OXYR_HUMAN Decreases Expression [57]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Affects Expression [45]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Decreases Methylation [71]
Melanoma-associated antigen 1 (MAGEA1) OTXAO193 MAGA1_HUMAN Decreases Methylation [71]
Melanoma-associated antigen 3 (MAGEA3) OTW3Y5M4 MAGA3_HUMAN Increases Expression [72]
Killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1) OTL1LBQJ KI2L1_HUMAN Increases Expression [73]
Killer cell immunoglobulin-like receptor 2DL2 (KIR2DL2) OTOVUTJD KI2L2_HUMAN Increases Expression [73]
Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3) OTFCN53B KI2L3_HUMAN Increases Expression [73]
Killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) OTPOSXFX KI3L1_HUMAN Increases Expression [73]
Killer cell immunoglobulin-like receptor 2DS4 (KIR2DS4) OT00N6UJ KI2S4_HUMAN Increases Expression [73]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Increases Response To Substance [54]
Stromal cell-derived factor 1 (CXCL12) OT2QX5LL SDF1_HUMAN Increases Expression [74]
Tuberin (TSC2) OT47LWI9 TSC2_HUMAN Increases Expression [75]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Response To Substance [54]
High mobility group protein HMGI-C (HMGA2) OTBMBHHL HMGA2_HUMAN Increases Expression [57]
Homeobox protein Nkx-2.5 (NKX2-5) OTS1SAWM NKX25_HUMAN Increases Expression [76]
Death-associated protein kinase 1 (DAPK1) OTNCNUCO DAPK1_HUMAN Affects Methylation [77]
Claudin-6 (CLDN6) OTEN8ID2 CLD6_HUMAN Increases Expression [52]
Claudin-8 (CLDN8) OT7IIWXG CLD8_HUMAN Increases Expression [52]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Decreases Phosphorylation [57]
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA) OT83PT85 PP2AA_HUMAN Increases Expression [78]
Cyclin-A1 (CCNA1) OTX4HD45 CCNA1_HUMAN Decreases Expression [79]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Decreases Activity [80]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Affects Localization [45]
Tight junction protein ZO-1 (TJP1) OTBDCUPK ZO1_HUMAN Increases Expression [52]
Dihydropyrimidine dehydrogenase (DPYD) OTWRF2NR DPYD_HUMAN Decreases Methylation [81]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) OT4SO7J4 BNIP3_HUMAN Increases Expression [82]
N-myc-interactor (NMI) OTYVG3NM NMI_HUMAN Increases Expression [57]
NAD(P) transhydrogenase, mitochondrial (NNT) OTAIOGZK NNTM_HUMAN Increases Expression [51]
Runt-related transcription factor 3 (RUNX3) OTITK1XD RUNX3_HUMAN Affects Methylation [83]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Expression [84]
Cyclin-G2 (CCNG2) OTII38K2 CCNG2_HUMAN Decreases Expression [57]
Occludin (OCLN) OTSUTVWL OCLN_HUMAN Increases Expression [52]
kinase isozyme 4, mitochondrial (PDK4) OTCMHMBZ PDK4_HUMAN Decreases Methylation [85]
Dual specificity protein phosphatase 6 (DUSP6) OT4H6RKW DUS6_HUMAN Increases Expression [57]
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B) OTE8GBUR RIR2B_HUMAN Increases Expression [86]
Sodium/iodide cotransporter (SLC5A5) OTU7E9G7 SC5A5_HUMAN Increases Expression [87]
Krueppel-like factor 6 (KLF6) OTQY9S7F KLF6_HUMAN Increases Expression [57]
Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4) OTXN18OA KI2L4_HUMAN Increases Expression [73]
Protein Niban 1 (NIBAN1) OTYOLI12 NIBA1_HUMAN Increases Expression [57]
Calcium homeostasis modulator protein 2 (CALHM2) OTWWM6HI CAHM2_HUMAN Increases Expression [51]
Homeobox protein SIX2 (SIX2) OTYOVGSC SIX2_HUMAN Decreases Expression [51]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1) OT9HYT7A PLCB1_HUMAN Increases Expression [88]
Sal-like protein 4 (SALL4) OTC08PR5 SALL4_HUMAN Affects Methylation [41]
Transcription factor MafB (MAFB) OTH2N3T8 MAFB_HUMAN Increases Expression [51]
Sodium/nucleoside cotransporter 1 (SLC28A1) OTXWVV9O S28A1_HUMAN Increases Response To Substance [89]
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⏷ Show the Full List of 275 DOT(s)

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