Details of the Drug Combination

General Information of Drug Combination (ID: DCQBPUF)

Drug Combination Name
Menthol Nicotine
Indication
Disease Entry Status REF
Nicotine Dependence Phase 1 [1]
Component Drugs Menthol   DMG2KW7 Nicotine   DMWX5CO
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Menthol
Disease Entry ICD 11 Status REF
Back pain ME84.Z Approved [2]
Pityriasis simplex N.A. Approved [2]
Throat irritation CA0Y Approved [3]
Tinea versicolor 1F2D.0 Approved [2]
Pruritus EC90 Investigative [2]
Menthol Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Long transient receptor potential channel 8 (TRPM8) TTXDKTO TRPM8_HUMAN Activator [10]
Transformation-sensitive protein p120 (TRPA1) TTELV3W TRPA1_HUMAN Activator [10]
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Menthol Interacts with 265 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Transient receptor potential cation channel subfamily M member 8 (TRPM8) OT7ACGYK TRPM8_HUMAN Decreases Response To Substance [11]
Deoxyribonuclease-2-alpha (DNASE2) OT6RC1BL DNS2A_HUMAN Decreases Expression [7]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) OTBPCU2O TR10A_HUMAN Increases Expression [7]
E3 SUMO-protein ligase CBX4 (CBX4) OT4XVRRF CBX4_HUMAN Increases Expression [7]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) OTQ4W7MT TR11B_HUMAN Decreases Expression [7]
Voltage-dependent L-type calcium channel subunit beta-4 (CACNB4) OTYAI1UO CACB4_HUMAN Decreases Expression [7]
TNF receptor-associated factor 5 (TRAF5) OTSBTLO0 TRAF5_HUMAN Decreases Expression [7]
Transcription factor E2F3 (E2F3) OT5VQMWY E2F3_HUMAN Decreases Expression [7]
Etoposide-induced protein 2.4 homolog (EI24) OTD4NOYS EI24_HUMAN Decreases Expression [7]
Apoptotic protease-activating factor 1 (APAF1) OTJWIVY0 APAF_HUMAN Increases Expression [7]
Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) OT1Q40TZ MP2K7_HUMAN Decreases Expression [7]
Programmed cell death protein 5 (PDCD5) OT6T2DDL PDCD5_HUMAN Decreases Expression [7]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Decreases Expression [7]
Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C) OTVHOL9B TR10C_HUMAN Decreases Expression [7]
Calpain-9 (CAPN9) OTE4IU5U CAN9_HUMAN Decreases Expression [7]
Protein Mdm4 (MDM4) OTU10BSF MDM4_HUMAN Increases Expression [7]
Phospholipid scramblase 1 (PLSCR1) OTGY9B5T PLS1_HUMAN Decreases Expression [7]
Tumor protein p73 (TP73) OT0LUO47 P73_HUMAN Decreases Expression [7]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Increases Expression [7]
Proline dehydrogenase 1, mitochondrial (PRODH) OT7SQ1C7 PROD_HUMAN Increases Expression [7]
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) OT0KMIYQ RIPK2_HUMAN Increases Expression [7]
Glutamate receptor ionotropic, delta-2 (GRID2) OTJ3R10R GRID2_HUMAN Increases Expression [7]
Voltage-dependent T-type calcium channel subunit alpha-1G (CACNA1G) OTGKBRE4 CAC1G_HUMAN Increases Expression [7]
Tumor necrosis factor ligand superfamily member 12 (TNFSF12) OT6FQ02V TNF12_HUMAN Decreases Expression [7]
Tumor necrosis factor ligand superfamily member 14 (TNFSF14) OT5QRF09 TNF14_HUMAN Decreases Expression [7]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) OTJKOMXE BNI3L_HUMAN Decreases Expression [7]
Lipid transferase CIDEA (CIDEA) OTDUTSOV CIDEA_HUMAN Increases Expression [7]
Immunoglobulin mu Fc receptor (FCMR) OTI7I47T FCMR_HUMAN Increases Expression [7]
Polyglutamine-binding protein 1 (PQBP1) OTXCBEAH PQBP1_HUMAN Increases Expression [7]
Voltage-dependent L-type calcium channel subunit alpha-1F (CACNA1F) OTQTXNGF CAC1F_HUMAN Increases Expression [7]
Nucleolar protein 3 (NOL3) OT1K0L0D NOL3_HUMAN Increases Expression [7]
Programmed cell death protein 6 (PDCD6) OT2YA5M8 PDCD6_HUMAN Decreases Expression [7]
Nucleoside diphosphate kinase 6 (NME6) OTJNKOFA NDK6_HUMAN Decreases Expression [7]
Tumor necrosis factor receptor superfamily member 21 (TNFRSF21) OT3EDGXO TNR21_HUMAN Decreases Expression [7]
Syntaxin-11 (STX11) OTHFRSFP STX11_HUMAN Decreases Expression [7]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [7]
Tumor necrosis factor ligand superfamily member 13 (TNFSF13) OT90OWIO TNF13_HUMAN Decreases Expression [7]
DNA fragmentation factor subunit beta (DFFB) OTPBW5N5 DFFB_HUMAN Increases Expression [7]
Signal recognition particle subunit SRP72 (SRP72) OTPV73W7 SRP72_HUMAN Decreases Expression [7]
Serine/threonine-protein kinase 17B (STK17B) OT4NYNO8 ST17B_HUMAN Decreases Expression [7]
Pleckstrin homology domain-containing family G member 5 (PLEKHG5) OTL0S21W PKHG5_HUMAN Increases Expression [7]
Tumor necrosis factor ligand superfamily member 15 (TNFSF15) OTNGA2BW TNF15_HUMAN Decreases Expression [7]
Voltage-dependent T-type calcium channel subunit alpha-1H (CACNA1H) OTM705TH CAC1H_HUMAN Decreases Expression [7]
Kinesin-like protein KIF20A (KIF20A) OTXOQHE0 KI20A_HUMAN Increases Expression [7]
CUGBP Elav-like family member 2 (CELF2) OTLJJ4VT CELF2_HUMAN Increases Expression [7]
Tumor necrosis factor alpha-induced protein 8 (TNFAIP8) OT1G9297 TFIP8_HUMAN Decreases Expression [7]
Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) OTKAN9G7 TNF6B_HUMAN Decreases Expression [7]
BAG family molecular chaperone regulator 4 (BAG4) OTUPX3M2 BAG4_HUMAN Increases Expression [7]
Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) OT4TMERS NFAC1_HUMAN Increases Expression [7]
BAG family molecular chaperone regulator 2 (BAG2) OTI6LD27 BAG2_HUMAN Decreases Expression [7]
BAG family molecular chaperone regulator 3 (BAG3) OTVXYUDQ BAG3_HUMAN Increases Expression [7]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Decreases Expression [7]
B-cell lymphoma/leukemia 10 (BCL10) OT47MCLI BCL10_HUMAN Decreases Expression [7]
Prelamin-A/C (LMNA) OT3SG7ZR LMNA_HUMAN Increases Expression [7]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Decreases Expression [7]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Decreases Expression [7]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Decreases Expression [7]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [7]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Increases Expression [7]
Calpain-1 catalytic subunit (CAPN1) OTK6OQZR CAN1_HUMAN Increases Expression [7]
Tumor necrosis factor receptor superfamily member 16 (NGFR) OTPKSM49 TNR16_HUMAN Increases Expression [7]
Heat shock protein HSP 90-beta (HSP90AB1) OTR69EG7 HS90B_HUMAN Decreases Expression [7]
Cytochrome c1, heme protein, mitochondrial (CYC1) OT0962IM CY1_HUMAN Decreases Expression [7]
Interleukin-3 (IL3) OT0CQ35N IL3_HUMAN Decreases Expression [7]
Transcriptional activator Myb (MYB) OTJH64IV MYB_HUMAN Decreases Expression [7]
60 kDa heat shock protein, mitochondrial (HSPD1) OTTO1Y11 CH60_HUMAN Decreases Expression [7]
Cation-independent mannose-6-phosphate receptor (IGF2R) OTDXPQVX MPRI_HUMAN Increases Expression [7]
ADP/ATP translocase 1 (SLC25A4) OTKYLK2J ADT1_HUMAN Decreases Expression [7]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Increases Expression [7]
Perforin-1 (PRF1) OTFVXD7H PERF_HUMAN Decreases Expression [7]
Transcription factor JunB (JUNB) OTG2JXV5 JUNB_HUMAN Decreases Expression [7]
Transcription factor JunD (JUND) OTNKACJD JUND_HUMAN Increases Expression [7]
General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2) OT1C8HQ4 ERCC2_HUMAN Increases Expression [7]
Large ribosomal subunit protein uL30 (RPL7) OT4WCQBE RL7_HUMAN Increases Expression [7]
General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) OTVAW3P1 ERCC3_HUMAN Increases Expression [7]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Expression [7]
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) OTDS2EAR TNR1B_HUMAN Increases Expression [7]
Lamin-B1 (LMNB1) OT100T3P LMNB1_HUMAN Increases Expression [7]
B-cell lymphoma 3 protein (BCL3) OT1M5B95 BCL3_HUMAN Increases Expression [7]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) OTVLI4DD TNAP3_HUMAN Decreases Expression [7]
Cadherin-3 (CDH3) OTKNLQU7 CADH3_HUMAN Increases Expression [7]
E3 ubiquitin-protein ligase CBL (CBL) OTTKELCU CBL_HUMAN Decreases Expression [7]
Insulin-like growth factor-binding protein 4 (IGFBP4) OT2HZRBD IBP4_HUMAN Decreases Expression [7]
Tumor necrosis factor ligand superfamily member 4 (TNFSF4) OTOCBX7P TNFL4_HUMAN Increases Expression [7]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Decreases Expression [7]
Insulin-like growth factor-binding protein 5 (IGFBP5) OTRE5V0C IBP5_HUMAN Decreases Expression [7]
Adenomatous polyposis coli protein (APC) OTKV0TIK APC_HUMAN Decreases Expression [7]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Decreases Expression [7]
Proteasome subunit alpha type-3 (PSMA3) OT52M10V PSA3_HUMAN Increases Expression [7]
Tumor necrosis factor receptor superfamily member 5 (CD40) OT5YU2XB TNR5_HUMAN Decreases Expression [7]
Elongation factor 1-gamma (EEF1G) OTW7DH2F EF1G_HUMAN Decreases Expression [7]
CD27 antigen (CD27) OTH7NA58 CD27_HUMAN Increases Expression [7]
Proteasome subunit alpha type-5 (PSMA5) OT38E6Y1 PSA5_HUMAN Increases Expression [7]
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8) OTJ8UM8O TNR8_HUMAN Decreases Expression [7]
DNA-3-methyladenine glycosylase (MPG) OTAHW80B 3MG_HUMAN Decreases Expression [7]
AT-rich interactive domain-containing protein 4A (ARID4A) OT1XKBZ0 ARI4A_HUMAN Increases Expression [7]
Protein PML (PML) OT6SM2GD PML_HUMAN Decreases Expression [7]
CD40 ligand (CD40LG) OT75Z6A6 CD40L_HUMAN Decreases Expression [7]
Peroxiredoxin-5, mitochondrial (PRDX5) OTUEKZ18 PRDX5_HUMAN Decreases Expression [7]
Caspase-14 (CASP14) OTKY93H9 CASPE_HUMAN Increases Expression [7]
CD70 antigen (CD70) OTHB2AL1 CD70_HUMAN Increases Expression [7]
Tumor necrosis factor ligand superfamily member 8 (TNFSF8) OTDYGDJ3 TNFL8_HUMAN Decreases Expression [7]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Decreases Expression [7]
Insulin-like growth factor-binding protein complex acid labile subunit (IGFALS) OTTWCZYM ALS_HUMAN Increases Expression [7]
Tumor necrosis factor receptor superfamily member 3 (LTBR) OT2HVZGV TNR3_HUMAN Increases Expression [7]
Nuclear pore glycoprotein p62 (NUP62) OTMN63DH NUP62_HUMAN Decreases Expression [7]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [7]
Tumor necrosis factor ligand superfamily member 9 (TNFSF9) OTV9L89D TNFL9_HUMAN Increases Expression [7]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Increases Expression [7]
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4) OTDK74C0 TNR4_HUMAN Decreases Expression [7]
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) OTZPZX11 MP2K4_HUMAN Increases Expression [7]
Small ribosomal subunit protein uS4 (RPS9) OTPV69Q0 RS9_HUMAN Decreases Expression [7]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Increases Expression [7]
Type-2 angiotensin II receptor (AGTR2) OTU8GU9M AGTR2_HUMAN Decreases Expression [7]
Serpin B9 (SERPINB9) OTJ811IF SPB9_HUMAN Increases Expression [7]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Decreases Expression [7]
Death-associated protein 1 (DAP) OT5YLL7E DAP1_HUMAN Decreases Expression [7]
Small ribosomal subunit protein mS29 (DAP3) OTNPEZYM RT29_HUMAN Decreases Expression [7]
Tyrosine-protein kinase Blk (BLK) OT1EB8MT BLK_HUMAN Decreases Expression [7]
Cyclin-G1 (CCNG1) OT17IA9L CCNG1_HUMAN Decreases Expression [7]
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6) OTK13JKC MP2K6_HUMAN Decreases Expression [7]
Death-associated protein kinase 1 (DAPK1) OTNCNUCO DAPK1_HUMAN Decreases Expression [7]
Mitogen-activated protein kinase 10 (MAPK10) OTC46VX1 MK10_HUMAN Decreases Expression [7]
UV excision repair protein RAD23 homolog B (RAD23B) OT0PGOG3 RD23B_HUMAN Decreases Expression [7]
Epithelial membrane protein 3 (EMP3) OTODMJ1D EMP3_HUMAN Increases Expression [7]
Cyclin-dependent kinase 4 inhibitor D (CDKN2D) OT2TTZPZ CDN2D_HUMAN Decreases Expression [7]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Increases Expression [7]
Nucleoside diphosphate kinase homolog 5 (NME5) OTE8OLFN NDK5_HUMAN Decreases Expression [7]
Caspase recruitment domain-containing protein 18 (CARD18) OTBMLB80 CAR18_HUMAN Decreases Expression [7]
Triosephosphate isomerase (TPI1) OT14KP4B TPIS_HUMAN Increases Expression [7]
Actin, cytoplasmic 1 (ACTB) OT1MCP2F ACTB_HUMAN Decreases Expression [7]
Small ribosomal subunit protein uS10 (RPS20) OTI8052R RS20_HUMAN Increases Expression [7]
Small ribosomal subunit protein eS1 (RPS3A) OTUEP7CL RS3A_HUMAN Increases Expression [7]
10 kDa heat shock protein, mitochondrial (HSPE1) OT7JSZLB CH10_HUMAN Decreases Expression [7]
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (DAD1) OTUUNQBT DAD1_HUMAN Decreases Expression [7]
Large ribosomal subunit protein eL31 (RPL31) OTV9E1OE RL31_HUMAN Decreases Expression [7]
Growth factor receptor-bound protein 2 (GRB2) OTOP7LTE GRB2_HUMAN Decreases Expression [7]
Elongation factor 1-alpha 1 (EEF1A1) OT00THXS EF1A1_HUMAN Decreases Expression [7]
Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) OTEO98CR IF4G2_HUMAN Decreases Expression [7]
T-complex protein 1 subunit beta (CCT2) OTW1VV4E TCPB_HUMAN Decreases Expression [7]
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) OTTM6KRB ADA17_HUMAN Increases Expression [7]
Tumor necrosis factor-inducible gene 6 protein (TNFAIP6) OT1SLUZH TSG6_HUMAN Decreases Expression [7]
Voltage-dependent N-type calcium channel subunit alpha-1B (CACNA1B) OTRM0XDW CAC1B_HUMAN Decreases Expression [7]
Protein BEX3 (BEX3) OTW1V1L5 BEX3_HUMAN Increases Expression [7]
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (PDE1B) OT9NPJCR PDE1B_HUMAN Decreases Expression [7]
Spectrin beta chain, non-erythrocytic 1 (SPTBN1) OTOVM4D4 SPTB2_HUMAN Increases Expression [7]
Nucleolysin TIAR (TIAL1) OTV2KFZH TIAR_HUMAN Decreases Expression [7]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Increases Expression [7]
Forkhead box protein K2 (FOXK2) OTFXDZ3R FOXK2_HUMAN Increases Expression [7]
Voltage-dependent L-type calcium channel subunit alpha-1D (CACNA1D) OTQFH2ZD CAC1D_HUMAN Decreases Expression [7]
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) OT1YFEP1 TNR17_HUMAN Increases Expression [7]
Voltage-dependent L-type calcium channel subunit beta-1 (CACNB1) OTV42SIT CACB1_HUMAN Decreases Expression [7]
Tumor necrosis factor alpha-induced protein 2 (TNFAIP2) OTRZH80H TNAP2_HUMAN Increases Expression [7]
Peroxiredoxin-1 (PRDX1) OTZ3BEC4 PRDX1_HUMAN Increases Expression [7]
Tumor necrosis factor receptor superfamily member 9 (TNFRSF9) OTNOM26L TNR9_HUMAN Increases Expression [7]
Voltage-dependent L-type calcium channel subunit beta-2 (CACNB2) OT53K8W2 CACB2_HUMAN Decreases Expression [7]
Retinoblastoma-like protein 2 (RBL2) OTBQSOE6 RBL2_HUMAN Decreases Expression [7]
Sterol regulatory element-binding protein 2 (SREBF2) OTBXUNPL SRBP2_HUMAN Decreases Expression [7]
Tyrosine-protein phosphatase non-receptor type 13 (PTPN13) OTESFZSO PTN13_HUMAN Increases Expression [7]
TNF receptor-associated factor 2 (TRAF2) OT1MEZZN TRAF2_HUMAN Decreases Expression [7]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2) OTVZD4H6 BNIP2_HUMAN Increases Expression [7]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) OT4SO7J4 BNIP3_HUMAN Decreases Expression [7]
Baculoviral IAP repeat-containing protein 1 (NAIP) OTLA925F BIRC1_HUMAN Increases Expression [7]
TNF receptor-associated factor 1 (TRAF1) OTTLM5RU TRAF1_HUMAN Decreases Expression [7]
TNF receptor-associated factor 3 (TRAF3) OT5TQBGV TRAF3_HUMAN Increases Expression [7]
FAS-associated death domain protein (FADD) OTV7GFHH FADD_HUMAN Decreases Expression [7]
Serine/threonine-protein kinase PAK 2 (PAK2) OTLUNCIH PAK2_HUMAN Increases Expression [7]
Nucleoside diphosphate kinase 3 (NME3) OT0CA0GF NDK3_HUMAN Decreases Expression [7]
Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) OTS3FVTY M3K1_HUMAN Increases Expression [7]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Decreases Expression [7]
Cyclin-dependent kinase 5 activator 2 (CDK5R2) OTNUTLPU CD5R2_HUMAN Increases Expression [7]
Bcl-2-interacting killer (BIK) OTTH1T3D BIK_HUMAN Increases Expression [7]
Nuclear factor of activated T-cells, cytoplasmic 2 (NFATC2) OTK5T6HZ NFAC2_HUMAN Increases Expression [7]
GRB2-associated-binding protein 1 (GAB1) OTQKE6V4 GAB1_HUMAN Increases Expression [7]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Decreases Expression [7]
Deoxyribonuclease gamma (DNASE1L3) OTEUIMC2 DNSL3_HUMAN Increases Expression [7]
Apoptosis-stimulating of p53 protein 2 (TP53BP2) OTOWJ2Y4 ASPP2_HUMAN Increases Expression [7]
Spectrin alpha chain, non-erythrocytic 1 (SPTAN1) OT6VY3A3 SPTN1_HUMAN Decreases Expression [7]
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (TNFAIP1) OT37EWR0 BACD2_HUMAN Decreases Expression [7]
Pro-interleukin-16 (IL16) OTZ2MO6B IL16_HUMAN Decreases Expression [7]
Dedicator of cytokinesis protein 1 (DOCK1) OTCFV3ON DOCK1_HUMAN Decreases Expression [7]
Transcription factor Dp-1 (TFDP1) OT6RZ7VT TFDP1_HUMAN Decreases Expression [7]
Transcription factor Dp-2 (TFDP2) OTKQFX5H TFDP2_HUMAN Decreases Expression [7]
Fas-activated serine/threonine kinase (FASTK) OTTHFZMP FASTK_HUMAN Decreases Expression [7]
Nuclear mitotic apparatus protein 1 (NUMA1) OTTKAVG4 NUMA1_HUMAN Increases Expression [7]
Protein disulfide-isomerase A6 (PDIA6) OT8YBR17 PDIA6_HUMAN Increases Expression [7]
Retinoblastoma-binding protein 5 (RBBP5) OT12W2MK RBBP5_HUMAN Decreases Expression [7]
Transcription factor E2F5 (E2F5) OT1XWING E2F5_HUMAN Decreases Expression [7]
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) OTBOSJHO TRADD_HUMAN Increases Expression [7]
Voltage-dependent R-type calcium channel subunit alpha-1E (CACNA1E) OTHATMLU CAC1E_HUMAN Decreases Expression [7]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Expression [7]
Quinone oxidoreductase PIG3 (TP53I3) OTSCM68G QORX_HUMAN Increases Expression [7]
Serine/threonine-protein kinase LMTK1 (AATK) OTVHAX5N LMTK1_HUMAN Decreases Expression [7]
E3 ubiquitin-protein ligase RBBP6 (RBBP6) OTTVG4HU RBBP6_HUMAN Increases Expression [7]
E3 ubiquitin-protein ligase SIAH1 (SIAH1) OT29A838 SIAH1_HUMAN Decreases Expression [7]
Secreted frizzled-related protein 1 (SFRP1) OT0U9G41 SFRP1_HUMAN Increases Expression [7]
TRAF3-interacting protein 1 (TRAF3IP1) OTLCC64B MIPT3_HUMAN Decreases Expression [7]
MAP kinase-activating death domain protein (MADD) OTUFYVGG MADD_HUMAN Increases Expression [7]
Unconventional myosin-XVIIIa (MYO18A) OT2YPT7O MY18A_HUMAN Increases Expression [7]
Protein FAN (NSMAF) OTYNVZ23 FAN_HUMAN Increases Expression [7]
Zinc finger protein ubi-d4 (DPF2) OTL0JH2C REQU_HUMAN Decreases Expression [7]
Bcl-2-like protein 2 (BCL2L2) OTMKVO0J B2CL2_HUMAN Increases Expression [7]
TRAF family member-associated NF-kappa-B activator (TANK) OTZSGFIK TANK_HUMAN Decreases Expression [7]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Increases Expression [7]
Tumor necrosis factor receptor superfamily member 14 (TNFRSF14) OTB82PFO TNR14_HUMAN Increases Expression [7]
Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) OTVZ7I3A TNR25_HUMAN Decreases Expression [7]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (ATP2A3) OTFYDEES AT2A3_HUMAN Increases Expression [7]
Modulator of apoptosis 1 (MOAP1) OTVF3LUG MOAP1_HUMAN Decreases Expression [7]
PRKC apoptosis WT1 regulator protein (PAWR) OTKY7W52 PAWR_HUMAN Increases Expression [7]
Bcl-2-modifying factor (BMF) OT90NSLI BMF_HUMAN Decreases Expression [7]
Parkinson disease protein 7 (PARK7) OT0SKNTG PARK7_HUMAN Decreases Expression [7]
Mitogen-activated protein kinase kinase kinase 14 (MAP3K14) OTT3DOOL M3K14_HUMAN Increases Expression [7]
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) OTT5JX1F LITAF_HUMAN Increases Expression [7]
Mitogen-activated protein kinase kinase kinase 3 (MAP3K3) OT53LJGW M3K3_HUMAN Decreases Expression [7]
BAG family molecular chaperone regulator 1 (BAG1) OTRQNIA4 BAG1_HUMAN Decreases Expression [7]
B-cell CLL/lymphoma 7 protein family member B (BCL7B) OT8DQQRD BCL7B_HUMAN Increases Expression [7]
Heterogeneous nuclear ribonucleoprotein U-like protein 1 (HNRNPUL1) OTJP4U7K HNRL1_HUMAN Increases Expression [7]
TNF receptor-associated factor 4 (TRAF4) OTJLRVMC TRAF4_HUMAN Decreases Expression [7]
E3 ubiquitin-protein ligase TRAIP (TRAIP) OTMPT9Y2 TRAIP_HUMAN Decreases Expression [7]
Caspase recruitment domain-containing protein 10 (CARD10) OT2RPM4I CAR10_HUMAN Decreases Expression [7]
Caspase recruitment domain-containing protein 6 (CARD6) OTEI1PJ1 CARD6_HUMAN Decreases Expression [7]
Caspase recruitment domain-containing protein 14 (CARD14) OTADQHOV CAR14_HUMAN Decreases Expression [7]
Caspase recruitment domain-containing protein 11 (CARD11) OTRCTLYC CAR11_HUMAN Decreases Expression [7]
Apoptosis facilitator Bcl-2-like protein 14 (BCL2L14) OT87E7HW B2L14_HUMAN Increases Expression [7]
NACHT, LRR and PYD domains-containing protein 1 (NLRP1) OT4BNNOS NLRP1_HUMAN Increases Expression [7]
Autophagy protein 5 (ATG5) OT4T5SMS ATG5_HUMAN Increases Expression [7]
Caspase recruitment domain-containing protein 9 (CARD9) OTJ81AWD CARD9_HUMAN Increases Expression [7]
Bcl-2-like protein 12 (BCL2L12) OTS6IFZY B2L12_HUMAN Decreases Expression [7]
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) OTPGYWKC NOD2_HUMAN Increases Expression [7]
p53-regulated apoptosis-inducing protein 1 (TP53AIP1) OT1XVNDP TPIP1_HUMAN Decreases Expression [7]
Bcl-2-like protein 10 (BCL2L10) OTYXQJ3I B2L10_HUMAN Increases Expression [7]
NLR family CARD domain-containing protein 4 (NLRC4) OTAIA3NA NLRC4_HUMAN Decreases Expression [7]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Increases Expression [7]
Voltage-dependent calcium channel subunit alpha-2/delta-2 (CACNA2D2) OTFJXVQQ CA2D2_HUMAN Decreases Expression [7]
Bifunctional apoptosis regulator (BFAR) OTTBG0V7 BFAR_HUMAN Decreases Expression [7]
Hematopoietic cell signal transducer (HCST) OTILCB4K HCST_HUMAN Decreases Expression [7]
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D) OTOSRDJT TR10D_HUMAN Decreases Expression [7]
Peflin (PEF1) OTY24CUW PEF1_HUMAN Increases Expression [7]
Serine/threonine-protein kinase 17A (STK17A) OTS87MOT ST17A_HUMAN Decreases Expression [7]
Death domain-associated protein 6 (DAXX) OTX6O7PL DAXX_HUMAN Decreases Expression [7]
Lipid transferase CIDEB (CIDEB) OT873IYM CIDEB_HUMAN Increases Expression [7]
NADH dehydrogenase 1 alpha subcomplex subunit 12 (NDUFA12) OTCD6I5M NDUAC_HUMAN Increases Expression [7]
Death-associated protein kinase 2 (DAPK2) OTWODUQG DAPK2_HUMAN Decreases Expression [7]
Inhibitor of growth protein 1 (ING1) OTEZBRKW ING1_HUMAN Increases Expression [7]
CASP8-associated protein 2 (CASP8AP2) OTTWT68S C8AP2_HUMAN Decreases Expression [7]
BAG family molecular chaperone regulator 5 (BAG5) OT0J97C6 BAG5_HUMAN Increases Expression [7]
Apoptosis-associated speck-like protein containing a CARD (PYCARD) OT67RON3 ASC_HUMAN Decreases Expression [7]
Calpain-11 (CAPN11) OTEHK57V CAN11_HUMAN Decreases Expression [7]
Bcl-2-related ovarian killer protein (BOK) OTDQPDIX BOK_HUMAN Decreases Expression [7]
Tumor necrosis factor ligand superfamily member 18 (TNFSF18) OT3ANRX1 TNF18_HUMAN Increases Expression [7]
Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) OTUN9GUS NOD1_HUMAN Decreases Expression [7]
Caspase recruitment domain-containing protein 8 (CARD8) OTXXZYWU CARD8_HUMAN Increases Expression [7]
Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) OTL1D484 RIPK3_HUMAN Increases Expression [7]
NF-kappa-B essential modulator (IKBKG) OTNWJWSD NEMO_HUMAN Decreases Expression [7]
Calpain-6 (CAPN6) OT8K5PR5 CAN6_HUMAN Decreases Expression [7]
Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A) OT1FISGN TNR11_HUMAN Decreases Expression [7]
NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial (NDUFB8) OTW4A4Q0 NDUB8_HUMAN Decreases Expression [12]
Cytochrome c oxidase subunit 2 (COX2) OTTMVBJJ COX2_HUMAN Decreases Expression [12]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Secretion [13]
Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) OTRE1M1T SDHB_HUMAN Decreases Expression [12]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Increases Phosphorylation [14]
Rho-related GTP-binding protein RhoB (RHOB) OTHQFQF7 RHOB_HUMAN Increases Expression [15]
Ras-related protein Rap-1A (RAP1A) OT5RH6TI RAP1A_HUMAN Increases Expression [15]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Increases Phosphorylation [13]
Transient receptor potential cation channel subfamily V member 1 (TRPV1) OTHHDR03 TRPV1_HUMAN Increases Activity [11]
------------------------------------------------------------------------------------
⏷ Show the Full List of 265 DOT(s)
Indication(s) of Nicotine
Disease Entry ICD 11 Status REF
Lung cancer 2C25.0 Approved [4]
Nicotine dependence 6C4A.2 Approved [5]
Pellagra N.A. Approved [4]
Tobacco dependence 6C4A.2 Clinical trial [6]
Nicotine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Nicotinic acetylcholine receptor (nAChR) TTJSZTB NOUNIPROTAC Antagonist [27]
------------------------------------------------------------------------------------
Nicotine Interacts with 13 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [28]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [28]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [29]
Cytochrome P450 2A6 (CYP2A6) DEJVYAZ CP2A6_HUMAN Metabolism [30]
Cytochrome P450 1A1 (CYP1A1) DE6OQ3W CP1A1_HUMAN Metabolism [28]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [28]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Metabolism [31]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [28]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [28]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Metabolism [32]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [28]
Cytochrome P450 2A13 (CYP2A13) DEXZA9U CP2AD_HUMAN Metabolism [33]
Nicotinate dehydrogenase (nicA) DE4AMLP NICA_PSEPK Metabolism [34]
------------------------------------------------------------------------------------
⏷ Show the Full List of 13 DME(s)
Nicotine Interacts with 290 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [35]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Increases Expression [16]
Regulatory factor X-associated protein (RFXAP) OTX46DKQ RFXAP_HUMAN Decreases Expression [17]
Receptor-type tyrosine-protein phosphatase alpha (PTPRA) OTZA82J1 PTPRA_HUMAN Decreases Expression [17]
Ras-related protein Rab-6A (RAB6A) OTLS86J5 RAB6A_HUMAN Decreases Expression [17]
Tissue factor pathway inhibitor 2 (TFPI2) OTZCRWOR TFPI2_HUMAN Decreases Expression [17]
Rho guanine nucleotide exchange factor 7 (ARHGEF7) OT9BPJCL ARHG7_HUMAN Decreases Expression [17]
E3 ubiquitin-protein ligase RBBP6 (RBBP6) OTTVG4HU RBBP6_HUMAN Decreases Expression [17]
Histone-lysine N-methyltransferase 2C (KMT2C) OTC59BCO KMT2C_HUMAN Decreases Expression [17]
Fasciculation and elongation protein zeta-1 (FEZ1) OTWCXPRE FEZ1_HUMAN Decreases Expression [17]
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) OTT5JX1F LITAF_HUMAN Decreases Expression [17]
Copper chaperone for superoxide dismutase (CCS) OTXHT3QO CCS_HUMAN Increases Expression [36]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Decreases Expression [36]
Syntaxin-binding protein 3 (STXBP3) OTTTYMAQ STXB3_HUMAN Increases Expression [18]
Segment polarity protein dishevelled homolog DVL-2 (DVL2) OTMNYNCM DVL2_HUMAN Decreases Expression [18]
Chromodomain-helicase-DNA-binding protein 2 (CHD2) OTRKL6YC CHD2_HUMAN Increases Expression [18]
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) OT1Z1ZXE OGT1_HUMAN Increases Expression [18]
Apoptosis regulatory protein Siva (SIVA1) OTDT0XZK SIVA_HUMAN Decreases Expression [18]
Cytoplasmic dynein 1 light intermediate chain 2 (DYNC1LI2) OTR7WJES DC1L2_HUMAN Increases Expression [18]
E3 ubiquitin-protein ligase parkin (PRKN) OTJBN41W PRKN_HUMAN Decreases Expression [18]
C-Jun-amino-terminal kinase-interacting protein 4 (SPAG9) OT45AHMB JIP4_HUMAN Increases Expression [18]
Serine protease 1 (PRSS1) OTA425AX TRY1_HUMAN Decreases Expression [18]
Laminin subunit beta-1 (LAMB1) OT6J9LJR LAMB1_HUMAN Increases Expression [18]
Myb-related protein B (MYBL2) OTZ3JX8Q MYBB_HUMAN Decreases Expression [18]
Complement component C7 (C7) OTZ27VJN CO7_HUMAN Increases Expression [18]
Nucleoprotein TPR (TPR) OTUBBA4W TPR_HUMAN Increases Expression [18]
Glucosidase 2 subunit beta (PRKCSH) OTJCQYUU GLU2B_HUMAN Decreases Expression [18]
Creatine kinase S-type, mitochondrial (CKMT2) OT1KNPI1 KCRS_HUMAN Decreases Expression [18]
Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2) OT8DXMS3 E2AK2_HUMAN Increases Expression [18]
Cellular retinoic acid-binding protein 2 (CRABP2) OTY01V9G RABP2_HUMAN Decreases Expression [18]
Stress-induced-phosphoprotein 1 (STIP1) OT7TXLOX STIP1_HUMAN Decreases Expression [18]
Cyclin-dependent kinases regulatory subunit 2 (CKS2) OTPTMHIV CKS2_HUMAN Increases Expression [18]
Patatin-like phospholipase domain-containing protein 4 (PNPLA4) OT5CVDJM PLPL4_HUMAN Decreases Expression [18]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) OTTOMI8J PK3CA_HUMAN Increases Expression [18]
Transcriptional regulator ATRX (ATRX) OT77RSQW ATRX_HUMAN Increases Expression [18]
Translation initiation factor IF-2, mitochondrial (MTIF2) OTAIOZ0J IF2M_HUMAN Increases Expression [18]
F-actin-capping protein subunit alpha-2 (CAPZA2) OTHAO4V2 CAZA2_HUMAN Increases Expression [18]
RNA-binding protein 25 (RBM25) OTVOUOAG RBM25_HUMAN Increases Expression [18]
DNA ligase 4 (LIG4) OT40DNXU DNLI4_HUMAN Increases Expression [18]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 (GNG10) OTLMZGBE GBG10_HUMAN Increases Expression [18]
Serpin H1 (SERPINH1) OTKGI7BS SERPH_HUMAN Decreases Expression [18]
H(+)/Cl(-) exchange transporter 3 (CLCN3) OTEEXNMU CLCN3_HUMAN Increases Expression [18]
Protein FosB (FOSB) OTW6C05J FOSB_HUMAN Increases Expression [18]
Protein transport protein Sec61 subunit gamma (SEC61G) OT7MJRXY SC61G_HUMAN Increases Expression [18]
Myosin light polypeptide 6 (MYL6) OT84YKPM MYL6_HUMAN Decreases Expression [18]
CMP-sialic acid transporter (SLC35A1) OTPWOOVA S35A1_HUMAN Increases Expression [18]
Centromere-associated protein E (CENPE) OTQ7AP04 CENPE_HUMAN Increases Expression [18]
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PPP2R3A) OTSK5GFC P2R3A_HUMAN Increases Expression [18]
Phosphatidylinositol-glycan biosynthesis class F protein (PIGF) OTJKE6VW PIGF_HUMAN Increases Expression [18]
Son of sevenless homolog 1 (SOS1) OTTCWXC3 SOS1_HUMAN Increases Expression [18]
Zinc finger protein Rlf (RLF) OTCSPZVK RLF_HUMAN Increases Expression [18]
Chromobox protein homolog 3 (CBX3) OTOP9RLD CBX3_HUMAN Increases Expression [18]
Origin recognition complex subunit 2 (ORC2) OTLIYP8M ORC2_HUMAN Increases Expression [18]
Zinc transporter ZIP6 (SLC39A6) OTCYF466 S39A6_HUMAN Increases Expression [18]
Golgin subfamily A member 4 (GOLGA4) OTCMEHNJ GOGA4_HUMAN Increases Expression [18]
Serine incorporator 3 (SERINC3) OTQ1LAJ1 SERC3_HUMAN Increases Expression [18]
Transformer-2 protein homolog alpha (TRA2A) OT5NHOO3 TRA2A_HUMAN Increases Expression [18]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) OTGM06VJ IDI1_HUMAN Increases Expression [18]
Thyroid receptor-interacting protein 11 (TRIP11) OT4FJEAR TRIPB_HUMAN Increases Expression [18]
Serine/threonine-protein kinase N2 (PKN2) OTW0SOID PKN2_HUMAN Increases Expression [18]
DNA damage-binding protein 1 (DDB1) OTTR2L3Z DDB1_HUMAN Decreases Expression [18]
NADH dehydrogenase 1 alpha subcomplex subunit 5 (NDUFA5) OTR848KZ NDUA5_HUMAN Increases Expression [18]
Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) OTN7XAUD LRRF1_HUMAN Increases Expression [18]
Transmembrane protein 41B (TMEM41B) OTW0B0KS TM41B_HUMAN Increases Expression [18]
Heterochromatin protein 1-binding protein 3 (HP1BP3) OTTJ5LX2 HP1B3_HUMAN Increases Expression [18]
Pre-mRNA-splicing factor 38B (PRPF38B) OTQLH551 PR38B_HUMAN Increases Expression [18]
Serine/threonine-protein kinase TAO1 (TAOK1) OTFFLV6Q TAOK1_HUMAN Increases Expression [18]
Ninein (NIN) OTVH3M4Z NIN_HUMAN Increases Expression [18]
Tribbles homolog 2 (TRIB2) OTHSX3MX TRIB2_HUMAN Increases Expression [18]
DNA topoisomerase 2-binding protein 1 (TOPBP1) OT6UPZPD TOPB1_HUMAN Increases Expression [18]
PHD finger protein 3 (PHF3) OTNOYLG9 PHF3_HUMAN Increases Expression [18]
Probable ATP-dependent RNA helicase DDX17 (DDX17) OTXRMMBP DDX17_HUMAN Increases Expression [18]
DNA repair protein RAD50 (RAD50) OTYMU9G1 RAD50_HUMAN Increases Expression [18]
snRNA-activating protein complex subunit 3 (SNAPC3) OTSGZZCJ SNPC3_HUMAN Increases Expression [18]
PHD finger protein 21A (PHF21A) OTU3FFG4 PF21A_HUMAN Increases Expression [18]
THO complex subunit 1 (THOC1) OTVABJ4Z THOC1_HUMAN Increases Expression [18]
Chloride channel CLIC-like protein 1 (CLCC1) OTTXCXVT CLCC1_HUMAN Increases Expression [18]
Protein SCAF11 (SCAF11) OTX59D0X SCAFB_HUMAN Increases Expression [18]
Mediator of RNA polymerase II transcription subunit 28 (MED28) OTEDM1L5 MED28_HUMAN Increases Expression [18]
Arginine and glutamate-rich protein 1 (ARGLU1) OTRVRZ4Z ARGL1_HUMAN Increases Expression [18]
DDB1- and CUL4-associated factor 16 (DCAF16) OT60PR7J DCA16_HUMAN Increases Expression [18]
Polypyrimidine tract-binding protein 2 (PTBP2) OTF4S7NE PTBP2_HUMAN Increases Expression [18]
Splicing factor 3B subunit 6 (SF3B6) OTPRKS6S SF3B6_HUMAN Increases Expression [18]
Protein PRRC2C (PRRC2C) OTBX3MXM PRC2C_HUMAN Increases Expression [18]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [37]
Beta-2 adrenergic receptor (ADRB2) OTSDOX4Q ADRB2_HUMAN Increases Expression [38]
Beta-1 adrenergic receptor (ADRB1) OTQBWN4U ADRB1_HUMAN Increases Expression [38]
Deoxyribonuclease-2-alpha (DNASE2) OT6RC1BL DNS2A_HUMAN Decreases Expression [19]
NF-kappa-B inhibitor epsilon (NFKBIE) OTLAYEL9 IKBE_HUMAN Decreases Expression [19]
Serine/threonine-protein kinase 25 (STK25) OT4YPNTF STK25_HUMAN Increases Expression [19]
Krueppel-like factor 11 (KLF11) OTKVQDJD KLF11_HUMAN Decreases Expression [19]
C-C motif chemokine 16 (CCL16) OTOOQI1F CCL16_HUMAN Decreases Expression [19]
Death effector domain-containing protein (DEDD) OTIL349E DEDD_HUMAN Decreases Expression [19]
DNA fragmentation factor subunit beta (DFFB) OTPBW5N5 DFFB_HUMAN Decreases Expression [19]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Decreases Expression [19]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Increases Expression [19]
CD59 glycoprotein (CD59) OTSUMQDH CD59_HUMAN Increases Expression [19]
POU domain, class 2, transcription factor 1 (POU2F1) OTK7ELJ0 PO2F1_HUMAN Increases Expression [19]
Ezrin (EZR) OTHBPF1Z EZRI_HUMAN Increases Expression [19]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) OT2D9DOV TNR1A_HUMAN Decreases Expression [19]
Transcription factor BTF3 (BTF3) OT5ZZFJL BTF3_HUMAN Decreases Expression [19]
E3 ubiquitin-protein ligase CBL (CBL) OTTKELCU CBL_HUMAN Increases Expression [19]
Nuclear transcription factor Y subunit beta (NFYB) OTXSE7KW NFYB_HUMAN Decreases Expression [19]
Pentraxin-related protein PTX3 (PTX3) OTPXHRKU PTX3_HUMAN Decreases Expression [19]
Hepatocyte growth factor-like protein (MST1) OTOC4UNG HGFL_HUMAN Decreases Expression [19]
Interleukin-3 receptor subunit alpha (IL3RA) OTDC3Y8O IL3RA_HUMAN Decreases Expression [19]
Embryonic growth/differentiation factor 1 (GDF1) OTZ1VRBH GDF1_HUMAN Increases Expression [19]
Proteasome subunit beta type-6 (PSMB6) OT9VXPNW PSB6_HUMAN Decreases Expression [19]
cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B) OTZEXEFH KAP3_HUMAN Increases Expression [19]
Receptor-type tyrosine-protein kinase FLT3 (FLT3) OTMSRYMK FLT3_HUMAN Decreases Expression [19]
Alpha-synuclein (SNCA) OTPWC1MR SYUA_HUMAN Increases Expression [19]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Decreases Expression [19]
Kappa-type opioid receptor (OPRK1) OTXCZF4L OPRK_HUMAN Decreases Expression [19]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Increases Expression [19]
Signal transducer and activator of transcription 2 (STAT2) OTO9G2RZ STAT2_HUMAN Decreases Expression [19]
Protein S100-A10 (S100A10) OTI71243 S10AA_HUMAN Decreases Expression [19]
Cyclin-dependent kinases regulatory subunit 1 (CKS1B) OTNUPLUJ CKS1_HUMAN Decreases Expression [19]
Large ribosomal subunit protein eL8 (RPL7A) OT6E6UKF RL7A_HUMAN Decreases Expression [19]
Small ribosomal subunit protein eS25 (RPS25) OTKLWED2 RS25_HUMAN Increases Expression [19]
Transcription elongation factor SPT4 (SUPT4H1) OTB3UCTB SPT4H_HUMAN Decreases Expression [19]
Protein CBFA2T1 (RUNX1T1) OT30DED5 MTG8_HUMAN Decreases Expression [19]
Regulator of G-protein signaling 1 (RGS1) OTGXJYMG RGS1_HUMAN Increases Expression [19]
Nucleoside diphosphate kinase 3 (NME3) OT0CA0GF NDK3_HUMAN Decreases Expression [19]
Transcription factor Dp-1 (TFDP1) OT6RZ7VT TFDP1_HUMAN Decreases Expression [19]
Helicase-like transcription factor (HLTF) OTRX2OSF HLTF_HUMAN Decreases Expression [19]
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF2) OTRHB9SR NHRF2_HUMAN Decreases Expression [19]
Cocaine- and amphetamine-regulated transcript protein (CARTPT) OTTE4V9S CART_HUMAN Decreases Expression [19]
POU domain class 2-associating factor 1 (POU2AF1) OTOO6WHL OBF1_HUMAN Decreases Expression [19]
Anti-Muellerian hormone type-2 receptor (AMHR2) OT95APPM AMHR2_HUMAN Decreases Expression [19]
Serine/threonine-protein kinase LMTK1 (AATK) OTVHAX5N LMTK1_HUMAN Increases Expression [19]
MAP kinase-activating death domain protein (MADD) OTUFYVGG MADD_HUMAN Decreases Expression [19]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Decreases Expression [19]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Increases Expression [39]
Transcription factor JunB (JUNB) OTG2JXV5 JUNB_HUMAN Increases Expression [39]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [39]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Decreases Expression [39]
Signal transducer and activator of transcription 5B (STAT5B) OTZVPEBT STA5B_HUMAN Increases Expression [39]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Affects Expression [40]
Metalloproteinase inhibitor 3 (TIMP3) OTDGQAD1 TIMP3_HUMAN Affects Expression [40]
Metalloproteinase inhibitor 4 (TIMP4) OT8A68SW TIMP4_HUMAN Affects Expression [40]
Matrilysin (MMP7) OTVT3SEJ MMP7_HUMAN Increases Expression [41]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Decreases Expression [41]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Increases Expression [41]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Increases Phosphorylation [42]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Increases Expression [42]
Steroidogenic acute regulatory protein, mitochondrial (STAR) OTFEZ5AI STAR_HUMAN Decreases Expression [43]
Zinc finger protein SNAI2 (SNAI2) OT7Y8EJ2 SNAI2_HUMAN Increases Expression [20]
Zinc finger protein SNAI1 (SNAI1) OTDPYAMC SNAI1_HUMAN Increases Expression [20]
POU domain, class 5, transcription factor 1 (POU5F1) OTDHHN7O PO5F1_HUMAN Increases Expression [20]
Homeobox protein NANOG (NANOG) OTUEY1FM NANOG_HUMAN Increases Expression [20]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Increases Expression [44]
Cyclin-G2 (CCNG2) OTII38K2 CCNG2_HUMAN Increases Expression [44]
Ankyrin repeat and BTB/POZ domain-containing protein 3 (ABTB3) OT3PLG38 ABTB3_HUMAN Increases Expression [21]
Envoplakin-like protein (EVPLL) OT1BCQEW EVPLL_HUMAN Increases Expression [21]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Increases Expression [21]
Leucine-rich repeat transmembrane protein FLRT2 (FLRT2) OTGD8TID FLRT2_HUMAN Increases Expression [21]
Ephrin-A2 (EFNA2) OTEAUKRX EFNA2_HUMAN Increases Expression [21]
Sushi repeat-containing protein SRPX2 (SRPX2) OT6A63TX SRPX2_HUMAN Increases Expression [21]
Kinesin-like protein KIF21B (KIF21B) OTFXFIU3 KI21B_HUMAN Increases Expression [21]
Immunoglobulin superfamily member 3 (IGSF3) OT6GWBAF IGSF3_HUMAN Increases Expression [21]
Gamma-glutamylcyclotransferase (GGCT) OTKAICP5 GGCT_HUMAN Increases Splicing [21]
Mediator of RNA polymerase II transcription subunit 24 (MED24) OTU4SJQ1 MED24_HUMAN Increases Expression [21]
CCN family member 5 (CCN5) OTADU8JJ CCN5_HUMAN Increases Expression [21]
2'-5'-oligoadenylate synthase 1 (OAS1) OT8ZLOCY OAS1_HUMAN Increases Expression [21]
Keratin, type II cytoskeletal 6B (KRT6B) OTBXJYHY K2C6B_HUMAN Increases Expression [21]
Metallothionein-1E (MT1E) OTXJKU4Y MT1E_HUMAN Increases Expression [21]
Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2) OTTLGRGH GNAI2_HUMAN Increases Splicing [21]
Coiled-coil domain-containing protein 159 (CCDC159) OTFKSPMZ CC159_HUMAN Increases Expression [21]
Ras-related C3 botulinum toxin substrate 2 (RAC2) OTAOHFNH RAC2_HUMAN Increases Expression [21]
Fumarylacetoacetase (FAH) OTGZA1YR FAAA_HUMAN Increases Expression [21]
Homeobox protein Hox-B9 (HOXB9) OTMVHQOU HXB9_HUMAN Increases Expression [21]
Keratin, type I cytoskeletal 15 (KRT15) OTS6WLF7 K1C15_HUMAN Increases Expression [21]
Small proline-rich protein 2D (SPRR2D) OT47THNK SPR2D_HUMAN Increases Expression [21]
Protein S100-A2 (S100A2) OTTGHJ1H S10A2_HUMAN Increases Expression [21]
Caspase-14 (CASP14) OTKY93H9 CASPE_HUMAN Increases Expression [21]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1) OTB06ESI ACSL1_HUMAN Increases Splicing [21]
Interferon alpha-inducible protein 27, mitochondrial (IFI27) OTI2XGIT IFI27_HUMAN Increases Expression [21]
Epithelial membrane protein 1 (EMP1) OTSZHUHQ EMP1_HUMAN Increases Expression [21]
ATP synthase subunit epsilon, mitochondrial (ATP5F1E) OTMPLAIS ATP5E_HUMAN Increases Splicing [21]
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7) OTV7VOV3 DHB7_HUMAN Increases Splicing [21]
Ribose-phosphate pyrophosphokinase 1 (PRPS1) OTN3A6CN PRPS1_HUMAN Increases Splicing [21]
Rho-related GTP-binding protein RhoE (RND3) OTXMXPIH RND3_HUMAN Increases Splicing [21]
Small ribosomal subunit protein eS24 (RPS24) OTSNKIL5 RS24_HUMAN Increases Splicing [21]
Keratin, type II cuticular Hb5 (KRT85) OT67IP7F KRT85_HUMAN Increases Expression [21]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Increases Expression [21]
Paired box protein Pax-8 (PAX8) OTRPD9MI PAX8_HUMAN Increases Expression [21]
Cytochrome P450 4F3 (CYP4F3) OTYNSQAM CP4F3_HUMAN Increases Expression [21]
Melatonin-related receptor (GPR50) OT0EJBM4 MTR1L_HUMAN Increases Expression [21]
Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1) OT1QHOS2 NF2L1_HUMAN Increases Splicing [21]
Protein Aster-B (GRAMD1B) OTCG1GX2 ASTRB_HUMAN Increases Expression [21]
Interferon-induced protein 44-like (IFI44L) OTXKORJP IF44L_HUMAN Increases Expression [21]
SH3 domain-containing protein 19 (SH3D19) OTVU3VS2 SH319_HUMAN Increases Splicing [21]
Late cornified envelope protein 1B (LCE1B) OT7BLO6L LCE1B_HUMAN Increases Expression [21]
Keratin, type II cytoskeletal 80 (KRT80) OTAU54U3 K2C80_HUMAN Increases Expression [21]
TMF-regulated nuclear protein 1 (TRNP1) OTYYV8LN TRNP1_HUMAN Increases Expression [21]
Solute carrier family 25 member 48 (SLC25A48) OTAMLAGE S2548_HUMAN Decreases Expression [21]
Activity-regulated cytoskeleton-associated protein (ARC) OTN2QQPG ARC_HUMAN Increases Expression [21]
5'-deoxynucleotidase HDDC2 (HDDC2) OTSO0JP4 HDDC2_HUMAN Increases Expression [21]
Low-density lipoprotein receptor class A domain-containing protein 3 (LDLRAD3) OTYAKC55 LRAD3_HUMAN Increases Splicing [21]
Neuronal PAS domain-containing protein 3 (NPAS3) OT8D1ILB NPAS3_HUMAN Decreases Expression [21]
Prominin-2 (PROM2) OTT8IVS7 PROM2_HUMAN Increases Expression [21]
Synaptopodin (SYNPO) OTICDJAB SYNPO_HUMAN Increases Expression [21]
Cilia- and flagella-associated protein 43 (CFAP43) OT6R8UGG CFA43_HUMAN Decreases Expression [21]
Protein FAM83F (FAM83F) OTGGJRO7 FA83F_HUMAN Increases Expression [21]
Interferon-induced protein 44 (IFI44) OTOKSZVA IFI44_HUMAN Increases Expression [21]
Retinoic acid early transcript 1E (RAET1E) OTLR3CEC RAE1E_HUMAN Increases Expression [21]
Glucose-6-phosphate exchanger SLC37A2 (SLC37A2) OTH77FBE G6PT3_HUMAN Increases Expression [21]
Prospero homeobox protein 1 (PROX1) OT68R6IO PROX1_HUMAN Increases Expression [21]
Phosphatidate cytidylyltransferase 1 (CDS1) OT2F591M CDS1_HUMAN Increases Splicing [21]
Solute carrier organic anion transporter family member 2A1 (SLCO2A1) OT3062CA SO2A1_HUMAN Increases Expression [21]
SH3 domain-containing kinase-binding protein 1 (SH3KBP1) OTIUA60B SH3K1_HUMAN Increases Expression [21]
Androgen-dependent TFPI-regulating protein (ADTRP) OTFI2BQX ADTRP_HUMAN Increases Expression [21]
Gasdermin-A (GSDMA) OT912R2E GSDMA_HUMAN Increases Expression [21]
SH3 and cysteine-rich domain-containing protein (STAC) OTRVBSLR STAC_HUMAN Increases Expression [21]
Cell growth regulator with EF hand domain protein 1 (CGREF1) OTBZQX97 CGRE1_HUMAN Increases Expression [21]
Melanophilin (MLPH) OT7ADCXL MELPH_HUMAN Increases Expression [21]
Protein Niban 1 (NIBAN1) OTYOLI12 NIBA1_HUMAN Increases Expression [21]
Tubulointerstitial nephritis antigen-like (TINAGL1) OTZZO56M TINAL_HUMAN Increases Expression [21]
Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19) OTH88TXU ADA19_HUMAN Increases Expression [21]
Transmembrane protein 222 (TMEM222) OTWFLPK2 TM222_HUMAN Increases Splicing [21]
Beta-defensin 129 (DEFB129) OT1R2LZM DB129_HUMAN Decreases Expression [21]
CXADR-like membrane protein (CLMP) OTU7C3GQ CLMP_HUMAN Increases Expression [21]
Protein S100-A14 (S100A14) OTVFJJ91 S10AE_HUMAN Increases Expression [21]
SH2 domain-containing protein 2A (SH2D2A) OTQSKW7U SH22A_HUMAN Increases Expression [21]
Triggering receptor expressed on myeloid cells 1 (TREM1) OTCVFEE6 TREM1_HUMAN Increases Expression [21]
Serine palmitoyltransferase 3 (SPTLC3) OTZDX6PT SPTC3_HUMAN Increases Expression [21]
G patch domain-containing protein 2 (GPATCH2) OT09TY4W GPTC2_HUMAN Increases Splicing [21]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Increases Expression [21]
Protocadherin Fat 2 (FAT2) OTRGT3E8 FAT2_HUMAN Increases Expression [21]
Myoferlin (MYOF) OTRFC3IJ MYOF_HUMAN Increases Splicing [21]
Coiled-coil domain-containing protein 167 (CCDC167) OTUIAUE7 CC167_HUMAN Increases Expression [21]
Cysteine-rich C-terminal protein 1 (CRCT1) OTPYME8V CRCT1_HUMAN Increases Expression [21]
STEAP1 protein (STEAP1) OTJMW5R9 STEA1_HUMAN Increases Expression [21]
Protein mono-ADP-ribosyltransferase PARP4 (PARP4) OTXBK59G PARP4_HUMAN Increases Splicing [21]
Hippocalcin-like protein 4 (HPCAL4) OT793RNP HPCL4_HUMAN Increases Expression [21]
Angiopoietin-4 (ANGPT4) OT881M3K ANGP4_HUMAN Increases Expression [21]
Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) OTJQL0I3 HEY1_HUMAN Increases Expression [21]
Adhesion G-protein coupled receptor G1 (ADGRG1) OTQBB8NT AGRG1_HUMAN Increases Expression [21]
Steroidogenic factor 1 (NR5A1) OTOULYR4 STF1_HUMAN Decreases Expression [45]
ETS domain-containing protein Elk-1 (ELK1) OTH9MXD6 ELK1_HUMAN Increases Phosphorylation [46]
RNA binding protein fox-1 homolog 3 (RBFOX3) OTL0F3D6 RFOX3_HUMAN Increases Expression [47]
Dynamin-1-like protein (DNM1L) OTXK1Q1G DNM1L_HUMAN Increases Expression [25]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Increases Expression [48]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Decreases Expression [49]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Increases Expression [50]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Increases Activity [51]
Lutropin subunit beta (LHB) OT5GBOVJ LSHB_HUMAN Increases Secretion [52]
Osteocalcin (BGLAP) OTK1YLWQ OSTCN_HUMAN Decreases Expression [53]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Increases Expression [50]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Increases Activity [51]
High affinity nerve growth factor receptor (NTRK1) OTJORQAU NTRK1_HUMAN Increases Expression [54]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Decreases Expression [55]
Neurofilament medium polypeptide (NEFM) OT8VCBNF NFM_HUMAN Increases Expression [47]
Involucrin (IVL) OT4VPNGY INVO_HUMAN Decreases Expression [55]
Heat shock protein HSP 90-alpha (HSP90AA1) OTLG1WPK HS90A_HUMAN Increases Expression [56]
Tumor necrosis factor receptor superfamily member 16 (NGFR) OTPKSM49 TNR16_HUMAN Increases Expression [54]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Increases Expression [50]
Integrin alpha-IIb (ITGA2B) OT4Y17PY ITA2B_HUMAN Decreases Expression [57]
Proto-oncogene tyrosine-protein kinase Src (SRC) OTETYX40 SRC_HUMAN Increases Phosphorylation [58]
Elongation factor 2 (EEF2) OTZ7SZ39 EF2_HUMAN Increases Expression [25]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1) OTNAZVKB 3BHS1_HUMAN Decreases Expression [59]
17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1) OT6EBDHM DHB1_HUMAN Decreases Expression [59]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Increases Expression [60]
Endothelial transcription factor GATA-2 (GATA2) OTBP2QQ2 GATA2_HUMAN Increases Expression [61]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [62]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Activity [63]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Increases Activity [64]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Decreases Expression [65]
Neuronal acetylcholine receptor subunit alpha-3 (CHRNA3) OTCZQY1U ACHA3_HUMAN Decreases Expression [66]
Reduced folate transporter (SLC19A1) OTWB0BTO S19A1_HUMAN Decreases Expression [67]
Collagenase 3 (MMP13) OTY8BZIE MMP13_HUMAN Increases Expression [50]
Histone H2B type 1-D (H2BC5) OTXDTDHN H2B1D_HUMAN Increases Expression [68]
Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A) OTIIGGZ2 RS27A_HUMAN Decreases Expression [69]
Casein kinase II subunit alpha (CSNK2A1) OT9T8WQM CSK21_HUMAN Increases Expression [68]
Histone H3.1 (H3C1) OTGBGOZW H31_HUMAN Increases Expression [68]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Decreases Secretion [70]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Increases Expression [71]
Tight junction protein ZO-1 (TJP1) OTBDCUPK ZO1_HUMAN Decreases Expression [72]
Histone RNA hairpin-binding protein (SLBP) OTVYYQRT SLBP_HUMAN Decreases Expression [68]
Neuronal acetylcholine receptor subunit alpha-6 (CHRNA6) OTT6W86V ACHA6_HUMAN Decreases Expression [66]
NACHT, LRR and PYD domains-containing protein 3 (NLRP3) OTZM6MHU NLRP3_HUMAN Increases Expression [73]
Flavin-containing monooxygenase 3 (FMO3) OT1G2EV3 FMO3_HUMAN Increases Metabolism [74]
Regulatory-associated protein of mTOR (RPTOR) OT4TQZ9F RPTOR_HUMAN Affects Response To Substance [75]
LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3) OTA7IBLE LYSM3_HUMAN Affects Response To Substance [75]
Tyrosine-protein kinase JAK2 (JAK2) OTBIDOOR JAK2_HUMAN Increases Response To Substance [76]
Pleckstrin homology domain-containing family G member 1 (PLEKHG1) OTDVYW2F PKHG1_HUMAN Affects Response To Substance [75]
Solute carrier family 22 member 2 (SLC22A2) OTGFK1AL S22A2_HUMAN Affects Response To Substance [77]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Increases ADR [78]
Plastin-2 (LCP1) OTK61F2A PLSL_HUMAN Affects Response To Substance [75]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB) OTO8JQJA PK3CB_HUMAN Increases ADR [78]
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References

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2 methyl salicylate FDA Label
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4 Nicotine FDA Label
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