Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM42EVG)

Drug Name
Ganoderic acid A Drug Info
Synonyms
Ganoderic acid A; 81907-62-2; UNII-548G37DF65; 548G37DF65; (2R,6R)-6-[(5R,7S,10S,13R,14R,15S,17R)-7,15-dihydroxy-4,4,10,13,14-pentamethyl-3,11-dioxo-2,5,6,7,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxoheptanoic acid; (2R,6R)-6-[(5R,7S,10S,13R,14R,15S,17R)-7,15-dihydroxy-4,4,10,13,14-pentamethyl-3,11-dioxo-2,5,6,7,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxo-heptanoic acid; CHEMBL602899; Ganoderic-acid-A; AC1LAM6R; HY-N1447; ZINC49767216; CS-5856; Lanost-8-en-26-oic
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
471002
ChEBI ID
CHEMBL602899
CAS Number
CAS 81907-62-2
TTD Drug ID
DM42EVG

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Approved Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
RG-7234 DM5RAB9 Type-2 diabetes 5A11 Phase 2 [3]
[(125)I] RB129 DMX0G7E Discovery agent N.A. Investigative [4]
3-acetyl-11-keto-beta-boswellic acid DMGO2D7 Discovery agent N.A. Investigative [1]
11-keto-beta-boswellicacid DMM6CJI Discovery agent N.A. Investigative [1]
Drug(s) Affected By Stearoyl-CoA desaturase (SCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [5]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [6]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [6]
Methotrexate DM2TEOL Anterior urethra cancer Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [8]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [9]
Fluoxetine DM3PD2C Bipolar depression Approved [6]
Fructose DM43AN2 Vomiting MD90 Approved [10]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [11]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [6]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [12]
Fluoxetine DM3PD2C Bipolar depression Approved [13]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [14]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [15]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [16]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [17]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [15]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [18]
Testosterone DM7HUNW Hot flushes GA30 Approved [19]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [20]
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Drug(s) Affected By Farnesyl pyrophosphate synthase (FDPS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [21]
Quercetin DM3NC4M Obesity 5B81 Approved [8]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [22]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [17]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [23]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [25]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [26]
Clozapine DMFC71L Schizophrenia 6A20 Approved [27]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [28]
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Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [29]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [30]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [6]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [6]
Quercetin DM3NC4M Obesity 5B81 Approved [32]
Fluoxetine DM3PD2C Bipolar depression Approved [6]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [22]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [14]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [11]
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Drug(s) Affected By Galactoside alpha-(1,2)-fucosyltransferase 2 (FUT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [33]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [34]
Drug(s) Affected By Sterol regulatory element-binding protein 2 (SREBF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [35]
Selenium DM25CGV N. A. N. A. Approved [36]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [37]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [16]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [39]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [40]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [42]
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Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [46]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [16]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [47]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [17]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [48]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stearoyl-CoA desaturase 5 (SCD5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [51]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [26]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [52]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [53]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [54]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [34]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [55]
OLEIC ACID DM54O1Z Discovery agent N.A. Investigative [56]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 7-dehydrocholesterol reductase (DHCR7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [36]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [8]
Fluoxetine DM3PD2C Bipolar depression Approved [13]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [17]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [58]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [59]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [60]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) TT9H85R DHI2_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
7-dehydrocholesterol reductase (DHCR7) OTLILBUI DHCR7_HUMAN Gene/Protein Processing [2]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Gene/Protein Processing [2]
Farnesyl pyrophosphate synthase (FDPS) OT6CKWV5 FPPS_HUMAN Gene/Protein Processing [2]
Galactoside alpha-(1,2)-fucosyltransferase 2 (FUT2) OTLXM6WI FUT2_HUMAN Gene/Protein Processing [2]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) OTCO26FV HMCS1_HUMAN Gene/Protein Processing [2]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Gene/Protein Processing [2]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Gene/Protein Processing [2]
Stearoyl-CoA desaturase 5 (SCD5) OTSSUQ3Z SCD5_HUMAN Gene/Protein Processing [2]
Sterol regulatory element-binding protein 2 (SREBF2) OTBXUNPL SRBP2_HUMAN Gene/Protein Processing [2]

References

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