Details of the Drug-Related molecule(s) Interaction Atlas

Ginsenoside Re Drug Info

Chikusetsusaponin IVc; Ginsenoside B2; Ginsenoside Re; PWAOOJDMFUQOKB-WCZZMFLVSA-N; Panaxoside RE; SCHEMBL669738; TR-036967; ZINC242620164; ginsenoside-Re; (20S)-ginsenoside Re; 2-O-(6-Deoxy-alpha-L-mannopyranosyl)-(3beta,6alpha,12beta)-20-(beta-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl-beta-D-glucopyranoside; 46F3R0BL3I; 51542-56-4; 52286-59-6; AKOS025310861; BDBM50378779; CHEBI:77148; CHEMBL510095; CS-3838; CTK8F0918; DB14815; EINECS 257-814-6; HY-N0044; MFCD00133369; NSC 308877; NSC-308877; UNII-46F3R0BL3I; s3811

Cross-matching ID

PubChem CID

441921

ChEBI ID

CHEMBL77148

CAS Number

CAS 52286-59-6

TTD Drug ID

DM46FVD

INTEDE Drug ID

DR2495

General Information of Drug (ID: DM46FVD)

Molecule-Related Drug Atlas

Molecule Type:

DME

DOT

Drug Status:

Preclinical Drug(s)

Investigative Drug(s)

Clinical Trial Drug(s)

Approved Drug(s)

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Drug(s) Metabolized By Alpha-L-rhamnosidase (lrA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
HY-N2258	DML4IAX	N. A.	N. A.	Preclinical	[1]
Rutin	DMEHRAJ	Discovery agent	N.A.	Investigative	[1]
naringin	DM4DG1Y	Discovery agent	N.A.	Investigative	[1]
PNA-l-rhamnopyranoside	DMZF7RQ	N. A.	N. A.	Investigative	[1]
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Drug(s) Metabolized By Beta-glucosidase (bglA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SC-46553	DM6XNJR	N. A.	N. A.	Phase 3	[2]
Ginsenoside Rb1	DMF70AB	N. A.	N. A.	Investigative	[2]
Ginsenoside Rg1	DMYE2SR	N. A.	N. A.	Investigative	[2]
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Drug(s) Affected By Immunity-related GTPase family M protein (IRGM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[9]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[10]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[11]
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Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[12]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[13]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[13]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[14]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[16]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[13]
Fructose	DM43AN2	Vomiting	MD90	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[13]
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Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[19]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[20]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[21]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[22]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[21]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[25]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
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Drug(s) Affected By Potassium voltage-gated channel subfamily E member 1 (KCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Pentobarbital	DMFNH7L	Brain ischaemia	8B1Z	Approved	[30]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[31]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[31]
Diltiazem	DMAI7ZV	Angina pectoris	BA40	Approved	[31]
Sotalol	DML60TN	Sinus rhythm disorder	BC9Y	Approved	[31]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[31]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[31]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[31]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[32]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[35]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[38]
Fructose	DM43AN2	Vomiting	MD90	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[40]
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Drug(s) Affected By Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[14]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[43]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[45]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[46]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
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Drug(s) Affected By Glucose-6-phosphatase catalytic subunit 1 (G6PC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[44]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[46]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[50]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[50]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[52]
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Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[55]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[56]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[57]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[59]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[62]
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Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[63]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[64]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[65]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[12]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[64]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[67]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[64]
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Drug(s) Affected By Serine/threonine-protein kinase STK11 (STK11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[69]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[72]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[73]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[75]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[76]
GDC-0980/RG7422	DMF3MV1	Non-hodgkin lymphoma	2B33.5	Phase 2	[77]
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Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[78]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[79]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[79]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[52]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[78]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[79]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[80]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[78]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[81]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[78]
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Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[82]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[82]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[83]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[31]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[84]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[85]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[87]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[88]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[89]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Alpha-L-rhamnosidase (lrA)	DEBI82Z	A0A1V8Q7P3_9BIF	Substrate	[1]
Beta-glucosidase (bglA)	DE9N4OU	C6WCL5_ACTMD	Substrate	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)	OT7TNF0L	AAPK1_HUMAN	Post-Translational Modifications	[3]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Regulation of Drug Effects	[4]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Regulation of Drug Effects	[4]
Glucose-6-phosphatase catalytic subunit 1 (G6PC1)	OTJ6FM9F	G6PC1_HUMAN	Gene/Protein Processing	[3]
Immunity-related GTPase family M protein (IRGM)	OTKD3O5Z	IRGM_HUMAN	Gene/Protein Processing	[5]
Nuclear receptor subfamily 0 group B member 2 (NR0B2)	OT7UVICX	NR0B2_HUMAN	Gene/Protein Processing	[3]
Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)	OTNWEJ5Y	PCKGC_HUMAN	Gene/Protein Processing	[3]
Potassium voltage-gated channel subfamily E member 1 (KCNE1)	OTZNQUW9	KCNE1_HUMAN	Gene/Protein Processing	[6]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Gene/Protein Processing	[7]
Serine/threonine-protein kinase STK11 (STK11)	OT1YZSP3	STK11_HUMAN	Post-Translational Modifications	[3]

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