Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDUN83)

• Drug Name: (L-)-S-adenosyl-L-homocysteine Drug Info
• Synonyms: S-Adenosyl-L-homocysteine; S-adenosylhomocysteine; S-adenosyl-L-homocysteine; 979-92-0; AdoHcy; S-(5'-adenosyl)-L-homocysteine; adenosylhomocysteine; Formycinylhomocysteine; Adenosyl-L-homocysteine; S-(5'-deoxyadenosin-5'-yl)-L-homocysteine; 2-S-adenosyl-L-homocysteine; 5'-Deoxy-S-adenosyl-L-homocysteine; S-adenosyl-homocysteine; S-Adenosyl Homocysteine; L-S-Adenosylhomocysteine; L-Homocysteine, S-(5'-deoxyadenosin-5'-yl)-; adenosylhomo-cys; adenosyl-homo-cys; UNII-8K31Q2S66S; (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine; BRN 5166233; SAH; S-Adenosylhomocysteine; S-Adenosyl-L-Homocysteine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 439155
  ChEBI ID: CHEBI:16680
  CAS Number: CAS 979-92-0
  TTD Drug ID: DMDUN83

Molecule-Related Drug Atlas

Drug(s) Targeting Histamine N-methyltransferase (HNMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diphenhydramine	DMKQTBA	Hyperemesis gravidarum		Approved	[8]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[9]
Metoprine	DM5GQD7	Advanced cancer	2A00-2F9Z	Phase 2	[8]
4-(DIMETHYLAMINO)BUTYL IMIDOTHIOCARBAMATE	DM68S9F	Discovery agent	N.A.	Investigative	[8]

Drug(s) Targeting DNA [cytosine-5]-methyltransferase 3B (DNMT3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[10]
PMID27376512-Compound-MTC-424	DMGNRZU	N. A.	N. A.	Patented	[11]
PMID27376512-Compound-MTC-427	DMWXEZD	N. A.	N. A.	Patented	[11]
PMID27376512-Compound-MTC-422	DM1MVQD	N. A.	N. A.	Patented	[11]
PMID27376512-Compound-MTC-423	DM9RSDX	N. A.	N. A.	Patented	[11]
NSC-622445	DME35CB	Discovery agent	N.A.	Investigative	[10]
NSC-622444	DMM5UT9	Discovery agent	N.A.	Investigative	[10]
NSC-138419	DMH684Q	Discovery agent	N.A.	Investigative	[10]
NSC-319745	DMF3G06	Discovery agent	N.A.	Investigative	[10]
NSC-348926	DM3TDEO	Discovery agent	N.A.	Investigative	[10]

Drug(s) Targeting DNA [cytosine-5]-methyltransferase (DNMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[12]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[10]
S-110	DMXY34J	Acute myeloid leukaemia	2A60	Phase 3	[13]
ASTX727	DM4HK8Z	Chronic myelogenous leukaemia	2A20.0	Phase 3	[14]
PMID27376512-Compound-PG-11047	DM5K4YF	N. A.	N. A.	Patented	[11]
PMID27376512-Compound-PG-11048	DM3U7RN	N. A.	N. A.	Patented	[11]
PMID27376512-Compound-MTC-434	DM70CTE	N. A.	N. A.	Patented	[11]
PMID27376512-Compound-CROs	DMBFUTL	N. A.	N. A.	Patented	[11]
NSC-622445	DME35CB	Discovery agent	N.A.	Investigative	[10]
NSC-622444	DMM5UT9	Discovery agent	N.A.	Investigative	[10]

Drug(s) Affected By Protein arginine N-methyltransferase 5 (PRMT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[15]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[6]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[18]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[23]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[24]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[25]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[26]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[29]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[30]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[31]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]

Drug(s) Affected By Collagen alpha-2(I) chain (COL1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[42]

Drug(s) Affected By DNA cytosine-5)-methyltransferase 1 (DNMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[43]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[45]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[49]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[51]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[52]

Drug(s) Affected By Histone-arginine methyltransferase CARM1 (CARM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[53]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[56]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[58]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[59]

Drug(s) Affected By Protein arginine N-methyltransferase 6 (PRMT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[60]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[62]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[64]

Drug(s) Affected By Protein arginine N-methyltransferase 1 (PRMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[15]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[54]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]

Drug(s) Affected By Protein arginine N-methyltransferase 7 (PRMT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[6]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[18]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[19]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[58]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[64]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[69]
Fructose	DM43AN2	Vomiting	MD90	Approved	[70]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[71]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Ketotifen	DM74XKS	Allergic conjunctivitis	9A60.02	Approved	[73]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[7]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[18]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[7]

Drug(s) Affected By Adenosylhomocysteinase (AHCY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[75]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[56]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[77]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[78]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[79]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
DNA [cytosine-5]-methyltransferase (DNMT)	TTHVCUP	NOUNIPROTAC	Inhibitor	[2]
DNA [cytosine-5]-methyltransferase 3B (DNMT3B)	TT6VZ78	DNM3B_HUMAN	Inhibitor	[2]
Histamine N-methyltransferase (HNMT)	TT2B6EV	HNMT_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Adenosylhomocysteinase (AHCY)	OT8UC40I	SAHH_HUMAN	Biotransformations	[3]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Gene/Protein Processing	[4]
Collagen alpha-2(I) chain (COL1A2)	OTY7G382	CO1A2_HUMAN	Gene/Protein Processing	[4]
DNA cytosine-5)-methyltransferase 1 (DNMT1)	OTM2DGTK	DNMT1_HUMAN	Gene/Protein Processing	[5]
Histone-arginine methyltransferase CARM1 (CARM1)	OT0IPRVR	CARM1_HUMAN	Gene/Protein Processing	[6]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)	OTHCDQ22	PRGC1_HUMAN	Gene/Protein Processing	[7]
Protein arginine N-methyltransferase 1 (PRMT1)	OTN8GTXW	ANM1_HUMAN	Gene/Protein Processing	[6]
Protein arginine N-methyltransferase 5 (PRMT5)	OTF6IGJS	ANM5_HUMAN	Gene/Protein Processing	[6]
Protein arginine N-methyltransferase 6 (PRMT6)	OT5V3XIN	ANM6_HUMAN	Gene/Protein Processing	[6]
Protein arginine N-methyltransferase 7 (PRMT7)	OTE73PO1	ANM7_HUMAN	Gene/Protein Processing	[6]

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