Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMECBWN)

Drug Name
Riluzole Drug Info
Synonyms
Rilutek; Riluzol; Riluzolum; Riluzole HCl; RP 54274; ALBB-006046; BF-37; PK-26124; R-116; RP-54274; Rilutek (TN); Riluzol [INN-Spanish]; Riluzole [USAN:INN]; Riluzolum [INN-Latin]; ZERO/001785; Amino-2 trifluoromethoxy-6 benzothiazole; Amino-2 trifluoromethoxy-6 benzothiazole [French]; Riluzole (JAN/USAN/INN); PK-26124, RP-54274, Rilutek, Riluzole; 2-Amino-6-(trifluoromethoxy)-benzothiazole; 2-Amino-6-(trifluoromethoxy)benzothiazole; 2-Amino-6-trifluoro-methoxybenzothiazole; 2-amino-6-(trifluoromethoxy)-1,3-benzothiazole; 2-amino-6-(trifluoromethoxy)benzo[d]thiazole; 2-amino-6-(trifluoromethoxyl)benzothiazole; 2-amino-6-trifluoromethoxybenzothiazole; 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine; 6-(trifluoromethoxy)benzo[d]thiazol-2-amine; 6-Trifluoromethoxy-benzothiazol-2-ylamine; 6-trifluoromethoxybenzothiazole-2-yl-amine
Indication
Disease Entry ICD 11 Status REF
Amyotrophic lateral sclerosis 8B60.0 Approved [1]
Therapeutic Class
Anticonvulsants
Cross-matching ID
PubChem CID
5070
ChEBI ID
CHEBI:8863
CAS Number
CAS 1744-22-5
TTD Drug ID
DMECBWN
VARIDT Drug ID
DR00205
INTEDE Drug ID
DR1425
ACDINA Drug ID
D00595

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Voltage-gated sodium channel alpha Nav1.9 (SCN11A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [11]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [12]
Lacosamide DMVM6QR Convulsion 8A68.Z Approved [13]
Tolperisone DMA2GHJ Muscle spasm MB47.3 Approved [14]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [15]
Eslicarbazepine DMZREFQ Seizure disorder 8A6Z Approved [13]
Oxcarbazepine DM5PU6O Epilepsy 8A60-8A68 Approved [16]
HP-184 DMNOMV2 Multiple sclerosis 8A40 Phase 2 [17]
QX-314 DMAV2FM Pain MG30-MG3Z Terminated [18]
PD-32577 DMBA15J Discovery agent N.A. Investigative [19]
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Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [20]
Methotrexate DM2TEOL Anterior urethra cancer Approved [21]
Folic Acid DMEMBJC Colorectal carcinoma Approved [22]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [23]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [25]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [26]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [25]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [27]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [28]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [29]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [30]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [31]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [32]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [33]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [34]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [35]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [36]
Verapamil DMA7PEW Angina pectoris BA40 Approved [37]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [38]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [39]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [40]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [41]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [42]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [45]
Metronidazole DMTIVEN Abscess Approved [46]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [47]
Ethanol DMDRQZU Chronic pain MG30 Approved [48]
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Drug(s) Metabolized By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [49]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [50]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [51]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [52]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [36]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [53]
Estrone DM5T6US Acne vulgaris ED80 Approved [54]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [55]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [56]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [57]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [58]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [59]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [60]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [61]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [62]
Ethacrynic acid DM60QMR Edema MG29 Approved [63]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [64]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [65]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [66]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [67]
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Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [68]
Diazepam DM08E9O Alcohol withdrawal Approved [68]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Selenium DM25CGV N. A. N. A. Approved [70]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [68]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [68]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [68]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [68]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [68]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [68]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [71]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [71]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [72]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [73]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [74]
Etidronic acid DM1XHYJ Bone Paget disease Approved [71]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [71]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [71]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [75]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [76]
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Drug(s) Affected By Prostate-specific antigen (KLK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [77]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [78]
Selenium DM25CGV N. A. N. A. Approved [79]
Quercetin DM3NC4M Obesity 5B81 Approved [80]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [81]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [82]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [83]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [84]
Testosterone DM7HUNW Hot flushes GA30 Approved [85]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [86]
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Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [87]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [88]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [89]
Etretinate DM2CZFA Keratosis ED56 Approved [90]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [91]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [92]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [93]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [94]
Quercetin DM3NC4M Obesity 5B81 Approved [95]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [96]
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Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [97]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [88]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [98]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [99]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [100]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [101]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [88]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [102]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [103]
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Drug(s) Affected By Kallikrein-2 (KLK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [80]
Testosterone DM7HUNW Hot flushes GA30 Approved [104]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [86]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [105]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [106]
Dutasteride DMQ4TJK Benign prostatic hyperplasia GA90 Approved [107]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [108]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [109]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [110]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [111]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [112]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [113]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [114]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [115]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [116]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [117]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [118]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [119]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [120]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [121]
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Drug(s) Affected By Caspase-4 (CASP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [122]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [123]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [124]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [97]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [125]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [126]
Testosterone DM7HUNW Hot flushes GA30 Approved [127]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [128]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [129]
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Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [130]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [123]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [131]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [132]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [8]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [8]
Methotrexate DM2TEOL Anterior urethra cancer Approved [133]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [134]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [135]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [136]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [137]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [138]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [139]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [140]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [141]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [142]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [143]
Meloxicam DM2AR7L Arthritis FA20 Approved [144]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [145]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [146]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [147]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [148]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [149]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [122]
Gefitinib DM15F0X Colon adenocarcinoma Approved [150]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [151]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [143]
Selenium DM25CGV N. A. N. A. Approved [70]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [145]
Methotrexate DM2TEOL Anterior urethra cancer Approved [152]
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Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [10]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [153]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [154]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [155]
Estrone DM5T6US Acne vulgaris ED80 Approved [156]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [157]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [158]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [159]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [160]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [161]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated sodium channel alpha Nav1.9 (SCN11A) TTN9VTF SCNBA_HUMAN Blocker [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 1A1 (CYP1A1) DE6OQ3W CP1A1_HUMAN Substrate [4]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Substrate [5]
Cytochrome P450 1A2 (CYP1A2) Main DME DEJGDUW CP1A2_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [7]
Caspase-4 (CASP4) OTVQTV1L CASP4_HUMAN Gene/Protein Processing [7]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Gene/Protein Processing [8]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Gene/Protein Processing [7]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [7]
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6) OTAFHAVI ATF6A_HUMAN Gene/Protein Processing [9]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [10]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Gene/Protein Processing [10]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Gene/Protein Processing [9]
Kallikrein-2 (KLK2) OT9RE37R KLK2_HUMAN Gene/Protein Processing [9]

References

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6 Association between CYP1A2 activity and riluzole clearance in patients with amyotrophic lateral sclerosis. Br J Clin Pharmacol. 2005 Mar;59(3):310-3.
7 Riluzole induces apoptotic cell death in human prostate cancer cells via endoplasmic reticulum stress. Anticancer Res. 2009 Jun;29(6):2195-204.
8 Palmitate increases the susceptibility of cells to drug-induced toxicity: an in vitro method to identify drugs with potential contraindications in patients with metabolic disease. Toxicol Sci. 2012 Oct;129(2):346-62. doi: 10.1093/toxsci/kfs208. Epub 2012 Jun 14.
9 Riluzole induces AR degradation via endoplasmic reticulum stress pathway in androgen-dependent and castration-resistant prostate cancer cells. Prostate. 2019 Feb;79(2):140-150. doi: 10.1002/pros.23719. Epub 2018 Oct 2.
10 Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
11 Mechanisms of analgesia of intravenous lidocaine. Rev Bras Anestesiol. 2008 May-Jun;58(3):280-6.
12 The effects of lamotrigine on the acquisition and expression of morphine-induced place preference in mice. Pak J Biol Sci. 2009 Jan 1;12(1):33-9.
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14 Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels. J Pharmacol Exp Ther. 2005 Dec;315(3):1237-46.
15 New antiarrhythmic agents for atrial fibrillation and atrial flutter. Expert Opin Emerg Drugs. 2005 May;10(2):311-22.
16 Debate: Does genetic information in humans help us treat patients PRO--genetic information in humans helps us treat patients. CON--genetic information does not help at all. Epilepsia. 2008 Dec;49 Suppl 9:13-24.
17 Emerging drugs for spinal cord injury. Expert Opin Emerg Drugs. 2008 Mar;13(1):63-80.
18 Voltage-gated sodium channel blockers for the treatment of chronic pain. Curr Top Med Chem. 2009;9(4):362-76.
19 Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2447-52.
20 Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol. 2007 Mar;30(3):717-25.
21 Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res. 2003 Sep 1;63(17):5538-43.
22 The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol. 2007 Jan;71(1):240-9.
23 Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10.
24 Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93.
25 Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51.
26 The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters. Cancer Lett. 2016 Jun 28;376(1):165-72.
27 Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res. 2009 Feb;26(2):480-7.
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29 Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63.
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31 Endoxifen and other metabolites of tamoxifen inhibit human hydroxysteroid sulfotransferase 2A1 (hSULT2A1). Drug Metab Dispos. 2014 Nov;42(11):1843-50.
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33 PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenet Genomics. 2015 Aug;25(8):416-26.
34 The effect of apigenin on pharmacokinetics of imatinib and its metabolite N-desmethyl imatinib in rats. Biomed Res Int. 2013;2013:789184.
35 Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos. 2007 Apr;28(3):151-6.
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37 Identification of P450 enzymes involved in metabolism of verapamil in humans. Naunyn Schmiedebergs Arch Pharmacol. 1993 Sep;348(3):332-7.
38 Metabolism and metabolic inhibition of xanthotoxol in human liver microsomes. Evid Based Complement Alternat Med. 2016;2016:5416509.
39 Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites. Cancer Res. 2009 Mar 1;69(5):1892-900.
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