General Information of Drug (ID: DMF1P6W)

Drug Name
SU 6656 Drug Info
Synonyms
su6656; 330161-87-0; SU-6656; SU6656; CHEMBL605003; (3z)-N,N-Dimethyl-2-Oxo-3-(4,5,6,7-Tetrahydro-1h-Indol-2-Ylmethylidene)-2,3-Dihydro-1h-Indole-5-Sulfonamide; (3Z)-N,N-dimethyl-2-oxo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-1H-indole-5-sulfonamide; SR-01000076237; 2,3-Dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1H-indole-5-sulfonamide; AC1NSM2X; Lopac-S-9692; Lopac0_000979; MLS002153475; GTPL6044; EX-A584; MolPort-003-959-609; HMS3229I04; HMS2232C04
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5312137
TTD Drug ID
DMF1P6W

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Discontinued Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [6]
VX-680 DM93YKJ Solid tumour/cancer 2A00-2F9Z Phase 2 [6]
JNJ-26483327 DMSQ3AZ Solid tumour/cancer 2A00-2F9Z Phase 1 [7]
ISIS-CRP DMQDUG4 Cardiovascular disease BA00-BE2Z Phase 1 [2]
RO-316233 DMAGLPW Discovery agent N.A. Investigative [8]
Bisindolylmaleimide-I DMOQJZC Discovery agent N.A. Investigative [8]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB Discovery agent N.A. Investigative [9]
CI-1040 DMF3DZX Discovery agent N.A. Investigative [8]
AMP-PNP DMTOK1D Discovery agent N.A. Investigative [10]
BMS-536924 DMXJB4N Discovery agent N.A. Investigative [11]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Acadesine DM1RMF5 Diabetic complication 5A2Y Phase 3 [12]
MB-11055 DM3RBJW Fatty liver disease DB92.Z Phase 2 [13]
Imeglimin DMMQFG2 Diabetic complication 5A2Y Phase 2 [14]
PXL-770 DMNSRY7 Non-alcoholic fatty liver disease DB92 Phase 2 [15]
ENERGI-F701 DMMIHSO Alopecia ED70 Phase 2 [16]
O-304 DMXM34I Type 2 diabetes 5A11 Phase 2 [17]
IM156 DM4MY9C Solid tumour/cancer 2A00-2F9Z Phase 1 [18]
Phenformin DMQ52JG Diabetic complication 5A2Y Withdrawn from market [19]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB Discovery agent N.A. Investigative [9]
PMID23639540C13a DMLXOAQ Discovery agent N.A. Investigative [20]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
PHA-739358 DMGYBZI Prostate cancer 2C82.0 Phase 2 [21]
Indirubin-3'-monoxime DMLRQH0 Discovery agent N.A. Investigative [22]
6-bromoindirubin-3-oxime DM12WYV Discovery agent N.A. Investigative [22]
7-fluoroindirubin-3-oxime DMQD34N Discovery agent N.A. Investigative [22]
PMID21742770C1 DME3JMH Discovery agent N.A. Investigative [23]
Indirubin-3-acetoxime DM3UR1E Discovery agent N.A. Investigative [22]
CGP-57380 DMFPOUC Discovery agent N.A. Investigative [2]
PMID20855207C25 DMNEB6J Discovery agent N.A. Investigative [24]
Indirubin-3-methoxime DMZ5ODC Discovery agent N.A. Investigative [22]
4-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine DM9MPHF Discovery agent N.A. Investigative [25]
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Drug(s) Targeting Proto-oncogene c-Src (SRC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [6]
Bosutinib DMTI8YE Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [6]
SKI-758 DMQ8E9R Ischemia 8B10-8B11 Approved [26]
Herbimycin A DM6YWBF Solid tumour/cancer 2A00-2F9Z Approved [27]
AL3818 DM3WP0N Alveolar soft part sarcoma 2A60-2C35 Phase 3 [18]
CP-868596 DMZIM37 Gastrointestinal cancer 2C11 Phase 3 [18]
Masitinib DMRSNEU Amyotrophic lateral sclerosis 8B60.0 Phase 3 [28]
KX-01 DMF0NA9 Actinic keratosis EK90.0 Phase 3 [29]
Saracatinib DMBLHGP Hematologic tumour 2B33.Y Phase 2 [30]
TPX-0046 DMIVE67 Solid tumour/cancer 2A00-2F9Z Phase 1/2 [31]
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Drug(s) Targeting Aurora kinase C (AURKC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PHA-739358 DMGYBZI Prostate cancer 2C82.0 Phase 2 [21]
ABT-348 DMMZOYN Haematological malignancy 2B33.Y Phase 2 [32]
HPP-607 DM5VSZR Solid tumour/cancer 2A00-2F9Z Phase 1 [33]
AMG 900 DMASGXJ Solid tumour/cancer 2A00-2F9Z Phase 1 [34]
SNS-314 DMAC5F2 Solid tumour/cancer 2A00-2F9Z Phase 1 [35]
GSK1070916 DMXRPT6 Advanced solid tumour 2A00-2F9Z Phase 1 [36]
GSK1070916A DMCJUI9 Solid tumour/cancer 2A00-2F9Z Phase 1 [36]
MK-6592 DMB5NOI Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 1 [37]
Indirubin-3'-monoxime DMLRQH0 Discovery agent N.A. Investigative [22]
6-bromoindirubin-3-oxime DM12WYV Discovery agent N.A. Investigative [22]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [38]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [39]
Selenium DM25CGV N. A. N. A. Approved [40]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [41]
Methotrexate DM2TEOL Anterior urethra cancer Approved [42]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Panobinostat DM58WKG Chronic graft versus host disease Approved [45]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [46]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [38]
Selenium DM25CGV N. A. N. A. Approved [40]
Methotrexate DM2TEOL Anterior urethra cancer Approved [42]
Quercetin DM3NC4M Obesity 5B81 Approved [48]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [49]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Panobinostat DM58WKG Chronic graft versus host disease Approved [45]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [50]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [51]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
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Drug(s) Affected By Amphiregulin (AREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [54]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Methotrexate DM2TEOL Anterior urethra cancer Approved [56]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Estrone DM5T6US Acne vulgaris ED80 Approved [59]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [60]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [61]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [62]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [65]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [67]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [68]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [69]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [70]
Testosterone DM7HUNW Hot flushes GA30 Approved [71]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [72]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [74]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [76]
Panobinostat DM58WKG Chronic graft versus host disease Approved [45]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [77]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [78]
Testosterone DM7HUNW Hot flushes GA30 Approved [79]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [80]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [81]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [39]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [84]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [85]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [86]
Urethane DM7NSI0 N. A. N. A. Phase 4 [87]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [88]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Selenium DM25CGV N. A. N. A. Approved [40]
Quercetin DM3NC4M Obesity 5B81 Approved [90]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Testosterone DM7HUNW Hot flushes GA30 Approved [91]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [91]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [92]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [93]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [94]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [95]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
AMP-activated protein kinase (AMPK) TTLAFZV AAPK1_HUMAN; AAKB1_HUMAN; AAKG1_HUMAN Inhibitor [2]
Aurora B messenger RNA (AURKB mRNA) TT9RTBL AURKB_HUMAN Inhibitor [2]
Aurora kinase C (AURKC) TTLYXIT AURKC_HUMAN Inhibitor [2]
LCK tyrosine protein kinase (LCK) TT860QF LCK_HUMAN Inhibitor [2]
Proto-oncogene c-Src (SRC) TT6PKBN SRC_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Amphiregulin (AREG) OTJFOR67 AREG_HUMAN Protein Interaction/Cellular Processes [3]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Protein Interaction/Cellular Processes [4]
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) OTPLXCDN DYR1A_HUMAN Gene/Protein Processing [5]
Keratin, type I cytoskeletal 18 (KRT18) OTVLQFIP K1C18_HUMAN Gene/Protein Processing [4]
Keratin, type II cytoskeletal 8 (KRT8) OTTM4X11 K2C8_HUMAN Gene/Protein Processing [4]
POU domain, class 5, transcription factor 1 (POU5F1) OTDHHN7O PO5F1_HUMAN Gene/Protein Processing [4]
Ribosomal protein S6 kinase alpha-1 (RPS6KA1) OTDOTWU4 KS6A1_HUMAN Gene/Protein Processing [5]

References

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38 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
39 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
40 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
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47 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
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50 Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
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52 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
53 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
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71 Anti-androgen 2-hydroxyflutamide modulates cadherin, catenin and androgen receptor phosphorylation in androgen-sensitive LNCaP and androgen-independent PC3 prostate cancer cell lines acting via PI3K/Akt and MAPK/ERK1/2 pathways. Toxicol In Vitro. 2017 Apr;40:324-335. doi: 10.1016/j.tiv.2017.01.019. Epub 2017 Feb 2.
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75 Quercetin in elimination of tumor initiating stem-like and mesenchymal transformation property in head and neck cancer. Head Neck. 2013 Mar;35(3):413-9. doi: 10.1002/hed.22982. Epub 2012 Mar 16.
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