Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHPYSM)

Drug Name
Ellipticine Drug Info
Synonyms
ellipticine; 519-23-3; Elliptisine; 5,11-Dimethyl-6H-pyrido[4,3-b]carbazole; NSC 71795; TCMDC-125546; NSC-71795; 5,11-Dimethyl-6H-pyrido(4,3-b)carbazole; ICIG 770; 5,11-Dimethylpyrido[4,3-b]carbazole; CCRIS 2003; CP 5; UNII-117VLW7484; NSC71795; EINECS 208-264-0; CHEMBL123; BRN 0221300; MLS000736786; MLS000028487; CHEBI:4776; 6H-Pyrido(4,3-b)carbazole, 5,11-dimethyl-; CCG-36483; 117VLW7484; SMR000058370; 6H-Pyrido[4,3-b]carbazole,5,11-dimethyl-; 6H-Pyrido[4,3-b]carbazole, 5,11-dimethyl-; SR-01000003083; elliptecine; Ellipticin
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
3213
ChEBI ID
CHEMBL123
CAS Number
CAS 519-23-3
TTD Drug ID
DMHPYSM

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting DNA topoisomerase II (TOP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [7]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [8]
Teniposide DMLW57T Acute lymphoblastic leukaemia 2A85 Approved [7]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [9]
Idarubicin DMM0XGL Acute myelogenous leukaemia 2A41 Approved [7]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [7]
Lomefloxacin DMVRH9C Bacterial infection 1A00-1C4Z Approved [10]
Dexrazoxane DMD7X1O Breast cancer 2C60-2C65 Approved [7]
Podofilox DMT2EJP Condyloma 1A95 Approved [11]
Enoxacin DMYTE6L Acute gonococcal cervicitis Approved [12]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [13]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [14]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [15]
Gefitinib DM15F0X Colon adenocarcinoma Approved [16]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [17]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [18]
Etretinate DM2CZFA Keratosis ED56 Approved [19]
Prednisone DM2HG4X Acute asthma CA23 Approved [20]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [21]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [23]
Gefitinib DM15F0X Colon adenocarcinoma Approved [24]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [26]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [27]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [21]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [27]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [28]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [29]
Methotrexate DM2TEOL Anterior urethra cancer Approved [30]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
Selenium DM25CGV N. A. N. A. Approved [33]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [34]
Etretinate DM2CZFA Keratosis ED56 Approved [35]
Methotrexate DM2TEOL Anterior urethra cancer Approved [36]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [37]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [38]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [41]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [42]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [43]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [44]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [45]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [46]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [47]
Gefitinib DM15F0X Colon adenocarcinoma Approved [48]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [49]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [51]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [42]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [52]
Paclitaxel DMLB81S Breast carcinoma Approved [53]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [54]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [41]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [55]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [44]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [45]
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Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Methotrexate DM2TEOL Anterior urethra cancer Approved [59]
Quercetin DM3NC4M Obesity 5B81 Approved [60]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [61]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [62]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [63]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [64]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [65]
Testosterone DM7HUNW Hot flushes GA30 Approved [66]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [67]
Gefitinib DM15F0X Colon adenocarcinoma Approved [68]
Prednisone DM2HG4X Acute asthma CA23 Approved [20]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [70]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [71]
Quercetin DM3NC4M Obesity 5B81 Approved [72]
Fluoxetine DM3PD2C Bipolar depression Approved [73]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
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Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [76]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [77]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [78]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [79]
Capsaicin DMGMF6V Back pain ME84.Z Approved [80]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [81]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [82]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [81]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [77]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [55]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
DNA topoisomerase II (TOP2) TT0IHXV TOP2A_HUMAN; TOP2B_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [2]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Gene/Protein Processing [3]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Regulation of Drug Effects [4]
E3 ubiquitin-protein ligase XIAP OT24GP9B XIAP_HUMAN Gene/Protein Processing [5]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Gene/Protein Processing [6]
M-phase inducer phosphatase 3 (CDC25C) OTPQI71S MPIP3_HUMAN Gene/Protein Processing [5]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [3]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [3]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [3]

References

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62 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
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69 Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. Arthritis Rheum. 2012 Jun;64(6):1780-9. doi: 10.1002/art.34342. Epub 2011 Dec 19.
70 Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. Melanoma Res. 2008 Apr;18(2):85-94. doi: 10.1097/CMR.0b013e3282f60097.
71 The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. Cancer Res. 2005 Jan 1;65(1):18-25.
72 Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1. Biochem Pharmacol. 2001 May 15;61(10):1205-15. doi: 10.1016/s0006-2952(01)00583-4.
73 Fluoxetine mediates G0/G1 arrest by inducing functional inhibition of cyclin dependent kinase subunit (CKS)1. Biochem Pharmacol. 2008 May 15;75(10):1924-34. doi: 10.1016/j.bcp.2008.02.013. Epub 2008 Feb 17.
74 Induction mechanism of apoptosis by troglitazone through peroxisome proliferator-activated receptor-gamma in gastric carcinoma cells. Anticancer Res. 2003 Jan-Feb;23(1A):267-73.
75 Down-regulation of CD44 contributes to the differentiation of HL-60 cells induced by ATRA or HMBA. Cell Mol Immunol. 2007 Feb;4(1):59-63.
76 Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol. Chem Biol Interact. 2014 May 25;215:62-8.
77 Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors. Chem Biol Interact. 2004 Apr 15;147(3):331-40.
78 The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis. Antimicrob Agents Chemother. 2004 Sep;48(9):3272-8.
79 Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class. Toxicol Lett. 2016 Jan 22;241:82-94.
80 Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo. J Asian Nat Prod Res. 2012;14(4):382-95.
81 Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. Drug Metab Dispos. 2001 Jan;29(1):30-5.
82 Stiripentol. Expert Opin Investig Drugs. 2005 Jul;14(7):905-11.