Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIGFOR)

Drug Name
I3C Drug Info
Synonyms
Indole-3-carbinol; 700-06-1; 3-Indolemethanol; INDOLE-3-METHANOL; (1H-Indol-3-yl)methanol; 1H-indol-3-ylmethanol; 3-Hydroxymethylindole; 1H-Indole-3-methanol; 3-Indolylcarbinol; Indinol; 3-(Hydroxymethyl)indole; 3-Indole methanol; Indole 3 carbinol; (1H-Indol-3-yl)-methanol; MFCD00005632; UNII-C11E72455F; CHEBI:24814; C11E72455F; NSC-525801; NCGC00090701-06; indol-3-ylmethan-1-ol; I0496; Indole-3-carbinol, 97%; SMR000385784; CCRIS 3261; EINECS 211-836-2; 1H-Indol-3-Yl-Methanol; NSC 525801; BRN 0121323; AI3-60090; 3-Indolecarbinol; 3-Indolylmethanol; Prevention 4 (indole-3-carbinol); indole-3-carbinole; zlchem 356; PubChem7265; 3-hydroxymethyl indole; Spectrum2_001710; Spectrum3_001973; ACMC-209oc7; DSSTox_CID_11458; DSSTox_RID_78876; DSSTox_GSID_31458; BSPBio_003573; MLS001333161; MLS001333162; SCHEMBL195520; SPECTRUM1505320; SPBio_001700; CHEMBL155625; 1H-Indole-3-methanol (9CI); 3-Phenoxybenzylaminehydrochloride; DTXSID7031458; GTPL10047; KBio3_002949; ZLC0198; HMS1789O22; HMS2235E10; HMS3369B02; HMS3651I18; HMS3749E07; ZINC158743; ACN-S002804; ACT03591; BCP00087; HY-N0170; INDOLE-3-CARBINOL (I3C); Tox21_400055; 9344AF; ANW-35813; CCG-38786; HSCI1_000097; NSC525801; s2313; SBB004095; AKOS001075120; AC-7583; CS-7780; DB12881; GS-0916; LS20980; MCULE-6344603304; SB14958; SDCCGMLS-0065970.P001; SDCCGMLS-0065970.P002; VI30396; Indole-3-methanol (Indole-3-carbinol); SMP2_000172; NCGC00090701-01; NCGC00090701-02; NCGC00090701-03; NCGC00090701-04; NCGC00090701-05; NCGC00090701-07; AK-53373; CAS-700-06-1; SY015976; AB0008317; DB-011567; A9256; FT-0615875; ST50308202; SW219849-1; I-2100; M-3233; A836732; SR-01000838318; Q1770257; SR-01000838318-3; BRD-K01815685-001-02-3; BRD-K01815685-001-07-2; Z85923165
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 3 [1]
Cross-matching ID
PubChem CID
3712
ChEBI ID
CHEMBL24814
CAS Number
CAS 700-06-1
TTD Drug ID
DMIGFOR

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting NF-kappa-B inhibitor alpha (NFKBIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fucoxanthin DMPQFTA Metabolic syndrome x 5C50-5D2Z Phase 2 [9]
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [10]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [11]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [12]
Gefitinib DM15F0X Colon adenocarcinoma Approved [13]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [14]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [15]
Etretinate DM2CZFA Keratosis ED56 Approved [16]
Prednisone DM2HG4X Acute asthma CA23 Approved [17]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [18]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [19]
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Drug(s) Affected By CD83 antigen (CD83)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [20]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [21]
Quercetin DM3NC4M Obesity 5B81 Approved [22]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [23]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [25]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [26]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [27]
Leflunomide DMR8ONJ Arthritis FA20 Approved [28]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [29]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [30]
Gefitinib DM15F0X Colon adenocarcinoma Approved [13]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [32]
Etretinate DM2CZFA Keratosis ED56 Approved [16]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [33]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [34]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [35]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [37]
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Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [38]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [39]
Methotrexate DM2TEOL Anterior urethra cancer Approved [20]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [40]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [44]
Ethacrynic acid DM60QMR Edema MG29 Approved [45]
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Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [46]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [47]
Fructose DM43AN2 Vomiting MD90 Approved [48]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [49]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [50]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [51]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [12]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [52]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [53]
Methotrexate DM2TEOL Anterior urethra cancer Approved [54]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [55]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [56]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [57]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [58]
Cepharanthine DM9Y5JB N. A. N. A. Approved [59]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [60]
Clozapine DMFC71L Schizophrenia 6A20 Approved [61]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [62]
Trifluoperazine DMKBYWI Anxiety Approved [63]
Olanzapine DMPFN6Y Bipolar depression Approved [61]
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Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [64]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [65]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [51]
Gefitinib DM15F0X Colon adenocarcinoma Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [68]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [70]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [71]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
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Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [72]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [73]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [75]
Methotrexate DM2TEOL Anterior urethra cancer Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [77]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [23]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
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Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor B (CDKN2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [81]
Gefitinib DM15F0X Colon adenocarcinoma Approved [82]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Prednisone DM2HG4X Acute asthma CA23 Approved [17]
Quercetin DM3NC4M Obesity 5B81 Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [84]
Testosterone DM7HUNW Hot flushes GA30 Approved [85]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [85]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [22]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [86]
Gefitinib DM15F0X Colon adenocarcinoma Approved [87]
Prednisone DM2HG4X Acute asthma CA23 Approved [17]
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [89]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [90]
Quercetin DM3NC4M Obesity 5B81 Approved [91]
Fluoxetine DM3PD2C Bipolar depression Approved [92]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [93]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [94]
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Drug(s) Affected By Cytochrome c (CYCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [95]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [96]
Gefitinib DM15F0X Colon adenocarcinoma Approved [97]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [98]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [99]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [100]
Methotrexate DM2TEOL Anterior urethra cancer Approved [101]
Quercetin DM3NC4M Obesity 5B81 Approved [22]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [102]
Pefloxacin DM49IGF Gonococcal urethritis 1A70.0Y Approved [103]
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Drug(s) Affected By Heat shock factor protein 1 (HSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [104]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [105]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [105]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [106]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [107]
Ceftazidime DM41GRA Bacteremia 1A73 Approved [105]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [105]
Ethacrynic acid DM60QMR Edema MG29 Approved [105]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [105]
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Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [95]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [108]
Selenium DM25CGV N. A. N. A. Approved [109]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [75]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [71]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [110]
Quercetin DM3NC4M Obesity 5B81 Approved [22]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [111]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [112]
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Drug(s) Affected By Peroxiredoxin-1 (PRDX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Etretinate DM2CZFA Keratosis ED56 Approved [114]
Methotrexate DM2TEOL Anterior urethra cancer Approved [76]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [115]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [116]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [118]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [117]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [119]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [120]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [121]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [32]
Selenium DM25CGV N. A. N. A. Approved [109]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [122]
Methotrexate DM2TEOL Anterior urethra cancer Approved [76]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [123]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [116]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [124]
Quercetin DM3NC4M Obesity 5B81 Approved [125]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [126]
Artemether DM48QOT Malaria 1F40-1F45 Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [128]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [129]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [130]
Estrone DM5T6US Acne vulgaris ED80 Approved [131]
Leflunomide DMR8ONJ Arthritis FA20 Approved [132]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [133]
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Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [134]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [134]
Gefitinib DM15F0X Colon adenocarcinoma Approved [135]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [48]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [136]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [137]
Methotrexate DM2TEOL Anterior urethra cancer Approved [138]
Quercetin DM3NC4M Obesity 5B81 Approved [139]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [140]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [141]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
NF-kappa-B inhibitor alpha (NFKBIA) TTSHAEB IKBA_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
14-3-3 protein theta OTWG7F3H 1433T_HUMAN Post-Translational Modifications [3]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [4]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [4]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [3]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Gene/Protein Processing [5]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Gene/Protein Processing [6]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Gene/Protein Processing [4]
CD83 antigen (CD83) OT1V4WQF CD83_HUMAN Gene/Protein Processing [7]
Cyclin-dependent kinase 4 inhibitor B (CDKN2B) OTAG24N1 CDN2B_HUMAN Gene/Protein Processing [4]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [8]

References

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2 Protective effect of Indole-3-carbinol, an NF-B inhibitor in experimental paradigm of Parkinson's disease: In silico and in vivo studies. Brain Behav Immun. 2020 Nov;90:108-137.
3 Anticarcinogenic effect of indole-3-carbinol (I3C) on human hepatocellular carcinoma SNU449 cells. Hum Exp Toxicol. 2019 Jan;38(1):136-147. doi: 10.1177/0960327118785235. Epub 2018 Jul 11.
4 Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. Cell Cycle. 2005 Sep;4(9):1201-15. doi: 10.4161/cc.4.9.1993. Epub 2005 Sep 6.
5 BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells. Br J Cancer. 2006 Feb 13;94(3):407-26. doi: 10.1038/sj.bjc.6602935.
6 Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. Toxicol Sci. 2007 Apr;96(2):227-36. doi: 10.1093/toxsci/kfl147. Epub 2006 Oct 31.
7 Aryl hydrocarbon receptor signaling modifies Toll-like receptor-regulated responses in human dendritic cells. Arch Toxicol. 2017 May;91(5):2209-2221.
8 The effect of indole-3-carbinol on the expression of CYP1A1, CYP1B1 and AhR genes and proliferation of MCF-7 cells. Acta Biochim Pol. 2007;54(1):113-7.
9 Fucoxanthin inhibits the inflammatory response by suppressing the activation of NF-B and MAPKs in lipopolysaccharide-induced RAW 264.7 macrophages. Eur J Pharmacol. 2010 Dec 15;649(1-3):369-75.
10 Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
11 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
12 Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
13 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
14 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
15 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
16 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
17 Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
18 Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
19 Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
20 Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol. 2007 Sep;34(9):1817-22. Epub 2007 Aug 1.
21 Differential effects of statins on relevant functions of human monocyte-derived dendritic cells. J Leukoc Biol. 2006 Mar;79(3):529-38. doi: 10.1189/jlb.0205064. Epub 2005 Dec 30.
22 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
23 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
24 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
25 Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
26 Vitamin D Counteracts an IL-23-Dependent IL-17A(+)IFN-(+) Response Driven by Urban Particulate Matter. Am J Respir Cell Mol Biol. 2017 Sep;57(3):355-366. doi: 10.1165/rcmb.2016-0409OC.
27 Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protective effects induced by exemestane. Bone. 2007 Apr;40(4):876-87. doi: 10.1016/j.bone.2006.11.029. Epub 2006 Dec 28.
28 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
29 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
30 mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
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