Details of the Drug-Related molecule(s) Interaction Atlas

BUTYLATEDHYDROXYTOLUENE Drug Info

2,6-Di-tert-butyl-4-methylphenol; 128-37-0; Butylated hydroxytoluene; Butylhydroxytoluene; 2,6-Di-tert-butyl-p-cresol; 2,6-Di-t-butyl-4-methylphenol; Ionol; DBPC; Stavox; Dibunol; BHT; Ionol CP; Topanol; Impruvol; Vianol; Dalpac; Ionole; Deenax; Antioxidant KB; 3,5-Di-tert-butyl-4-hydroxytoluene; Sumilizer BHT; Antioxidant 4K; Topanol O; Topanol OC; Vanlube PC; Vanlube PCX; Sustane BHT; Tenamene 3; Antioxidant DBPC; Antioxidant 29; Antioxidant 30; Tenox BHT; Nonox TBC; Chemanox 11; Ionol 1; Agidol; Catalin CAO-3; Advastab 401; Ionol (antioxidan

Cross-matching ID

PubChem CID

31404

ChEBI ID

CHEBI:34247

CAS Number

CAS 128-37-0

TTD Drug ID

DMJ56MS

General Information of Drug (ID: DMJ56MS)

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Carbonic anhydrase II (CA-II)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[9]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[10]
Dorzolamide	DMA17D0	Ocular hypertension	9C61.01	Approved	[11]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[12]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[13]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[13]
Cyclothiazide	DMJ4AWC	Congestive heart failure	BD10	Approved	[14]
Ethinamate	DMK57GB	Insomnia	7A00-7A0Z	Approved	[15]
Benzthiazide	DMQWZ0H	High blood pressure	BA00	Approved	[16]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[17]
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Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[18]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[19]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[20]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[21]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[22]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[23]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[24]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[25]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[26]
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Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[27]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[28]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[29]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[30]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[31]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[32]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[33]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[34]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[35]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[36]
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Drug(s) Affected By Carbonic anhydrase 2 (CA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[37]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[41]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[42]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[43]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
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Drug(s) Affected By Cytochrome P450 2J2 (CYP2J2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[49]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[50]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[52]
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Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[54]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[55]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[56]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
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Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[62]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[63]
Fructose	DM43AN2	Vomiting	MD90	Approved	[64]
Ketoprofen	DMRKXPT	Bursitis		Approved	[64]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[65]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[66]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[67]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[68]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[69]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[71]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[73]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[74]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[75]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[76]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[78]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
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Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[82]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[83]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[84]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[85]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[86]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[87]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[88]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[89]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[90]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Carbonic anhydrase 2 (CA2)	OTJRMUAG	CAH2_HUMAN	Gene/Protein Processing	[2]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[3]
Cytochrome P450 2B6 (CYP2B6)	OTOYO4S7	CP2B6_HUMAN	Gene/Protein Processing	[4]
Cytochrome P450 2J2 (CYP2J2)	OTJBTEH8	CP2J2_HUMAN	Gene/Protein Processing	[5]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Gene/Protein Processing	[4]
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Gene/Protein Processing	[6]
Phospholipid-transporting ATPase ABCA1 (ABCA1)	OT94G6BQ	ABCA1_HUMAN	Gene/Protein Processing	[7]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Gene/Protein Processing	[8]

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