Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJDVW4)

Drug Name
GSK2816126 Drug Info
Synonyms GSK 126; GSK-126
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Cross-matching ID
PubChem CID
68210102
ChEBI ID
CHEMBL3287735
CAS Number
CAS 1346574-57-9
TTD Drug ID
DMJDVW4

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Enhancer of zeste homolog 2 (EZH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tazemetostat DMWP1BH Follicular lymphoma 2A80 Approved [5]
DS-3201b DMI69E5 T-cell leukaemia 2A90 Phase 2 [6]
CPI-1205 DM3XWJ8 Prostate cancer 2C82.0 Phase 1/2 [7]
SHR2554 DMMUCH0 Prostate cancer 2C82.0 Phase 1/2 [8]
CPI-0209 DMJEXLI Solid tumour/cancer 2A00-2F9Z Phase 1/2 [9]
DS-3201 DMRLPFG Acute lymphoblastic leukaemia 2A85 Phase 1 [7]
HH2853 DMQIE58 Non-hodgkin lymphoma 2B33.5 Phase 1 [10]
PF-06821497 DML3WT6 Diffuse large B-cell lymphoma 2A81 Phase 1 [11]
PMID28394193-Compound-56 DMQRFZK N. A. N. A. Patented [12]
PMID28394193-Compound-46 DMYMPNA N. A. N. A. Patented [12]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [13]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [14]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [15]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [16]
Methotrexate DM2TEOL Anterior urethra cancer Approved [17]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [18]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [20]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [21]
Panobinostat DM58WKG Chronic graft versus host disease Approved [22]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [23]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [24]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [25]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [26]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [23]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [29]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [30]
Capsaicin DMGMF6V Back pain ME84.Z Approved [31]
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Drug(s) Affected By Integrin-binding sialoprotein (IBSP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [33]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [34]
Calcidiol DMN4CV5 Hypophosphatemia Approved [33]
Magnesium DMU4ORS Ischemic stroke 8B11.5Z Approved [35]
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [36]
Camptothecin DM6CHNJ Solid tumour/cancer 2A00-2F9Z Phase 3 [37]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [38]
EUGENOL DM7US1H Discovery agent N.A. Patented [39]
alpha-ketoglutaric acid DM5LFYN Discovery agent N.A. Investigative [40]
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Drug(s) Affected By Homeobox protein MSX-2 (MSX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Panobinostat DM58WKG Chronic graft versus host disease Approved [22]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [42]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [43]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [44]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [45]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [46]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [47]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [22]
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Drug(s) Affected By Homeobox protein Nkx-3.2 (NKX3-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [50]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [51]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [52]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [53]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [38]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [54]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [21]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [55]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [56]
Leflunomide DMR8ONJ Arthritis FA20 Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [58]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [59]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [60]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [50]
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Drug(s) Affected By Polycomb protein EED (EED)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [61]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [4]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [62]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [50]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [63]
Methotrexate DM2TEOL Anterior urethra cancer Approved [64]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [65]
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Drug(s) Affected By Polycomb protein SUZ12 (SUZ12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Selenium DM25CGV N. A. N. A. Approved [67]
Testosterone DM7HUNW Hot flushes GA30 Approved [68]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [69]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [70]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [61]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [4]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [71]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [63]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [72]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Enhancer of zeste homolog 2 (EZH2) TT9MZCQ EZH2_HUMAN Modulator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Fatty acid-binding protein, adipocyte (FABP4) OT3DKFOU FABP4_HUMAN Gene/Protein Processing [3]
Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) OTJQL0I3 HEY1_HUMAN Gene/Protein Processing [3]
Homeobox protein MSX-2 (MSX2) OT1WDKE1 MSX2_HUMAN Gene/Protein Processing [3]
Homeobox protein Nkx-3.2 (NKX3-2) OTH4NRH7 NKX32_HUMAN Gene/Protein Processing [3]
Integrin-binding sialoprotein (IBSP) OT29944Y SIAL_HUMAN Gene/Protein Processing [3]
Polycomb protein EED (EED) OTJFHCDF EED_HUMAN Gene/Protein Processing [4]
Polycomb protein SUZ12 (SUZ12) OT655XF8 SUZ12_HUMAN Gene/Protein Processing [4]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) OTQ4W7MT TR11B_HUMAN Gene/Protein Processing [3]
Twist-related protein 2 OTYH4BDG TWST2_HUMAN Gene/Protein Processing [3]

References

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