General Information of Drug (ID: DMLB0EZ)

Drug Name
Tamoxifen Drug Info
Synonyms
tamoxifen; 10540-29-1; trans-Tamoxifen; Crisafeno; Soltamox; Tamoxifene; Diemon; Tamoxifenum; Tamoxifeno; Tamizam; Istubol; Tamoxen; Citofen; Oncomox; Valodex; Retaxim; Tamoxifene [INN-French]; Tamoxifenum [INN-Latin]; Tamoxifeno [INN-Spanish]; Tamoxifen (Z); Tamoxifen and its salts; Tamoxifen [INN:BAN]; ICI-46474; ICI 47699; TRANS FORM OF TAMOXIFEN; CCRIS 3275; UNII-094ZI81Y45; HSDB 6782; CHEMBL83; EINECS 234-118-0; 1-p-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene; Citofen; Nourytam; Novaldex; Tamone; Tamoxifeno;Tamoxifenum; Tomaxithen; Gen-Tamoxifen; Istubal (TN); Nolvadex (TN); Nolvadex-D; Novo-Tamoxifen; Pms-Tamoxifen; Tamoplex (TN); Tamoxifen (INN); Tamoxifen (TN); Trans-Tamoxifen; Valodex (TN); TAMOXIFEN (TAMOXIFEN CITRATE (54965-24-1)); Trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine; (Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene; (Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine; (Z)-2-(4-(1,2-diphenylbut-1-enyl)phenoxy)-N,N-dimethylethanamine; (Z)-2-(para-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine (IUPAC); (Z)-2-[4-(1,2)-DIPHENYL-1-BUTENYL)-PHENOXY]-N,N-DIMETHYLETHANAMINE; (Z)-2-[p-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine; 1-p-beta-Dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; 1-para-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene; 2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine; 2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine; Tamoxifen (Hormonal therapy); [3H]tamoxifen
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Approved [1]
Inflammatory breast cancer 2C62 Approved [2]
Invasive ductal breast carcinoma Approved [2]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
2733526
ChEBI ID
CHEBI:41774
CAS Number
CAS 10540-29-1
TTD Drug ID
DMLB0EZ
VARIDT Drug ID
DR00193
INTEDE Drug ID
DR1529
ACDINA Drug ID
D00650

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug(s) Targeting Estrogen receptor (ESR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [23]
Estrone DM5T6US Acne vulgaris ED80 Approved [23]
Estradiol Valerate DM8MC6O Hormone replacement therapy 8E01 Approved [24]
Estradiol Acetate DM07U2A Hormone replacement therapy 8E01 Approved [24]
Estradiol Cypionate DM27Z5T Hormone replacement therapy 8E01 Approved [24]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [25]
Raloxifene DMDKF3M Osteoporosis FB83.0 Approved [26]
Ospemifene DMC4GEI Dyspareunia GA12 Approved [27]
Toremifene DMQYUWG Breast cancer 2C60-2C65 Approved [28]
Mestranol DMG3F94 Contraception QA21 Approved [29]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [30]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [31]
Methotrexate DM2TEOL Anterior urethra cancer Approved [6]
Folic Acid DMEMBJC Colorectal carcinoma Approved [32]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [6]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [6]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [33]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [34]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [35]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [36]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Folic Acid DMEMBJC Colorectal carcinoma Approved [39]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [40]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [41]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [42]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [42]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [43]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [44]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [45]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [4]
Tenofovir DM1IS6U Chronic hepatitis B virus infection Approved [46]
Paclitaxel DMLB81S Breast carcinoma Approved [4]
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [48]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [49]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [50]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [51]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [52]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [53]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [48]
Verapamil DMA7PEW Angina pectoris BA40 Approved [54]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [55]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [56]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [57]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [58]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [59]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [60]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [52]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [61]
Verapamil DMA7PEW Angina pectoris BA40 Approved [62]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [63]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [64]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [65]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [66]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [67]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [68]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [69]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [70]
Metronidazole DMTIVEN Abscess Approved [71]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [72]
Ethanol DMDRQZU Chronic pain MG30 Approved [73]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [74]
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Drug(s) Metabolized By Cytochrome P450 2A6 (CYP2A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [56]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [75]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [50]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [76]
Metronidazole DMTIVEN Abscess Approved [77]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [78]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [75]
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Drug(s) Metabolized By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [80]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [81]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [82]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [61]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [83]
Estrone DM5T6US Acne vulgaris ED80 Approved [84]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [85]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [86]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [87]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [88]
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Drug(s) Metabolized By Sulfotransferase 1A1 (SULT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [89]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [90]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [91]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [92]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [93]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [94]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [95]
Epinephrine DM3KJBC Acute asthma CA23 Approved [96]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [97]
Teicoplanin DMAQ2LK Bacterial infection 1A00-1C4Z Approved [98]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [99]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [100]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [50]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [54]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [101]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [102]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [103]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [88]
Propranolol DM79NTF Angina pectoris BA40 Approved [104]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [105]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [106]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [107]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [17]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [108]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [109]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [110]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [111]
Verapamil DMA7PEW Angina pectoris BA40 Approved [112]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [17]
Estrone DM5T6US Acne vulgaris ED80 Approved [113]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [114]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [115]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [116]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [117]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [61]
Verapamil DMA7PEW Angina pectoris BA40 Approved [75]
Estrone DM5T6US Acne vulgaris ED80 Approved [118]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [119]
Ethanol DMDRQZU Chronic pain MG30 Approved [120]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [121]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Thiopurine methyltransferase (TPMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [122]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [123]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [124]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [125]
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [126]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [127]
Epinephrine DM3KJBC Acute asthma CA23 Approved [128]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [129]
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [130]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [131]
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Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [132]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [17]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [17]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [75]
Verapamil DMA7PEW Angina pectoris BA40 Approved [133]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [17]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [17]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [17]
Metronidazole DMTIVEN Abscess Approved [77]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [134]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [135]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [136]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [75]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [137]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [75]
Verapamil DMA7PEW Angina pectoris BA40 Approved [138]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [139]
Estrone DM5T6US Acne vulgaris ED80 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [142]
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Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [75]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [143]
Estrone DM5T6US Acne vulgaris ED80 Approved [136]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [144]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [145]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [146]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [147]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [148]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [149]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [150]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [135]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [151]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [75]
Verapamil DMA7PEW Angina pectoris BA40 Approved [152]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [83]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [153]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [78]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [75]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [154]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [54]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [155]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [156]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [54]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [157]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [158]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [159]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [160]
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [54]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [161]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [162]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [158]
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [54]
Naproxen DMZ5RGV Bursitis Approved [163]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [54]
Raloxifene DMDKF3M Osteoporosis FB83.0 Approved [164]
Bazedoxifene DMY85QW Hot flushes GA30 Approved [165]
BCP-13498 DM2BO9W N. A. N. A. Phase 2 [166]
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Drug(s) Affected By Coagulation factor V (F5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [167]
Testosterone DM7HUNW Hot flushes GA30 Approved [168]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [168]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [169]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [170]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [171]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [172]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [173]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [174]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Estrogen receptor (ESR) TTZAYWL ESR1_HUMAN Antagonist [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance-associated protein 7 (ABCC10) DTPS120 MRP7_HUMAN Substrate [4]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [5]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [7]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Substrate [8]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [9]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [10]
Cytochrome P450 1A1 (CYP1A1) DE6OQ3W CP1A1_HUMAN Substrate [11]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Substrate [12]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [13]
Cytochrome P450 2A6 (CYP2A6) DEJVYAZ CP2A6_HUMAN Substrate [8]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [14]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [15]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Substrate [16]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Substrate [17]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DEB3CV1 UD2B7_HUMAN Substrate [18]
Sulfotransferase 2A1 (SULT2A1) Main DME DE0P6LK ST2A1_HUMAN Substrate []
Sulfotransferase 1A1 (SULT1A1) DEYWLRK ST1A1_HUMAN Substrate [19]
UDP-glucuronosyltransferase 1A10 (UGT1A10) DEL5N6Y UD110_HUMAN Substrate [20]
Thiopurine methyltransferase (TPMT) DEFQ8VO TPMT_HUMAN Substrate [21]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Coagulation factor V (F5) OTDMZ3LT FA5_HUMAN Drug Response [22]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1016).
2 Tamoxifen FDA Label
3 Modulators of vascular sex hormone receptors and their effects in estrogen-deficiency states associated with menopause. Recent Pat Cardiovasc Drug Discov. 2008 Nov;3(3):165-86.
4 Modulation of the ATPase and transport activities of broad-acting multidrug resistance factor ABCC10 (MRP7). Cancer Res. 2012 Dec 15;72(24):6457-67.
5 The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters. Cancer Lett. 2016 Jun 28;376(1):165-72.
6 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
7 Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.
8 Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing human cytochrome P450s. Carcinogenesis. 1994 Jan;15(1):5-9.
9 CYP2D6 polymorphisms and tamoxifen metabolism: clinical relevance. Curr Oncol Rep. 2010 Jan;12(1):7-15.
10 Tamoxifen inhibits cytochrome P450 2C9 activity in breast cancer patients. J Chemother. 2006 Aug;18(4):421-4.
11 Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos. 2002 Aug;30(8):869-74.
12 Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites. Cancer Res. 2009 Mar 1;69(5):1892-900.
13 Cytochrome P450 pharmacogenetics and cancer. Oncogene. 2006 Mar 13;25(11):1679-91.
14 Endoxifen and other metabolites of tamoxifen inhibit human hydroxysteroid sulfotransferase 2A1 (hSULT2A1). Drug Metab Dispos. 2014 Nov;42(11):1843-50.
15 Polymorphisms in cytochrome P4503A5 (CYP3A5) may be associated with race and tumor characteristics, but not metabolism and side effects of tamoxifen in breast cancer patients. Cancer Lett. 2005 Jan 10;217(1):61-72.
16 Effect of tamoxifen on the enzymatic activity of human cytochrome CYP2B6. J Pharmacol Exp Ther. 2002 Jun;301(3):945-52.
17 Drug Interactions Flockhart Table
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