Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLGZPO)

Drug Name
PMID26560530-Compound-34 Drug Info
Cross-matching ID
PubChem CID
47318
ChEBI ID
CHEMBL178459
CAS Number
CAS 64224-21-1
TTD Drug ID
DMLGZPO

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Tissue transglutaminase (TG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ZED1227 DMDXEN5 Coeliac disease DA95 Phase 2 [6]
PMID26560530-Compound-13 DMKF26Z N. A. N. A. Patented [1]
PMID26560530-Compound-54 DM2X4R0 N. A. N. A. Patented [1]
Triazole derivative 1 DM9QB2S N. A. N. A. Patented [1]
Acyl piperidine derivative 3 DMIDUB4 N. A. N. A. Patented [1]
PMID26560530-Compound-14 DM52MIK N. A. N. A. Patented [1]
PMID26560530-Compound-1 DMSI7F2 N. A. N. A. Patented [1]
PMID26560530-Compound-3 DM92OT0 N. A. N. A. Patented [1]
PMID26560530-Compound-11 DMZ5UST N. A. N. A. Patented [1]
Chloroacetyl ester derivative 1 DMW4J0P N. A. N. A. Patented [1]
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Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [7]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [8]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [9]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [10]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [11]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [12]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [13]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [14]
Dacarbazine DMNPZL4 Adenocarcinoma 2D40 Approved [15]
Topotecan DMP6G8T Central nervous system neoplasm Approved [16]
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Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [17]
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [19]
Calcipotriol DM03CP7 Psoriasis EA90 Approved [20]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [21]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [22]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [23]
Prednisone DM2HG4X Acute asthma CA23 Approved [24]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [25]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [26]
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Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [29]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [34]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [10]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [36]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [37]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [37]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [38]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [36]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [37]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [39]
Gefitinib DM15F0X Colon adenocarcinoma Approved [36]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [40]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [36]
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Drug(s) Affected By Involucrin (IVL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [41]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [44]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [45]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [41]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [4]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [46]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [47]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [42]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [48]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [49]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [50]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [51]
Cepharanthine DM9Y5JB N. A. N. A. Approved [52]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [53]
Clozapine DMFC71L Schizophrenia 6A20 Approved [54]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [55]
Trifluoperazine DMKBYWI Anxiety Approved [56]
Olanzapine DMPFN6Y Bipolar depression Approved [54]
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Drug(s) Affected By Solute carrier organic anion transporter family member 1B3 (SLCO1B3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [57]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [58]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [59]
Trospium chloride DM32XZT Discovery agent N.A. Approved [60]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [61]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [62]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [63]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [61]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [64]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [65]
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Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [66]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [66]
Gefitinib DM15F0X Colon adenocarcinoma Approved [67]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [68]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [69]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [70]
Methotrexate DM2TEOL Anterior urethra cancer Approved [71]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [72]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [73]
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Drug(s) Affected By Solute carrier family 22 member 7 (SLC22A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [74]
Methotrexate DM2TEOL Anterior urethra cancer Approved [75]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [72]
Paclitaxel DMLB81S Breast carcinoma Approved [76]
Allopurinol DMLPAOB Gout FA25 Approved [76]
Bumetanide DMRV7H0 Congestive heart failure BD10 Approved [76]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [76]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [76]
Tetracycline DMZA017 Acne vulgaris ED80 Approved [76]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [77]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tissue transglutaminase (TG2) TT2F4OL TGM2_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Gene/Protein Processing [2]
ATP-binding cassette sub-family C member 4 (ABCC4) OTO27PAL MRP4_HUMAN Gene/Protein Processing [3]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [2]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [2]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Gene/Protein Processing [2]
Involucrin (IVL) OT4VPNGY INVO_HUMAN Gene/Protein Processing [4]
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Gene/Protein Processing [5]
Solute carrier family 22 member 7 (SLC22A7) OTKTNH1W S22A7_HUMAN Gene/Protein Processing [2]
Solute carrier organic anion transporter family member 1B3 (SLCO1B3) OTOM3BUH SO1B3_HUMAN Gene/Protein Processing [2]

References

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59 Transcellular movement of hydroxyurea is mediated by specific solute carrier transporters. Exp Hematol. 2011 Apr;39(4):446-56.
60 Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. Mol Pharm. 2015 Jan 5;12(1):171-8.
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67 Pharmacogenetics of ABCG2 and adverse reactions to gefitinib. J Natl Cancer Inst. 2006 Dec 6;98(23):1739-42.
68 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
69 ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin. Clin Pharmacol Ther. 2010 May;87(5):558-62.
70 Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
71 Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
72 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
73 Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps. Cancer Biol Ther. 2005 Jul;4(7):747-52.
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75 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
76 Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]). J Pharm Pharmacol. 2005 May;57(5):573-8.
77 A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther. 2005 Oct;315(1):337-45.