Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLSV74)

Drug Name
Sotorasib Drug Info
Synonyms
AMG-510; AMG510; AMG-510 racemate; 2252403-56-6; AMG 510; Kras G12C inhibitor 9; 2296729-00-3; UNII-2B2VM6UC8G; 2B2VM6UC8G; CHEMBL4535757; 2296729-00-3 (racemate); 4-((S)-4-Acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one; 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one; Sotorasib [INN]; 6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-((2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl)pyrido(2,3-d)pyrimidin-2-one; AMG510 racemate; Sotorasib [USAN]; AMG-510(racemate); Kras mutant-targeting AMG 510; SCHEMBL20560375; GTPL10678; AMG 510 pound>>AMG-510; AMY16918; BCP30452; BCP33368; EX-A3538; BDBM50514402; NSC818433; s8830; WHO 11370; DB15569; NSC-818433; BS-16684; HY-114277; CS-0081316; compound (R)-38 [PMID: 31820981]; AMG510 ; AMG 510; AMG-510; AMG510; (1m)-6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(propan-2-yl)pyridin-3-yl)-4-((2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl)pyrido(2,3-d)pyrimidin-2(1H)-one; (1S)-4-((S)-4-Acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one; 2296729-66-1; Pyrido(2,3-d)pyrimidin-2(1H)-one, 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(1-methylethyl)-3-pyridinyl)-4-((2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl)-
Indication
Disease Entry ICD 11 Status REF
Non-small-cell lung cancer 2C25 Approved [1]
Cross-matching ID
PubChem CID
137278711
CAS Number
CAS 2252403-56-6
TTD Drug ID
DMLSV74

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting KRAS G12C mutant (KRAS G12C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Adagrasib DMDV4EP Non-small-cell lung cancer 2C25 Approved [4]
JDQ443 DMHI7CQ Non-small-cell lung cancer 2C25 Phase 3 [5]
LY3499446 DMA1CSR Solid tumour/cancer 2A00-2F9Z Phase 1/2 [6]
RG6330 DMSX5NJ Solid tumour/cancer 2A00-2F9Z Phase 1 [7]
JNJ-74699157 DMY7CW1 Solid tumour/cancer 2A00-2F9Z Phase 1 [6]
Drug(s) Affected By Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [8]
Gefitinib DM15F0X Colon adenocarcinoma Approved [9]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [10]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [11]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [12]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [13]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [14]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [15]
Selenium DM25CGV N. A. N. A. Approved [16]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [17]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [18]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [19]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [20]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [21]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [22]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [23]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [24]
Gefitinib DM15F0X Colon adenocarcinoma Approved [25]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [26]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [27]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [28]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [19]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [29]
Paclitaxel DMLB81S Breast carcinoma Approved [30]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [31]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [18]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [32]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [33]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [21]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [22]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [34]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [35]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [36]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [37]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [38]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [39]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [40]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [41]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [42]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [43]
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Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [44]
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [46]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [47]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [48]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [49]
Testosterone DM7HUNW Hot flushes GA30 Approved [50]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [51]
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
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Drug(s) Affected By GTPase KRas (KRAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [54]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Tiazofurin DM5JWV9 Solid tumour/cancer 2A00-2F9Z Approved [57]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [58]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [59]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [60]
Testosterone enanthate DMB6871 N. A. N. A. Approved [61]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
KRAS G12C mutant (KRAS G12C) TT3LH46 RASK_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [3]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Post-Translational Modifications [3]
GTPase KRas (KRAS) OT78QCN8 RASK_HUMAN Drug Response [3]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [3]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [3]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Post-Translational Modifications [3]

References

1 FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 214665.
2 Clinical pipeline report, company report or official report of Amgen.
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