Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNWIYM)

Drug Name
Flavanone Drug Info
Synonyms
FLAVANONE; 487-26-3; 2-Phenylchroman-4-one; 2,3-Dihydroflavone; 2-Phenyl-4-chromanone; 4-Flavanone; 2,3-Dihydro-2-phenyl-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 2,3-dihydro-2-phenyl-; 2-Phenyl-2,3-dihydro-4H-chromen-4-one; NSC-50393; 2,3-Dihydro-2-phenyl-4H-benzopyran-4-one; 2-Phenyl-chroman-4-one; 2-phenyl-3,4-dihydro-2H-1-benzopyran-4-one; EINECS 207-654-8; NSC 50393; BRN 0183227; MLS002667384; CHEMBL274318; CHEBI:5070; ZONYXWQDUYMKFB-UHFFFAOYSA-N; NSC50393; 2-phenyl-2,3-dihydrochromen-4-one; MFCD00006841; (-)-Flavanone
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10251
ChEBI ID
CHEMBL274318
CAS Number
CAS 487-26-3
TTD Drug ID
DMNWIYM
INTEDE Drug ID
DR2357

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Clinical Trial Drug(s)
Approved Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
GLYCYRRHIZIN DM8M2N3 Influenza virus infection 1E30-1E32 Phase 3 [7]
BVT.2733 DM6RUKX Lupus 4A40 Phase 3 [8]
INCB13739 DMLQ3PO Type-2 diabetes 5A11 Phase 2a [9]
URSOLIC ACID DM4SOAW Metabolic syndrome x 5C50-5D2Z Phase 2 [10]
JTT-654 DM50M2R Type-2 diabetes 5A11 Phase 2 [11]
RG-4929 DMT4QRD Metabolic disorder 5C50-5D2Z Phase 2 [11]
BMS-770767 DMTVGY7 Hypercholesterolaemia 5C80.0 Phase 2 [11]
UE-2343 DMIERPK Alzheimer disease 8A20 Phase 2 [12]
AZD-4017 DML9M5S Ocular hypertension 9C61.01 Phase 2 [11]
Xanamem DM580GT Alzheimer disease 8A20 Phase 1/2 [13]
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Drug(s) Targeting Monoamine oxidase type B (MAO-B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selegiline Hydrochloride DM3VR1L Parkinson disease 8A00.0 Approved [14]
Phenelzine DMHIDUE Depression 6A70-6A7Z Approved [15]
Tranylcypromine DMGB5RE Major depressive disorder 6A70.3 Approved [16]
Selegiline DM6034S Major depressive disorder 6A70.3 Approved [17]
Safinamide mesylate DM0J2ZT Parkinson disease 8A00.0 Approved [18]
Rasagiline DM3WKQ4 Parkinson disease 8A00.0 Approved [19]
Sulphadoxine DMZI2UF Malaria 1F40-1F45 Approved [20]
Pargyline DMM0HR1 Hypertension BA00-BA04 Approved [21]
Indeloxazine DMWO3N6 Dementia 6D80-6D86 Approved [22]
Budipine DMODHQI Migraine 8A80 Approved [23]
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Drug(s) Metabolized By Biphenyl dioxygenase (bphC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isoflavone DM7U58J N. A. N. A. Phase 4 [3]
AUS-131 DMUXO3Z Hot flushes GA30 Phase 2 [3]
flavone DMEQH6J Discovery agent N.A. Investigative [3]
Drug(s) Affected By Sex hormone-binding globulin (SHBG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [24]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Fructose DM43AN2 Vomiting MD90 Approved [26]
Oxcarbazepine DM5PU6O Epilepsy 8A60-8A68 Approved [27]
Estrone DM5T6US Acne vulgaris ED80 Approved [6]
Testosterone DM7HUNW Hot flushes GA30 Approved [28]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [29]
Dienestrol DMBSXI0 Atrophic vaginitis GA30.2 Approved [6]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [6]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [6]
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Drug(s) Affected By Retinoblastoma-associated protein (RB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [30]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [31]
Gefitinib DM15F0X Colon adenocarcinoma Approved [32]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [33]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [35]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [36]
Methotrexate DM2TEOL Anterior urethra cancer Approved [37]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [39]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Gefitinib DM15F0X Colon adenocarcinoma Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [43]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [44]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [45]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [44]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [46]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [47]
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [49]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [43]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Epinephrine DM3KJBC Acute asthma CA23 Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Fructose DM43AN2 Vomiting MD90 Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [56]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [57]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [58]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [59]
Gefitinib DM15F0X Colon adenocarcinoma Approved [60]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [33]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Etretinate DM2CZFA Keratosis ED56 Approved [61]
Prednisone DM2HG4X Acute asthma CA23 Approved [62]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [45]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [63]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [31]
Gefitinib DM15F0X Colon adenocarcinoma Approved [64]
Prednisone DM2HG4X Acute asthma CA23 Approved [62]
Methotrexate DM2TEOL Anterior urethra cancer Approved [65]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [66]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [67]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Fluoxetine DM3PD2C Bipolar depression Approved [69]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
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Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [72]
Gefitinib DM15F0X Colon adenocarcinoma Approved [73]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Epinephrine DM3KJBC Acute asthma CA23 Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [76]
Fructose DM43AN2 Vomiting MD90 Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [77]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [78]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [79]
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Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [80]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [72]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [82]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [83]
Quercetin DM3NC4M Obesity 5B81 Approved [84]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [85]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [86]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [87]
Testosterone DM7HUNW Hot flushes GA30 Approved [88]
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Drug(s) Affected By Cytochrome c (CYCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [90]
Gefitinib DM15F0X Colon adenocarcinoma Approved [41]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [91]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [92]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [93]
Methotrexate DM2TEOL Anterior urethra cancer Approved [82]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [94]
Pefloxacin DM49IGF Gonococcal urethritis 1A70.0Y Approved [95]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [96]
Quercetin DM3NC4M Obesity 5B81 Approved [97]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [98]
Artemether DM48QOT Malaria 1F40-1F45 Approved [99]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [100]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [101]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [102]
Estrone DM5T6US Acne vulgaris ED80 Approved [5]
Leflunomide DMR8ONJ Arthritis FA20 Approved [103]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) TTN7BL9 DHI1_HUMAN Inhibitor [2]
Monoamine oxidase type B (MAO-B) TTGP7BY AOFB_HUMAN Inhibitor [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Biphenyl dioxygenase (bphC) Main DME DEUX61H BPHC_PSEFK Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [4]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Gene/Protein Processing [4]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Protein Interaction/Cellular Processes [4]
Nuclear receptor subfamily 1 group I member 3 (NR1I3) OTS3SGH7 NR1I3_HUMAN Gene/Protein Processing [5]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Gene/Protein Processing [4]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [4]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Post-Translational Modifications [4]
Sex hormone-binding globulin (SHBG) OTPWU5IW SHBG_HUMAN Protein Interaction/Cellular Processes [6]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Gene/Protein Processing [4]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Gene/Protein Processing [4]

References

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40 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
41 Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. Chem Biol Interact. 2013 Apr 25;203(2):412-22. doi: 10.1016/j.cbi.2013.03.011. Epub 2013 Mar 22.
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46 Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
47 Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther. 2005 Feb;4(2):291-304.
48 Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4+ T cells. Clin Exp Immunol. 2007 May;148(2):288-95. doi: 10.1111/j.1365-2249.2007.03335.x. Epub 2007 Feb 7.
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50 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
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56 Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
57 Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
58 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
59 Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
60 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
61 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
62 Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
63 Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
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