Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOEVK6)

Drug Name
Ammonia Drug Info
Synonyms Ammonia N13
Indication
Disease Entry ICD 11 Status REF
Coronary artery disease BA80 Approved [1]
Cross-matching ID
PubChem CID
222
ChEBI ID
CHEBI:16134
CAS Number
CAS 7664-41-7
TTD Drug ID
DMOEVK6
VARIDT Drug ID
DR00194
INTEDE Drug ID
DR0100

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Affected By Ammonium transporter Rh type C (RHCG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [10]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [11]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [12]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [13]
Milchsaure DM462BT Pruritus EC90 Investigative [14]
BRN-3548355 DM4KXT0 N. A. N. A. Investigative [15]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [16]
3-iodothyronamine DM3L0F8 Discovery agent N.A. Investigative [17]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [18]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [19]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [20]
Verapamil DMA7PEW Angina pectoris BA40 Approved [21]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [22]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [23]
Selenium DM25CGV N. A. N. A. Approved [24]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [25]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [26]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
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Drug(s) Affected By Glial fibrillary acidic protein (GFAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penicillin V DMKVOYF Acute otitis media AB00 Approved [28]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [28]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [30]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [31]
Testosterone DM7HUNW Hot flushes GA30 Approved [32]
Haloperidol DM96SE0 Delirium Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Ethanol DMDRQZU Chronic pain MG30 Approved [36]
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Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [12]
Indomethacin DMSC4A7 Bursitis Approved [37]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [39]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [40]
Quercetin DM3NC4M Obesity 5B81 Approved [41]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [42]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [43]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [44]
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Drug(s) Affected By Aquaporin-4 (AQP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [44]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [46]
Guanfacine extended release DMB1CZ8 Attention deficit hyperactivity disorder 6A05.Z Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Olanzapine DMPFN6Y Bipolar depression Approved [47]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [48]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [49]
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Drug(s) Affected By Sodium- and chloride-dependent creatine transporter 1 (SLC6A8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Selenium DM25CGV N. A. N. A. Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [52]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [54]
Panobinostat DM58WKG Chronic graft versus host disease Approved [55]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ampicillin DMHWE7P Acute epiglottitis Approved [52]
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Drug(s) Affected By Glycine amidinotransferase, mitochondrial (GATM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [52]
Testosterone DM7HUNW Hot flushes GA30 Approved [32]
Leflunomide DMR8ONJ Arthritis FA20 Approved [58]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Clozapine DMFC71L Schizophrenia 6A20 Approved [33]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [60]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [61]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [62]
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Drug(s) Affected By Guanidinoacetate N-methyltransferase (GAMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [61]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [62]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [63]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [64]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [65]
Methotrexate DM2TEOL Anterior urethra cancer Approved [66]
Urethane DM7NSI0 N. A. N. A. Phase 4 [67]
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Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [63]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [68]
Minoxidil DMA2Z4F Alopecia ED70 Approved [69]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [70]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [69]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Methotrexate DM2TEOL Anterior urethra cancer Approved [73]
Quercetin DM3NC4M Obesity 5B81 Approved [52]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amine oxidase 3 (AOC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [76]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [77]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [79]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [61]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [12]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [13]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [80]
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Drug(s) Affected By Arylamine N-acetyltransferase 2 (NAT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [81]
Hydralazine DMU8JGH Chronic heart failure BD1Z Approved [82]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [83]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [84]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [85]
Quercetin DM3NC4M Obesity 5B81 Approved [86]
Testosterone DM7HUNW Hot flushes GA30 Approved [87]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [88]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
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Drug(s) Affected By Arylamine N-acetyltransferase 1 (NAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [89]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [85]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [90]
Methotrexate DM2TEOL Anterior urethra cancer Approved [89]
Testosterone DM7HUNW Hot flushes GA30 Approved [87]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [87]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Folic Acid DMEMBJC Colorectal carcinoma Approved [89]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [91]
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Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [92]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [93]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [94]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [95]
Estrone DM5T6US Acne vulgaris ED80 Approved [96]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [97]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [98]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [99]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [100]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [20]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Ammonium transporter Rh type C (SLC42A3) DTF3LTV RHCG_HUMAN Substrate [2]
Ammonium transporter Rh type B (SLC42A2) DTU6IF7 RHBG_HUMAN Substrate [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Glutamine synthetase (GLUL) Main DME DE5UC73 GLNA_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Amine oxidase 3 (AOC3) OT30YKV0 AOC3_HUMAN Biotransformations [4]
Ammonium transporter Rh type C (RHCG) OT1MTYUH RHCG_HUMAN Regulation of Drug Effects [5]
Aquaporin-4 (AQP4) OTA9MYD5 AQP4_HUMAN Gene/Protein Processing [6]
Arylamine N-acetyltransferase 1 (NAT1) OTCCNQ3H ARY1_HUMAN Biotransformations [7]
Arylamine N-acetyltransferase 2 (NAT2) OTBPDQOY ARY2_HUMAN Drug Response [8]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Regulation of Drug Effects [7]
Glial fibrillary acidic protein (GFAP) OTQ01ZAS GFAP_HUMAN Gene/Protein Processing [6]
Glycine amidinotransferase, mitochondrial (GATM) OTIJ4Z11 GATM_HUMAN Gene/Protein Processing [9]
Guanidinoacetate N-methyltransferase (GAMT) OTVC87ES GAMT_HUMAN Gene/Protein Processing [9]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Gene/Protein Processing [6]

References

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53 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
54 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
55 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
56 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
57 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
58 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
59 The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
60 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
61 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
62 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
63 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
64 Dissecting progressive stages of 5-fluorouracil resistance in vitro using RNA expression profiling. Int J Cancer. 2004 Nov 1;112(2):200-12. doi: 10.1002/ijc.20401.
65 Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
66 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
67 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
68 Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate. J Endocrinol. 2001 Dec;171(3):525-32.
69 Enzymatic characterization and interspecies difference of phenol sulfotransferases, ST1A forms. Drug Metab Dispos. 2001 Mar;29(3):274-81.
70 Sulfation of benzyl alcohol by the human cytosolic sulfotransferases (SULTs): a systematic analysis. J Appl Toxicol. 2016 Sep;36(9):1090-4.
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