Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPI98T)

Drug Name
Doxepin Drug Info
Synonyms
Zonalon; doxepin; Doxepine; Doxepinum [INN-Latin]; Doxepina [INN-Spanish]; Doxepin [USAN]; trans-doxepin; (e)-doxepin; 1668-19-5; Quitaxon; MF 10; UNII-851NLB57HQ; Sinequan; CCRIS 9176; HSDB 3069; Sinequan (TN); Cidoxepina; Cidoxepinum; 851NLB57HQ; 11-(3-(Dimethylamino)propylidene)-6H-dibenz(b,e)oxepine; 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz(b,e)oxipin; 11-(3-Dimethylamino-propyliden)-6,11-dihydro-dibenz(b,e)oxipin; N,N-Dimethyldibenz(b,e)oxepin-delta(11(6H),gamma)-propylamine; Cidoxepin [INN]; Curatin; Adapin; Cidoxepin; Doxepina; Doxepinum; Triadapin; Doxepin Hydrochloride; MOLI001594; Adapine (TN); Aponal (TN); Cis-doxepin; Deptran (TN); Doxepin (INN); Doxepin, Hydrochloride; Sinquan (TN); Xepin (TN); Zonalon (TN); Doxepin (Z)-isomer; Cis-N-(3-(6H-Dibenz(b,e)oxepin-11-yliden)propyl)-N,N-dimethylamin; (3E)-3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine; (3E)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine; (3Z)-3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-di(methyl)propan-1-amine; (3Z)-3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine; (3Z)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine; (Z)-Doxepin; 3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine; 3-Dibenz[b,e]oxepin-11(6H)-ylidene-N,N-dimethyl-1-propanamine; 3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine; [11C]doxepin
Indication
Disease Entry ICD 11 Status REF
Anxiety Approved [1]
Bipolar depression Approved [1]
Depression 6A70-6A7Z Approved [2]
Insomnia 7A00-7A0Z Approved [1]
Pruritus EC90 Investigative [1]
Therapeutic Class
Antidepressants
Cross-matching ID
PubChem CID
667477
CAS Number
CAS 1668-19-5
TTD Drug ID
DMPI98T
VARIDT Drug ID
DR00542
INTEDE Drug ID
DR0544
ACDINA Drug ID
D00626

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Histamine H1 receptor (H1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [11]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [12]
Azelastine DMXTMBJ Allergic conjunctivitis 9A60.02 Approved [13]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [14]
Cinnarizine DM7U5QJ Meniere disease AB31.0 Approved [15]
Diphenhydramine DMKQTBA Hyperemesis gravidarum Approved [13]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [13]
Epinastine DMX0K3Q Allergic conjunctivitis 9A60.02 Approved [16]
Desloratadine DM56YN7 Allergic rhinitis CA08.0 Approved [17]
Tranilast DME5Y64 Allergic rhinitis CA08.0 Approved [18]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [19]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [20]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [21]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [22]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [23]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [24]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [25]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [26]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [20]
Verapamil DMA7PEW Angina pectoris BA40 Approved [27]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [28]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [29]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [30]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [32]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [33]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [25]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [34]
Verapamil DMA7PEW Angina pectoris BA40 Approved [35]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [36]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [37]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [38]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [23]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [27]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [40]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [41]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [42]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [43]
Propranolol DM79NTF Angina pectoris BA40 Approved [44]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [61]
Paliperidone DM7NPJS Psychotic disorder 6A20-6A25 Approved [62]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [63]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Oxatomide DM1F42Z Hay fever CA08.00 Approved [65]
Cinacalcet DMCX0K3 Hyperparathyroidism 5A51 Approved [66]
Capsaicin DMGMF6V Back pain ME84.Z Approved [67]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [68]
Quinidine DMLPICK N. A. N. A. Approved [69]
Buprenorphine DMPRI8G Opioid dependence 6C43.2Z Approved [70]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [45]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [46]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [47]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [48]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [49]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [48]
Verapamil DMA7PEW Angina pectoris BA40 Approved [50]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [51]
Estrone DM5T6US Acne vulgaris ED80 Approved [52]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [53]
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Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [54]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [45]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [55]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [56]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [48]
Verapamil DMA7PEW Angina pectoris BA40 Approved [57]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [58]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [53]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [59]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [60]
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Drug(s) Affected By Glutathione S-transferase P (GSTP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [71]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [72]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [73]
Chlorambucil DMRKE63 Chronic lymphocytic leukaemia 2A82.0 Approved [73]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [74]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Selenium DM25CGV N. A. N. A. Approved [77]
Etretinate DM2CZFA Keratosis ED56 Approved [78]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [10]
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Drug(s) Affected By Nuclear protein 1 (NUPR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [80]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [81]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [7]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [80]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Fluoxetine DM3PD2C Bipolar depression Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [81]
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Drug(s) Affected By Alpha-1-antichymotrypsin (SERPINA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [80]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [84]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [7]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [80]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [80]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [85]
Fluoxetine DM3PD2C Bipolar depression Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [86]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [86]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [80]
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Drug(s) Affected By Fatty acid-binding protein, liver (FABP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [80]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [87]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [7]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [80]
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Fluoxetine DM3PD2C Bipolar depression Approved [80]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [89]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [81]
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Drug(s) Affected By Asparagine synthetase (ASNS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [90]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [80]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [91]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [80]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [92]
Methotrexate DM2TEOL Anterior urethra cancer Approved [93]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [81]
Fluoxetine DM3PD2C Bipolar depression Approved [80]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [94]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [95]
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Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [96]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [80]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [7]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [80]
Methotrexate DM2TEOL Anterior urethra cancer Approved [97]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Fluoxetine DM3PD2C Bipolar depression Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [98]
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Drug(s) Affected By Lanosterol synthase (LSS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [80]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [99]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [80]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Fluoxetine DM3PD2C Bipolar depression Approved [80]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [100]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [101]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [81]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [80]
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Drug(s) Affected By Inhibin beta E chain (INHBE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [80]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [7]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [80]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Fluoxetine DM3PD2C Bipolar depression Approved [80]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [101]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [81]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [80]
Panobinostat DM58WKG Chronic graft versus host disease Approved [102]
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Drug(s) Affected By Transgelin (TAGLN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [80]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [103]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [7]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [80]
Methotrexate DM2TEOL Anterior urethra cancer Approved [104]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Fluoxetine DM3PD2C Bipolar depression Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [105]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [7]
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Drug(s) Affected By Lysophospholipase D GDPD3 (GDPD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [80]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [7]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [80]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [81]
Fluoxetine DM3PD2C Bipolar depression Approved [81]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [80]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [106]
Testosterone DM7HUNW Hot flushes GA30 Approved [107]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [107]
Haloperidol DM96SE0 Delirium Approved [81]
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Drug(s) Affected By Protein DEPP1 (DEPP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [80]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [81]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [108]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [80]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Fluoxetine DM3PD2C Bipolar depression Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [109]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [81]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [81]
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Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [8]
Diazepam DM08E9O Alcohol withdrawal Approved [8]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [87]
Selenium DM25CGV N. A. N. A. Approved [77]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [8]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [8]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [8]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [8]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [8]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [8]
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Drug(s) Affected By Angiotensin-converting enzyme 2 (ACE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Captopril DM458UM Chronic heart failure BD1Z Approved [110]
Diazepam DM08E9O Alcohol withdrawal Approved [8]
Dantrolene DM1D8XY Hyperthermia MG26 Approved [8]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [8]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [8]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [8]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [8]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [8]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [8]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histamine H1 receptor (H1R) TTTIBOJ HRH1_HUMAN Inhibitor [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [4]
Cytochrome P450 2D6 (CYP2D6) Main DME DECB0K3 CP2D6_HUMAN Substrate [5]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [6]
Mephenytoin 4-hydroxylase (CYP2C19) Main DME DEGTFWK CP2CJ_HUMAN Substrate [6]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alpha-1-antichymotrypsin (SERPINA3) OT9BP2S0 AACT_HUMAN Gene/Protein Processing [7]
Angiotensin-converting enzyme 2 (ACE2) OTTRZGU7 ACE2_HUMAN Gene/Protein Processing [8]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Gene/Protein Processing [7]
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Drug Response [9]
Fatty acid-binding protein, liver (FABP1) OTR34ETM FABPL_HUMAN Gene/Protein Processing [7]
Glutathione S-transferase P (GSTP1) OTLP0A0Y GSTP1_HUMAN Gene/Protein Processing [10]
Inhibin beta E chain (INHBE) OTOI2NYG INHBE_HUMAN Gene/Protein Processing [7]
Lanosterol synthase (LSS) OT9W2SFH LSS_HUMAN Gene/Protein Processing [7]
Lysophospholipase D GDPD3 (GDPD3) OTOHM9QM GDPD3_HUMAN Gene/Protein Processing [7]
Nuclear protein 1 (NUPR1) OT4FU8C0 NUPR1_HUMAN Gene/Protein Processing [7]

References

1 Doxepin FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1225).
3 Novel therapeutic usage of low-dose doxepin hydrochloride. Expert Opin Investig Drugs. 2007 Aug;16(8):1295-305.
4 The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19. Pharm Res. 2002 Jul;19(7):1034-7.
5 Doxepin inhibits CYP2D6 activity in vivo. Pol J Pharmacol. 2004 Jul-Aug;56(4):491-4.
6 Contributions of CYP2D6, CYP2C9 and CYP2C19 to the biotransformation of E- and Z-doxepin in healthy volunteers. Pharmacogenetics. 2002 Oct;12(7):571-80.
7 In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies. Toxicol Sci. 2007 Sep;99(1):162-73.
8 Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Arch Toxicol. 2020 Dec;94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. Epub 2020 Aug 17.
9 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
10 Glutathione S-transferase pi as a target for tricyclic antidepressants in human brain. Acta Biochim Pol. 2004;51(1):207-12.
11 Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6.
12 Clinical research of Ibudilast on treating the steroid resistant allergic rhinitis. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Jan;23(2):63-6.
13 Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization. J Pharmacol Sci. 2008 May;107(1):66-79.
14 Update on prescription and over-the-counter histamine inverse agonists in rhinitis therapy. Curr Allergy Asthma Rep. 2009 Mar;9(2):140-8.
15 Central effects of cinnarizine: restricted use in aircrew. Aviat Space Environ Med. 2002 Jun;73(6):570-4.
16 Influence of epinastine hydrochloride, an H1-receptor antagonist, on the function of mite allergen-pulsed murine bone marrow-derived dendritic cell... Mediators Inflamm. 2009;2009:738038.
17 Examining the tolerability of the non-sedating antihistamine desloratadine: a prescription-event monitoring study in England. Drug Saf. 2009;32(2):169-79.
18 Emerging drugs for ocular allergy. Expert Opin Emerg Drugs. 2005 Aug;10(3):505-20.
19 Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. Cancer. 2007 Mar 1;109(5):957-65.
20 Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. Xenobiotica. 1998 Jun;28(6):539-47.
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