General Information of Drug (ID: DMRQAM0)

Drug Name
Phenacetin Drug Info
Synonyms
phenacetin; 62-44-2; Acetophenetidin; N-(4-Ethoxyphenyl)acetamide; Acetphenetidin; Acetophenetidine; Acetophenetin; Phenacetine; p-Acetophenetidide; Contradouleur; Commotional; Achrocidin; Phenazetin; Contradol; Codempiral; 4'-Ethoxyacetanilide; 4-Ethoxyacetanilide; Acetamide, N-(4-ethoxyphenyl)-; p-Acetophenetidine; Fenacetina; Phenidin; Pyraphen; Phenacitin; Phenacetinum; Fenidina; Phenedina; Phenacet; Pertonal; Fenina; Phenin; Kalmin; p-Acetphenetidin; p-Acetophenetide; Phenazetina; Tetracydin; p-Ethoxyacetanilide; Stellacyl; Phenodyne; Imidazo[4,5-e][1,4]diazapine nucleotide (I)
Indication
Disease Entry ICD 11 Status REF
Analgesia MB40.8 Withdrawn from market [1]
Cross-matching ID
PubChem CID
4754
ChEBI ID
CHEBI:8050
CAS Number
CAS 62-44-2
TTD Drug ID
DMRQAM0
VARIDT Drug ID
DR00653
INTEDE Drug ID
DR1270

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [15]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [16]
Merimepodib DM0HS92 Breast cancer 2C60-2C65 Approved [17]
Tiazofurin DM5JWV9 Solid tumour/cancer 2A00-2F9Z Approved [18]
Mizoribine DMW6F0S Transplant rejection NE84 Approved [17]
Viramidine DMJFNR9 Hepatitis C virus infection 1E51.1 Phase 3 [19]
VX-944 DME321B Solid tumour/cancer 2A00-2F9Z Phase 2 [20]
VX-148 DML32R8 Psoriasis vulgaris EA90 Patented [21]
PMID28074661-Compound-US20100022547C81 DMM9E1U N. A. N. A. Patented [20]
PMID28074661-Compound-US20120264760C80 DM75QVW N. A. N. A. Patented [20]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [22]
Naproxen DMZ5RGV Bursitis Approved [23]
Mesalazine DMOL5IU Diverticulitis Approved [24]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [25]
Bromfenac DMKB79O Pain MG30-MG3Z Approved [26]
Aminosalicylic Acid DMENSL5 Crohn disease DD70 Approved [27]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [28]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [27]
Suprofen DMKXJZ7 Miosis LA11.62 Approved [29]
Gamma-Homolinolenic acid DMSXKYG Malnutrition 5B50-5B71 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [31]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [32]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [33]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [34]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [35]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [36]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [37]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [38]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [32]
Verapamil DMA7PEW Angina pectoris BA40 Approved [39]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [40]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [41]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [42]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [43]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [44]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [45]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [37]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [46]
Verapamil DMA7PEW Angina pectoris BA40 Approved [47]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [48]
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [95]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [95]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [95]
Capsaicin DMGMF6V Back pain ME84.Z Approved [96]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [97]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [98]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [99]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [100]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [101]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [102]
⏷ Show the Full List of 20 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2A6 (CYP2A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [40]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [49]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [50]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [35]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
Metronidazole DMTIVEN Abscess Approved [52]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [53]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [55]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [56]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [57]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [58]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [46]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [59]
Estrone DM5T6US Acne vulgaris ED80 Approved [60]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [61]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [62]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [63]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [64]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [65]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [66]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [35]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [39]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [67]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [68]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [69]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [70]
Propranolol DM79NTF Angina pectoris BA40 Approved [71]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [72]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [73]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [50]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [74]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [75]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [46]
Verapamil DMA7PEW Angina pectoris BA40 Approved [49]
Estrone DM5T6US Acne vulgaris ED80 Approved [76]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [77]
Ethanol DMDRQZU Chronic pain MG30 Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [79]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [80]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [81]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [49]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [82]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [49]
Verapamil DMA7PEW Angina pectoris BA40 Approved [83]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [84]
Estrone DM5T6US Acne vulgaris ED80 Approved [85]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [87]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [79]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [88]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [89]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [49]
Verapamil DMA7PEW Angina pectoris BA40 Approved [90]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [59]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [91]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [53]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [9]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [9]
Dextromethorphan DMUDJZM Allergic rhinitis CA08.0 Approved [9]
Testosterone cypionate DMC1TEV N. A. N. A. Approved [9]
ANW-32821 DMMJOZD N. A. N. A. Phase 2 [92]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [9]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [9]
Dextromethorphan DMUDJZM Allergic rhinitis CA08.0 Approved [9]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [103]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [104]
Arsenic DMTL2Y1 N. A. N. A. Approved [105]
Testosterone DM7HUNW Hot flushes GA30 Approved [9]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [106]
ANW-32821 DMMJOZD N. A. N. A. Phase 2 [9]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [107]
⏷ Show the Full List of 15 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2A13 (CYP2A13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [93]
Testosterone cypionate DMC1TEV N. A. N. A. Approved [94]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [108]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [12]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [12]
Quercetin DM3NC4M Obesity 5B81 Approved [109]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [12]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [12]
Succinic acid DMDWICP Malnutrition 5B50-5B71 Approved [110]
Mefenamic acid DMK7HFI Dysmenorrhea GA34.3 Approved [12]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [111]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [12]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [12]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [12]
Quercetin DM3NC4M Obesity 5B81 Approved [112]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [113]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [114]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [12]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [12]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [103]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [115]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [116]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [12]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [12]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [116]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [12]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [12]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [117]
Mefenamic acid DMK7HFI Dysmenorrhea GA34.3 Approved [12]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [118]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [12]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [119]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [12]
Methotrexate DM2TEOL Anterior urethra cancer Approved [120]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [113]
Paclitaxel DMLB81S Breast carcinoma Approved [121]
Allopurinol DMLPAOB Gout FA25 Approved [121]
Bumetanide DMRV7H0 Congestive heart failure BD10 Approved [121]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [121]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [121]
Tetracycline DMZA017 Acne vulgaris ED80 Approved [121]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [123]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [124]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [125]
Quercetin DM3NC4M Obesity 5B81 Approved [126]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [127]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [129]
Bupivacaine DM4PRFC Anaesthesia 9A78.6 Approved [130]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [129]
Panobinostat DM58WKG Chronic graft versus host disease Approved [131]
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Drug(s) Affected By Xaa-Pro dipeptidase (PEPD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [132]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [133]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [103]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [104]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [134]
Gentamicin DMKINJO Bacteremia 1A73 Approved [135]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [136]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [137]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [138]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [139]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [116]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [103]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [115]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [116]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [116]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [140]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [103]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [141]
Rifapentine DMCHV4I Pulmonary tuberculosis 1B10.Z Approved [141]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) TTL7C8Q IMDH1_HUMAN Inhibitor [2]
Prostaglandin G/H synthase 1 (COX-1) TT8NGED PGH1_HUMAN Inhibitor [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [4]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Substrate [4]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [5]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [6]
Cytochrome P450 1A1 (CYP1A1) DE6OQ3W CP1A1_HUMAN Substrate [7]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [6]
Cytochrome P450 2A6 (CYP2A6) DEJVYAZ CP2A6_HUMAN Substrate [6]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [8]
Cytochrome P450 2A13 (CYP2A13) DEXZA9U CP2AD_HUMAN Substrate [8]
Cholesterol 24-hydroxylase (CYP46A1) DEKP5HX CP46A_HUMAN Substrate [9]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Arylacetamide deacetylase (AADAC) OT8VACT2 AAAD_HUMAN Biotransformations [10]
Cholesterol 24-hydroxylase (CYP46A1) OTJ27FOX CP46A_HUMAN Biotransformations [9]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Biotransformations [11]
Organic anion transporter 7 (SLC22A9) OTO4BJCC S22A9_HUMAN Gene/Protein Processing [12]
Prostaglandin G/H synthase 1 (PTGS1) OTHCRLEC PGH1_HUMAN Gene/Protein Processing [13]
Solute carrier family 22 member 11 (SLC22A11) OTAJLNJZ S22AB_HUMAN Gene/Protein Processing [12]
Solute carrier family 22 member 6 (SLC22A6) OTKRCBVM S22A6_HUMAN Gene/Protein Processing [12]
Solute carrier family 22 member 7 (SLC22A7) OTKTNH1W S22A7_HUMAN Gene/Protein Processing [12]
Xaa-Pro dipeptidase (PEPD) OT3LFY7S PEPD_HUMAN Gene/Protein Processing [14]

References

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3 Direct toxicity of nonsteroidal antiinflammatory drugs for renal medullary cells. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5317-22.
4 Involvement of CYP2E1 as A low-affinity enzyme in phenacetin O-deethylation in human liver microsomes. Drug Metab Dispos. 1999 Aug;27(8):860-5.
5 Human cytochromes P450 mediating phenacetin O-deethylation in vitro: validation of the high affinity component as an index of CYP1A2 activity. J Pharm Sci. 1998 Dec;87(12):1502-7.
6 Activation of phenacetin O-deethylase activity by alpha-naphthoflavone in human liver microsomes. Xenobiotica. 1999 Sep;29(9):885-98.
7 Identification of CYP3A4 as the enzyme involved in the mono-N-dealkylation of disopyramide enantiomers in humans. Drug Metab Dispos. 2000 Aug;28(8):937-44.
8 CYP2A13 metabolizes the substrates of human CYP1A2, phenacetin, and theophylline. Drug Metab Dispos. 2007 Mar;35(3):335-9.
9 Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain. Biochemistry. 2003 Dec 9;42(48):14284-92.
10 Species differences in tissue distribution and enzyme activities of arylacetamide deacetylase in human, rat, and mouse. Drug Metab Dispos. 2012 Apr;40(4):671-9. doi: 10.1124/dmd.111.043067. Epub 2011 Dec 29.
11 A population approach to enzyme characterization and identification: application to phenacetin O-deethylation. Pharm Res. 2000 Dec;17(12):1531-6. doi: 10.1023/a:1007665310830.
12 Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 2002 Nov;303(2):534-9.
13 Cloning, expression, and functional characterization of human cyclooxygenase-1 splicing variants: evidence for intron 1 retention. J Pharmacol Exp Ther. 2005 Dec;315(3):1298-305.
14 Kinetic study of paracetamol on prolidase activity in erythrocytes by capillary electrophoresis with Ru(bpy)(3) (2+) electrochemiluminescence detection. Electrophoresis. 2006 Oct;27(20):4047-51. doi: 10.1002/elps.200600197.
15 Clinical pharmacology and pharmacogenetics of thiopurines. Eur J Clin Pharmacol. 2008 Aug;64(8):753-67.
16 Treating HCV with ribavirin analogues and ribavirin-like molecules. J Antimicrob Chemother. 2006 Jan;57(1):8-13.
17 VX-497: a novel, selective IMPDH inhibitor and immunosuppressive agent. J Pharm Sci. 2001 May;90(5):625-37.
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19 Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25.
20 Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690.
21 Characterization of pharmacological efficacy of VX-148, a new, potent immunosuppressive inosine 5'-monophosphate dehydrogenase inhibitor. J Pharmacol Exp Ther. 2002 Sep;302(3):1272-7.
22 The C50T polymorphism of the cyclooxygenase-1 gene and the risk of thrombotic events during low-dose therapy with acetyl salicylic acid. Thromb Haemost. 2008 Jul;100(1):70-5.
23 Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers. J Clin Pharmacol. 2000 Oct;40(10):1109-20.
24 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
25 Cox-2 inhibitory effects of naturally occurring and modified fatty acids. J Nat Prod. 2001 Jun;64(6):745-9.
26 Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium. Curr Med Res Opin. 2006 Jun;22(6):1133-40.
27 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
28 Ouellet M, Percival MD: Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms. Biochem J. 1995 Feb 15;306 ( Pt 1):247-51.
29 Differential binding mode of diverse cyclooxygenase inhibitors. J Mol Graph Model. 2002 Mar;20(5):359-71.
30 Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2. Biochem J. 2002 Jul 15;365(Pt 2):489-96.
31 Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. Cancer. 2007 Mar 1;109(5):957-65.
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