Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRWLB2)

Drug Name
Fluticasone propionate Drug Info
Synonyms
FLUTICASONE PROPIONATE; Flovent; Cutivate; Flixotide; Flonase; Flixonase; Flovent HFA; Flunase; Flutide; Fluspiral; Flusonal; atemur; Flutivate; Fluinol; Axotide; Asmatil; Brethal; Flovent Diskus 50; Flixotide Disks; Flixotide Disk; Flovent Diskus; Flovent Diskus 100; Flovent Diskus 250; Flixotide Inhaler; Trialona; Rinosone; Inalacor; Cultivate; Ubizol; Zoflut; Flixonase Nasal Spray; Flonase Aq; Fluticasonpropionat Allen; Fluticasone (propionate); UNII-O2GMZ0LF5W; CCI-18781; CCI 18781; MFCD00866007; O2GMZ0LF5W
Indication
Disease Entry ICD 11 Status REF
Allergic asthma CA23.0 Approved [1]
Allergic rhinitis CA08.0 Approved [1]
Bronchiolitis Approved [1]
Exanthem Approved [1]
Granuloma annulare Approved [1]
Intrinsic asthma Approved [1]
Primary cutaneous T-cell lymphoma Approved [1]
Pulmonary emphysema CA21.Z Approved [1]
Cross-matching ID
PubChem CID
444036
ChEBI ID
CHEMBL1473
CAS Number
CAS 80474-14-2
TTD Drug ID
DMRWLB2
VARIDT Drug ID
DR01643

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [10]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [11]
Methotrexate DM2TEOL Anterior urethra cancer Approved [12]
Folic Acid DMEMBJC Colorectal carcinoma Approved [13]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [12]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [12]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [14]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [12]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [15]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [16]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [17]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [18]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [19]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [20]
Cepharanthine DM9Y5JB N. A. N. A. Approved [21]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [22]
Clozapine DMFC71L Schizophrenia 6A20 Approved [23]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [24]
Trifluoperazine DMKBYWI Anxiety Approved [25]
Olanzapine DMPFN6Y Bipolar depression Approved [23]
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Drug(s) Affected By Glutathione hydrolase 5 proenzyme (GGT5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [30]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [31]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [32]
Beclomethasone dipropionate DM5NW1E Allergic rhinitis CA08.0 Phase 4 [6]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [33]
Maleic Acid DM4L0R7 Discovery agent N.A. Investigative [34]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [35]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [35]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [36]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [37]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [7]
Etidronic acid DM1XHYJ Bone Paget disease Approved [35]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [35]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [35]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [38]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [39]
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Drug(s) Affected By Osteocalcin (BGLAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [40]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [43]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [45]
Pamidronate DMB4AVP Bone Paget disease Approved [46]
Falecalcitrol DMBI9ZJ Hyperparathyroidism 5A51 Approved [47]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
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Drug(s) Affected By Antileukoproteinase (SLPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [50]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [50]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [50]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [50]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [50]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [50]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [50]
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Drug(s) Affected By Annexin A1 (ANXA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [52]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Panobinostat DM58WKG Chronic graft versus host disease Approved [55]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [57]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [58]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [59]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Annexin A1 (ANXA1) OT5OFDJC ANXA1_HUMAN Protein Interaction/Cellular Processes [3]
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Gene/Protein Processing [4]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Regulation of Drug Effects [5]
Glutathione hydrolase 5 proenzyme (GGT5) OTDJYEO7 GGT5_HUMAN Gene/Protein Processing [6]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Gene/Protein Processing [7]
Osteocalcin (BGLAP) OTK1YLWQ OSTCN_HUMAN Gene/Protein Processing [8]
Vascular cell adhesion protein 1 OTP74K37 VCAM1_HUMAN Protein Interaction/Cellular Processes [9]

References

1 Fluticasone propionate FDA Label
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22 Clinical pharmacokinetic monitoring of itraconazole is warranted in only a subset of patients. Ther Drug Monit. 2005 Jun;27(3):322-33. doi: 10.1097/01.ftd.0000150135.22645.ea.
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26 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
27 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
28 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
29 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
30 Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod. 2011 Jul;26(7):1813-25.
31 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
32 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
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58 Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
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