Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMT5E36)

Drug Name
BICARBONATE Drug Info
Synonyms
bicarbonate; Hydrogen carbonate; Bicarbonate ion; Carbonate, hydrogen; Hydrogencarbonate; Bicarbonate ions; 71-52-3; UNII-HN1ZRA3Q20; HCO3-; HN1ZRA3Q20; Bicarbonate anion; Hydrocarbonate(1-); Monohydrogen carbonate; Hydrogen carbonate ion; Hydrogen carbonate anion; Carbonate (HCO31-); Bicarbonates; Carbonate ion (HCO31-); Carboxyolate; Acid carbonate; hydrogen-carbonate; HYDROXYFORMATE; hydrogencarbonate(1-); HCO3; Carbonic acid, ion(1-); hydrogentrioxocarbonate(IV); hydrogentrioxocarbonate(1-); AC1L19ZH
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
769
ChEBI ID
CHEBI:17544
CAS Number
CAS 71-52-3
TTD Drug ID
DMT5E36
VARIDT Drug ID
DR00138

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Carbonic anhydrase IX (CA-IX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [13]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [14]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [13]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [15]
INDISULAM DM9SX6Y Lymphoma 2A80-2A86 Phase 2 [16]
Girentuximab I-124 DMG3O2Z Renal cell carcinoma 2C90 Phase 2 [17]
SULFAMIDE DMMAS3K N. A. N. A. Phase 1 [1]
BAY 79-4620 DM14XQN Solid tumour/cancer 2A00-2F9Z Phase 1 [18]
90Y-cG250 DMJR6TC Solid tumour/cancer 2A00-2F9Z Phase 1 [19]
FERULIC ACID DMJC7NF Discovery agent N.A. Patented [14]
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Drug(s) Transported By Sulfate anion transporter 1 (SLC26A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
SULFATE DMW0ZBF Discovery agent N.A. Investigative [20]
oxalate DM40SEU Discovery agent N.A. Investigative [20]
Drug(s) Transported By Anion exchange transporter (SLC26A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
SULFATE DMW0ZBF Discovery agent N.A. Investigative [21]
oxalate DM40SEU Discovery agent N.A. Investigative [22]
Drug(s) Transported By Anion exchange transporter (SLC26A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
SULFATE DMW0ZBF Discovery agent N.A. Investigative [23]
NITRATE DMVFB93 Discovery agent N.A. Investigative [23]
oxalate DM40SEU Discovery agent N.A. Investigative [23]
Drug(s) Affected By Solute carrier family 26 member 6 (SLC26A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [25]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [26]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [24]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [27]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [28]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [29]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [24]
Oxalic Acid DMLN2GQ Discovery agent N.A. Investigative [12]
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Drug(s) Affected By Cystic fibrosis transmembrane conductance regulator (CFTR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivacaftor DMZC1HS Cystic fibrosis CA25 Approved [30]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [32]
Quercetin DM3NC4M Obesity 5B81 Approved [33]
Miglustat DM5J64S Niemann-Pick disease type C Approved [34]
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [35]
Milrinone DM8TUPF Congestive heart failure BD10 Approved [32]
Oxidized glutathione DM9EQC0 Breast cancer 2C60-2C65 Approved [36]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [36]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [37]
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Drug(s) Affected By Adenylate cyclase type 10 (ADCY10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [38]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [39]
Drug(s) Affected By Carbonic anhydrase 3 (CA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [37]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [43]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [44]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [38]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [45]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [46]
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Drug(s) Affected By Chloride anion exchanger (SLC26A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [47]
Quercetin DM3NC4M Obesity 5B81 Approved [48]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [49]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [50]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Morniflumate DM9UTDE Otitis media AA80-AB0Z Approved [10]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Folic Acid DMEMBJC Colorectal carcinoma Approved [52]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [53]
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Drug(s) Affected By Carbonic anhydrase 2 (CA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetazolamide DM1AF5U Absence epilepsy Approved [54]
Epinephrine DM3KJBC Acute asthma CA23 Approved [55]
Quercetin DM3NC4M Obesity 5B81 Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [56]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [57]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [58]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [59]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [60]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [61]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
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Drug(s) Affected By Carbonic anhydrase 1 (CA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [62]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [63]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [61]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [64]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [65]
Candesartan DMRK8OT Chronic heart failure BD1Z Approved [63]
Indomethacin DMSC4A7 Bursitis Approved [54]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [66]
Phenylephrine DMZHUO5 Allergic rhinitis CA08.0 Approved [67]
GUAIACOL DMN4E7T N. A. N. A. Phase 3 [64]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase IX (CA-IX) TT2LVK8 CAH9_HUMAN Inhibitor [1]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Anion exchange protein 2 (SLC4A2) DTF7GAL B3A2_HUMAN Substrate [2]
Sulfate anion transporter 1 (SLC26A1) DTJ785O S26A1_HUMAN Substrate [3]
Anion exchange transporter (SLC26A7) DTOTME4 S26A7_HUMAN Substrate [4]
Anion exchange protein 3 (SLC4A3) DT4X2AH B3A3_HUMAN Substrate [5]
Anion transporter/exchanger protein 9 (SLC26A9) DT0TZPS S26A9_HUMAN Substrate [6]
Anion exchange transporter (SLC26A6) DTVGOLN S26A6_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Adenylate cyclase type 10 (ADCY10) OTYSTB0R ADCYA_HUMAN Gene/Protein Processing [8]
Carbonic anhydrase 1 (CA1) OTNFBVVQ CAH1_HUMAN Biotransformations [9]
Carbonic anhydrase 2 (CA2) OTJRMUAG CAH2_HUMAN Biotransformations [9]
Carbonic anhydrase 3 (CA3) OT9ILP2U CAH3_HUMAN Biotransformations [9]
Chloride anion exchanger (SLC26A3) OTBNK2U2 S26A3_HUMAN Regulation of Drug Effects [10]
Cystic fibrosis transmembrane conductance regulator (CFTR) OT6B22QH CFTR_HUMAN Gene/Protein Processing [11]
Solute carrier family 26 member 6 (SLC26A6) OTR8LTK0 S26A6_HUMAN Regulation of Drug Effects [12]

References

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3 SLC26A Gene Family Participate in pH Regulation during Enamel Maturation. PLoS One. 2015 Dec 15;10(12):e0144703.
4 Vasopressin induces expression of the Cl-/HCO3- exchanger SLC26A7 in kidney medullary collecting ducts of Brattleboro rats. Am J Physiol Renal Physiol. 2006 May;290(5):F1194-201.
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