Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMT5E36)

Drug Name
BICARBONATE Drug Info
Synonyms
bicarbonate; Hydrogen carbonate; Bicarbonate ion; Carbonate, hydrogen; Hydrogencarbonate; Bicarbonate ions; 71-52-3; UNII-HN1ZRA3Q20; HCO3-; HN1ZRA3Q20; Bicarbonate anion; Hydrocarbonate(1-); Monohydrogen carbonate; Hydrogen carbonate ion; Hydrogen carbonate anion; Carbonate (HCO31-); Bicarbonates; Carbonate ion (HCO31-); Carboxyolate; Acid carbonate; hydrogen-carbonate; HYDROXYFORMATE; hydrogencarbonate(1-); HCO3; Carbonic acid, ion(1-); hydrogentrioxocarbonate(IV); hydrogentrioxocarbonate(1-); AC1L19ZH
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
769
ChEBI ID
CHEMBL17544
CAS Number
CAS 71-52-3
TTD Drug ID
DMT5E36
VARIDT Drug ID
DR00138

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Carbonic anhydrase IX (CA-IX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [12]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [13]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [12]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [14]
INDISULAM DM9SX6Y Lymphoma 2A80-2A86 Phase 2 [15]
Girentuximab I-124 DMG3O2Z Renal cell carcinoma 2C90 Phase 2 [16]
SULFAMIDE DMMAS3K N. A. N. A. Phase 1 [1]
BAY 79-4620 DM14XQN Solid tumour/cancer 2A00-2F9Z Phase 1 [17]
90Y-cG250 DMJR6TC Solid tumour/cancer 2A00-2F9Z Phase 1 [18]
FERULIC ACID DMJC7NF Discovery agent N.A. Patented [13]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Sulfate anion transporter 1 (SLC26A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
SULFATE DMW0ZBF Discovery agent N.A. Investigative [19]
oxalate DM40SEU Discovery agent N.A. Investigative [19]
Drug(s) Transported By Anion exchange transporter (SLC26A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
SULFATE DMW0ZBF Discovery agent N.A. Investigative [20]
oxalate DM40SEU Discovery agent N.A. Investigative [21]
Drug(s) Transported By Anion exchange transporter (SLC26A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
SULFATE DMW0ZBF Discovery agent N.A. Investigative [22]
NITRATE DMVFB93 Discovery agent N.A. Investigative [22]
oxalate DM40SEU Discovery agent N.A. Investigative [22]
Drug(s) Affected By Solute carrier family 26 member 6 (SLC26A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [23]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [25]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [23]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [26]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [27]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [28]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [23]
Oxalic Acid DMLN2GQ Discovery agent N.A. Investigative [11]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Adenylate cyclase type 10 (ADCY10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [29]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [30]
Drug(s) Affected By Carbonic anhydrase 3 (CA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [32]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [35]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [36]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [29]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [37]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [38]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Chloride anion exchanger (SLC26A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [41]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [42]
Testosterone DM7HUNW Hot flushes GA30 Approved [43]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [43]
Morniflumate DM9UTDE Otitis media AA80-AB0Z Approved [10]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [23]
Folic Acid DMEMBJC Colorectal carcinoma Approved [44]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [45]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase IX (CA-IX) TT2LVK8 CAH9_HUMAN Inhibitor [1]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Anion exchange protein 2 (SLC4A2) DTF7GAL B3A2_HUMAN Substrate [2]
Sulfate anion transporter 1 (SLC26A1) DTJ785O S26A1_HUMAN Substrate [3]
Anion exchange transporter (SLC26A7) DTOTME4 S26A7_HUMAN Substrate [4]
Anion exchange protein 3 (SLC4A3) DT4X2AH B3A3_HUMAN Substrate [5]
Anion transporter/exchanger protein 9 (SLC26A9) DT0TZPS S26A9_HUMAN Substrate [6]
Anion exchange transporter (SLC26A6) DTVGOLN S26A6_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Adenylate cyclase type 10 (ADCY10) OTYSTB0R ADCYA_HUMAN Gene/Protein Processing [8]
Carbonic anhydrase 3 (CA3) OT9ILP2U CAH3_HUMAN Biotransformations [9]
Chloride anion exchanger (SLC26A3) OTBNK2U2 S26A3_HUMAN Regulation of Drug Effects [10]
Solute carrier family 26 member 6 (SLC26A6) OTR8LTK0 S26A6_HUMAN Regulation of Drug Effects [11]

References

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2 HCO3-/Cl- anion exchanger SLC4A2 is required for proper osteoclast differentiation and function. Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16934-9.
3 SLC26A Gene Family Participate in pH Regulation during Enamel Maturation. PLoS One. 2015 Dec 15;10(12):e0144703.
4 Vasopressin induces expression of the Cl-/HCO3- exchanger SLC26A7 in kidney medullary collecting ducts of Brattleboro rats. Am J Physiol Renal Physiol. 2006 May;290(5):F1194-201.
5 The SLC4 family of bicarbonate (HCO??) transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):159-82.
6 SLC26A9 is expressed in gastric surface epithelial cells, mediates Cl-/HCO3- exchange, and is inhibited by NH4+. Am J Physiol Cell Physiol. 2005 Aug;289(2):C493-505.
7 Metabolon disruption: a mechanism that regulates bicarbonate transport. EMBO J. 2005 Jul 20;24(14):2499-511.
8 [HCO3-]-regulated expression and activity of soluble adenylyl cyclase in corneal endothelial and Calu-3 cells. BMC Physiol. 2004 Apr 29;4:8. doi: 10.1186/1472-6793-4-8.
9 Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides. Bioorg Med Chem. 2007 Dec 1;15(23):7229-36.
10 Acute regulation of the SLC26A3 congenital chloride diarrhoea anion exchanger (DRA) expressed in Xenopus oocytes. J Physiol. 2003 May 15;549(Pt 1):3-19. doi: 10.1113/jphysiol.2003.039818. Epub 2003 Mar 21.
11 Estrogen treatment reduced oxalate transporting activity and enhanced migration through the involvement of SLC26A6 in lung cancer cells. Toxicol In Vitro. 2022 Aug;82:105373. doi: 10.1016/j.tiv.2022.105373. Epub 2022 Apr 29.
12 Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.
13 Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164.
14 Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-r... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6.
15 Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-assoc... Bioorg Med Chem Lett. 2004 Jan 5;14(1):217-23.
16 Potential role of (124)I-girentuximab in the presurgical diagnosis of clear-cell renal cell cancer. Biologics. 2012;6:395-407.
17 Therapeutic mechanism and efficacy of the antibody-drug conjugate BAY 79-4620 targeting human carbonic anhydrase 9. Mol Cancer Ther. 2012 Feb;11(2):340-9.
18 Application of monoclonal antibody G250 recognizing carbonic anhydrase IX in renal cell carcinoma. Int J Mol Sci. 2013 May 29;14(6):11402-23.
19 Mutations in SLC26A1 Cause Nephrolithiasis. Am J Hum Genet. 2016 Jun 2;98(6):1228-1234.
20 The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.53.2.7)
21 Oxalate (urine, plasma)
22 The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.53.2.6)
23 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
24 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
25 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
26 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
27 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
28 Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
29 Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
30 Cellular reactions to long-term volatile organic compound (VOC) exposures. Sci Rep. 2016 Dec 1;6:37842. doi: 10.1038/srep37842.
31 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
32 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
33 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
34 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
35 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
36 Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
37 Bisphenol A and bisphenol S induce distinct transcriptional profiles in differentiating human primary preadipocytes. PLoS One. 2016 Sep 29;11(9):e0163318.
38 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
39 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
40 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
41 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
42 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
43 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
44 Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
45 Gene expression responses reflecting 5-FU-induced toxicity: Comparison between patient colon tissue and 3D human colon organoids. Toxicol Lett. 2022 Dec 1;371:17-24. doi: 10.1016/j.toxlet.2022.09.013. Epub 2022 Sep 29.