Details of the Drug

General Information of Drug (ID: DMGLX0T)

Drug Name
Grepafloxacin
Synonyms
Raxar; Grepafloxacin [INN]; Grepafloxacin (unspecified); Raxar (TN); (+-)-1-Cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-Cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
Indication
Disease Entry ICD 11 Status REF
Chronic bronchitis CA20.1 Approved [1]
Bacterial infection 1A00-1C4Z Withdrawn from market [2]
Therapeutic Class
Antibiotics
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 359.4
Logarithm of the Partition Coefficient (xlogp) -0.2
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 7
ADMET Property
Bioavailability
The bioavailability of drug is 70% []
Clearance
The drug present in the plasma can be removed from the body at the rate of 5.9 mL/min/kg [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 15 +/- 3 hours [3]
Metabolism
The drug is metabolized via the hepatic []
Unbound Fraction
The unbound fraction of drug in plasma is 0.82% [3]
Chemical Identifiers
Formula
C19H22FN3O3
IUPAC Name
1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
Canonical SMILES
CC1CN(CCN1)C2=C(C(=C3C(=C2)N(C=C(C3=O)C(=O)O)C4CC4)C)F
InChI
InChI=1S/C19H22FN3O3/c1-10-8-22(6-5-21-10)15-7-14-16(11(2)17(15)20)18(24)13(19(25)26)9-23(14)12-3-4-12/h7,9-10,12,21H,3-6,8H2,1-2H3,(H,25,26)
InChIKey
AIJTTZAVMXIJGM-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
72474
ChEBI ID
CHEBI:5543
CAS Number
119914-60-2
DrugBank ID
DB00365
TTD ID
D0JL2K
VARIDT ID
DR00638
INTEDE ID
DR0790
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial DNA gyrase (Bact gyrase) TTN6J5F GYRA_STAAU ; GYRB_STAAU Modulator [4]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [5]
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Substrate [6]
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [7]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [8]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [9]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [10]
Cytochrome P450 1A2 (CYP1A2)
Main DME 		DEJGDUW CP1A2_HUMAN Substrate [11]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Grepafloxacin (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Tretinoin DM49DUI Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Tretinoin. Acne vulgaris [ED80] [12]
Ivosidenib DM8S6T7 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Ivosidenib. Acute myeloid leukaemia [2A60] [13]
Midostaurin DMI6E0R Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Midostaurin. Acute myeloid leukaemia [2A60] [14]
Daunorubicin DMQUSBT Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Daunorubicin. Acute myeloid leukaemia [2A60] [14]
Arn-509 DMT81LZ Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Arn-509. Acute myeloid leukaemia [2A60] [14]
Gilteritinib DMTI0ZO Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Gilteritinib. Acute myeloid leukaemia [2A60] [14]
Oliceridine DM6MDCF Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Oliceridine. Acute pain [MG31] [13]
Magnesium Sulfate DMVEK07 Moderate Decreased absorption of Grepafloxacin due to formation of complexes caused by Magnesium Sulfate. Acute pain [MG31] [15]
Loratadine DMF3AN7 Moderate Decreased metabolism of Grepafloxacin caused by Loratadine mediated inhibition of CYP450 enzyme. Allergic/hypersensitivity disorder [4A80-4A8Z] [16]
Galantamine DMEO794 Moderate Increased risk of ventricular arrhythmias by the combination of Grepafloxacin and Galantamine. Alzheimer disease [8A20] [17]
Rivastigmine DMG629M Moderate Increased risk of ventricular arrhythmias by the combination of Grepafloxacin and Rivastigmine. Alzheimer disease [8A20] [17]
Donepezil DMIYG7Z Moderate Decreased metabolism of Grepafloxacin caused by Donepezil mediated inhibition of CYP450 enzyme. Alzheimer disease [8A20] [16]
Metronidazole DMTIVEN Minor Increased risk of prolong QT interval by the combination of Grepafloxacin and Metronidazole. Amoebiasis [1A36] [13]
Ivabradine DM0L594 Major Increased risk of ventricular arrhythmias by the combination of Grepafloxacin and Ivabradine. Angina pectoris [BA40] [18]
Dronedarone DMA8FS5 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Dronedarone. Angina pectoris [BA40] [17]
Nifedipine DMSVOZT Moderate Decreased metabolism of Grepafloxacin caused by Nifedipine mediated inhibition of CYP450 enzyme. Angina pectoris [BA40] [16]
Bedaquiline DM3906J Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Bedaquiline. Antimicrobial drug resistance [MG50-MG52] [14]
Clorazepate DMC3JST Moderate Decreased metabolism of Grepafloxacin caused by Clorazepate mediated inhibition of CYP450 enzyme. Anxiety disorder [6B00-6B0Z] [16]
Alprazolam DMC7XDN Moderate Decreased metabolism of Grepafloxacin caused by Alprazolam mediated inhibition of CYP450 enzyme. Anxiety disorder [6B00-6B0Z] [16]
Hydroxyzine DMF8Y74 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Hydroxyzine. Anxiety disorder [6B00-6B0Z] [14]
Chlordiazepoxide DMTN5XI Moderate Decreased metabolism of Grepafloxacin caused by Chlordiazepoxide mediated inhibition of CYP450 enzyme. Anxiety disorder [6B00-6B0Z] [16]
Cilostazol DMZMSCT Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Cilostazol. Arterial occlusive disease [BD40] [14]
Voriconazole DMAOL2S Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Voriconazole. Aspergillosis [1F20] [14]
Posaconazole DMUL5EW Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Posaconazole. Aspergillosis [1F20] [14]
Levalbuterol DM5YBO1 Moderate Increased risk of prolong QT interval by the combination of Grepafloxacin and Levalbuterol. Asthma [CA23] [19]
Terbutaline DMD4381 Major Increased risk of ventricular arrhythmias by the combination of Grepafloxacin and Terbutaline. Asthma [CA23] [20]
Pirbuterol DMI5678 Moderate Increased risk of ventricular arrhythmias by the combination of Grepafloxacin and Pirbuterol. Asthma [CA23] [19]
Budesonide DMJIBAW Moderate Decreased metabolism of Grepafloxacin caused by Budesonide mediated inhibition of CYP450 enzyme. Asthma [CA23] [21]
Aminophylline DML2NIB Moderate Decreased metabolism of Grepafloxacin caused by Aminophylline mediated inhibition of CYP450 enzyme. Asthma [CA23] [22]
Salbutamol DMN9CWF Moderate Increased risk of ventricular arrhythmias by the combination of Grepafloxacin and Salbutamol. Asthma [CA23] [23]
Roflumilast DMPGHY8 Moderate Decreased metabolism of Grepafloxacin caused by Roflumilast mediated inhibition of CYP450 enzyme. Asthma [CA23] [18]
Formoterol DMSOURV Moderate Increased risk of ventricular arrhythmias by the combination of Grepafloxacin and Formoterol. Asthma [CA23] [20]
Zileuton DMVRIC2 Moderate Decreased metabolism of Grepafloxacin caused by Zileuton mediated inhibition of CYP450 enzyme. Asthma [CA23] [16]
Lisdexamfetamine DM6W8V5 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Lisdexamfetamine. Attention deficit hyperactivity disorder [6A05] [14]
Desipramine DMT2FDC Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Desipramine. Attention deficit hyperactivity disorder [6A05] [14]
Clarithromycin DM4M1SG Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Clarithromycin. Bacterial infection [1A00-1C4Z] [14]
Sulfamethoxazole DMB08GE Minor Increased risk of prolong QT interval by the combination of Grepafloxacin and Sulfamethoxazole. Bacterial infection [1A00-1C4Z] [17]
Telithromycin DMZ4P3A Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Telithromycin. Bacterial infection [1A00-1C4Z] [13]
Retigabine DMGNYIH Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Retigabine. Behcet disease [4A62] [13]
Cariprazine DMJYDVK Moderate Decreased metabolism of Grepafloxacin caused by Cariprazine mediated inhibition of CYP450 enzyme. Bipolar disorder [6A60] [18]
Loperamide DMOJZQ9 Moderate Increased risk of prolong QT interval by the combination of Grepafloxacin and Loperamide. Bowel habit change [ME05] [24]
Temozolomide DMKECZD Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Temozolomide. Brain cancer [2A00] [12]
Lomustine DMMWSUL Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Lomustine. Brain cancer [2A00] [12]
Eribulin DM1DX4Q Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Eribulin. Breast cancer [2C60-2C6Y] [14]
Ixabepilone DM2OZ3G Moderate Decreased metabolism of Grepafloxacin caused by Ixabepilone mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [25]
Lapatinib DM3BH1Y Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Lapatinib. Breast cancer [2C60-2C6Y] [14]
Palbociclib DMD7L94 Moderate Decreased metabolism of Grepafloxacin caused by Palbociclib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [18]
Thiotepa DMIZKOP Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Thiotepa. Breast cancer [2C60-2C6Y] [12]
Cabazitaxel DMPAZHC Moderate Decreased metabolism of Grepafloxacin caused by Cabazitaxel mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [26]
Toremifene DMQYUWG Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Toremifene. Breast cancer [2C60-2C6Y] [14]
Bosutinib DMTI8YE Moderate Decreased clearance of Grepafloxacin due to the transporter inhibition by Bosutinib. Breast cancer [2C60-2C6Y] [18]
Sotalol DML60TN Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Sotalol. Cardiac arrhythmia [BC9Z] [14]
Atorvastatin DMF28YC Moderate Decreased metabolism of Grepafloxacin caused by Atorvastatin mediated inhibition of CYP450 enzyme. Cardiovascular disease [BA00-BE2Z] [27]
Macitentan DMP79A1 Moderate Decreased metabolism of Grepafloxacin caused by Macitentan mediated inhibition of CYP450 enzyme. Cardiovascular disease [BA00-BE2Z] [28]
PF-04449913 DMSB068 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and PF-04449913. Chronic myelomonocytic leukaemia [2A40] [13]
Olodaterol DM62B78 Moderate Increased risk of ventricular arrhythmias by the combination of Grepafloxacin and Olodaterol. Chronic obstructive pulmonary disease [CA22] [20]
Vilanterol DMF5EK1 Moderate Increased risk of ventricular arrhythmias by the combination of Grepafloxacin and Vilanterol. Chronic obstructive pulmonary disease [CA22] [19]
Salmeterol DMIEU69 Moderate Increased risk of ventricular arrhythmias by the combination of Grepafloxacin and Salmeterol. Chronic obstructive pulmonary disease [CA22] [20]
Indacaterol DMQJHR7 Moderate Increased risk of prolong QT interval by the combination of Grepafloxacin and Indacaterol. Chronic obstructive pulmonary disease [CA22] [20]
Arformoterol DMYM974 Moderate Increased risk of prolong QT interval by the combination of Grepafloxacin and Arformoterol. Chronic obstructive pulmonary disease [CA22] [20]
Ketoprofen DMRKXPT Moderate Additive CNS depression effects by the combination of Grepafloxacin and Ketoprofen. Chronic pain [MG30] [29]
Irinotecan DMP6SC2 Moderate Decreased metabolism of Grepafloxacin caused by Irinotecan mediated inhibition of UGT. Colorectal cancer [2B91] [17]
Oxaliplatin DMQNWRD Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Oxaliplatin. Colorectal cancer [2B91] [14]
Capecitabine DMTS85L Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Capecitabine. Colorectal cancer [2B91] [12]
Isoproterenol DMK7MEY Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Isoproterenol. Conduction disorder [BC63] [20]
Ulipristal DMBNI20 Minor Decreased metabolism of Grepafloxacin caused by Ulipristal mediated inhibition of CYP450 enzyme. Contraceptive management [QA21] [18]
Mestranol DMG3F94 Moderate Decreased absorption of Grepafloxacin due to formation of complexes caused by Mestranol. Contraceptive management [QA21] [30]
Halothane DM80OZ5 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Halothane. Corneal disease [9A76-9A78] [14]
Propofol DMB4OLE Moderate Increased risk of prolong QT interval by the combination of Grepafloxacin and Propofol. Corneal disease [9A76-9A78] [31]
Sevoflurane DMC9O43 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Sevoflurane. Corneal disease [9A76-9A78] [14]
Cocaine DMSOX7I Moderate Decreased metabolism of Grepafloxacin caused by Cocaine mediated inhibition of CYP450 enzyme. Corneal disease [9A76-9A78] [16]
Alfentanil DMVO0UB Moderate Decreased metabolism of Grepafloxacin caused by Alfentanil mediated inhibition of CYP450 enzyme. Corneal disease [9A76-9A78] [32]
Nimodipine DMQ0RKZ Moderate Decreased metabolism of Grepafloxacin caused by Nimodipine mediated inhibition of CYP450 enzyme. Coronary vasospastic disease [BA85] [16]
Clofazimine DMEBOFW Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Clofazimine. Crohn disease [DD70] [13]
Mycophenolic acid DMRBMAU Moderate Altered absorption of Grepafloxacin due to GI flora changes caused by Mycophenolic acid. Crohn disease [DD70] [33]
Mifepristone DMGZQEF Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Mifepristone. Cushing syndrome [5A70] [17]
Pasireotide DMHM7JS Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Pasireotide. Cushing syndrome [5A70] [14]
Osilodrostat DMIJC9X Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Osilodrostat. Cushing syndrome [5A70] [13]
Ivacaftor DMZC1HS Moderate Decreased metabolism of Grepafloxacin caused by Ivacaftor mediated inhibition of CYP450 enzyme. Cystic fibrosis [CA25] [34]
Aprepitant DM053KT Moderate Decreased metabolism of Grepafloxacin caused by Aprepitant mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [35]
Sertraline DM0FB1J Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Sertraline. Depression [6A70-6A7Z] [14]
Trimipramine DM1SC8M Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Trimipramine. Depression [6A70-6A7Z] [14]
Cyclobenzaprine DM1YBRM Moderate Decreased metabolism of Grepafloxacin caused by Cyclobenzaprine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [16]
Imipramine DM2NUH3 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Imipramine. Depression [6A70-6A7Z] [14]
Fluoxetine DM3PD2C Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Fluoxetine. Depression [6A70-6A7Z] [14]
Nortriptyline DM4KDYJ Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Nortriptyline. Depression [6A70-6A7Z] [14]
Nefazodone DM4ZS8M Moderate Decreased metabolism of Grepafloxacin caused by Nefazodone mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [16]
Duloxetine DM9BI7M Moderate Decreased metabolism of Grepafloxacin caused by Duloxetine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [36]
Escitalopram DMFK9HG Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Escitalopram. Depression [6A70-6A7Z] [14]
Clomipramine DMINRKW Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Clomipramine. Depression [6A70-6A7Z] [14]
Trazodone DMK1GBJ Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Trazodone. Depression [6A70-6A7Z] [14]
Amoxapine DMKITQE Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Amoxapine. Depression [6A70-6A7Z] [14]
Mirtazapine DML53ZJ Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Mirtazapine. Depression [6A70-6A7Z] [14]
Doxepin DMPI98T Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Doxepin. Depression [6A70-6A7Z] [14]
Maprotiline DMPWB7T Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Maprotiline. Depression [6A70-6A7Z] [14]
Polatuzumab vedotin DMF6Y0L Moderate Decreased metabolism of Grepafloxacin caused by Polatuzumab vedotin mediated inhibition of CYP450 enzyme. Diffuse large B-cell lymphoma [2A81] [37]
Tetrabenazine DMYWQ0O Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Tetrabenazine. Dissociative neurological symptom disorder [6B60] [14]
Deutetrabenazine DMUPFLI Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Deutetrabenazine. Dystonic disorder [8A02] [14]
Ingrezza DMVPLNC Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Ingrezza. Dystonic disorder [8A02] [14]
Diazepam DM08E9O Moderate Decreased metabolism of Grepafloxacin caused by Diazepam mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [16]
Zonisamide DM0DTF7 Moderate Decreased metabolism of Grepafloxacin caused by Zonisamide mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [38]
Ethosuximide DMDZ9LT Moderate Decreased metabolism of Grepafloxacin caused by Ethosuximide mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [16]
Tiagabine DMKSQG0 Moderate Decreased metabolism of Grepafloxacin caused by Tiagabine mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [16]
Clonazepam DMTO13J Moderate Decreased metabolism of Grepafloxacin caused by Clonazepam mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [16]
Carbamazepine DMZOLBI Moderate Decreased metabolism of Grepafloxacin caused by Carbamazepine mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [16]
Nicardipine DMCDYW7 Moderate Decreased metabolism of Grepafloxacin caused by Nicardipine mediated inhibition of CYP450 enzyme. Essential hypertension [BA00] [16]
Mefenamic acid DMK7HFI Moderate Additive CNS stimulant effects by the combination of Grepafloxacin and Mefenamic acid. Female pelvic pain [GA34] [29]
Solifenacin DMG592Q Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Solifenacin. Functional bladder disorder [GC50] [14]
Mirabegron DMS1GYT Minor Decreased metabolism of Grepafloxacin caused by Mirabegron mediated inhibition of CYP450 enzyme. Functional bladder disorder [GC50] [39]
Darifenacin DMWXLYZ Moderate Decreased metabolism of Grepafloxacin caused by Darifenacin mediated inhibition of CYP450 enzyme. Functional bladder disorder [GC50] [40]
Itraconazole DMCR1MV Moderate Decreased metabolism of Grepafloxacin caused by Itraconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [16]
Pentamidine DMHZJCG Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Pentamidine. Fungal infection [1F29-1F2F] [14]
Miconazole DMPMYE8 Moderate Decreased metabolism of Grepafloxacin caused by Miconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [16]
Ketoconazole DMPZI3Q Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Ketoconazole. Fungal infection [1F29-1F2F] [14]
Ripretinib DM958QB Moderate Decreased metabolism of Grepafloxacin caused by Ripretinib mediated inhibition of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [13]
Sunitinib DMCBJSR Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Sunitinib. Gastrointestinal stromal tumour [2B5B] [14]
Avapritinib DMK2GZX Moderate Decreased metabolism of Grepafloxacin caused by Avapritinib mediated inhibition of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [18]
Ergotamine DMKR3C5 Moderate Decreased metabolism of Grepafloxacin caused by Ergotamine mediated inhibition of CYP450 enzyme. Headache [8A80-8A84] [41]
Procarbazine DMIK367 Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Procarbazine. Hodgkin lymphoma [2B30] [12]
MK-1439 DM215WE Minor Decreased metabolism of Grepafloxacin caused by MK-1439 mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [42]
Delavirdine DM3NF5G Moderate Decreased metabolism of Grepafloxacin caused by Delavirdine mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [16]
Fostemsavir DM50ILT Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Fostemsavir. Human immunodeficiency virus disease [1C60-1C62] [13]
Efavirenz DMC0GSJ Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Efavirenz. Human immunodeficiency virus disease [1C60-1C62] [14]
Dolutegravir DMCZGRE Minor Decreased metabolism of Grepafloxacin caused by Dolutegravir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [43]
Saquinavir DMG814N Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Saquinavir. Human immunodeficiency virus disease [1C60-1C62] [14]
Didanosine DMI2QPE Moderate Decreased absorption of Grepafloxacin due to formation of complexes caused by Didanosine. Human immunodeficiency virus disease [1C60-1C62] [44]
Lopinavir DMITQS0 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Lopinavir. Human immunodeficiency virus disease [1C60-1C62] [13]
Rilpivirine DMJ0QOW Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Rilpivirine. Human immunodeficiency virus disease [1C60-1C62] [14]
Ritonavir DMU764S Moderate Decreased metabolism of Grepafloxacin caused by Ritonavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [16]
Bempedoic acid DM1CI9R Major Increased risk of tendinitis/tendon rupture by the combination of Grepafloxacin and Bempedoic acid. Hyper-lipoproteinaemia [5C80] [45]
BMS-201038 DMQTAGO Moderate Decreased metabolism of Grepafloxacin caused by BMS-201038 mediated inhibition of CYP450 enzyme. Hyper-lipoproteinaemia [5C80] [46]
Losartan DM72JXH Moderate Decreased metabolism of Grepafloxacin caused by Losartan mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [16]
Nisoldipine DM7ISKJ Moderate Decreased metabolism of Grepafloxacin caused by Nisoldipine mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [16]
Levamlodipine DM92S6N Moderate Decreased metabolism of Grepafloxacin caused by Levamlodipine mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [16]
Verapamil DMA7PEW Moderate Decreased metabolism of Grepafloxacin caused by Verapamil mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [16]
Amlodipine DMBDAZV Moderate Decreased metabolism of Grepafloxacin caused by Amlodipine mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [16]
Felodipine DMOSW35 Moderate Decreased metabolism of Grepafloxacin caused by Felodipine mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [16]
Fludrocortisone DMUDIR8 Major Increased risk of tendinitis/tendon rupture by the combination of Grepafloxacin and Fludrocortisone. Hypo-osmolality/hyponatraemia [5C72] [47]
Meclofenamic acid DM05FXR Moderate Additive CNS stimulant effects by the combination of Grepafloxacin and Meclofenamic acid. Inflammatory spondyloarthritis [FA92] [48]
Suvorexant DM0E6S3 Moderate Decreased metabolism of Grepafloxacin caused by Suvorexant mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [13]
Ramelteon DM7IW9J Moderate Decreased metabolism of Grepafloxacin caused by Ramelteon mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [49]
Flurazepam DMAL4G0 Moderate Decreased metabolism of Grepafloxacin caused by Flurazepam mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [16]
Triazolam DMETYK5 Moderate Decreased metabolism of Grepafloxacin caused by Triazolam mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [16]
Melatonin DMKWFBT Moderate Decreased metabolism of Grepafloxacin caused by Melatonin mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [16]
Tasimelteon DMLOQ1V Moderate Decreased metabolism of Grepafloxacin caused by Tasimelteon mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [50]
ITI-007 DMUQ1DO Moderate Decreased metabolism of Grepafloxacin caused by ITI-007 mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [51]
Estazolam DMZGXUM Moderate Decreased metabolism of Grepafloxacin caused by Estazolam mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [16]
Iron DMAP8MV Moderate Decreased absorption of Grepafloxacin due to formation of complexes caused by Iron. Iron deficiency anaemia [3A00] [52]
Polyethylene glycol DM4I1JP Major Increased risk of ventricular arrhythmias by the combination of Grepafloxacin and Polyethylene glycol. Irritable bowel syndrome [DD91] [53]
Alosetron DML2A03 Moderate Decreased metabolism of Grepafloxacin caused by Alosetron mediated inhibition of CYP450 enzyme. Irritable bowel syndrome [DD91] [54]
Pemigatinib DM819JF Moderate Decreased metabolism of Grepafloxacin caused by Pemigatinib mediated inhibition of CYP450 enzyme. Liver cancer [2C12] [55]
Testosterone DM7HUNW Moderate Decreased metabolism of Grepafloxacin caused by Testosterone mediated inhibition of CYP450 enzyme. Low bone mass disorder [FB83] [16]
Crizotinib DM4F29C Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Crizotinib. Lung cancer [2C25] [14]
Brigatinib DM7W94S Moderate Decreased metabolism of Grepafloxacin caused by Brigatinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [13]
Ceritinib DMB920Z Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Ceritinib. Lung cancer [2C25] [14]
Erlotinib DMCMBHA Moderate Decreased metabolism of Grepafloxacin caused by Erlotinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [56]
Lurbinectedin DMEFRTZ Moderate Decreased metabolism of Grepafloxacin caused by Lurbinectedin mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [57]
Osimertinib DMRJLAT Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Osimertinib. Lung cancer [2C25] [14]
Pralsetinib DMWU0I2 Moderate Decreased metabolism of Grepafloxacin caused by Pralsetinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [58]
Selpercatinib DMZR15V Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Selpercatinib. Lung cancer [2C25] [13]
Lumefantrine DM29GAD Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Lumefantrine. Malaria [1F40-1F45] [13]
Chloroquine DMSI5CB Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Chloroquine. Malaria [1F40-1F45] [14]
Hydroxychloroquine DMSIVND Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Hydroxychloroquine. Malaria [1F40-1F45] [14]
Quinine DMSWYF5 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Quinine. Malaria [1F40-1F45] [14]
Primaquine DMWQ16I Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Primaquine. Malaria [1F40-1F45] [14]
Inotuzumab ozogamicin DMAC130 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Inotuzumab ozogamicin. Malignant haematopoietic neoplasm [2B33] [14]
Fludarabine DMVRLT7 Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Fludarabine. Malignant haematopoietic neoplasm [2B33] [12]
Pentostatin DM0HXDS Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Pentostatin. Mature B-cell leukaemia [2A82] [12]
Idelalisib DM602WT Moderate Decreased clearance of Grepafloxacin due to the transporter inhibition by Idelalisib. Mature B-cell leukaemia [2A82] [59]
GDC-0199 DMH0QKA Moderate Decreased metabolism of Grepafloxacin caused by GDC-0199 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [13]
IPI-145 DMWA24P Moderate Decreased metabolism of Grepafloxacin caused by IPI-145 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [60]
Arsenic trioxide DM61TA4 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Arsenic trioxide. Mature B-cell lymphoma [2A85] [14]
Acalabrutinib DM7GCVW Moderate Decreased metabolism of Grepafloxacin caused by Acalabrutinib mediated inhibition of CYP450 enzyme. Mature B-cell lymphoma [2A85] [61]
Clofarabine DMCVJ86 Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Clofarabine. Mature B-cell lymphoma [2A85] [12]
Ibrutinib DMHZCPO Moderate Decreased metabolism of Grepafloxacin caused by Ibrutinib mediated inhibition of CYP450 enzyme. Mature B-cell lymphoma [2A85] [62]
Vincristine DMINOX3 Moderate Decreased metabolism of Grepafloxacin caused by Vincristine mediated inhibition of CYP450 enzyme. Mature B-cell lymphoma [2A85] [16]
Teniposide DMLW57T Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Teniposide. Mature B-cell lymphoma [2A85] [12]
Mercaptopurine DMTM2IK Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Mercaptopurine. Mature B-cell lymphoma [2A85] [12]
Cytarabine DMZD5QR Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Cytarabine. Mature B-cell lymphoma [2A85] [12]
Mechlorethamine DM0CVXA Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Mechlorethamine. Mature T-cell lymphoma [2A90] [12]
Vemurafenib DM62UG5 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Vemurafenib. Melanoma [2C30] [14]
Selumetinib DMC7W6R Moderate Decreased metabolism of Grepafloxacin caused by Selumetinib mediated inhibition of CYP450 enzyme. Melanoma [2C30] [63]
Dacarbazine DMNPZL4 Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Dacarbazine. Melanoma [2C30] [12]
LGX818 DMNQXV8 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and LGX818. Melanoma [2C30] [14]
Ethinyl estradiol DMODJ40 Moderate Decreased absorption of Grepafloxacin due to formation of complexes caused by Ethinyl estradiol. Menopausal disorder [GA30] [30]
Ubrogepant DM749I3 Moderate Decreased metabolism of Grepafloxacin caused by Ubrogepant mediated inhibition of CYP450 enzyme. Migraine [8A80] [64]
Lanthanum carbonate DMMJQSH Moderate Decreased absorption of Grepafloxacin due to formation of complexes caused by Lanthanum carbonate. Mineral absorption/transport disorder [5C64] [17]
Midazolam DMXOELT Moderate Decreased metabolism of Grepafloxacin caused by Midazolam mediated inhibition of CYP450 enzyme. Mood/affect symptom [MB24] [16]
Riluzole DMECBWN Minor Decreased metabolism of Grepafloxacin caused by Riluzole mediated inhibition of CYP450 enzyme. Motor neuron disease [8B60] [65]
Panobinostat DM58WKG Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Panobinostat. Multiple myeloma [2A83] [14]
Thalidomide DM70BU5 Moderate Increased risk of ventricular arrhythmias by the combination of Grepafloxacin and Thalidomide. Multiple myeloma [2A83] [13]
Melphalan DMOLNHF Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Melphalan. Multiple myeloma [2A83] [12]
Siponimod DM2R86O Major Increased risk of ventricular arrhythmias by the combination of Grepafloxacin and Siponimod. Multiple sclerosis [8A40] [13]
Fingolimod DM5JVAN Major Increased risk of ventricular arrhythmias by the combination of Grepafloxacin and Fingolimod. Multiple sclerosis [8A40] [17]
Ozanimod DMT6AM2 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Ozanimod. Multiple sclerosis [8A40] [14]
Methoxsalen DME8FZ9 Moderate Increased risk of photosensitivity reactions by the combination of Grepafloxacin and Methoxsalen. Mycosis fungoides [2B01] [13]
Romidepsin DMT5GNL Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Romidepsin. Mycosis fungoides [2B01] [13]
Nilotinib DM7HXWT Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Nilotinib. Myeloproliferative neoplasm [2A20] [14]
Ruxolitinib DM7Q98D Minor Decreased metabolism of Grepafloxacin caused by Ruxolitinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [18]
Imatinib DM7RJXL Moderate Decreased metabolism of Grepafloxacin caused by Imatinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [66]
Dasatinib DMJV2EK Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Dasatinib. Myeloproliferative neoplasm [2A20] [14]
Hydroxyurea DMOQVU9 Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Hydroxyurea. Myeloproliferative neoplasm [2A20] [12]
Busulfan DMXYJ9C Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Busulfan. Myeloproliferative neoplasm [2A20] [12]
Modafinil DMYILBE Minor Decreased metabolism of Grepafloxacin caused by Modafinil mediated inhibition of CYP450 enzyme. Narcolepsy [7A20] [13]
Droperidol DM0DXA8 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Droperidol. Nausea/vomiting [MD90] [14]
Prochlorperazine DM53SRA Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Prochlorperazine. Nausea/vomiting [MD90] [14]
Promethazine DM6I5GR Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Promethazine. Nausea/vomiting [MD90] [14]
Palonosetron DMBHMOX Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Palonosetron. Nausea/vomiting [MD90] [14]
Granisetron DMIUW25 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Granisetron. Nausea/vomiting [MD90] [14]
Dolasetron DMMG26Z Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Dolasetron. Nausea/vomiting [MD90] [14]
Ondansetron DMOTQ1I Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Ondansetron. Nausea/vomiting [MD90] [14]
Bupropion DM5PCS7 Major Increased risk of lowers seizure threshold by the combination of Grepafloxacin and Bupropion. Nicotine use disorder [6C4A] [67]
Entrectinib DMMPTLH Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Entrectinib. Non-small cell lung cancer [2C25] [13]
Sibutramine DMFJTDI Minor Decreased metabolism of Grepafloxacin caused by Sibutramine mediated inhibition of CYP450 enzyme. Obesity [5B80-5B81] [68]
Lofexidine DM1WXA6 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Lofexidine. Opioid use disorder [6C43] [14]
Diclofenac DMPIHLS Moderate Additive CNS depression effects by the combination of Grepafloxacin and Diclofenac. Osteoarthritis [FA00-FA05] [29]
Naproxen DMZ5RGV Moderate Additive CNS stimulant effects by the combination of Grepafloxacin and Naproxen. Osteoarthritis [FA00-FA05] [29]
Olaparib DM8QB1D Moderate Decreased metabolism of Grepafloxacin caused by Olaparib mediated inhibition of CYP450 enzyme. Ovarian cancer [2C73] [69]
Rucaparib DM9PVX8 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Rucaparib. Ovarian cancer [2C73] [14]
Carboplatin DMG281S Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Carboplatin. Ovarian cancer [2C73] [12]
Altretamine DMKLAYG Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Altretamine. Ovarian cancer [2C73] [12]
Topotecan DMP6G8T Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Topotecan. Ovarian cancer [2C73] [12]
Dextropropoxyphene DM23HCX Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Dextropropoxyphene. Pain [MG30-MG3Z] [13]
Aspirin DM672AH Moderate Additive CNS stimulant effects by the combination of Grepafloxacin and Aspirin. Pain [MG30-MG3Z] [48]
Etodolac DM6WJO9 Moderate Additive CNS depression effects by the combination of Grepafloxacin and Etodolac. Pain [MG30-MG3Z] [29]
Diflunisal DM7EN8I Moderate Additive CNS depression effects by the combination of Grepafloxacin and Diflunisal. Pain [MG30-MG3Z] [29]
Ibuprofen DM8VCBE Moderate Additive CNS depression effects by the combination of Grepafloxacin and Ibuprofen. Pain [MG30-MG3Z] [29]
Nabumetone DMAT2XH Moderate Additive CNS stimulant effects by the combination of Grepafloxacin and Nabumetone. Pain [MG30-MG3Z] [29]
Buprenorphine DMPRI8G Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Buprenorphine. Pain [MG30-MG3Z] [14]
Piroxicam DMTK234 Moderate Additive CNS stimulant effects by the combination of Grepafloxacin and Piroxicam. Pain [MG30-MG3Z] [29]
Oxycodone DMXLKHV Moderate Decreased metabolism of Grepafloxacin caused by Oxycodone mediated inhibition of CYP450 enzyme. Pain [MG30-MG3Z] [13]
Streptozocin DMOF7AT Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Streptozocin. Pancreatic cancer [2C10] [12]
Thiabendazole DM7YCK3 Moderate Decreased metabolism of Grepafloxacin caused by Thiabendazole mediated inhibition of CYP450 enzyme. Parasitic worm infestation [1F90] [16]
Triclabendazole DMPWGBR Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Triclabendazole. Parasitic worm infestation [1F90] [13]
Albendazole DMYZ57N Moderate Decreased metabolism of Grepafloxacin caused by Albendazole mediated inhibition of CYP450 enzyme. Parasitic worm infestation [1F90] [16]
Rasagiline DM3WKQ4 Major Decreased metabolism of Grepafloxacin caused by Rasagiline mediated inhibition of CYP450 enzyme. Parkinsonism [8A00] [13]
Pimavanserin DMR7IVC Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Pimavanserin. Parkinsonism [8A00] [14]
Bromocriptine DMVE3TK Moderate Decreased metabolism of Grepafloxacin caused by Bromocriptine mediated inhibition of CYP450 enzyme. Parkinsonism [8A00] [16]
Apomorphine DMX38HQ Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Apomorphine. Parkinsonism [8A00] [14]
Lindane DMB8CNL Moderate Increased risk of lowers seizure threshold by the combination of Grepafloxacin and Lindane. Pediculosis [1G00] [70]
Famotidine DMRL3AB Moderate Increased risk of prolong QT interval by the combination of Grepafloxacin and Famotidine. Peptic ulcer [DA61] [13]
Macimorelin DMQYJIR Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Macimorelin. Pituitary gland disorder [5A60-5A61] [71]
Lefamulin DME6G97 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Lefamulin. Pneumonia [CA40] [13]
Prednisone DM2HG4X Major Increased risk of tendinitis/tendon rupture by the combination of Grepafloxacin and Prednisone. Postoperative inflammation [1A00-CA43] [47]
Choline salicylate DM8P137 Moderate Additive CNS stimulant effects by the combination of Grepafloxacin and Choline salicylate. Postoperative inflammation [1A00-CA43] [48]
Betamethasone DMAHJEF Major Increased risk of tendinitis/tendon rupture by the combination of Grepafloxacin and Betamethasone. Postoperative inflammation [1A00-CA43] [47]
Hydrocortisone DMGEMB7 Major Increased risk of tendinitis/tendon rupture by the combination of Grepafloxacin and Hydrocortisone. Postoperative inflammation [1A00-CA43] [47]
Ketorolac DMI4EL5 Moderate Additive CNS depression effects by the combination of Grepafloxacin and Ketorolac. Postoperative inflammation [1A00-CA43] [29]
Lonafarnib DMGM2Z6 Major Decreased metabolism of Grepafloxacin caused by Lonafarnib mediated inhibition of CYP450 enzyme. Premature ageing appearance [LD2B] [72]
Progesterone DMUY35B Moderate Decreased metabolism of Grepafloxacin caused by Progesterone mediated inhibition of CYP450 enzyme. Preterm labour/delivery [JB00] [16]
Degarelix DM3O8QY Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Degarelix. Prostate cancer [2C82] [14]
ABIRATERONE DM8V75C Major Increased risk of prolong QT interval by the combination of Grepafloxacin and ABIRATERONE. Prostate cancer [2C82] [14]
Nilutamide DMFN07X Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Nilutamide. Prostate cancer [2C82] [14]
Enzalutamide DMGL19D Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Enzalutamide. Prostate cancer [2C82] [14]
Flutamide DMK0O7U Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Flutamide. Prostate cancer [2C82] [14]
Bicalutamide DMZMSPF Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Bicalutamide. Prostate cancer [2C82] [14]
Silodosin DMJSBT6 Moderate Decreased metabolism of Grepafloxacin caused by Silodosin mediated inhibition of CYP450 enzyme. Prostate hyperplasia [GA90] [73]
Dutasteride DMQ4TJK Moderate Decreased metabolism of Grepafloxacin caused by Dutasteride mediated inhibition of CYP450 enzyme. Prostate hyperplasia [GA90] [74]
Verteporfin DMIY6DB Moderate Increased risk of photosensitivity reactions by the combination of Grepafloxacin and Verteporfin. Psoriasis [EA90] [18]
Fluphenazine DMIT8LX Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Fluphenazine. Psychotic disorder [6A20-6A25] [14]
Bosentan DMIOGBU Moderate Decreased metabolism of Grepafloxacin caused by Bosentan mediated inhibition of CYP450 enzyme. Pulmonary hypertension [BB01] [75]
Axitinib DMGVH6N Moderate Decreased metabolism of Grepafloxacin caused by Axitinib mediated inhibition of CYP450 enzyme. Renal cell carcinoma [2C90] [18]
Temsirolimus DMS104F Moderate Decreased metabolism of Grepafloxacin caused by Temsirolimus mediated inhibition of CYP450 enzyme. Renal cell carcinoma [2C90] [76]
Sorafenib DMS8IFC Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Sorafenib. Renal cell carcinoma [2C90] [14]
Meloxicam DM2AR7L Moderate Additive CNS stimulant effects by the combination of Grepafloxacin and Meloxicam. Rheumatoid arthritis [FA20] [29]
Sulindac DM2QHZU Moderate Additive CNS stimulant effects by the combination of Grepafloxacin and Sulindac. Rheumatoid arthritis [FA20] [29]
Celecoxib DM6LOQU Moderate Additive CNS depression effects by the combination of Grepafloxacin and Celecoxib. Rheumatoid arthritis [FA20] [29]
Oxaprozin DM9UB0P Moderate Additive CNS stimulant effects by the combination of Grepafloxacin and Oxaprozin. Rheumatoid arthritis [FA20] [29]
Flurbiprofen DMGN4BY Moderate Additive CNS depression effects by the combination of Grepafloxacin and Flurbiprofen. Rheumatoid arthritis [FA20] [29]
Fenoprofen DML5VQ0 Moderate Additive CNS depression effects by the combination of Grepafloxacin and Fenoprofen. Rheumatoid arthritis [FA20] [29]
Dexamethasone DMMWZET Major Increased risk of tendinitis/tendon rupture by the combination of Grepafloxacin and Dexamethasone. Rheumatoid arthritis [FA20] [47]
Tolmetin DMWUIJE Moderate Additive CNS stimulant effects by the combination of Grepafloxacin and Tolmetin. Rheumatoid arthritis [FA20] [29]
Quetiapine DM1N62C Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Quetiapine. Schizophrenia [6A20] [14]
Mesoridazine DM2ZGAN Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Mesoridazine. Schizophrenia [6A20] [13]
Thioridazine DM35M8J Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Thioridazine. Schizophrenia [6A20] [18]
Aripiprazole DM3NUMH Moderate Decreased metabolism of Grepafloxacin caused by Aripiprazole mediated inhibition of CYP450 enzyme. Schizophrenia [6A20] [13]
Iloperidone DM6AUFY Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Iloperidone. Schizophrenia [6A20] [14]
Paliperidone DM7NPJS Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Paliperidone. Schizophrenia [6A20] [14]
Perphenazine DMA4MRX Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Perphenazine. Schizophrenia [6A20] [14]
Chlorpromazine DMBGZI3 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Chlorpromazine. Schizophrenia [6A20] [14]
Trifluoperazine DMKBYWI Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Trifluoperazine. Schizophrenia [6A20] [14]
Risperidone DMN6DXL Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Risperidone. Schizophrenia [6A20] [14]
Amisulpride DMSJVAM Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Amisulpride. Schizophrenia [6A20] [14]
Asenapine DMSQZE2 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Asenapine. Schizophrenia [6A20] [14]
Pimozide DMW83TP Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Pimozide. Schizophrenia [6A20] [18]
Fentanyl DM8WAHT Moderate Decreased metabolism of Grepafloxacin caused by Fentanyl mediated inhibition of CYP450 enzyme. Sensation disturbance [MB40] [16]
Sufentanil DMU7YEL Moderate Decreased metabolism of Grepafloxacin caused by Sufentanil mediated inhibition of CYP450 enzyme. Sensation disturbance [MB40] [16]
Tadalafil DMJZHT1 Moderate Decreased metabolism of Grepafloxacin caused by Tadalafil mediated inhibition of CYP450 enzyme. Sexual dysfunction [HA00-HA01] [77]
Vardenafil DMTBGW8 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Vardenafil. Sexual dysfunction [HA00-HA01] [14]
LDE225 DMM9F25 Moderate Decreased metabolism of Grepafloxacin caused by LDE225 mediated inhibition of CYP450 enzyme. Skin cancer [2C30-2C37] [78]
Larotrectinib DM26CQR Moderate Decreased clearance of Grepafloxacin due to the transporter inhibition by Larotrectinib. Solid tumour/cancer [2A00-2F9Z] [13]
Dactinomycin DM2YGNW Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Dactinomycin. Solid tumour/cancer [2A00-2F9Z] [12]
Methylprednisolone DM4BDON Major Increased risk of tendinitis/tendon rupture by the combination of Grepafloxacin and Methylprednisolone. Solid tumour/cancer [2A00-2F9Z] [47]
Cyclophosphamide DM4O2Z7 Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Cyclophosphamide. Solid tumour/cancer [2A00-2F9Z] [12]
Vinblastine DM5TVS3 Moderate Decreased metabolism of Grepafloxacin caused by Vinblastine mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [16]
Ifosfamide DMCT3I8 Moderate Decreased metabolism of Grepafloxacin caused by Ifosfamide mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [16]
Docetaxel DMDI269 Moderate Decreased clearance of Grepafloxacin due to the transporter inhibition by Docetaxel. Solid tumour/cancer [2A00-2F9Z] [79]
Trabectedin DMG3Y89 Moderate Decreased metabolism of Grepafloxacin caused by Trabectedin mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [18]
Armodafinil DMGB035 Minor Decreased metabolism of Grepafloxacin caused by Armodafinil mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [13]
Mitoxantrone DMM39BF Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Mitoxantrone. Solid tumour/cancer [2A00-2F9Z] [12]
LEE011 DMMX75K Major Increased risk of prolong QT interval by the combination of Grepafloxacin and LEE011. Solid tumour/cancer [2A00-2F9Z] [14]
Etoposide DMNH3PG Moderate Decreased metabolism of Grepafloxacin caused by Etoposide mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [16]
Epirubicin DMPDW6T Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Epirubicin. Solid tumour/cancer [2A00-2F9Z] [14]
Prednisolone DMQ8FR2 Major Increased risk of tendinitis/tendon rupture by the combination of Grepafloxacin and Prednisolone. Solid tumour/cancer [2A00-2F9Z] [47]
Cisplatin DMRHGI9 Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Cisplatin. Solid tumour/cancer [2A00-2F9Z] [12]
Vandetanib DMRICNP Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Vandetanib. Solid tumour/cancer [2A00-2F9Z] [14]
Gemcitabine DMSE3I7 Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Gemcitabine. Solid tumour/cancer [2A00-2F9Z] [12]
Triptorelin DMTK4LS Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Triptorelin. Solid tumour/cancer [2A00-2F9Z] [14]
Norethindrone DMTY169 Moderate Decreased metabolism of Grepafloxacin caused by Norethindrone mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [16]
Fluorouracil DMUM7HZ Minor Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Fluorouracil. Solid tumour/cancer [2A00-2F9Z] [12]
Taxol DMUOT9V Moderate Decreased metabolism of Grepafloxacin caused by Taxol mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [80]
Doxorubicin DMVP5YE Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Doxorubicin. Solid tumour/cancer [2A00-2F9Z] [14]
Pitolisant DM8RFNJ Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Pitolisant. Somnolence [MG42] [14]
Telavancin DM58VQX Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Telavancin. Staphylococcal/streptococcal disease [1B5Y] [14]
Adenosine DMM2NSK Major Increased risk of ventricular arrhythmias by the combination of Grepafloxacin and Adenosine. Supraventricular tachyarrhythmia [BC81] [81]
Lenvatinib DMB1IU4 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Lenvatinib. Thyroid cancer [2D10] [14]
Cabozantinib DMIYDT4 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Cabozantinib. Thyroid cancer [2D10] [14]
Papaverine DMCA9QP Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Papaverine. Tonus and reflex abnormality [MB47] [82]
Tizanidine DMR2IQ4 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Tizanidine. Tonus and reflex abnormality [MB47] [14]
Sirolimus DMGW1ID Moderate Decreased metabolism of Grepafloxacin caused by Sirolimus mediated inhibition of CYP450 enzyme. Transplant rejection [NE84] [13]
Mycophenolate mofetil DMPQAGE Moderate Altered absorption of Grepafloxacin due to GI flora changes caused by Mycophenolate mofetil. Transplant rejection [NE84] [33]
Triamcinolone DM98IXF Major Increased risk of tendinitis/tendon rupture by the combination of Grepafloxacin and Triamcinolone. Vasomotor/allergic rhinitis [CA08] [47]
Procainamide DMNMXR8 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Procainamide. Ventricular tachyarrhythmia [BC71] [14]
Propafenone DMPIBJK Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Propafenone. Ventricular tachyarrhythmia [BC71] [14]
Flecainide DMSQDLE Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Flecainide. Ventricular tachyarrhythmia [BC71] [14]
Amiodarone DMUTEX3 Major Increased risk of prolong QT interval by the combination of Grepafloxacin and Amiodarone. Ventricular tachyarrhythmia [BC71] [14]
⏷ Show the Full List of 326 DDI Information of This Drug

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