Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRKE63)

Drug Name
Chlorambucil Drug Info
Synonyms
Ambochlorin; Amboclorin; Chlocambucil; Chloorambucol; Chlorambucilum; Chloraminophen; Chloraminophene; Chlorbutin; Chlorbutine; Chlorbutinum; Chloroambucil; Chlorobutin; Chlorobutine; Clorambucile; Clorambucilo; Ecloril; Elcoril; Elcorin; Leukeran; Leukersan; Leukoran; Linfolizin; Linfolysin; Lympholysin; Clorambucile [DCIT]; Glaxo Wellcome Brand of Chlorambucil; GlaxoSmithKline Brand of Chlorambucil; Leuk ersan; Leukeran tablets; Phenylbutyric acid nitrogen mustard; Wellcome Brand of Chlorambucil; C0253; CB 1348; CB1348; Cb l348; CB-1348; Chlorambucil [INN:BAN]; Chlorambucilum [INN-Latin]; Clorambucilo [INN-Spanish]; LEUKERAN (TN); Leukeran (TN); Phenylbuttersaeure-lost; Phenylbuttersaeure-lost[German]; Chlorambucil (USP/INN)
Indication
Disease Entry ICD 11 Status REF
Chronic lymphocytic leukaemia 2A82.0 Approved [1]
Small lymphocytic lymphoma 2A82.0 Approved [2]
Classic Hodgkin lymphoma Investigative [2]
Follicular lymphoma 2A80 Investigative [2]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
2708
ChEBI ID
CHEBI:28830
CAS Number
CAS 305-03-3
TTD Drug ID
DMRKE63
VARIDT Drug ID
DR00895
INTEDE Drug ID
DR0297
ACDINA Drug ID
D00119

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting DNA replication (DNA repli)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [15]
Ozenoxacin DM6KZMG Impetigo 1B72 Approved [16]
Elliptinium acetate DMZC6GT Solid tumour/cancer 2A00-2F9Z Approved [17]
DFP-10917 DM1WNGJ Acute myeloid leukaemia 2A60 Phase 3 [18]
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [19]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [20]
Methotrexate DM2TEOL Anterior urethra cancer Approved [5]
Folic Acid DMEMBJC Colorectal carcinoma Approved [21]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [5]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [5]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [22]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [5]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [23]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [24]
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Drug(s) Transported By Organic anion transporting polypeptide 1A2 (SLCO1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [25]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [26]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [27]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [28]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [29]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [30]
Saquinavir DMG814N Human immunodeficiency virus infection 1C62 Approved [31]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [32]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [33]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [34]
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Drug(s) Metabolized By Glutathione S-transferase pi (GSTP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [35]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [36]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [37]
Carboplatin DMG281S Adenocarcinoma 2D40 Approved [37]
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [38]
Drug(s) Affected By Glutathione S-transferase P (GSTP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [39]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [40]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [41]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [42]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
Selenium DM25CGV N. A. N. A. Approved [45]
Etretinate DM2CZFA Keratosis ED56 Approved [46]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [47]
Quercetin DM3NC4M Obesity 5B81 Approved [48]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [49]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [50]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [51]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [52]
Cepharanthine DM9Y5JB N. A. N. A. Approved [53]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [54]
Clozapine DMFC71L Schizophrenia 6A20 Approved [55]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [56]
Trifluoperazine DMKBYWI Anxiety Approved [57]
Olanzapine DMPFN6Y Bipolar depression Approved [55]
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Drug(s) Affected By Glutathione S-transferase A1 (GSTA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [58]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [59]
Thiotepa DMIZKOP Breast cancer 2C60-2C65 Approved [60]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [61]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [62]
Ethacrynic acid DM60QMR Edema MG29 Approved [63]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [64]
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Methotrexate DM2TEOL Anterior urethra cancer Approved [67]
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Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [71]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [72]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [73]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [74]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [8]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [76]
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Drug(s) Affected By Leukemia inhibitory factor (LIF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [77]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Methotrexate DM2TEOL Anterior urethra cancer Approved [79]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [81]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [82]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [83]
Leflunomide DMR8ONJ Arthritis FA20 Approved [84]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
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Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [85]
Diazepam DM08E9O Alcohol withdrawal Approved [86]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [87]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [85]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [88]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [85]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [89]
Testosterone DM7HUNW Hot flushes GA30 Approved [90]
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Drug(s) Affected By Bcl-2-interacting killer (BIK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [91]
Methotrexate DM2TEOL Anterior urethra cancer Approved [92]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [93]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [94]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [95]
Leflunomide DMR8ONJ Arthritis FA20 Approved [84]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [96]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Clozapine DMFC71L Schizophrenia 6A20 Approved [98]
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Drug(s) Affected By F-box only protein 30 (FBXO30)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [99]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [83]
Leflunomide DMR8ONJ Arthritis FA20 Approved [84]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [100]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [100]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [101]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [100]
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Drug(s) Affected By Histone chaperone ASF1A (ASF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [101]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [103]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [8]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [104]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [68]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [105]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [106]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [79]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [107]
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [108]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [109]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [110]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [111]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [112]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [101]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [113]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [114]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [115]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [116]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [117]
Selenium DM25CGV N. A. N. A. Approved [118]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [113]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [119]
Methotrexate DM2TEOL Anterior urethra cancer Approved [67]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [119]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [120]
Gefitinib DM15F0X Colon adenocarcinoma Approved [121]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [122]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [123]
Etretinate DM2CZFA Keratosis ED56 Approved [124]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [125]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [126]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [127]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [129]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [130]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [131]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [132]
Gefitinib DM15F0X Colon adenocarcinoma Approved [133]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [134]
Selenium DM25CGV N. A. N. A. Approved [135]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [136]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [137]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [138]
Methotrexate DM2TEOL Anterior urethra cancer Approved [139]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [140]
Methotrexate DM2TEOL Anterior urethra cancer Approved [139]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [141]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [142]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [143]
Paclitaxel DMLB81S Breast carcinoma Approved [144]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [145]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [146]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [147]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [148]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [149]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [150]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [151]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [152]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [153]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [77]
Verapamil DMA7PEW Angina pectoris BA40 Approved [154]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [155]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [156]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [157]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [158]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [159]
Selenium DM25CGV N. A. N. A. Approved [45]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [160]
Etretinate DM2CZFA Keratosis ED56 Approved [161]
Methotrexate DM2TEOL Anterior urethra cancer Approved [162]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [163]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [164]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [165]
Quercetin DM3NC4M Obesity 5B81 Approved [166]
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Drug(s) Affected By HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [45]
Fluoxetine DM3PD2C Bipolar depression Approved [167]
Cinoxacin DM4EWNS Urinary tract infection GC08 Approved [167]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [168]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [169]
Testosterone DM7HUNW Hot flushes GA30 Approved [90]
Valdecoxib DMAY7H4 Osteoarthritis FA00-FA05 Approved [167]
Testosterone enanthate DMB6871 N. A. N. A. Approved [170]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [167]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [171]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [123]
Methotrexate DM2TEOL Anterior urethra cancer Approved [172]
Epinephrine DM3KJBC Acute asthma CA23 Approved [173]
Quercetin DM3NC4M Obesity 5B81 Approved [174]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [175]
Fructose DM43AN2 Vomiting MD90 Approved [176]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [171]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [177]
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Drug(s) Affected By 14-3-3 protein sigma (SFN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [178]
Gefitinib DM15F0X Colon adenocarcinoma Approved [179]
Methotrexate DM2TEOL Anterior urethra cancer Approved [180]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [181]
Quercetin DM3NC4M Obesity 5B81 Approved [182]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [183]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [181]
Panobinostat DM58WKG Chronic graft versus host disease Approved [184]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [185]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [186]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [187]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [188]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [189]
Gefitinib DM15F0X Colon adenocarcinoma Approved [121]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [190]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Etretinate DM2CZFA Keratosis ED56 Approved [124]
Prednisone DM2HG4X Acute asthma CA23 Approved [191]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [192]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [113]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [193]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [194]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [195]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [143]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [196]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [197]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [198]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [199]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [200]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [201]
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Drug(s) Affected By Histone H4 (H4C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [77]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Selenium DM25CGV N. A. N. A. Approved [45]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [125]
Methotrexate DM2TEOL Anterior urethra cancer Approved [67]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [202]
Panobinostat DM58WKG Chronic graft versus host disease Approved [203]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [204]
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Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [115]
Flucytosine DM13VTW Cryptococcal meningitis Approved [205]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [205]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [206]
Methotrexate DM2TEOL Anterior urethra cancer Approved [79]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [207]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [141]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [208]
Amifostine DM5FL14 Mucositis CA00 Approved [209]
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Drug(s) Affected By DNA repair protein RAD51 homolog 1 (RAD51)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [178]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [120]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [210]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [211]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [212]
Testosterone DM7HUNW Hot flushes GA30 Approved [213]
Quizartinib DM8Y4JS Acute myeloid leukaemia 2A60 Approved [214]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [213]
Leflunomide DMR8ONJ Arthritis FA20 Approved [84]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [149]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [201]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [77]
Verapamil DMA7PEW Angina pectoris BA40 Approved [154]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [171]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [215]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [190]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
Meloxicam DM2AR7L Arthritis FA20 Approved [216]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [192]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [217]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [218]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [219]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [115]
Gefitinib DM15F0X Colon adenocarcinoma Approved [220]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [221]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [123]
Selenium DM25CGV N. A. N. A. Approved [45]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [222]
Methotrexate DM2TEOL Anterior urethra cancer Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By kinase isozyme 4, mitochondrial (PDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [223]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [224]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [225]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [226]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [100]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [100]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [100]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [101]
Testosterone enanthate DMB6871 N. A. N. A. Approved [170]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [123]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [125]
Methotrexate DM2TEOL Anterior urethra cancer Approved [162]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [227]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [228]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [229]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [230]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [95]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [231]
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Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [232]
Verapamil DMA7PEW Angina pectoris BA40 Approved [233]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [131]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [234]
Selenium DM25CGV N. A. N. A. Approved [45]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [235]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [236]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [237]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [238]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dihydrofolate reductase (DHFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [239]
Methotrexate DM2TEOL Anterior urethra cancer Approved [240]
Ceftazidime DM41GRA Bacteremia 1A73 Approved [241]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [202]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [168]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [242]
Tubocurarine DMBZIVP Anaesthesia 9A78.6 Approved [243]
Ceftriaxone DMCEW64 Acute gonococcal cervicitis Approved [241]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [244]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [245]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytidine deaminase (CDA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [246]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [247]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [202]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [248]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [168]
Testosterone DM7HUNW Hot flushes GA30 Approved [90]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [249]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [96]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fanconi anemia group G protein (FANCG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [178]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [80]
Testosterone DM7HUNW Hot flushes GA30 Approved [213]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [213]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [101]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [244]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [245]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [104]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [250]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [251]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [201]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [252]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [253]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [254]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [255]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [256]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [257]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [258]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [259]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [260]
Folic Acid DMEMBJC Colorectal carcinoma Approved [261]
Methotrexate DM2TEOL Anterior urethra cancer Approved [262]
Quercetin DM3NC4M Obesity 5B81 Approved [263]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [12]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [264]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [265]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [266]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [267]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [267]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lopinavir DMITQS0 Human immunodeficiency virus infection 1C62 Approved [268]
Sulfinpyrazone DMEV954 Gout FA25 Approved [11]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [269]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [270]
Methotrexate DM2TEOL Anterior urethra cancer Approved [262]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [271]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [272]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [265]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [273]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [274]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [39]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [275]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [276]
Ethanol DMDRQZU Chronic pain MG30 Approved [277]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [278]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [278]
Methyldopa DM5I621 Hypertension BA00-BA04 Approved [279]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [169]
Testosterone DM7HUNW Hot flushes GA30 Approved [213]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [213]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fanconi anemia group C protein (FANCC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [178]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [202]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [280]
Testosterone DM7HUNW Hot flushes GA30 Approved [213]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [213]
Testosterone enanthate DMB6871 N. A. N. A. Approved [170]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [244]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [281]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [282]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [283]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
DNA replication (DNA repli) TTABD5E NOUNIPROTAC Intercalator [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Substrate [4]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Glutathione S-transferase pi (GSTP1) Main DME DEK6079 GSTP1_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Gene/Protein Processing [7]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Gene/Protein Processing [8]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Gene/Protein Processing [8]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [9]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [10]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Regulation of Drug Effects [11]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [12]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Drug Response [13]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [14]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Gene/Protein Processing [14]

References

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2 Chlorambucil FDA Label
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