Details of Disease

General Information of Disease (ID: DISD09EH)

• Disease Name: Bipolar I disorder
• Synonyms: bipolar I disorder; bipolar 1 disorder
• Definition: A bipolar disorder that is characterized by at least one manic or mixed episode.
• Disease Hierarchy:
  DISAM7J2: Bipolar disorder
  DISD09EH: Bipolar I disorder
• Disease Identifiers:
  MONDO ID: MONDO_0001866
  UMLS CUI: C0853193
  MedGen ID: 678499
  SNOMED CT ID: 371596008

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Aripiprazole	DM3NUMH	Approved	Small molecular drug	[1]
Quetiapine	DM1N62C	Approved	Small molecular drug	[2]
Risperidone	DMN6DXL	Approved	Small molecular drug	[3]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 11 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
TPH2	TT3KLDP	Limited	Biomarker	[4]
CHRNA2	TTF4E0J	Strong	Genetic Variation	[5]
COMT	TTKWFB8	Strong	Genetic Variation	[6]
DAO	TT7Y3EJ	Strong	Altered Expression	[7]
GABRA5	TTNZPQ1	Strong	Genetic Variation	[8]
GABRP	TT3E0DI	Strong	Genetic Variation	[9]
GRM7	TT0I76D	Strong	Genetic Variation	[10]
HTR2C	TTWJBZ5	Strong	Genetic Variation	[11]
TRPC7	TT06GRA	Strong	Altered Expression	[12]
KAT6B	TTH4VJL	Definitive	Genetic Variation	[13]
PON1	TT9LX82	Definitive	Biomarker	[14]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
MSRA	DEU2ZBY	Strong	Biomarker	[15]

This Disease Is Related to 17 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
BAG1	OTRQNIA4	Limited	Genetic Variation	[16]
DTNBP1	OT9UQT2S	Limited	Genetic Variation	[17]
EGR3	OTGPJIRA	Limited	Biomarker	[18]
RTN3	OTGZ51QF	Limited	Genetic Variation	[16]
SAFB	OTGRV2LW	Limited	Genetic Variation	[16]
ARID3B	OTUP9MS4	Disputed	Biomarker	[19]
PPM1K	OTNZ4N4E	Disputed	Biomarker	[19]
ANKK1	OT0OM1O0	Strong	Biomarker	[20]
CDS1	OT2F591M	Strong	Biomarker	[21]
DAOA	OT7NFEO6	Strong	Genetic Variation	[22]
DLX4	OTLWVCN4	Strong	Biomarker	[23]
GABRA6	OTX4UC3O	Strong	Genetic Variation	[9]
NDUFV2	OTSZF7D6	Strong	Altered Expression	[24]
NR2E1	OTW47GKM	Strong	Biomarker	[25]
ST8SIA2	OTRBBBD8	Strong	Biomarker	[26]
GADL1	OTJM4A0R	Definitive	Genetic Variation	[27]
NRXN3	OTJ0I7HJ	Definitive	Genetic Variation	[13]

References

• [1] Aripiprazole FDA Label
• [2] Quetiapine FDA Label
• [3] Risperidone FDA Label
• [4] Genes in the serotonin pathway are associated with bipolar affective disorder in a Han Chinese population.Neurosci Bull. 2014 Feb;30(1):33-42. doi: 10.1007/s12264-013-1380-5. Epub 2013 Oct 17.
• [5] No association between common variations in the neuronal nicotinic acetylcholine receptor alpha2 subunit gene (CHRNA2) and bipolar I disorder.Psychiatry Res. 2005 Jun 30;135(3):171-7. doi: 10.1016/j.psychres.2005.04.004.
• [6] The T Allele of MTHFR c.C677T and Its Synergism with G (Val 158) Allele of COMT c.G472A Polymorphism Are Associated with the Risk of Bipolar I Disorder.Genet Test Mol Biomarkers. 2016 Sep;20(9):510-5. doi: 10.1089/gtmb.2016.0061. Epub 2016 Jul 22.
• [7] Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios.Am J Hum Genet. 2005 Dec;77(6):918-36. doi: 10.1086/497703. Epub 2005 Oct 28.
• [8] The GABA type A receptor alpha5 subunit gene is associated with bipolar I disorder.Neurosci Lett. 2005 Jun 10-17;381(1-2):108-13. doi: 10.1016/j.neulet.2005.02.010. Epub 2005 Feb 25.
• [9] Contribution of genes in the GABAergic pathway to bipolar disorder and its executive function deficit in the Chinese Han population.Am J Med Genet B Neuropsychiatr Genet. 2018 Jan;177(1):50-67. doi: 10.1002/ajmg.b.32601. Epub 2017 Nov 14.
• [10] Association of the human kainate receptor GluR7 gene (GRIK3) with recurrent major depressive disorder.Am J Med Genet B Neuropsychiatr Genet. 2007 Jan 5;144B(1):20-6. doi: 10.1002/ajmg.b.30374.
• [11] The serotonin transporter (5-HTTLPR) but not serotonin receptor (5-HT2C Cys23Ser) variant is associated with bipolar I disorder in Kurdish population from Western Iran.Neurosci Lett. 2015 Mar 17;590:91-5. doi: 10.1016/j.neulet.2015.01.027. Epub 2015 Jan 14.
• [12] Altered TRPC7 gene expression in bipolar-I disorder.Biol Psychiatry. 2001 Oct 15;50(8):620-6. doi: 10.1016/s0006-3223(01)01077-0.
• [13] Identification of novel loci for bipolar I disorder in a multi-stage genome-wide association study.Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jun 3;51:58-64. doi: 10.1016/j.pnpbp.2014.01.003. Epub 2014 Jan 18.
• [14] Association between bipolar I disorder and the L55M and Q192R polymorphisms of the paraoxonase 1 (PON1) gene.J Affect Disord. 2012 Jun;139(1):12-7. doi: 10.1016/j.jad.2011.06.029. Epub 2011 Jul 23.
• [15] Methionine sulfoxide reductase A (MsrA) associated with bipolar I disorder and executive functions in A Han Chinese population.J Affect Disord. 2015 Sep 15;184:235-8. doi: 10.1016/j.jad.2015.06.004. Epub 2015 Jun 14.
• [16] The association of white matter volume in psychotic disorders with genotypic variation in NRG1, MOG and CNP: a voxel-based analysis in affected individuals and their unaffected relatives.Transl Psychiatry. 2012 Oct 9;2(10):e167. doi: 10.1038/tp.2012.82.
• [17] Dysbindin gene variants are associated with bipolar I disorder in a Korean population.Neurosci Lett. 2007 May 18;418(3):272-5. doi: 10.1016/j.neulet.2007.03.037. Epub 2007 Mar 21.
• [18] Family-based association study of early growth response gene 3 with child bipolar I disorder.J Affect Disord. 2012 May;138(3):387-96. doi: 10.1016/j.jad.2012.01.011. Epub 2012 Feb 25.
• [19] Electrophysiological correlates of emotional scene processing in bipolar disorder.J Psychiatr Res. 2020 Jan;120:83-90. doi: 10.1016/j.jpsychires.2019.10.005. Epub 2019 Oct 8.
• [20] The ALDH2 and DRD2/ANKK1 genes interacted in bipolar II but not bipolar I disorder.Pharmacogenet Genomics. 2010 Aug;20(8):500-6. doi: 10.1097/FPC.0b013e32833caa2b.
• [21] Alcoholism and drug abuse in three groups--bipolar I, unipolars and their acquaintances.J Affect Disord. 1998 Sep;50(2-3):81-9. doi: 10.1016/s0165-0327(98)00108-6.
• [22] Cognitive manic symptoms in bipolar disorder associated with polymorphisms in the DAOA and COMT genes.PLoS One. 2013 Jul 5;8(7):e67450. doi: 10.1371/journal.pone.0067450. Print 2013.
• [23] Multisystem component phenotypes of bipolar disorder for genetic investigations of extended pedigrees.JAMA Psychiatry. 2014 Apr;71(4):375-87. doi: 10.1001/jamapsychiatry.2013.4100.
• [24] Expression of mitochondrial complex I subunit gene NDUFV2 in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia.Neurosci Res. 2009 Mar;63(3):199-204. doi: 10.1016/j.neures.2008.12.004. Epub 2008 Dec 24.
• [25] Hyperactivity, startle reactivity and cell-proliferation deficits are resistant to chronic lithium treatment in adult Nr2e1(frc/frc) mice.Genes Brain Behav. 2010 Oct;9(7):681-94. doi: 10.1111/j.1601-183X.2010.00602.x. Epub 2010 Jun 21.
• [26] Association between ST8SIA2 and the Risk of Schizophrenia and Bipolar I Disorder across Diagnostic Boundaries.PLoS One. 2015 Sep 29;10(9):e0139413. doi: 10.1371/journal.pone.0139413. eCollection 2015.
• [27] Immunophenotypes associated with bipolar disorder and lithium treatment.Sci Rep. 2019 Nov 25;9(1):17453. doi: 10.1038/s41598-019-53745-7.