Details of the Drug

General Information of Drug (ID: DM3NUMH)

• Drug Name: Aripiprazole
• Synonyms: 129722-12-9; Abilify; Abilitat; Abilify Discmelt; OPC-14597; Discmelt; Opc 14597; OPC 31; OPC-31; 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydrocarbostyril; UNII-82VFR53I78; C23H27Cl2N3O2; HSDB 7320; 7-(4-(4-(2,3-DICHLOROPHENYL)PIPERAZIN-1-YL)BUTOXY)-3,4-DIHYDROQUINOLIN-2(1H)-ONE; CHEMBL1112; 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-1,2,3,4-tetrahydroquinolin-2-one; 7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butyloxy)-3,4-dihydro-2(1H)-quinolinone; CHEBI:31236; Abilify; Aripiprazol; Aripiprazolum; Aripirazole; Arpizol; Asprito; Pripiprazole; Aripiprazole [USAN]; Otsuka brand of aripiprazole; OPC 14597; ALKS-9070; Abilify (TN); BMS-337039; Bristol-Myers Squibb brand of aripiprazole; Discmelt (TN); KS-1030; S06-0010; Aripiprazole (JAN/USAN/INN); 7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydro-2(1H)-quinolinone; 7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydrocarbostyril; 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one; 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one; ALKS9070/ALKS9072; Aripiprazole/escitalopram fixed-dose combination

Indication

Disease Entry	ICD 11	Status	REF
Bipolar I disorder	N.A.	Approved	[1]
Erythropoietic porphyrias	5C58.12	Approved	[2]
Schizoaffective disorder	6A21	Approved	[1]
Schizophrenia	6A20	Approved	[3]
Major depressive disorder	6A70.3	Phase 3	[4]
Bipolar disorder	6A60	Application submitted	[5]
Autism	N.A.	Investigative	[1]

• Therapeutic Class: Antipsychotic Agents
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 448.4
  Logarithm of the Partition Coefficient (xlogp); 4.6
  Rotatable Bond Count (rotbonds); 7
  Hydrogen Bond Donor Count (hbonddonor); 1
  Hydrogen Bond Acceptor Count (hbondacc); 4
• ADMET Property:
  BDDCS Class: Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 2: low solubility and high permeability [6]
  Bioavailability: 87% of drug becomes completely available to its intended biological destination(s) [7]
  Clearance: The clearance of drug is 0.8 mL/min/kg [8]
  Elimination: 25% of a given dose will be eliminated in urine and 55% in the feces [9]
  Half-life: The concentration or amount of drug in body reduced by one-half in 75 hours [10]
  Metabolism: The drug is metabolized via the hepatic [8]
  MRTD: The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 0.55754 micromolar/kg/day [11]
  Unbound Fraction: The unbound fraction of drug in plasma is 0.01% [12]
  Vd: The volume of distribution (Vd) of drug is 404 L or 4.9 L/kg []
  Water Solubility: The ability of drug to dissolve in water is measured as 0.0001 mg/mL [6]
• Chemical Identifiers:
  Formula: C23H27Cl2N3O2
  IUPAC Name: 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one
  Canonical SMILES: C1CC(=O)NC2=C1C=CC(=C2)OCCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl
  InChI: InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
  InChIKey: CEUORZQYGODEFX-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 60795
  ChEBI ID: CHEBI:31236
  CAS Number: 129722-12-9
  DrugBank ID: DB01238
  TTD ID: D0H3HM
  VARIDT ID: DR00766
  INTEDE ID: DR0136
  ACDINA ID: D00043
• Repurposed Drugs (RPD): Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Agonist	[13]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[14]
Cytochrome P450 2D6 (CYP2D6) Main DME	DECB0K3	CP2D6_HUMAN	Substrate	[14]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Substrate	[15]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Substrate	[15]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
5-hydroxytryptamine receptor 2A (HTR2A)	OTWXJX0M	5HT2A_HUMAN	Drug Response	[16]
Cancer/testis antigen 1 (CTAG1B)	OTIQGW6U	CTG1B_HUMAN	Gene/Protein Processing	[17]
Fasciculation and elongation protein zeta-1 (FEZ1)	OTWCXPRE	FEZ1_HUMAN	Gene/Protein Processing	[17]
Fibronectin (FN1)	OTB5ZN4Q	FINC_HUMAN	Gene/Protein Processing	[17]
G antigen 1 (GAGE1)	OT53E50E	GAGE1_HUMAN	Gene/Protein Processing	[17]
Interferon beta (IFNB1)	OTYQGUB5	IFNB_HUMAN	Gene/Protein Processing	[17]
Interferon-stimulated gene 20 kDa protein (ISG20)	OTCWRJJW	ISG20_HUMAN	Gene/Protein Processing	[17]
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2)	OTPGYWKC	NOD2_HUMAN	Gene/Protein Processing	[17]
Potassium voltage-gated channel subfamily H member 2 (KCNH2)	OTZX881H	KCNH2_HUMAN	Gene/Protein Processing	[18]
Prolactin (PRL)	OTWFQGX7	PRL_HUMAN	Gene/Protein Processing	[19]

Molecular Expression Atlas of This Drug

• ICD Disease Classification: 06 Mental, behavioural or neurodevelopmental disorder
• Disease Class: ICD-11: 6A20 Schizophrenia
• The Studied Tissue: Pre-frontal cortex
• The Studied Disease: Schizophrenia [ICD-11:6A20]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dopamine D2 receptor (D2R)	DTT	DRD2	9.39E-01	-0.01	-0.05
Dopamine D2 receptor (D2R)	DTT	DRD2	9.91E-01	-0.02	-0.28
Cytochrome P450 3A5 (CYP3A5)	DME	CYP3A5	1.17E-01	-3.87E-02	-2.23E-01
Cytochrome P450 3A5 (CYP3A5)	DME	CYP3A5	9.74E-01	7.48E-03	1.37E-01
Cytochrome P450 2D6 (CYP2D6)	DME	CYP2D6	2.59E-01	6.29E-02	3.14E-01
Cytochrome P450 2D6 (CYP2D6)	DME	CYP2D6	4.84E-01	-8.38E-02	-8.46E-01
Cytochrome P450 3A4 (CYP3A4)	DME	CYP3A4	4.66E-01	4.25E-02	1.20E-01
Cytochrome P450 3A4 (CYP3A4)	DME	CYP3A4	4.75E-01	5.15E-02	3.64E-01

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Aripiprazole

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Disease	REF
Iloperidone	DM6AUFY	Moderate	Additive anticholinergic effects by the combination of Aripiprazole and Iloperidone.	Schizophrenia [6A20]	[20]
Paliperidone	DM7NPJS	Moderate	Additive anticholinergic effects by the combination of Aripiprazole and Paliperidone.	Schizophrenia [6A20]	[20]
Molindone	DMAH70G	Moderate	Additive anticholinergic effects by the combination of Aripiprazole and Molindone.	Schizophrenia [6A20]	[20]
Thiothixene	DMDINC4	Moderate	Additive anticholinergic effects by the combination of Aripiprazole and Thiothixene.	Schizophrenia [6A20]	[20]
Amisulpride	DMSJVAM	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Amisulpride.	Schizophrenia [6A20]	[21]
Asenapine	DMSQZE2	Moderate	Additive anticholinergic effects by the combination of Aripiprazole and Asenapine.	Schizophrenia [6A20]	[20]

Coadministration of a Drug Treating the Disease Different from Aripiprazole (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Ivosidenib	DM8S6T7	Moderate	Increased metabolism of Aripiprazole caused by Ivosidenib mediated induction of CYP450 enzyme.	Acute myeloid leukaemia [2A60]	[22]
Midostaurin	DMI6E0R	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Midostaurin.	Acute myeloid leukaemia [2A60]	[21]
Arn-509	DMT81LZ	Moderate	Increased metabolism of Aripiprazole caused by Arn-509 mediated induction of CYP450 enzyme.	Acute myeloid leukaemia [2A60]	[22]
Gilteritinib	DMTI0ZO	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Gilteritinib.	Acute myeloid leukaemia [2A60]	[21]
Oliceridine	DM6MDCF	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Oliceridine.	Acute pain [MG31]	[21]
Mepyramine	DMB4SFH	Moderate	Additive anticholinergic effects by the combination of Aripiprazole and Mepyramine.	Allergic/hypersensitivity disorder [4A80-4A8Z]	[23]
Phenyltoloxamine	DMKAEQW	Moderate	Additive anticholinergic effects by the combination of Aripiprazole and Phenyltoloxamine.	Allergic/hypersensitivity disorder [4A80-4A8Z]	[23]
Bepridil	DM0RKS4	Moderate	Additive hypotensive effects by the combination of Aripiprazole and Bepridil.	Angina pectoris [BA40]	[24]
Dronedarone	DMA8FS5	Moderate	Decreased metabolism of Aripiprazole caused by Dronedarone mediated inhibition of CYP450 enzyme.	Angina pectoris [BA40]	[22]
Amyl nitrite	DMJKO05	Moderate	Additive hypotensive effects by the combination of Aripiprazole and Amyl nitrite.	Angina pectoris [BA40]	[24]
Bedaquiline	DM3906J	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Bedaquiline.	Antimicrobial drug resistance [MG50-MG52]	[21]
Posaconazole	DMUL5EW	Moderate	Decreased metabolism of Aripiprazole caused by Posaconazole mediated inhibition of CYP450 enzyme.	Aspergillosis [1F20]	[22]
Levalbuterol	DM5YBO1	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Levalbuterol.	Asthma [CA23]	[21]
Pirbuterol	DMI5678	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Pirbuterol.	Asthma [CA23]	[21]
Lisdexamfetamine	DM6W8V5	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Lisdexamfetamine.	Attention deficit hyperactivity disorder [6A05]	[21]
Dalfopristin	DM4LTKV	Moderate	Decreased metabolism of Aripiprazole caused by Dalfopristin mediated inhibition of CYP450 enzyme.	Bacterial infection [1A00-1C4Z]	[25]
Troleandomycin	DMUZNIG	Moderate	Decreased metabolism of Aripiprazole caused by Troleandomycin mediated inhibition of CYP450 enzyme.	Bacterial infection [1A00-1C4Z]	[22]
Cariprazine	DMJYDVK	Moderate	Additive anticholinergic effects by the combination of Aripiprazole and Cariprazine.	Bipolar disorder [6A60]	[20]
Pexidartinib	DMS2J0Z	Moderate	Increased metabolism of Aripiprazole caused by Pexidartinib mediated induction of CYP450 enzyme.	Bone/articular cartilage neoplasm [2F7B]	[22]
Eribulin	DM1DX4Q	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Eribulin.	Breast cancer [2C60-2C6Y]	[21]
Lapatinib	DM3BH1Y	Moderate	Decreased metabolism of Aripiprazole caused by Lapatinib mediated inhibition of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[21]
Tucatinib	DMBESUA	Moderate	Decreased metabolism of Aripiprazole caused by Tucatinib mediated inhibition of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[22]
Bosutinib	DMTI8YE	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Bosutinib.	Breast cancer [2C60-2C6Y]	[21]
Acetylcholine	DMDF79Z	Moderate	Antagonize the effect of Aripiprazole when combined with Acetylcholine.	Cataract [9B10]	[26]
PF-04449913	DMSB068	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and PF-04449913.	Chronic myelomonocytic leukaemia [2A40]	[21]
Umeclidinium	DM4E8O9	Moderate	Additive anticholinergic effects by the combination of Aripiprazole and Umeclidinium.	Chronic obstructive pulmonary disease [CA22]	[27]
Olodaterol	DM62B78	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Olodaterol.	Chronic obstructive pulmonary disease [CA22]	[21]
Vilanterol	DMF5EK1	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Vilanterol.	Chronic obstructive pulmonary disease [CA22]	[21]
Tiotropium	DMFDC0Q	Moderate	Additive anticholinergic effects by the combination of Aripiprazole and Tiotropium.	Chronic obstructive pulmonary disease [CA22]	[27]
Revefenacin	DMMP5SI	Moderate	Additive anticholinergic effects by the combination of Aripiprazole and Revefenacin.	Chronic obstructive pulmonary disease [CA22]	[27]
Indacaterol	DMQJHR7	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Indacaterol.	Chronic obstructive pulmonary disease [CA22]	[21]
Arformoterol	DMYM974	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Arformoterol.	Chronic obstructive pulmonary disease [CA22]	[21]
Dihydrocodeine	DMB0FWL	Major	Additive CNS depression effects by the combination of Aripiprazole and Dihydrocodeine.	Chronic pain [MG30]	[28]
Probucol	DMVZQ2M	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Probucol.	Coronary atherosclerosis [BA80]	[21]
Pasireotide	DMHM7JS	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Pasireotide.	Cushing syndrome [5A70]	[21]
Osilodrostat	DMIJC9X	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Osilodrostat.	Cushing syndrome [5A70]	[21]
Lumacaftor	DMCLWDJ	Moderate	Increased metabolism of Aripiprazole caused by Lumacaftor mediated induction of CYP450 enzyme.	Cystic fibrosis [CA25]	[22]
Ivacaftor	DMZC1HS	Moderate	Decreased metabolism of Aripiprazole caused by Ivacaftor mediated inhibition of CYP450 enzyme.	Cystic fibrosis [CA25]	[22]
MK-8228	DMOB58Q	Moderate	Decreased metabolism of Aripiprazole caused by MK-8228 mediated inhibition of CYP450 enzyme.	Cytomegaloviral disease [1D82]	[22]
Cyclandelate	DMO0R76	Moderate	Additive hypotensive effects by the combination of Aripiprazole and Cyclandelate.	Dementia [6D80-6D8Z]	[24]
OPC-34712	DMHG57U	Moderate	Additive anticholinergic effects by the combination of Aripiprazole and OPC-34712.	Depression [6A70-6A7Z]	[20]
Clomipramine	DMINRKW	Moderate	Additive anticholinergic effects by the combination of Aripiprazole and Clomipramine.	Depression [6A70-6A7Z]	[20]
Esketamine	DMVU687	Moderate	Additive CNS depression effects by the combination of Aripiprazole and Esketamine.	Depression [6A70-6A7Z]	[21]
Mepenzolate	DM8YU2F	Moderate	Additive anticholinergic effects by the combination of Aripiprazole and Mepenzolate.	Digestive system disease [DE2Z]	[20]
Tetrabenazine	DMYWQ0O	Major	Increased risk of prolong QT interval by the combination of Aripiprazole and Tetrabenazine.	Dissociative neurological symptom disorder [6B60]	[29]
Deutetrabenazine	DMUPFLI	Major	Additive antidopaminergic effects by the combination of Aripiprazole and Deutetrabenazine.	Dystonic disorder [8A02]	[30]
Cenobamate	DM8KLU9	Moderate	Increased metabolism of Aripiprazole caused by Cenobamate mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[22]
Stiripentol	DMMSDOY	Moderate	Decreased metabolism of Aripiprazole caused by Stiripentol mediated inhibition of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[22]
Fosphenytoin	DMOX3LB	Moderate	Increased metabolism of Aripiprazole caused by Fosphenytoin mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[22]
Eslicarbazepine	DMZREFQ	Moderate	Increased metabolism of Aripiprazole caused by Eslicarbazepine mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[22]
Tazemetostat	DMWP1BH	Moderate	Increased metabolism of Aripiprazole caused by Tazemetostat mediated induction of CYP450 enzyme.	Follicular lymphoma [2A80]	[22]
Solifenacin	DMG592Q	Moderate	Additive anticholinergic effects by the combination of Aripiprazole and Solifenacin.	Functional bladder disorder [GC50]	[20]
Mirabegron	DMS1GYT	Moderate	Decreased metabolism of Aripiprazole caused by Mirabegron mediated inhibition of CYP450 enzyme.	Functional bladder disorder [GC50]	[22]
Sunitinib	DMCBJSR	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Sunitinib.	Gastrointestinal stromal tumour [2B5B]	[21]
Telaprevir	DMMRV29	Moderate	Decreased metabolism of Aripiprazole caused by Telaprevir mediated inhibition of CYP450 enzyme.	Hepatitis virus infection [1E50-1E51]	[22]
Fosamprenavir	DM4W9B3	Moderate	Decreased metabolism of Aripiprazole caused by Fosamprenavir mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[22]
Fostemsavir	DM50ILT	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Fostemsavir.	Human immunodeficiency virus disease [1C60-1C62]	[21]
Cobicistat	DM6L4H2	Moderate	Decreased metabolism of Aripiprazole caused by Cobicistat mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[22]
Rilpivirine	DMJ0QOW	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Rilpivirine.	Human immunodeficiency virus disease [1C60-1C62]	[21]
Darunavir	DMN3GCH	Moderate	Decreased metabolism of Aripiprazole caused by Darunavir mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[22]
BMS-201038	DMQTAGO	Moderate	Decreased metabolism of Aripiprazole caused by BMS-201038 mediated inhibition of CYP450 enzyme.	Hyper-lipoproteinaemia [5C80]	[22]
Penbutolol	DM4ES8F	Moderate	Additive hypotensive effects by the combination of Aripiprazole and Penbutolol.	Hypertension [BA00-BA04]	[24]
Nebivolol	DM7F1PA	Moderate	Additive hypotensive effects by the combination of Aripiprazole and Nebivolol.	Hypertension [BA00-BA04]	[24]
Levamlodipine	DM92S6N	Moderate	Additive hypotensive effects by the combination of Aripiprazole and Levamlodipine.	Hypertension [BA00-BA04]	[24]
TAK-491	DMCF6SX	Moderate	Additive hypotensive effects by the combination of Aripiprazole and TAK-491.	Hypertension [BA00-BA04]	[24]
Hydralazine	DMU8JGH	Moderate	Additive hypotensive effects by the combination of Aripiprazole and Hydralazine.	Hypertension [BA00-BA04]	[24]
Clevidipine butyrate	DMW4M97	Moderate	Additive hypotensive effects by the combination of Aripiprazole and Clevidipine butyrate.	Hypertension [BA00-BA04]	[24]
Givosiran	DM5PFIJ	Moderate	Decreased metabolism of Aripiprazole caused by Givosiran mediated inhibition of CYP450 enzyme.	Inborn porphyrin/heme metabolism error [5C58]	[22]
Lesinurad	DMUR64T	Moderate	Increased metabolism of Aripiprazole caused by Lesinurad mediated induction of CYP450 enzyme.	Inborn purine/pyrimidine/nucleotide metabolism error [5C55]	[22]
Belladonna	DM2RBWK	Moderate	Additive anticholinergic effects by the combination of Aripiprazole and Belladonna.	Infectious gastroenteritis/colitis [1A40]	[20]
Amobarbital	DM0GQ8N	Moderate	Increased metabolism of Aripiprazole caused by Amobarbital mediated induction of CYP450 enzyme.	Insomnia [7A00-7A0Z]	[22]
ITI-007	DMUQ1DO	Moderate	Additive anticholinergic effects by the combination of Aripiprazole and ITI-007.	Insomnia [7A00-7A0Z]	[20]
Polyethylene glycol	DM4I1JP	Moderate	Increased risk of lowers seizure threshold by the combination of Aripiprazole and Polyethylene glycol.	Irritable bowel syndrome [DD91]	[31]
Glycerol phenylbutyrate	DMDGRQO	Moderate	Decreased metabolism of Aripiprazole caused by Glycerol phenylbutyrate mediated inhibition of CYP450 enzyme.	Liver disease [DB90-DB9Z]	[22]
Crizotinib	DM4F29C	Moderate	Decreased metabolism of Aripiprazole caused by Crizotinib mediated inhibition of CYP450 enzyme.	Lung cancer [2C25]	[22]
Ceritinib	DMB920Z	Moderate	Decreased metabolism of Aripiprazole caused by Ceritinib mediated inhibition of CYP450 enzyme.	Lung cancer [2C25]	[22]
PF-06463922	DMKM7EW	Moderate	Increased metabolism of Aripiprazole caused by PF-06463922 mediated induction of CYP450 enzyme.	Lung cancer [2C25]	[22]
Dacomitinib	DMOH8VY	Moderate	Decreased metabolism of Aripiprazole caused by Dacomitinib mediated inhibition of CYP450 enzyme.	Lung cancer [2C25]	[22]
Osimertinib	DMRJLAT	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Osimertinib.	Lung cancer [2C25]	[21]
Selpercatinib	DMZR15V	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Selpercatinib.	Lung cancer [2C25]	[21]
Lumefantrine	DM29GAD	Moderate	Decreased metabolism of Aripiprazole caused by Lumefantrine mediated inhibition of CYP450 enzyme.	Malaria [1F40-1F45]	[25]
Hydroxychloroquine	DMSIVND	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Hydroxychloroquine.	Malaria [1F40-1F45]	[21]
Inotuzumab ozogamicin	DMAC130	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Inotuzumab ozogamicin.	Malignant haematopoietic neoplasm [2B33]	[21]
Idelalisib	DM602WT	Moderate	Decreased metabolism of Aripiprazole caused by Idelalisib mediated inhibition of CYP450 enzyme.	Mature B-cell leukaemia [2A82]	[22]
IPI-145	DMWA24P	Moderate	Decreased metabolism of Aripiprazole caused by IPI-145 mediated inhibition of CYP450 enzyme.	Mature B-cell leukaemia [2A82]	[22]
Vemurafenib	DM62UG5	Moderate	Decreased metabolism of Aripiprazole caused by Vemurafenib mediated inhibition of CYP450 enzyme.	Melanoma [2C30]	[21]
LGX818	DMNQXV8	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and LGX818.	Melanoma [2C30]	[21]
Dabrafenib	DMX6OE3	Moderate	Increased metabolism of Aripiprazole caused by Dabrafenib mediated induction of CYP450 enzyme.	Melanoma [2C30]	[22]
Danazol	DML8KTN	Moderate	Decreased metabolism of Aripiprazole caused by Danazol mediated inhibition of CYP450 enzyme.	Menstrual cycle bleeding disorder [GA20]	[22]
Allopregnanolone	DMNLHAC	Moderate	Additive CNS depression effects by the combination of Aripiprazole and Allopregnanolone.	Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z]	[32]
Lasmiditan	DMXLVDT	Moderate	Additive CNS depression effects by the combination of Aripiprazole and Lasmiditan.	Migraine [8A80]	[33]
Exjade	DMHPRWG	Moderate	Increased metabolism of Aripiprazole caused by Exjade mediated induction of CYP450 enzyme.	Mineral absorption/transport disorder [5C64]	[22]
Flibanserin	DM70DTN	Moderate	Additive CNS depression effects by the combination of Aripiprazole and Flibanserin.	Mood disorder [6A60-6E23]	[34]
Panobinostat	DM58WKG	Moderate	Decreased metabolism of Aripiprazole caused by Panobinostat mediated inhibition of CYP450 enzyme.	Multiple myeloma [2A83]	[22]
Siponimod	DM2R86O	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Siponimod.	Multiple sclerosis [8A40]	[21]
Fingolimod	DM5JVAN	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Fingolimod.	Multiple sclerosis [8A40]	[21]
Ozanimod	DMT6AM2	Major	Increased risk of ventricular arrhythmias by the combination of Aripiprazole and Ozanimod.	Multiple sclerosis [8A40]	[35]
Romidepsin	DMT5GNL	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Romidepsin.	Mycosis fungoides [2B01]	[21]
Fedratinib	DM4ZBK6	Moderate	Decreased metabolism of Aripiprazole caused by Fedratinib mediated inhibition of CYP450 enzyme.	Myeloproliferative neoplasm [2A20]	[22]
Nilotinib	DM7HXWT	Moderate	Decreased metabolism of Aripiprazole caused by Nilotinib mediated inhibition of CYP450 enzyme.	Myeloproliferative neoplasm [2A20]	[21]
Phenindamine	DMDTC7R	Moderate	Additive anticholinergic effects by the combination of Aripiprazole and Phenindamine.	Nasopharyngitis [CA00]	[20]
Rolapitant	DM8XP26	Moderate	Decreased metabolism of Aripiprazole caused by Rolapitant mediated inhibition of CYP450 enzyme.	Nausea/vomiting [MD90]	[36]
Netupitant	DMEKAYI	Moderate	Decreased metabolism of Aripiprazole caused by Netupitant mediated inhibition of CYP450 enzyme.	Nausea/vomiting [MD90]	[25]
Entrectinib	DMMPTLH	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Entrectinib.	Non-small cell lung cancer [2C25]	[21]
Lorcaserin	DMG6OYJ	Moderate	Decreased metabolism of Aripiprazole caused by Lorcaserin mediated inhibition of CYP450 enzyme.	Obesity [5B80-5B81]	[37]
Polythiazide	DMCH80F	Moderate	Additive hypotensive effects by the combination of Aripiprazole and Polythiazide.	Oedema [MG29]	[24]
Lofexidine	DM1WXA6	Moderate	Additive hypotensive effects by the combination of Aripiprazole and Lofexidine.	Opioid use disorder [6C43]	[24]
Rucaparib	DM9PVX8	Moderate	Decreased metabolism of Aripiprazole caused by Rucaparib mediated inhibition of CYP450 enzyme.	Ovarian cancer [2C73]	[21]
Triclabendazole	DMPWGBR	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Triclabendazole.	Parasitic worm infestation [1F90]	[21]
Opicapone	DM1BKA6	Moderate	Antagonize the effect of Aripiprazole when combined with Opicapone.	Parkinsonism [8A00]	[38]
Pimavanserin	DMR7IVC	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Pimavanserin.	Parkinsonism [8A00]	[21]
Abametapir	DM2RX0I	Moderate	Decreased metabolism of Aripiprazole caused by Abametapir mediated inhibition of CYP450 enzyme.	Pediculosis [1G00]	[39]
Methylscopolamine	DM5VWOB	Moderate	Additive anticholinergic effects by the combination of Aripiprazole and Methylscopolamine.	Peptic ulcer [DA61]	[20]
Macimorelin	DMQYJIR	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Macimorelin.	Pituitary gland disorder [5A60-5A61]	[21]
Lefamulin	DME6G97	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Lefamulin.	Pneumonia [CA40]	[21]
Lonafarnib	DMGM2Z6	Moderate	Decreased metabolism of Aripiprazole caused by Lonafarnib mediated inhibition of CYP450 enzyme.	Premature ageing appearance [LD2B]	[22]
Degarelix	DM3O8QY	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Degarelix.	Prostate cancer [2C82]	[21]
ABIRATERONE	DM8V75C	Moderate	Decreased metabolism of Aripiprazole caused by ABIRATERONE mediated inhibition of CYP450 enzyme.	Prostate cancer [2C82]	[21]
Silodosin	DMJSBT6	Moderate	Additive hypotensive effects by the combination of Aripiprazole and Silodosin.	Prostate hyperplasia [GA90]	[24]
Levomepromazine	DMIKFEL	Moderate	Additive anticholinergic effects by the combination of Aripiprazole and Levomepromazine.	Psychotic disorder [6A20-6A25]	[20]
Temsirolimus	DMS104F	Moderate	Increased plasma concentrations of Aripiprazole and Temsirolimus due to competitive inhibition of the same metabolic pathway.	Renal cell carcinoma [2C90]	[40]
Neupro	DMHEAB1	Moderate	Additive hypotensive effects by the combination of Aripiprazole and Neupro.	Restless legs syndrome [7A80]	[38]
Voxelotor	DMCS6M5	Moderate	Decreased metabolism of Aripiprazole caused by Voxelotor mediated inhibition of CYP450 enzyme.	Sickle-cell disorder [3A51]	[22]
Telotristat ethyl	DMDIYFZ	Moderate	Increased metabolism of Aripiprazole caused by Telotristat ethyl mediated induction of CYP450 enzyme.	Small intestine developmental anomaly [DA90]	[41]
Larotrectinib	DM26CQR	Moderate	Decreased metabolism of Aripiprazole caused by Larotrectinib mediated inhibition of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[22]
Armodafinil	DMGB035	Minor	Increased metabolism of Aripiprazole caused by Armodafinil mediated induction of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[42]
LEE011	DMMX75K	Moderate	Decreased metabolism of Aripiprazole caused by LEE011 mediated inhibition of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[22]
Vandetanib	DMRICNP	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Vandetanib.	Solid tumour/cancer [2A00-2F9Z]	[21]
Triptorelin	DMTK4LS	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Triptorelin.	Solid tumour/cancer [2A00-2F9Z]	[21]
Pitolisant	DM8RFNJ	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Pitolisant.	Somnolence [MG42]	[41]
Telavancin	DM58VQX	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Telavancin.	Staphylococcal/streptococcal disease [1B5Y]	[21]
Fostamatinib	DM6AUHV	Moderate	Decreased metabolism of Aripiprazole caused by Fostamatinib mediated inhibition of CYP450 enzyme.	Thrombocytopenia [3B64]	[43]
Brilinta	DMBR01X	Moderate	Decreased metabolism of Aripiprazole caused by Brilinta mediated inhibition of CYP450 enzyme.	Thrombosis [DB61-GB90]	[22]
Lenvatinib	DMB1IU4	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Lenvatinib.	Thyroid cancer [2D10]	[21]
Cabozantinib	DMIYDT4	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Cabozantinib.	Thyroid cancer [2D10]	[21]
Elagolix	DMB2C0E	Moderate	Increased metabolism of Aripiprazole caused by Elagolix mediated induction of CYP450 enzyme.	Uterine fibroid [2E86]	[22]
Trimeprazine	DMEMV9D	Moderate	Increased risk of prolong QT interval by the combination of Aripiprazole and Trimeprazine.	Vasomotor/allergic rhinitis [CA08]	[21]
Acrivastine	DMTIGA0	Moderate	Additive anticholinergic effects by the combination of Aripiprazole and Acrivastine.	Vasomotor/allergic rhinitis [CA08]	[20]

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Acesulfame	E00341	36573	Flavoring agent
Allura red AC dye	E00338	33258	Colorant
Aspartame	E00402	134601	Flavoring agent
FD&C blue no. 2	E00446	2723854	Colorant
Isopropyl alcohol	E00070	3776	Antimicrobial preservative; Solvent
Mannitol	E00103	6251	Diluent; Flavoring agent; Lyophilization aid; Plasticizing agent; Tonicity agent
Calcium silicate	E00533	21910000	Adsorbent; Anticaking agent; Diluent; Opacifying agent
Calcium stearate	E00244	15324	lubricant
Carmellose sodium	E00625	Not Available	Disintegrant
Crospovidone	E00626	Not Available	Disintegrant
Disodium hydrogenorthophosphate	E00283	24203	Buffering agent; Complexing agent
Eisenoxyd	E00585	56841934	Colorant
Ferric hydroxide oxide yellow	E00539	23320441	Colorant
Lactose monohydrate	E00393	104938	Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate	E00208	11177	lubricant
Polysorbate 20	E00664	Not Available	Dispersing agent; Emollient; Emulsifying agent; Plasticizing agent; Solubilizing agent; Surfactant; Suspending agent
Silicon dioxide	E00670	Not Available	Anticaking agent; Opacifying agent; Viscosity-controlling agent
Sodium chloride	E00077	5234	Diluent; Tonicity agent
Sodium citrate dihydrate	E00369	71474	Alkalizing agent; Buffering agent; Complexing agent; Emulsifying agent
Sodium dihydrogenorthophosphate	E00559	23672064	Buffering agent; Complexing agent
Sorbitan monolaurate	E00508	11046239	Dispersing agent; Emulsifying agent; Solubilizing agent; Surfactant; Suspending agent; Vaccine adjuvant
Tartaric acid	E00029	875	Acidulant; Complexing agent; Flavoring agent
Water	E00035	962	Solvent
Xylitol	E00136	6912	Coating agent; Diluent; Emollient; Flavoring agent; Humectant

Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Aripiprazole 10 mg tablet	10 mg	Disintegrating Oral Tablet	Oral
Aripiprazole 15 mg tablet	15 mg	Disintegrating Oral Tablet	Oral
Aripiprazole 2 mg tablet	2 mg	Oral Tablet	Oral
Aripiprazole 5 mg tablet	5 mg	Oral Tablet	Oral
Aripiprazole Lauroxil 662mg/2.4ml extended release suspension	662mg/2.4ml	Extended Release Suspension	Intramuscular
Aripiprazole Lauroxil 1064mg/3.9ml extended release suspension	1064mg/3.9ml	Extended Release Suspension	Intramuscular
Aripiprazole Lauroxil 441mg/1.6ml extended release suspension	441mg/1.6ml	Extended Release Suspension	Intramuscular
Aripiprazole Lauroxil 882mg/3.2ml extended release suspension	882mg/3.2ml	Extended Release Suspension	Intramuscular
Aripiprazole 10 mg tablet	10 mg	Oral Tablet	Oral
Aripiprazole 15 mg tablet	15 mg	Oral Tablet	Oral
Aripiprazole 30 mg tablet	30 mg	Oral Tablet	Oral
Aripiprazole 20 mg tablet	20 mg	Oral Tablet	Oral
Aripiprazole Lauroxil 675mg/2.4ml extended release suspension	675mg/2.4ml	Extended Release Suspension	Intramuscular

Jump to Detail Pharmaceutical Formulation Page of This Drug

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