Details of Disease

General Information of Disease (ID: DISEAYGH)

• Disease Name: Brucellosis
• Synonyms: Malta fever; Rock fever; Gibraltar fever; Mediterranean fever; bang's disease; Cyprus fever; undulant fever; Maltese fever
• Definition: Brucellosis is a bacterial infection that spreads from animals to people via unpasteurized dairy products or by exposure to contaminated animal products or infected animals. Animals that are most commonly infected include sheep, cattle, goats, pigs, and dogs. Brucellosis can cause of range of signs and symptoms, some of which may persist or recur. Initial symptoms may include fever, sweats, malaise, anorexia, headache, fatigue, and/or pain in the muscles, joints, and/or back. Symptoms that may persist or recur include fevers, arthritis, swelling of the testicle and scrotum, swelling of the heart (endocarditis), neurologic symptoms (in up to 5% of cases), chronic fatigue, depression, and/or swelling of the liver or spleen. People who are in jobs or settings that increase exposure to the bacteria are at increased risk for infection. Antibiotics are used to treat brucellosis. Recovery may take a few weeks to several months, and relapses are common. Death from brucellosis is rare, occurring in no more than 2% of cases.
• Disease Hierarchy:
  DIS8ZVFW: Primary bacterial infectious disease
  DISEAYGH: Brucellosis
• Disease Identifiers:
  MONDO ID: MONDO_0005683
  MESH ID: D002006
  UMLS CUI: C0006309
  MedGen ID: 674
  Orphanet ID: 1304
  SNOMED CT ID: 75702008

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 8 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Amphotericin B	DMTAJQE	Approved	Small molecular drug	[1]
Demeclocycline	DMZEPFJ	Approved	Small molecular drug	[2]
Doxycycline	DM7ICNU	Approved	Small molecular drug	[3]
Fusidic Acid	DMWVCF3	Approved	Small molecular drug	[4]
Minocycline	DMVN5OH	Approved	Small molecular drug	[5]
Oxytetracycline	DMOVH1M	Approved	Small molecular drug	[6]
Streptomycin	DME1LQN	Approved	Small molecular drug	[7]
Tetracycline	DMZA017	Approved	Small molecular drug	[8]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
IL12B	TTGW72V	Strong	Genetic Variation	[9]
PDE4A	TTZ97H5	Strong	Biomarker	[10]

This Disease Is Related to 18 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
BLZF1	OT5QD8FG	Disputed	Biomarker	[11]
CPQ	OTTNZNLD	Disputed	Biomarker	[12]
MDH2	OT7364GY	Disputed	Biomarker	[13]
P3H3	OTRC8QCM	Disputed	Biomarker	[14]
RPL12	OTIUAQDN	Disputed	Biomarker	[15]
RPL7	OT4WCQBE	Disputed	Biomarker	[16]
RSL1D1	OT3CL4R3	Disputed	Biomarker	[15]
CBLIF	OTNE20WU	Strong	Altered Expression	[17]
LAMP3	OTN0XL3W	Strong	Biomarker	[18]
LSAMP	OTYXVQX2	Strong	Biomarker	[18]
MEFV	OTRJ6S6K	Strong	Genetic Variation	[19]
NPC1	OTRIPICX	Strong	Biomarker	[20]
REV1	OTHIKICX	Strong	Biomarker	[21]
SYNJ2BP	OT2Q677P	Strong	Biomarker	[22]
KALRN	OT8WRCBH	Definitive	Genetic Variation	[23]
RAB5A	OTFR2KM4	Definitive	Genetic Variation	[23]
SLN	OTERIU75	Definitive	Biomarker	[24]
TNMD	OTHLVA9G	Definitive	Biomarker	[25]

References

• [1] Amphotericin B FDA Label
• [2] Demeclocycline FDA Label
• [3] Doxycycline FDA Label
• [4] A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
• [5] Minocycline FDA Label
• [6] Oxytetracycline FDA Label
• [7] Streptomycin FDA Label
• [8] Tetracycline FDA Label
• [9] Association between polymorphisms of cytokine genes and brucellosis: A comprehensive systematic review and meta-analysis.Cytokine. 2020 Mar;127:154949. doi: 10.1016/j.cyto.2019.154949. Epub 2019 Dec 6.
• [10] The effects of increased cAMP content on inflammation, oxidative stress and PDE4 transcripts during Brucella melitensis infection.Res Vet Sci. 2008 Feb;84(1):18-25. doi: 10.1016/j.rvsc.2007.02.003. Epub 2007 Mar 29.
• [11] Diminished production of T helper 1 cytokines correlates with T cell unresponsiveness to Brucella cytoplasmic proteins in chronic human brucellosis.J Infect Dis. 2002 Jul 15;186(2):252-9. doi: 10.1086/341449. Epub 2002 Jun 17.
• [12] Purification and characterization of an immunogenic aminopeptidase of Brucella melitensis.Infect Immun. 2003 Sep;71(9):5238-44. doi: 10.1128/IAI.71.9.5238-5244.2003.
• [13] Characterization of the immunogenicity and pathogenicity of malate dehydrogenase in Brucella abortus.World J Microbiol Biotechnol. 2014 Jul;30(7):2063-70. doi: 10.1007/s11274-014-1631-2. Epub 2014 Mar 8.
• [14] The identification of two protective DNA vaccines from a panel of five plasmid constructs encoding Brucella melitensis 16M genes.Vaccine. 2007 Jan 2;25(1):43-54. doi: 10.1016/j.vaccine.2006.07.046. Epub 2006 Aug 4.
• [15] Escheriosome-mediated delivery of recombinant ribosomal L7/L12 protein confers protection against murine brucellosis.Vaccine. 2007 Nov 14;25(46):7873-84. doi: 10.1016/j.vaccine.2007.09.008. Epub 2007 Sep 20.
• [16] Production and targeting of the Brucella abortus antigen L7/L12 in Lactococcus lactis: a first step towards food-grade live vaccines against brucellosis.Appl Environ Microbiol. 2002 Feb;68(2):910-6. doi: 10.1128/AEM.68.2.910-916.2002.
• [17] A potential marker in brucellosis, long non coding RNA IFNG-AS1.Mol Biol Rep. 2019 Dec;46(6):6495-6500. doi: 10.1007/s11033-019-05095-w. Epub 2019 Oct 8.
• [18] Lateral flow biosensor combined with loop-mediated isothermal amplification for simple, rapid, sensitive, and reliable detection of Brucella spp.Infect Drug Resist. 2019 Jul 30;12:2343-2353. doi: 10.2147/IDR.S211644. eCollection 2019.
• [19] Familial mediterranean fever: assessment of clinical manifestations, pregnancy, genetic mutational analyses, and disease severity in a national cohort.Rheumatol Int. 2020 Jan;40(1):29-40. doi: 10.1007/s00296-019-04443-0. Epub 2019 Sep 14.
• [20] Macrophage plasma membrane cholesterol contributes to Brucella abortus infection of mice.Infect Immun. 2002 Sep;70(9):4818-25. doi: 10.1128/IAI.70.9.4818-4825.2002.
• [21] GFP tagging of Brucella melitensis Rev1 allows the identification of vaccinated sheep.Transbound Emerg Dis. 2019 Jan;66(1):505-516. doi: 10.1111/tbed.13053. Epub 2018 Nov 26.
• [22] Integrative Bioinformatics Indentification of the Autophagic Pathway-Associated miRNA-mRNA Networks in RAW264.7 Macrophage Cells Infected with Omp25 Brucella melitensis.Inflammation. 2020 Apr;43(2):532-539. doi: 10.1007/s10753-019-01135-6.
• [23] Association of an IRF3 putative functional uORF variant with resistance to Brucella infection: A candidate gene based analysis of InDel polymorphisms in goats.Cytokine. 2019 Mar;115:109-115. doi: 10.1016/j.cyto.2018.11.024. Epub 2018 Nov 23.
• [24] Doxycycline-encapsulated solid lipid nanoparticles for the enhanced antibacterial potential to treat the chronic brucellosis and preventing its relapse: in vivo study.Ann Clin Microbiol Antimicrob. 2019 Nov 9;18(1):33. doi: 10.1186/s12941-019-0333-x.
• [25] The detection of brucellosis antibody in whole serum based on the low-fouling electrochemical immunosensor fabricated with magnetic Fe(3)O(4)@Au@PEG@HA nanoparticles.Biosens Bioelectron. 2018 Oct 15;117:138-144. doi: 10.1016/j.bios.2018.06.010. Epub 2018 Jun 6.