Details of Disease

General Information of Disease (ID: DISIVIAL)

• Disease Name: Sexually transmitted infection
• Synonyms: disease, venereal; disease, sexually Transmitted; diseases, venereal; STIs; sexually Transmitted infections; venereal disease; infection, sexually Transmitted; sexually Transmitted infection; Transmitted infection, sexually; STI; diseases, sexually Transmitted; venereal diseases; infections, sexually Transmitted; STDs; Transmitted infections, sexually; STD; VD; VD, venereal disease; disease (VD), venereal; sexually Transmitted disorder; sexually transmitted disease; venereal disease (VD)
• Disease Class: 1A9Y-1A9Z: Sexually transmitted infection
• Definition: A Disease due to or propagated by sexual contact.
• Disease Hierarchy:
  DIS7W23Z: Reproductive system disorder
  DISEM33Q: Infectious disease
  DISIVIAL: Sexually transmitted infection
• ICD Code: ICD-11: ICD-11: 1A9Z
• Disease Identifiers:
  MONDO ID: MONDO_0021681
  MESH ID: D012749
  UMLS CUI: C0036916
  MedGen ID: 11402
  SNOMED CT ID: 8098009

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Methamphetamine	DMPM4SK	Approved	Small molecular drug	[1]

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Glyminox	DMQCZ4N	Phase 3	Small molecular drug	[2]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 4 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
KLK3	TTS78AZ	Limited	Biomarker	[3]
AGRP	TT4DE1O	Strong	Biomarker	[4]
PREP	TTNGKET	Strong	Biomarker	[5]
ZAP70	TTUMHT8	Strong	Genetic Variation	[6]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
SULT2A1	DE0P6LK	Strong	Genetic Variation	[6]

This Disease Is Related to 19 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ESPL1	OTMGEVOK	Limited	Genetic Variation	[7]
IFNE	OTXO5MHZ	Limited	Biomarker	[8]
IMPACT	OTQ923OB	Limited	Genetic Variation	[9]
NDUFAB1	OTF906UR	Limited	Altered Expression	[10]
SARS1	OTFKXQ1O	Limited	Biomarker	[11]
SARS2	OTU4T99W	Limited	Biomarker	[11]
PLXNA3	OTMZIBVG	moderate	Biomarker	[12]
ARSH	OTG0X9UQ	Strong	Biomarker	[13]
ARTN	OTWIWGL6	Strong	Biomarker	[4]
CRLS1	OT7XNL0K	Strong	Biomarker	[14]
DDX41	OT6KEIHP	Strong	Biomarker	[15]
DEFA5	OT95CBQ9	Strong	Biomarker	[16]
EMB	OT67E3Q1	Strong	Biomarker	[17]
EXTL3	OT2BRUBN	Strong	Biomarker	[18]
LHPP	OT9AGAIJ	Strong	Biomarker	[19]
MLST8	OT8DNJSD	Strong	Biomarker	[20]
PKHD1	OTAH8SMF	Strong	Biomarker	[21]
SMC5	OT91M6N4	Strong	Biomarker	[22]
MESP2	OT7H4LYA	Definitive	Genetic Variation	[23]

References

• [1] Methamphetamine FDA Label
• [2] ClinicalTrials.gov (NCT00129532) Trial of SAVVY and HIV in Ghana. U.S. National Institutes of Health.
• [3] PrEP Use Among Female Sex Workers: No Evidence for Risk Compensation.J Acquir Immune Defic Syndr. 2019 Nov 1;82(3):257-264. doi: 10.1097/QAI.0000000000002134.
• [4] Incidence rate of sexually transmitted infections among HIV infected patients on long-term ART in an urban and a rural clinic in Uganda.BMC Public Health. 2019 Jan 18;19(1):87. doi: 10.1186/s12889-019-6417-x.
• [5] A randomised controlled trial of a telephone administered brief HIV risk reduction intervention amongst men who have sex with men prescribed post-exposure prophylaxis for HIV after sexual exposure in the UK: Project PEPSE.PLoS One. 2019 May 23;14(5):e0216855. doi: 10.1371/journal.pone.0216855. eCollection 2019.
• [6] Changes in Sexual Behavior and STI Diagnoses Among MSM Initiating PrEP in a Clinic Setting.AIDS Behav. 2019 Feb;23(2):548-555. doi: 10.1007/s10461-018-2252-9.
• [7] The Influence of Relationship Power and Partner Communication on the Syndemic Factor among Hispanic Women.Womens Health Issues. 2017 Jul-Aug;27(4):478-484. doi: 10.1016/j.whi.2017.02.005. Epub 2017 Apr 11.
• [8] Interferon epsilon in the reproductive tract of healthy and genital herpes simplex virus-infected pregnant women: Results of a pilot study.Am J Reprod Immunol. 2018 Sep;80(3):e12995. doi: 10.1111/aji.12995. Epub 2018 Jun 14.
• [9] Study protocol of the iMPaCT project: a longitudinal cohort study assessing psychological determinants, sexual behaviour and chlamydia (re)infections in heterosexual STI clinic visitors.BMC Infect Dis. 2018 Nov 13;18(1):559. doi: 10.1186/s12879-018-3498-6.
• [10] Structure of the Recombinant Neisseria gonorrhoeae Adhesin Complex Protein (rNg-ACP) and Generation of Murine Antibodies with Bactericidal Activity against Gonococci.mSphere. 2018 Oct 10;3(5):e00331-18. doi: 10.1128/mSphere.00331-18.
• [11] Surface enhanced Raman spectroscopy of Chlamydia trachomatis and Neisseria gonorrhoeae for diagnostics, and extra-cellular metabolomics and biochemical monitoring.Sci Rep. 2018 Mar 26;8(1):5163. doi: 10.1038/s41598-018-23562-5.
• [12] Sexual Probability Discounting: A Mechanism for Sexually Transmitted Infection Among Undergraduate Students.Arch Sex Behav. 2019 Feb;48(2):495-505. doi: 10.1007/s10508-018-1155-1. Epub 2018 Mar 26.
• [13] Randomized pilot trial of a cognitive-behavioral alcohol, self-harm, and HIV prevention program for teens in mental health treatment.Behav Res Ther. 2017 Feb;89:49-56. doi: 10.1016/j.brat.2016.11.005. Epub 2016 Nov 12.
• [14] Condomless sex in HIV-diagnosed men who have sex with men in the UK: prevalence, correlates, and implications for HIV transmission.Sex Transm Infect. 2017 Dec;93(8):590-598. doi: 10.1136/sextrans-2016-053029. Epub 2017 Jul 5.
• [15] Poor correlation between reactive syphilis serology and human immunodeficiency virus testing among potential cornea donors.Am J Ophthalmol. 1995 Jan;119(1):1-6. doi: 10.1016/s0002-9394(14)73806-1.
• [16] Key Determinants of Human -Defensin 5 and 6 for Enhancement of HIV Infectivity.Viruses. 2017 Aug 29;9(9):244. doi: 10.3390/v9090244.
• [17] Seroprevalence of xenotropic murine leukemia virus-related virus in normal and retrovirus-infected blood donors.Transfusion. 2012 Feb;52(2):307-16. doi: 10.1111/j.1537-2995.2011.03395.x. Epub 2011 Oct 24.
• [18] The PICASSO Cohort: baseline characteristics of a cohort of men who have sex with men and male-to-female transgender women at high risk for syphilis infection in Lima, Peru.BMC Infect Dis. 2017 Apr 11;17(1):255. doi: 10.1186/s12879-017-2332-x.
• [19] The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene.Neuropsychopharmacology. 2017 Feb;42(3):598-605. doi: 10.1038/npp.2016.153. Epub 2016 Aug 17.
• [20] Men who have sex with men diagnosed with a sexually transmitted infection are significantly more likely to engage in sexualised drug use.Int J STD AIDS. 2017 Jan;28(1):91-93. doi: 10.1177/0956462416666753. Epub 2016 Aug 20.
• [21] Screening for wart virus infection in normal and abnormal cervices by DNA hybridisation of cervical scrapes.Lancet. 1985 Jan 12;1(8420):65-7. doi: 10.1016/s0140-6736(85)91963-4.
• [22] The SMC5/6 Complex Interacts with the Papillomavirus E2 Protein and Influences Maintenance of Viral Episomal DNA.J Virol. 2018 Jul 17;92(15):e00356-18. doi: 10.1128/JVI.00356-18. Print 2018 Aug 1.
• [23] Mutations in the MESP2 gene cause spondylothoracic dysostosis/Jarcho-Levin syndrome. Am J Hum Genet. 2008 Jun;82(6):1334-41. doi: 10.1016/j.ajhg.2008.04.014. Epub 2008 May 15.