Details of Disease

General Information of Disease (ID: DISL1D9U)

• Disease Name: Chorioamnionitis
• Synonyms: intra-amniotic infection; inflammation of foetal membrane; inflammation of fetal membrane; foetal membrane inflammation; fetal membrane inflammation
• Definition: A morphologic finding indicating inflammation of the fetal sac membranes. It is characterized by neutrophilic infiltration of the amnion and chorion.
• Disease Hierarchy:
  DISWD40R: Disease
  DIS5QJ9S: Bacterial infection
  DIS184KT: Skin inflammation
  DIS0CAPN: Disorder of extraembryonic membrane
  DISL1D9U: Chorioamnionitis
• Disease Identifiers:
  MONDO ID: MONDO_0000409
  MESH ID: D002821
  UMLS CUI: C0008495
  MedGen ID: 3056
  SNOMED CT ID: 11612004

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Ampicillin	DMHWE7P	Approved	Small molecular drug	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 7 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
IL1A	TTPM6HI	Limited	Biomarker	[2]
CALCRL	TTY6O0Q	Strong	Biomarker	[3]
CASP4	TT6KIOT	Strong	Altered Expression	[4]
CXCL9	TTWE5PB	Strong	Biomarker	[5]
RORC	TTGV6LY	Strong	Altered Expression	[6]
SERPINH1	TTPSWQG	Strong	Biomarker	[7]
TLR5	TTCXP8J	Strong	Biomarker	[8]

This Disease Is Related to 3 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
ABCB9	DT68UV2	Strong	Altered Expression	[9]
SLC25A12	DT85HYR	Strong	Biomarker	[10]
SLC26A3	DTN1FMD	Strong	Biomarker	[11]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
HPGD	DEHKSC6	Strong	Biomarker	[12]

This Disease Is Related to 15 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ABCF2	OTXIBZ3N	Strong	Altered Expression	[9]
BCS1L	OT5PY5CY	Strong	Biomarker	[9]
CD68	OTOYEY3J	Strong	Biomarker	[13]
COMMD1	OT7WUD5R	Strong	Altered Expression	[14]
DEFB103B	OT8RWY64	Strong	Altered Expression	[15]
GIT2	OTQ2EQJ1	Strong	Altered Expression	[16]
NLRC4	OTAIA3NA	Strong	Altered Expression	[4]
NRSN1	OT1KKXC8	Strong	Altered Expression	[17]
PCP4	OTM1XXYX	Strong	Altered Expression	[18]
PELI1	OTMLBCLC	Strong	Altered Expression	[19]
PGP	OT6QQ7OR	Strong	Biomarker	[20]
PLAGL1	OTZAO900	Strong	Biomarker	[21]
SFTPB	OTOHS07E	Strong	Altered Expression	[22]
TMED2	OTBLO7RW	Strong	Altered Expression	[17]
TPPP	OTCFMSUF	Strong	Altered Expression	[17]

References

• [1] Ampicillin FDA Label
• [2] IL-1 signaling mediates intrauterine inflammation and chorio-decidua neutrophil recruitment and activation.JCI Insight. 2018 Mar 22;3(6):e98306. doi: 10.1172/jci.insight.98306.
• [3] Decreased mature adrenomedullin levels in feto-maternal tissues of pregnant women with histologic chorioamnionitis.Biochem Biophys Res Commun. 2003 Feb 7;301(2):437-42. doi: 10.1016/s0006-291x(02)03059-0.
• [4] A Role for the Inflammasome in Spontaneous Labor at Term with Acute Histologic Chorioamnionitis.Reprod Sci. 2017 Jun;24(6):934-953. doi: 10.1177/1933719116675058. Epub 2016 Nov 16.
• [5] Chronic inflammatory lesions of the placenta are associated with an up-regulation of amniotic fluid CXCR3: A marker of allograft rejection.J Perinat Med. 2018 Feb 23;46(2):123-137. doi: 10.1515/jpm-2017-0042.
• [6] Pro-inflammatory immune responses in leukocytes of premature infants exposed to maternal chorioamnionitis or funisitis.Pediatr Res. 2017 Feb;81(2):384-390. doi: 10.1038/pr.2016.232. Epub 2016 Nov 4.
• [7] Comparison of obstetrical outcomes in patients undergoing cerclage with or without amniocentesis.J Matern Fetal Neonatal Med. 2021 Apr;34(7):1104-1108. doi: 10.1080/14767058.2019.1625882. Epub 2019 Jun 10.
• [8] The expression of Toll-like receptor 5 in preterm histologic chorioamnionitis.J Clin Biochem Nutr. 2018 Jan;62(1):63-67. doi: 10.3164/jcbn.16-103. Epub 2017 Oct 11.
• [9] Chorioamnionitis Induces a Specific Signature of Placental ABC Transporters Associated with an Increase of miR-331-5p in the Human Preterm Placenta.Cell Physiol Biochem. 2018;45(2):591-604. doi: 10.1159/000487100. Epub 2018 Jan 29.
• [10] The cost-effectiveness of ertapenem for the treatment of chorioamnionitis after cesarean delivery.J Matern Fetal Neonatal Med. 2020 Dec;33(24):4096-4101. doi: 10.1080/14767058.2019.1597042. Epub 2019 Mar 28.
• [11] Paths of causal influence from prenatal inflammation and preterm gestation to childhood asthma symptoms.J Asthma. 2019 Aug;56(8):823-832. doi: 10.1080/02770903.2018.1493603. Epub 2018 Aug 24.
• [12] Prostaglandin pathway gene expression in human placenta, amnion and choriodecidua is differentially affected by preterm and term labour and by uterine inflammation.BMC Pregnancy Childbirth. 2014 Jul 22;14:241. doi: 10.1186/1471-2393-14-241.
• [13] Histological changes in the umbilical artery following severe chorioamnionitis and funisitis may be indicative of early atherosclerosis.Placenta. 2017 Feb;50:40-43. doi: 10.1016/j.placenta.2016.12.021. Epub 2016 Dec 24.
• [14] Copper metabolism domain-containing 1 represses the mediators involved in the terminal effector pathways of human labour and delivery.Mol Hum Reprod. 2016 Apr;22(4):299-310. doi: 10.1093/molehr/gav075. Epub 2016 Jan 4.
• [15] Increased production of beta-defensin 3 (hBD-3) by human amniotic epithelial cells (HAEC) after activation of toll-like receptor 4 in chorioamnionitis.Inflamm Res. 2008;57 Suppl 1:S67-8. doi: 10.1007/s00011-007-0633-z.
• [16] GIT2 deficiency attenuates inflammation-induced expression of pro-labor mediators in human amnion and myometrial cells?"Lim R.Biol Reprod. 2019 Jun 1;100(6):1617-1629. doi: 10.1093/biolre/ioz041.
• [17] Risk factors for perinatal transmission of human immunodeficiency virus type 1 in women treated with zidovudine. Pediatric AIDS Clinical Trials Group Study 185 Team.N Engl J Med. 1999 Aug 5;341(6):385-93. doi: 10.1056/NEJM199908053410601.
• [18] Expression, Regulation, and Function of the Calmodulin Accessory Protein PCP4/PEP-19 in Myometrium.Reprod Sci. 2019 Dec;26(12):1650-1660. doi: 10.1177/1933719119828072. Epub 2019 Feb 11.
• [19] Pellino 1 is a novel regulator of TNF and TLR signalling in human myometrial and amnion cells.J Reprod Immunol. 2018 Jun;127:24-35. doi: 10.1016/j.jri.2018.04.003. Epub 2018 Apr 14.
• [20] Ureaplasma infection-mediated release of matrix metalloproteinase-9 and PGP: a novel mechanism of preterm rupture of membranes and chorioamnionitis.Pediatr Res. 2017 Jan;81(1-1):75-79. doi: 10.1038/pr.2016.176. Epub 2016 Sep 15.
• [21] DNA methylation at imprint regulatory regions in preterm birth and infection.Am J Obstet Gynecol. 2013 May;208(5):395.e1-7. doi: 10.1016/j.ajog.2013.02.006. Epub 2013 Mar 8.
• [22] Surfactant Components and Tracheal Aspirate Inflammatory Markers in Preterm Infants with Respiratory Distress Syndrome.J Pediatr. 2018 Dec;203:442-446. doi: 10.1016/j.jpeds.2018.08.019. Epub 2018 Sep 27.