General Information of Disease (ID: DISQ1H57)

Disease Name Heroin dependence
Synonyms Heroin addiction
Definition Physical and psychological dependence on the drug heroin.
Disease Hierarchy
DIS6WEHK: Opioid dependence
DISQ1H57: Heroin dependence
Disease Identifiers
MONDO ID
MONDO_0005367
MESH ID
D006556
UMLS CUI
C0019337
MedGen ID
5532
HPO ID
HP:0033517
SNOMED CT ID
231477003

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 28 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CSNK1E TTA8PLI Limited Genetic Variation [1]
GRIN2A TTKJEMQ Limited Biomarker [2]
GABRB2 TTZA1NY moderate Genetic Variation [3]
OPRM1 TTKWM86 moderate Genetic Variation [4]
POMC TT21AKM moderate Biomarker [5]
ABAT TTT2LD9 Strong Biomarker [6]
ADIPOQ TTXKA7D Strong Biomarker [7]
ANTXR2 TTOD34I Strong Biomarker [8]
BRSK2 TTHZN4X Strong Genetic Variation [9]
CRHBP TT3PKZE Strong Genetic Variation [10]
DLG4 TT9PB26 Strong Biomarker [11]
DRD2 TTEX248 Strong Altered Expression [12]
DRD3 TT4C8EA Strong Biomarker [13]
FKBP5 TT0J5KQ Strong Genetic Variation [14]
GABRA2 TTBMV1G Strong Biomarker [15]
GALR1 TTX3HNZ Strong Genetic Variation [14]
GLRA1 TTF45NW Strong Biomarker [16]
GRK5 TTTCXO0 Strong Biomarker [17]
GRM2 TTXJ47W Strong Altered Expression [18]
HTR3B TTR6K75 Strong Genetic Variation [19]
LEP TTBJEZ5 Strong Biomarker [7]
MC2R TTPWFDX Strong Genetic Variation [20]
MUSK TT6SA0X Strong Genetic Variation [21]
NPY1R TTRK9JT Strong Biomarker [16]
NTF4 TTIM2WO Strong Altered Expression [22]
OPRK1 TTQW87Y Strong Biomarker [23]
TPH2 TT3KLDP Strong Genetic Variation [24]
HTR3A TTPC4TU Definitive Genetic Variation [25]
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⏷ Show the Full List of 28 DTT(s)
This Disease Is Related to 19 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CCDC42 OTFJY6UD Limited Genetic Variation [9]
AGBL4 OTOX2H61 moderate Genetic Variation [26]
CTNNA2 OTJ8G92T moderate Genetic Variation [26]
MPDZ OT9WY1QM moderate Genetic Variation [27]
ANKS1B OT26DGM9 Strong Altered Expression [26]
AUTS2 OTAEXHSC Strong Genetic Variation [28]
CEBPG OTGNAX3H Strong Biomarker [29]
FLAD1 OTY8R02L Strong Genetic Variation [21]
GABRB3 OT80C3D4 Strong Genetic Variation [30]
GRIN3A OTQS9GYY Strong Genetic Variation [31]
GRIN3B OT7T1OJP Strong Genetic Variation [31]
HNRNPH1 OTFRWOLM Strong Genetic Variation [32]
HNRNPH2 OTMGP4J7 Strong Genetic Variation [32]
LRRFIP1 OTN7XAUD Strong Biomarker [33]
PDYN OTEJ6430 Strong Genetic Variation [34]
PENK OT8P3HMP Strong Biomarker [35]
RAPSN OTGMSWDQ Strong Genetic Variation [21]
RETN OTW5Z1NH Strong Biomarker [7]
RGS9 OTRA1LOC Strong Genetic Variation [36]
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⏷ Show the Full List of 19 DOT(s)

References

1 Dopaminergic pathway polymorphisms and heroin addiction: further support for association of CSNK1E variants.Pharmacogenomics. 2014 Dec;15(16):2001-9. doi: 10.2217/pgs.14.145.
2 Functional polymorphisms of the glutamate receptor N-methyl D-aspartate 2A gene are associated with heroin addiction.Genet Mol Res. 2014 Oct 27;13(4):8714-21. doi: 10.4238/2014.October.27.12.
3 GABRB2 Haplotype Association with Heroin Dependence in Chinese Population.PLoS One. 2015 Nov 12;10(11):e0142049. doi: 10.1371/journal.pone.0142049. eCollection 2015.
4 A cis-eQTL in OPRM1 is Associated with Subjective Response to Alcohol and Alcohol Use.Alcohol Clin Exp Res. 2017 May;41(5):929-938. doi: 10.1111/acer.13369. Epub 2017 Apr 10.
5 OPRD1 gene affects disease vulnerability and environmental stress in patients with heroin dependence in Han Chinese.Prog Neuropsychopharmacol Biol Psychiatry. 2019 Mar 8;89:109-116. doi: 10.1016/j.pnpbp.2018.08.028. Epub 2018 Aug 30.
6 Increased mesolimbic GABA concentration blocks heroin self-administration in the rat.J Pharmacol Exp Ther. 2000 Aug;294(2):613-9.
7 Adipocyte-derived hormones in heroin addicts: the influence of methadone maintenance treatment. Physiol Res. 2005;54(1):73-78. doi: 10.33549/physiolres.930568.
8 High-Frequency Stimulation of the Subthalamic Nucleus Blocks Compulsive-Like Re-Escalation of Heroin Taking in Rats.Neuropsychopharmacology. 2017 Aug;42(9):1850-1859. doi: 10.1038/npp.2016.270. Epub 2016 Dec 5.
9 Genome-Wide Association of Heroin Dependence in Han Chinese.PLoS One. 2016 Dec 9;11(12):e0167388. doi: 10.1371/journal.pone.0167388. eCollection 2016.
10 Association between stress pathway gene (CRHR1CRHBP) polymorphisms and heroin dependence.J Clin Neurosci. 2018 Aug;54:33-38. doi: 10.1016/j.jocn.2018.05.009. Epub 2018 May 28.
11 Effect of Sirtuin-1 on Synaptic Plasticity in Nucleus Accumbens in a Rat Model of Heroin Addiction.Med Sci Monit. 2018 Jun 5;24:3789-3803. doi: 10.12659/MSM.910550.
12 Significant association of DRD2 enhancer variant rs12364283 with heroin addiction in a Pakistani population.Ann Hum Genet. 2019 Sep;83(5):367-372. doi: 10.1111/ahg.12322. Epub 2019 Apr 26.
13 Changes in Expression of Dopamine, Its Receptor, and Transporter in Nucleus Accumbens of Heroin-Addicted Rats with Brain-Derived Neurotrophic Factor (BDNF) Overexpression.Med Sci Monit. 2017 Jun 9;23:2805-2815. doi: 10.12659/msm.904670.
14 Drug addiction and stress-response genetic variability: association study in African Americans.Ann Hum Genet. 2014 Jul;78(4):290-8. doi: 10.1111/ahg.12064. Epub 2014 Apr 26.
15 The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence.Biol Psychiatry. 2010 Jan 1;67(1):20-7. doi: 10.1016/j.biopsych.2009.08.019.
16 Stress-related genes and heroin addiction: a role for a functional FKBP5 haplotype.Psychoneuroendocrinology. 2014 Jul;45:67-76. doi: 10.1016/j.psyneuen.2014.03.017. Epub 2014 Apr 6.
17 GRK5 Is Associated with the Regulation of Methadone Dosage in Heroin Dependence.Int J Neuropsychopharmacol. 2018 Oct 1;21(10):910-917. doi: 10.1093/ijnp/pyy066.
18 N-acetylaspartylglutamate Inhibits Heroin Self-Administration and Heroin-Seeking Behaviors Induced by Cue or Priming in Rats.Neurosci Bull. 2017 Aug;33(4):396-404. doi: 10.1007/s12264-017-0140-3. Epub 2017 May 22.
19 Polymorphisms in the 5-hydroxytryptamine receptor 3B gene are associated with heroin dependence in the Chinese Han population.Neurosci Lett. 2016 Dec 2;635:123-129. doi: 10.1016/j.neulet.2016.10.033. Epub 2016 Oct 20.
20 Association of polymorphisms in the melanocortin receptor type 2 (MC2R, ACTH receptor) gene with heroin addiction.Neurosci Lett. 2008 Apr 25;435(3):234-9. doi: 10.1016/j.neulet.2008.02.042. Epub 2008 Feb 26.
21 Genetic polymorphisms of FADS1, FADS2, and FADS3 and fatty acid profiles in subjects received methadone maintenance therapy. Prostaglandins Leukot Essent Fatty Acids. 2018 Sep;136:117-121.
22 Expression of brain-derived neurotrophic factors, neurotrophin-3, and neurotrophin-4 in the nucleus accumbens during heroin dependency and withdrawal.Neuroreport. 2017 Aug 2;28(11):654-660. doi: 10.1097/WNR.0000000000000810.
23 Contribution of Genetic Polymorphisms and Haplotypes in DRD2, BDNF, and Opioid Receptors to Heroin Dependence and Endophenotypes Among the Han Chinese.OMICS. 2017 Jul;21(7):404-412. doi: 10.1089/omi.2017.0057.
24 TPH2 and TPH1: association of variants and interactions with heroin addiction.Behav Genet. 2008 Mar;38(2):133-50. doi: 10.1007/s10519-007-9187-7. Epub 2008 Jan 8.
25 Functional genetic variants that increase synaptic serotonin and 5-HT3 receptor sensitivity predict alcohol and drug dependence.Mol Psychiatry. 2011 Nov;16(11):1139-46. doi: 10.1038/mp.2010.94. Epub 2010 Sep 14.
26 Identification of novel risk loci with shared effects on alcoholism, heroin, and methamphetamine dependence.Mol Psychiatry. 2021 Apr;26(4):1152-1161. doi: 10.1038/s41380-019-0497-y. Epub 2019 Aug 28.
27 Synaptic Plasticity and Signal Transduction Gene Polymorphisms and Vulnerability to Drug Addictions in Populations of European or African Ancestry.CNS Neurosci Ther. 2015 Nov;21(11):898-904. doi: 10.1111/cns.12450. Epub 2015 Sep 19.
28 The evidence for the contribution of the autism susceptibility candidate 2 (AUTS2) gene in heroin dependence susceptibility.J Mol Neurosci. 2014 Dec;54(4):811-9. doi: 10.1007/s12031-014-0421-5. Epub 2014 Nov 15.
29 Genetic signatures of heroin addiction.Medicine (Baltimore). 2016 Aug;95(31):e4473. doi: 10.1097/MD.0000000000004473.
30 Association analysis of GABRB3 promoter variants with heroin dependence.PLoS One. 2014 Jul 15;9(7):e102227. doi: 10.1371/journal.pone.0102227. eCollection 2014.
31 Association between genetic variations of NMDA receptor NR3 subfamily genes and heroin addiction in male Han Chinese.Neurosci Lett. 2016 Sep 19;631:122-125. doi: 10.1016/j.neulet.2016.08.025. Epub 2016 Aug 16.
32 A heroin addiction severity-associated intronic single nucleotide polymorphism modulates alternative pre-mRNA splicing of the opioid receptor gene OPRM1 via hnRNPH interactions.J Neurosci. 2014 Aug 13;34(33):11048-66. doi: 10.1523/JNEUROSCI.3986-13.2014.
33 Weighted gene co-expression network analysis to explore the mechanism of heroin addiction in human nucleus accumbens.J Cell Biochem. 2020 Feb;121(2):1870-1879. doi: 10.1002/jcb.29422. Epub 2019 Nov 6.
34 Genetic association analyses and meta-analysis of Dynorphin-Kappa Opioid system potential functional variants with heroin dependence.Neurosci Lett. 2018 Oct 15;685:75-82. doi: 10.1016/j.neulet.2018.08.023. Epub 2018 Aug 20.
35 Proenkephalin mediates the enduring effects of adolescent cannabis exposure associated with adult opiate vulnerability.Biol Psychiatry. 2012 Nov 15;72(10):803-10. doi: 10.1016/j.biopsych.2012.04.026. Epub 2012 Jun 8.
36 Evidence for the contribution of genetic variations in regulator of G protein signaling 9 to the genetic susceptibility of heroin dependence.Mol Med Rep. 2015 May;11(5):3908-13. doi: 10.3892/mmr.2015.3210. Epub 2015 Jan 16.