Details of the Drug Combination

General Information of Drug Combination (ID: DCEOE6X)

Drug Combination Name
Bleomycin Dactinomycin
Indication
Disease Entry Status REF
High grade ovarian serous adenocarcinoma Investigative [1]
Component Drugs Bleomycin   DMNER5S Dactinomycin   DM2YGNW
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL is unavailable
High-throughput Screening Result Testing Cell Line: OVCAR-4
Zero Interaction Potency (ZIP) Score: 0.97
Bliss Independence Score: 3.82
Loewe Additivity Score: 3.33
LHighest Single Agent (HSA) Score: 3.35

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Bleomycin
Disease Entry ICD 11 Status REF
Cervical cancer 2C77.0 Approved [2]
Head and neck cancer 2D42 Approved [2]
Hodgkin lymphoma 2B30 Approved [3]
Penile cancer N.A. Approved [2]
Testicular germ cell tumor N.A. Approved [2]
Classic Hodgkin lymphoma N.A. Investigative [2]
Follicular lymphoma 2A80 Investigative [2]
Bleomycin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Breaker [10]
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Bleomycin Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Bleomycin hydrolase (BLMH) DECH1VP BLMH_HUMAN Metabolism [11]
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Bleomycin Interacts with 41 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Bleomycin hydrolase (BLMH) OT2QPWQJ BLMH_HUMAN Affects Response To Substance [12]
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Increases Expression [13]
Catalase (CAT) OTHEBX9R CATA_HUMAN Increases Expression [13]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Increases Expression [13]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Increases Expression [14]
Granulocyte-macrophage colony-stimulating factor (CSF2) OT1M7D28 CSF2_HUMAN Increases Expression [14]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [14]
C-X-C motif chemokine 2 (CXCL2) OTEJCYMY CXCL2_HUMAN Increases Expression [14]
Mucin-5AC (MUC5AC) OTJV8O04 MUC5A_HUMAN Increases Expression [14]
Proheparin-binding EGF-like growth factor (HBEGF) OTLU00JS HBEGF_HUMAN Increases Expression [14]
Transmembrane protein 250 (TMEM250) OTLJ4G5G TM250_HUMAN Increases Expression [6]
Suppressor of cytokine signaling 1 (SOCS1) OTWA9KFU SOCS1_HUMAN Decreases Expression [15]
Serine/threonine-protein kinase Chk2 (CHEK2) OT8ZPCNS CHK2_HUMAN Increases Phosphorylation [16]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Increases Expression [7]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Expression [17]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Expression [7]
Fibronectin (FN1) OTB5ZN4Q FINC_HUMAN Increases Expression [7]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Expression [18]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Expression [7]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [19]
Cathepsin S (CTSS) OT3PXIPM CATS_HUMAN Increases Expression [20]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Increases Phosphorylation [21]
Max-interacting protein 1 (MXI1) OTUQ9E0D MXI1_HUMAN Decreases Expression [6]
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Increases Expression [7]
Unconventional myosin-Ie (MYO1E) OTM9YSIZ MYO1E_HUMAN Decreases Expression [6]
Transcription intermediary factor 1-beta (TRIM28) OTE38OBF TIF1B_HUMAN Increases Phosphorylation [16]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Increases Phosphorylation [16]
Structural maintenance of chromosomes protein 1A (SMC1A) OT9ZMRK9 SMC1A_HUMAN Increases Phosphorylation [16]
7SK snRNA methylphosphate capping enzyme (MEPCE) OTRBQEYP MEPCE_HUMAN Increases Expression [6]
Transmembrane protein 87A (TMEM87A) OT8ATDVX TM87A_HUMAN Increases Expression [6]
Terminal nucleotidyltransferase 4B (TENT4B) OTUF6FWW PAPD5_HUMAN Decreases Expression [6]
Lipase member H (LIPH) OTRGYLKL LIPH_HUMAN Decreases Expression [6]
Abasic site processing protein HMCES (HMCES) OTVRDL6U HMCES_HUMAN Decreases Expression [6]
Small integral membrane protein 14 (SMIM14) OT47IF19 SIM14_HUMAN Decreases Expression [6]
Kelch-like protein 42 (KLHL42) OTK6WARI KLH42_HUMAN Increases Expression [6]
Inactive cell surface hyaluronidase CEMIP2 (CEMIP2) OT9I1XUO CEIP2_HUMAN Decreases Expression [6]
ERBB receptor feedback inhibitor 1 (ERRFI1) OT7VZ2IZ ERRFI_HUMAN Decreases Expression [6]
Transmembrane and coiled-coil domain protein 3 (TMCC3) OTAIQ6V6 TMCC3_HUMAN Decreases Expression [6]
Lactosylceramide alpha-2,3-sialyltransferase (ST3GAL5) OT27CCUF SIAT9_HUMAN Decreases Expression [6]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Decreases Response To Substance [22]
DNA cytosine-5)-methyltransferase 1 (DNMT1) OTM2DGTK DNMT1_HUMAN Affects Response To Substance [23]
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⏷ Show the Full List of 41 DOT(s)
Indication(s) of Dactinomycin
Disease Entry ICD 11 Status REF
Adult kidney Wilms tumor N.A. Approved [4]
Advanced cancer 2A00-2F9Z Approved [4]
Beckwith-Wiedemann syndrome N.A. Approved [4]
Childhood kidney Wilms tumor N.A. Approved [4]
Gestational trophoblastic neoplasia 2F33-2F76 Approved [4]
Hamartoma N.A. Approved [4]
Solid tumour/cancer 2A00-2F9Z Approved [5]
Wilms tumor N.A. Approved [4]
Dactinomycin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Breaker [27]
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Dactinomycin Interacts with 3 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [28]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [29]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [30]
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Dactinomycin Interacts with 85 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Decreases Response To Substance [31]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Response To Substance [32]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Increases Expression [24]
Dihydropyrimidinase-related protein 4 (DPYSL4) OT3SBS2S DPYL4_HUMAN Increases Expression [24]
Integral membrane protein GPR137B (GPR137B) OT1CINQQ G137B_HUMAN Increases Expression [24]
Integrin alpha-IIb (ITGA2B) OT4Y17PY ITA2B_HUMAN Increases Expression [24]
Ras-related protein R-Ras (RRAS) OTBBF28C RRAS_HUMAN Increases Expression [24]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [24]
Stomatin (STOM) OTC8R6EH STOM_HUMAN Increases Expression [24]
Cellular retinoic acid-binding protein 2 (CRABP2) OTY01V9G RABP2_HUMAN Increases Expression [24]
Tyrosine-protein kinase receptor UFO (AXL) OTKA2SUX UFO_HUMAN Increases Expression [24]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [24]
Tumor necrosis factor ligand superfamily member 9 (TNFSF9) OTV9L89D TNFL9_HUMAN Increases Expression [24]
Galectin-7 (LGALS7) OTMSVI7R LEG7_HUMAN Increases Expression [24]
Large ribosomal subunit protein eL34 (RPL34) OT0U9VMQ RL34_HUMAN Increases Expression [24]
Rho GDP-dissociation inhibitor 2 (ARHGDIB) OT9PD6CS GDIR2_HUMAN Increases Expression [24]
Epithelial membrane protein 1 (EMP1) OTSZHUHQ EMP1_HUMAN Increases Expression [24]
Epithelial membrane protein 3 (EMP3) OTODMJ1D EMP3_HUMAN Increases Expression [24]
Protein ripply3 (RIPPLY3) OT1HK35I DSCR6_HUMAN Increases Expression [24]
Endonuclease III-like protein 1 (NTHL1) OTPQXPT1 NTH_HUMAN Decreases Expression [24]
Antigen peptide transporter 1 (TAP1) OTJL27PW TAP1_HUMAN Increases Expression [24]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [24]
Kinesin-like protein KIF1A (KIF1A) OT3JVEGV KIF1A_HUMAN Increases Expression [24]
Protein AF1q (MLLT11) OTG5RVHC AF1Q_HUMAN Increases Expression [24]
Laminin subunit gamma-2 (LAMC2) OTJMTM72 LAMC2_HUMAN Increases Expression [24]
Filamin-C (FLNC) OT3F8J6Y FLNC_HUMAN Increases Expression [24]
Immediate early response gene 5 protein (IER5) OTJPTXMD IER5_HUMAN Increases Expression [24]
Keratin, type II cytoskeletal 80 (KRT80) OTAU54U3 K2C80_HUMAN Increases Expression [24]
All-trans-retinol 13,14-reductase (RETSAT) OTC3AOPX RETST_HUMAN Increases Expression [24]
Interleukin-27 receptor subunit alpha (IL27RA) OTSQBAKI I27RA_HUMAN Increases Expression [24]
Neuropilin and tolloid-like protein 2 (NETO2) OT0YAMC0 NETO2_HUMAN Increases Expression [24]
Mitochondria-eating protein (SPATA18) OTOEHTHU MIEAP_HUMAN Increases Expression [24]
Phospholipase ABHD3 (ABHD3) OTH8P977 ABHD3_HUMAN Increases Expression [24]
Homer protein homolog 3 (HOMER3) OTQ6D9X1 HOME3_HUMAN Increases Expression [24]
BSD domain-containing protein 1 (BSDC1) OT853CP9 BSDC1_HUMAN Increases Expression [24]
Stathmin-3 (STMN3) OT20F289 STMN3_HUMAN Increases Expression [24]
Endothelial protein C receptor (PROCR) OTRHED17 EPCR_HUMAN Increases Expression [24]
Fatty acid desaturase 3 (FADS3) OT9RVXGE FADS3_HUMAN Increases Expression [24]
Protein O-mannosyl-transferase 1 (POMT1) OTGQSHL5 POMT1_HUMAN Increases Expression [24]
Tissue factor (F3) OT3MSU3B TF_HUMAN Decreases Expression [33]
Tumor protein p53-inducible protein 11 (TP53I11) OTFPDYZU P5I11_HUMAN Decreases Expression [34]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Decreases Expression [35]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [36]
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) OTUXEASC M3K7_HUMAN Decreases Expression [37]
Prominin-1 (PROM1) OTBHV8NX PROM1_HUMAN Decreases Expression [38]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [37]
Low-density lipoprotein receptor (LDLR) OTH559LU LDLR_HUMAN Decreases Expression [39]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Response To Substance [40]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Decreases Expression [41]
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) OTBPMIMW G3P_HUMAN Increases Expression [37]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Activity [42]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Decreases Expression [43]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Secretion [41]
Proto-oncogene tyrosine-protein kinase ROS (ROS1) OTDSKUGE ROS1_HUMAN Increases Expression [37]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Decreases Expression [44]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Decreases Expression [45]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [46]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [47]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Decreases Expression [48]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Decreases Expression [49]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [38]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Decreases Expression [37]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Expression [37]
Lamin-B1 (LMNB1) OT100T3P LMNB1_HUMAN Decreases Expression [37]
rRNA 2'-O-methyltransferase fibrillarin (FBL) OTRODIE5 FBRL_HUMAN Affects Localization [50]
DNA-directed RNA polymerase II subunit RPB1 (POLR2A) OTHJQ1DZ RPB1_HUMAN Decreases Phosphorylation [51]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [52]
Signal transducer and activator of transcription 1-alpha/beta (STAT1) OTLMBUZ6 STAT1_HUMAN Increases Expression [37]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Decreases Expression [37]
Caspase-2 (CASP2) OTUDYSPP CASP2_HUMAN Increases Cleavage [53]
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) OTZPZX11 MP2K4_HUMAN Decreases Expression [37]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Decreases Expression [37]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Decreases Expression [54]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [55]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Expression [56]
Son of sevenless homolog 1 (SOS1) OTTCWXC3 SOS1_HUMAN Decreases Expression [37]
FAS-associated death domain protein (FADD) OTV7GFHH FADD_HUMAN Decreases Expression [37]
Growth arrest-specific protein 6 (GAS6) OTPOPUUE GAS6_HUMAN Increases Degradation [57]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Decreases Expression [37]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [47]
Proheparin-binding EGF-like growth factor (HBEGF) OTLU00JS HBEGF_HUMAN Decreases Expression [44]
Transcription factor SOX-17 (SOX17) OT9H4WWE SOX17_HUMAN Decreases Localization [58]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Decreases Expression [38]
Hyaluronidase-1 (HYAL1) OT2SJN0X HYAL1_HUMAN Increases ADR [59]
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) OTPYQX3K C1QBP_HUMAN Decreases Response To Substance [60]
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⏷ Show the Full List of 85 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Adult acute myeloid leukemia DCXYOZ9 HL-60(TB) Investigative [61]
Adult T acute lymphoblastic leukemia DC7ZZAT MOLT-4 Investigative [61]
Anaplastic large cell lymphoma DCH479N SR Investigative [61]
Astrocytoma DC175PE SNB-19 Investigative [61]
Childhood T acute lymphoblastic leukemia DCA3W4I CCRF-CEM Investigative [61]
Chronic myelogenous leukemia DCQN99X K-562 Investigative [61]
Glioma DCN9NG6 SF-539 Investigative [61]
Glioma DCZZOSY SF-268 Investigative [61]
Plasma cell myeloma DCFGECB RPMI-8226 Investigative [61]
Breast adenocarcinoma DCSZH1K MDA-MB-468 Investigative [62]
Carcinoma DCPTL03 RXF 393 Investigative [62]
Colon adenocarcinoma DC8GBTZ COLO 205 Investigative [62]
Adenocarcinoma DCYBE7C SW-620 Investigative [1]
Adenocarcinoma DCP9DDC HCT116 Investigative [1]
Adenocarcinoma DCQZ2UE HCT-15 Investigative [1]
High grade ovarian serous adenocarcinoma DCGIMQP OVCAR-5 Investigative [1]
High grade ovarian serous adenocarcinoma DCLVSGQ OVCAR-8 Investigative [1]
Large cell lung carcinoma DCA5K57 NCI-H460 Investigative [1]
Lung adenocarcinoma DC43V2C HOP-62 Investigative [1]
Lung adenocarcinoma DCGRZJ3 NCI-H522 Investigative [1]
Malignant melanoma DCSTT63 LOX IMVI Investigative [1]
Melanoma DCSUD22 SK-MEL-2 Investigative [1]
Melanoma DCUTRBN MALME-3M Investigative [1]
Mixed endometrioid and clear cell carcinoma DC96W2W IGROV1 Investigative [1]
Ovarian serous cystadenocarcinoma DCZ87XA SK-OV-3 Investigative [1]
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⏷ Show the Full List of 25 DrugCom(s)

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