Details of the Drug Combination

General Information of Drug Combination (ID: DCZL2D8)

• Drug Combination Name: Imipenem + Idarubicin
• Indication: Glioblastoma?; Status: Investigative [1]
• Component Drugs:
  Imipenem (DMI9FBP): Small molecular drug
  Idarubicin (DMM0XGL): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: T98G
  Zero Interaction Potency (ZIP) Score: 3.74
  Bliss Independence Score: 3.74
  Loewe Additivity Score: 0.98
  LHighest Single Agent (HSA) Score: 0.98

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Imipenem

Disease Entry	ICD 11	Status	REF
Bacteremia	1A73	Approved	[2]
Bacterial infection	1A00-1C4Z	Approved	[3]
Endometritis	N.A.	Approved	[2]
Peritonitis	N.A.	Approved	[2]
Pelvic inflammatory disease	GA05	Investigative	[2]

Imipenem Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Bacterial Penicillin binding protein 2 (Bact mrdA)	TTHWB7G	MRDA_ECOLI	Binder	[6]

Imipenem Interacts with 17 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Beta-lactamase (blaB)	DEC3G7M	A0A1S7IV31_ENTAS	Metabolism	[7]
Beta-lactamase (blaB)	DE7IH52	AMPC_CITFR	Metabolism	[8]
AmpC beta-lactamase (ampC)	DERI7LO	A0A0H3KQ39_BURM1	Metabolism	[9]
Beta-lactamase (blaB)	DEYIEO5	AMPC_SERMA	Metabolism	[8]
Beta-lactamase (blaB)	DEBKS91	A0A1B1FBM9_ACIBA	Metabolism	[10]
Beta-lactamase (blaB)	DEUHIQS	A0A1S7IV31_ENTAS	Metabolism	[11]
Beta-lactamase (blaB)	DECWSA9	AMPC_MORMO	Metabolism	[12]
Carbapenemase (cphA)	DEB90AL	BLAB_AERHY	Metabolism	[13]
Carbapenemase (cphA)	DETRKSD	A0A3G1JAD7_ALCXX	Metabolism	[14]
Beta-lactamase (blaB)	DECB2MX	A0A1M5PLB6_9FLAO	Metabolism	[15]
Beta-lactamase (blaB)	DEEQ3RW	K0GG60_CITBR	Metabolism	[16]
Carbapenemase (cphA)	DEQ4LIN	Q8L1M8_9ENTR	Metabolism	[17]
Beta-lactamase (blaB)	DEQ0K5J	A0A223JZR3_9ENTR	Metabolism	[16]
Beta-lactamase (blaB)	DE7MYGB	A0A291NY45_PROSP	Metabolism	[8]
Carbapenemase (cphA)	DE9QNXV	A0A366EJX1_9ENTR	Metabolism	[18]
Beta-lactamase (blaB)	DEL6894	A0A2S8DM15_SHIBO	Metabolism	[16]
Beta-lactamase (blaB)	DE8KH4C	A0A3B7D7C4_9VIBR	Metabolism	[19]

Imipenem Interacts with 1 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Increases Activity	[20]

Indication(s) of Idarubicin

Disease Entry	ICD 11	Status	REF
Acute myelogenous leukaemia	2A41	Approved	[4]
Acute myeloid leukaemia	2A60	Approved	[5]
Adult acute monocytic leukemia	N.A.	Approved	[4]
Childhood acute megakaryoblastic leukemia	N.A.	Approved	[4]
Leukemia	N.A.	Approved	[4]

Idarubicin Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
DNA topoisomerase II (TOP2)	TT0IHXV	TOP2A_HUMAN; TOP2B_HUMAN	Modulator	[22]

Idarubicin Interacts with 3 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Multidrug resistance-associated protein 1 (ABCC1)	DTSYQGK	MRP1_HUMAN	Substrate	[23]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[24]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[24]

Idarubicin Interacts with 2 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Metabolism	[25]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Metabolism	[25]

Idarubicin Interacts with 9 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Estrogen receptor (ESR1)	OTKLU61J	ESR1_HUMAN	Decreases Activity	[21]
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Increases Expression	[26]
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Increases Activity	[21]
Natriuretic peptides B (NPPB)	OTSN2IPY	ANFB_HUMAN	Increases Expression	[27]
Peroxisome proliferator-activated receptor gamma (PPARG)	OTHMARHO	PPARG_HUMAN	Decreases Activity	[21]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Activity	[28]
Peroxisome proliferator-activated receptor delta (PPARD)	OTI4WTOP	PPARD_HUMAN	Decreases Activity	[21]
Potassium voltage-gated channel subfamily H member 2 (KCNH2)	OTZX881H	KCNH2_HUMAN	Decreases Activity	[29]
Bile acid receptor (NR1H4)	OTWZLPTB	NR1H4_HUMAN	Decreases Activity	[21]

References

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