Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0DQM5)

• Drug Name: Amlexanox Drug Info
• Synonyms: ANW; Amlenanox; Amlexanoxo; Amlexanoxum; Amoxanox; Aphthasol; Aptheal; Apthera; Elics; OraDisc; OraRinse; Solfa; Amlexanoxo [Spanish]; Amlexanoxum [Latin]; GlaxoSmithKline brand of amlexanox; OraDisc A; AA 673; CHX 3673; AA-673; Aphthasol (TN); CHX-3673; Solfa (TN); Amlexanox [USAN:INN:JAN]; Amlexanox (JAN/USAN/INN); 2-Amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3-b)pyridine-3-carboxylic acid; 2-amino-5-oxo-7-(propan-2-yl)-5H-chromeno[2,3-b]pyridine-3-carboxylic acid; 2-amino-5-oxo-7-propan-2-ylchromeno[2,3-b]pyridine-3-carboxylic acid; 2-amino-7-(1-methylethyl)-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid; 2-amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3b)pyridine-3-carboxylic acid

Indication

Disease Entry	ICD 11	Status	REF
Respiratory tract inflammation	CA07	Approved	[1]

• Therapeutic Class: Antiulcer Agents
• Cross-matching ID:
  PubChem CID: 2161
  ChEBI ID: CHEBI:31205
  CAS Number: CAS 68302-57-8
  TTD Drug ID: DM0DQM5
  ACDINA Drug ID: D00836

Molecule-Related Drug Atlas

Drug(s) Targeting Heat shock protein 90 alpha (HSP90A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cromoglicate	DM74LZK	Asthma	CA23	Approved	[2]
NVP-AUY922	DMTYXQF	Multiple myeloma	2A83	Phase 2	[5]
BIIB-021	DMPAJ41	Breast cancer	2C60-2C65	Phase 2	[6]
KW-2478	DMJGL72	Solid tumour/cancer	2A00-2F9Z	Phase 2	[7]
VER 50589	DMFLZPC	Breast cancer	2C60-2C65	Phase 2	[5]
Tanespimycin	DMNLQHK	Breast cancer	2C60-2C65	Phase 2	[8]
Efungumab	DMBHP56	Breast cancer	2C60-2C65	Phase 2	[9]
SNX-5422	DMIU0VP	Haematological malignancy	2B33.Y	Phase 1/2	[10]
PU3	DMJO0BP	Solid tumour/cancer	2A00-2F9Z	Phase 1	[5]
Debio 0932	DMWP3G1	Solid tumour/cancer	2A00-2F9Z	Phase 1	[11]

Drug(s) Affected By Glutathione peroxidase 1 (GPX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[12]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[13]
Selenium	DM25CGV	N. A.	N. A.	Approved	[14]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[19]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[20]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[22]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[24]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[25]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[26]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[26]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[24]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[27]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[13]

Drug(s) Affected By Serine/threonine-protein kinase TBK1 (TBK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[29]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[35]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[36]
Flavonoid derivative 1	DMCQP0B	N. A.	N. A.	Patented	[30]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[37]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Heat shock protein 90 alpha (HSP90A)	TT78R5H	HS90A_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Glutathione peroxidase 1 (GPX1)	OTE2O72Q	GPX1_HUMAN	Protein Interaction/Cellular Processes	[3]
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE)	OT5VYOSM	IKKE_HUMAN	Gene/Protein Processing	[4]
Regulator of nonsense transcripts 1	OTAIA3HP	RENT1_HUMAN	Protein Interaction/Cellular Processes	[3]
Serine/threonine-protein kinase TBK1 (TBK1)	OT1P06NV	TBK1_HUMAN	Gene/Protein Processing	[4]

References

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