Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5DMCH)

• Drug Name: Ro-4396686 Drug Info
• Synonyms: SCHEMBL5809947; CHEMBL606964

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 11396738
  TTD Drug ID: DM5DMCH

Molecule-Related Drug Atlas

Drug(s) Targeting Fyn tyrosine protein kinase (FYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[2]
JNJ-26483327	DMSQ3AZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
PMID15546730C2	DMOPUIH	Discovery agent	N.A.	Investigative	[4]
CEP-5104	DMV43GY	Discovery agent	N.A.	Investigative	[5]
CEP-6331	DMNXBTD	Discovery agent	N.A.	Investigative	[5]
JNJ-10198409	DM9GDP5	Discovery agent	N.A.	Investigative	[6]
1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane	DMD7WNV	Discovery agent	N.A.	Investigative	[7]

Drug(s) Targeting PRKACA messenger RNA (PRKACA mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VFEDEOUBYBLDKN-AAFJCEBUSA-N	DMH9ION	N. A.	N. A.	Patented	[8]
XHPNYYOUZWOWNT-PYUWXLGESA-N	DM5Q93Y	N. A.	N. A.	Patented	[8]
AGGGWZCOULSEER-PYUWXLGESA-N	DM2L83Y	N. A.	N. A.	Patented	[8]
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[9]
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol	DMSKJ1X	Discovery agent	N.A.	Investigative	[10]
NM-PP1	DMS8H5Q	Discovery agent	N.A.	Investigative	[11]
ISIS 102633	DMWT7BK	Discovery agent	N.A.	Investigative	[12]
ISIS 102604	DMZ6X9B	Discovery agent	N.A.	Investigative	[12]
ISIS 102619	DMXH9IT	Discovery agent	N.A.	Investigative	[12]
ISIS 102462	DMXNC0B	Discovery agent	N.A.	Investigative	[12]

Drug(s) Targeting FGFR4 messenger RNA (FGFR4 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS-FGFR4	DMNVZDT	Obesity	5B81	Phase 2	[13]
FGF401	DMWEJ0C	Hepatocellular carcinoma	2C12.02	Phase 1/2	[14]
H3B-6527	DMAYTRK	Hepatocellular carcinoma	2C12.02	Phase 1	[14]
BLU-554	DM27J3D	Hepatocellular carcinoma	2C12.02	Phase 1	[14]
PD-0183812	DMWYP86	Retinoblastoma	2D02.2	Terminated	[15]

Drug(s) Targeting Fibroblast growth factor receptor 1 (FGFR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[16]
Intedanib	DMSTA36	Colorectal cancer	2B91.Z	Approved	[17]
Pemigatinib	DM819JF	Cholangiocarcinoma	2C12.10	Approved	[18]
Infigratinib	DMNKBEC	Cholangiocarcinoma	2C12.10	Approved	[19]
E-3810	DM42PFT	Solid tumour/cancer	2A00-2F9Z	Phase 3	[20]
Sulfatinib	DMPOTM4	Neuroendocrine cancer	2B72.1	Phase 3	[21]
ARQ-087	DM02BVQ	Intrahepatic cholangiocarcinoma	2C12.10	Phase 3	[22]
AZD4547	DM3827C	Solid tumour/cancer	2A00-2F9Z	Phase 2/3	[23]
Debio 1347	DMZW50O	Solid tumour/cancer	2A00-2F9Z	Phase 2	[14]
AM-001	DMGVQI8	Actinic keratosis	EK90.0	Phase 2	[24]

Drug(s) Targeting Platelet-derived growth factor receptor alpha (PDGFRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[25]
Ripretinib	DM958QB	Gastrointestinal stromal tumour	2B5B	Approved	[26]
Olaratumab	DMNYOIX	Soft tissue sarcoma	2B57	Approved	[27]
Avapritinib	DMK2GZX	Gastrointestinal stromal tumour	2B5B	Approved	[28]
E-3810	DM42PFT	Solid tumour/cancer	2A00-2F9Z	Phase 3	[20]
CP-868596	DMZIM37	Gastrointestinal cancer	2C11	Phase 3	[29]
Famitinib	DMSFWT7	Solid tumour/cancer	2A00-2F9Z	Phase 2	[30]
XL-820	DMMHX9K	Solid tumour/cancer	2A00-2F9Z	Phase 2	[31]
MP470	DMELUAK	Solid tumour/cancer	2A00-2F9Z	Phase 2	[32]
MEDI-575	DMI9WVM	Glioblastoma multiforme	2A00.0	Phase 2	[33]

Drug(s) Targeting Fibroblast growth factor receptor 2 (FGFR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pemigatinib	DM819JF	Cholangiocarcinoma	2C12.10	Approved	[18]
Interferon Alfa-2a, Recombinant	DMUTZ8S	Chronic HCV-1 infection	1E51.1	Approved	[34]
Palifermin	DM9JOYP	Oral mucositis	DA01.11	Approved	[35]
E-3810	DM42PFT	Solid tumour/cancer	2A00-2F9Z	Phase 3	[20]
Trafermin	DMLKI2B	Periodontitis	DA0C	Phase 3	[36]
Debio 1347	DMZW50O	Solid tumour/cancer	2A00-2F9Z	Phase 2	[14]
LY2874455	DMZ0DMY	Solid tumour/cancer	2A00-2F9Z	Phase 2	[37]
MK-2461	DM21WBH	Alzheimer disease	8A20	Phase 1/2	[38]
AEE-788	DMEOS5K	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[2]
BAY1179470	DM7L91K	Solid tumour/cancer	2A00-2F9Z	Phase 1	[39]

Drug(s) Targeting Extracellular signal-regulated kinase 2 (ERK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BVD-523	DMNB4XK	Melanoma	2C30	Phase 2	[40]
HH2710	DM0C5MV	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[41]
ASTX029	DMVZXIA	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[42]
VAN-10-4-eluting stent	DM3ZW6A	Artery stenosis	BD52	Phase 1	[43]
GDC-0994	DMFC2OY	Solid tumour/cancer	2A00-2F9Z	Phase 1	[44]
JSI-1187	DMVJWBS	Solid tumour/cancer	2A00-2F9Z	Phase 1	[45]
LY3214996	DMFDAY7	Solid tumour/cancer	2A00-2F9Z	Phase 1	[14]
CHIR-99021	DMB8MNU	Allergic inflammation	4A80-4A85	Patented	[46]
COR-D	DMLXMCB	T-cell leukaemia	2A90	Preclinical	[47]
SB220025	DMSBUET	Arthritis	FA20	Terminated	[7]

Drug(s) Targeting Platelet-derived growth factor receptor beta (PDGFRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[48]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[25]
Becaplermin	DM1R5X4	Diabetic complication	5A2Y	Approved	[49]
E-3810	DM42PFT	Solid tumour/cancer	2A00-2F9Z	Phase 3	[20]
Famitinib	DMSFWT7	Solid tumour/cancer	2A00-2F9Z	Phase 2	[30]
XL-820	DMMHX9K	Solid tumour/cancer	2A00-2F9Z	Phase 2	[31]
MK-2461	DM21WBH	Alzheimer disease	8A20	Phase 1/2	[38]
SNN-0031	DM2X3BR	Brain injury	NA07.Z	Phase 1/2	[50]
TAK-593	DMNFZOT	Solid tumour/cancer	2A00-2F9Z	Phase 1	[51]
Pyridine derivative 18	DMBZMYT	N. A.	N. A.	Patented	[52]

Drug(s) Targeting Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[53]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[54]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[55]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[56]
Vandetanib	DMRICNP	Solid tumour/cancer	2A00-2F9Z	Approved	[2]
Dacomitinib	DMOH8VY	Non-small-cell lung cancer	2C25.Y	Approved	[57]
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[58]
SKI-758	DMQ8E9R	Ischemia	8B10-8B11	Approved	[59]
Epidermal growth factor	DMVONE6	Vulnerary	ND56.Z	Approved	[57]
Merimepodib	DM0HS92	Breast cancer	2C60-2C65	Approved	[60]

Drug(s) Targeting cAMP protein kinase type II-beta (PRKAR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[9]
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol	DMSKJ1X	Discovery agent	N.A.	Investigative	[10]
[3H]cAMP	DMZRQU7	Discovery agent	N.A.	Investigative	[7]
AdoC(Dpr)2AlaArg6	DM2TWSZ	Discovery agent	N.A.	Investigative	[61]
AdcAhxArg4NH(CH2)6NH2	DMSYMRJ	Discovery agent	N.A.	Investigative	[62]
AdcAhxArg4Lys-PEGOMe	DMQ2C8X	Discovery agent	N.A.	Investigative	[62]
AdoC(GABA)Arg6	DMMWNPT	Discovery agent	N.A.	Investigative	[61]
AdcAhxArg4Lys(biotin)-PEG-OMe	DMZYJHV	Discovery agent	N.A.	Investigative	[62]
AdoC(Aun)Arg6	DMDLHAB	Discovery agent	N.A.	Investigative	[61]
AdoCGlyArg6	DMVQJP0	Discovery agent	N.A.	Investigative	[61]

Drug(s) Targeting Vascular endothelial growth factor receptor 2 (KDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[48]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[16]
Regorafenib	DMHSY1I	Gastrointestinal stromal tumour	2B5B	Approved	[63]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[64]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[65]
Vandetanib	DMRICNP	Solid tumour/cancer	2A00-2F9Z	Approved	[2]
Pazopanib HCl	DM6U9CQ	Renal cell carcinoma	2C90	Approved	[66]
Fruquintinib	DMHOSCQ	Colorectal cancer	2B91.Z	Approved	[67]
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[68]
Tivozanib	DMUKC5L	Renal cell carcinoma	2C90	Approved	[69]

Drug(s) Targeting Fungal Protein kinase A (Fung ypkA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[9]
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol	DMSKJ1X	Discovery agent	N.A.	Investigative	[10]
PMID20005102C1	DMMESBW	Discovery agent	N.A.	Investigative	[70]
[3H]cAMP	DMZRQU7	Discovery agent	N.A.	Investigative	[71]
PMID19364658C33	DMSE1C3	Discovery agent	N.A.	Investigative	[72]
BX-912	DMZA45C	Discovery agent	N.A.	Investigative	[73]
BX-795	DMRIMLJ	Discovery agent	N.A.	Investigative	[73]
chelerythrine	DMCP1G9	Discovery agent	N.A.	Investigative	[74]
PMID21742770C1	DME3JMH	Discovery agent	N.A.	Investigative	[75]
Rp-adenosine 3',5'-cyclic monophosphothioate triethylamine (Rp-cAMPS)	DM1JWGH	Discovery agent	N.A.	Investigative	[76]

Drug(s) Targeting Fibroblast growth factor receptor 3 (FGFR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pemigatinib	DM819JF	Cholangiocarcinoma	2C12.10	Approved	[18]
Trapidil	DMY67U8	Acute coronary syndrome	BA41	Phase 4	[77]
E-3810	DM42PFT	Solid tumour/cancer	2A00-2F9Z	Phase 3	[20]
TKI258	DMYLT67	Renal cell carcinoma	2C90	Phase 3	[2]
BMS-582664	DMDAN8H	Hepatocellular carcinoma	2C12.02	Phase 3	[2]
Debio 1347	DMZW50O	Solid tumour/cancer	2A00-2F9Z	Phase 2	[14]
B-701	DMOMDA4	Bladder cancer	2C94	Phase 2	[78]
Recifercept	DML8N3Y	Achondroplasia	LD24.00	Phase 2	[79]
MK-2461	DM21WBH	Alzheimer disease	8A20	Phase 1/2	[38]
AEE-788	DMEOS5K	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[2]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
cAMP protein kinase type II-beta (PRKAR2B)	TTW4Y2M	KAP3_HUMAN	Inhibitor	[1]
Epidermal growth factor receptor (EGFR)	TTGKNB4	EGFR_HUMAN	Inhibitor	[1]
Extracellular signal-regulated kinase 2 (ERK2)	TT4TQBX	MK01_HUMAN	Inhibitor	[1]
FGFR4 messenger RNA (FGFR4 mRNA)	TT1KX2S	FGFR4_HUMAN	Inhibitor	[1]
Fibroblast growth factor receptor 1 (FGFR1)	TTRLW2X	FGFR1_HUMAN	Inhibitor	[1]
Fibroblast growth factor receptor 2 (FGFR2)	TTGJVQM	FGFR2_HUMAN	Inhibitor	[1]
Fibroblast growth factor receptor 3 (FGFR3)	TTST7KB	FGFR3_HUMAN	Inhibitor	[1]
Fungal Protein kinase A (Fung ypkA)	TTYVI76	Q56921_YEREN	Inhibitor	[1]
Fyn tyrosine protein kinase (FYN)	TT2B9KF	FYN_HUMAN	Inhibitor	[1]
Platelet-derived growth factor receptor alpha (PDGFRA)	TT8FYO9	PGFRA_HUMAN	Inhibitor	[1]
Platelet-derived growth factor receptor beta (PDGFRB)	TTI7421	PGFRB_HUMAN	Inhibitor	[1]
PRKACA messenger RNA (PRKACA mRNA)	TT5U49F	KAPCA_HUMAN	Inhibitor	[1]
Vascular endothelial growth factor receptor 2 (KDR)	TTUTJGQ	VGFR2_HUMAN	Inhibitor	[1]

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