Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5MUNG)

• Drug Name: PMID30124346-Compound-LDT8 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Benign prostatic hyperplasia	GA90	Patented	[1]

• Cross-matching ID: TTD Drug ID: DM5MUNG

Molecule-Related Drug Atlas

Drug(s) Targeting 5-HT 2A receptor (HTR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[2]
ZOTEPINE	DMF3VXA	Anxiety disorder	6B00-6B0Z	Approved	[3]
Iloperidone	DM6AUFY	Schizophrenia	6A20	Approved	[4]
Flibanserin	DM70DTN	Depression	6A70-6A7Z	Approved	[5]
Lurasidone hydrochloride	DMCVPXO	Schizophrenia	6A20	Approved	[6]
Aniracetam	DMOIFW0	Cerebrovascular ischaemia	8B1Z	Approved	[7]
lumateperone tosylate	DMQ8HOJ	Schizophrenia	6A20	Approved	[8]
Sarpogrelate	DMGLP6S	Diabetic complication	5A2Y	Approved	[9]
Pimavanserin	DMR7IVC	Parkinson disease	8A00.0	Approved	[10]
Zicronapine	DMP8ESD	Schizophrenia	6A20	Phase 3	[11]

Drug(s) Targeting Adrenergic receptor alpha-1D (ADRA1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxazosin	DM9PLRH	Benign prostatic hyperplasia	GA90	Approved	[12]
Armodafinil	DMGB035	Malignant glioma	2A00.0	Approved	[13]
Alfuzosin	DMZVMKF	Benign prostatic hyperplasia	GA90	Approved	[14]
Moxisylyte	DMFCLYW	Erectile dysfunction	HA01.1	Approved	[15]
Terazosin	DM3JCVS	Benign prostatic hyperplasia	GA90	Approved	[16]
Bunazosin	DM4I8O7	Glaucoma/ocular hypertension	9C61	Approved	[17]
Trimazosin	DM1QLST	Congestive heart failure	BD10	Approved	[18]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[19]
DL-017	DMM8GZT	Hypertension	BA00-BA04	Phase 1	[20]
PMID30124346-Compound-LDT66	DMJMTNL	Benign prostatic hyperplasia	GA90	Patented	[1]

Drug(s) Targeting 5-HT 1A receptor (HTR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[21]
Buspirone	DMBS632	Anxiety disorder	6B00-6B0Z	Approved	[22]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[23]
Vilazodone	DM4LECQ	Major depressive disorder	6A70.3	Approved	[24]
Flibanserin	DM70DTN	Depression	6A70-6A7Z	Approved	[5]
Gepirone	DMGX5Q0	Major depressive disorder	6A70.3	Approved	[25]
TERTATOLOL	DM2L3D5	Hypertension	BA00-BA04	Approved	[26]
Urapidil	DMD59GI	Hypertension	BA00-BA04	Approved	[27]
Treximet	DMU54QB	Migraine	8A80	Approved	[28]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[29]

Drug(s) Targeting Adrenergic receptor alpha-1A (ADRA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SILODOSIN	DMJSBT6	Benign prostatic hyperplasia	GA90	Approved	[30]
NAFTOPIDIL	DMQ8R4E	Hypertension	BA00-BA04	Approved	[30]
Tamsulosin	DM5QF9V	Benign prostatic hyperplasia	GA90	Approved	[21]
Xatral	DMLHOA0	Benign prostatic hyperplasia	GA90	Approved	[31]
Dutasteride + tamsulosin	DM6P8HU	Benign prostatic hyperplasia	GA90	Phase 3	[28]
Besipirdine	DMLVNTA	Cognitive impairment	6D71	Phase 3	[32]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[19]
PMID30124346-Compound-LDT66	DMJMTNL	Benign prostatic hyperplasia	GA90	Patented	[1]
TIOSPIRONE	DME5QDP	N. A.	N. A.	Discontinued in Phase 3	[33]
Sunepitron	DM6M8ZX	N. A.	N. A.	Discontinued in Phase 3	[34]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Antagonist	[1]
5-HT 2A receptor (HTR2A)	TTJQOD7	5HT2A_HUMAN	Antagonist	[1]
Adrenergic receptor alpha-1A (ADRA1A)	TTNGILX	ADA1A_HUMAN	Antagonist	[1]
Adrenergic receptor alpha-1D (ADRA1D)	TT34BHT	ADA1D_HUMAN	Antagonist	[1]

References

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