Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6EIZG)

• Drug Name: BIM23A760 Drug Info
• Synonyms: Lonapalene; LONAPALENE; RS-43179; 91431-42-4; UNII-WIF31Q54NJ; WIF31Q54NJ; CHEMBL36648; Lonapalenum; Lonapaleno; Lonapalenum [Latin]; Lonapaleno [Spanish]; Lonapalene (USAN); Lonapalene [USAN:INN]; RS 43179; 6-Chloro-2,3-dimethoxy-1,4-naphthalenediol diacetate; (4-acetyloxy-6-chloro-2,3-dimethoxynaphthalen-1-yl) acetate; AC1L1KN9; SCHEMBL120134; ZINC1630; DTXSID00238563; IFWMVQUGSGWCRP-UHFFFAOYSA-N; HY-U00156; BDBM50004677; CS-7197; ZB000377; D04770; 6-chloro-1,4-diacetoxy-2,3-dimethoxynaphthalene

Indication

Disease Entry	ICD 11	Status	REF
Acromegaly	5A60.0	Phase 2	[1]
Carcinoid syndrome	5B10	Phase 2	[1]
Psoriasis vulgaris	EA90	Discontinued in Phase 3	[2]

• Cross-matching ID:
  PubChem CID: 56237
  CAS Number: CAS 91431-42-4
  TTD Drug ID: DM6EIZG

Molecule-Related Drug Atlas

Drug(s) Targeting Arachidonate 5-lipoxygenase (5-LOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[5]
Diethylcarbamazine	DM1TJ8F	Elephantiasis		Approved	[6]
Silymarin	DMXBYQR	N. A.	N. A.	Phase 4	[7]
3,4-Dihydroxycinnamic Acid	DMVZL26	Thrombocytopenia	3B64	Phase 4	[8]
Avastin+/-Tarceva	DMA86FL	Non-small-cell lung cancer	2C25.Y	Phase 3	[9]
ABT-761	DM3FIC2	Asthma	CA23	Phase 3	[10]
Tenidap	DMHQRYE	Rheumatoid arthritis	FA20	Phase 3	[11]
FPL-62064	DMGF8MZ	Inflammation	1A00-CA43.1	Phase 3	[12]
Flobufen	DMPSG4D	Rheumatoid arthritis	FA20	Phase 3	[13]
Darbufelone	DMYVKM5	Asthma	CA23	Phase 2/3	[14]

Drug(s) Targeting Dopamine D2 receptor (D2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[15]
Haloperidol	DM96SE0	Delirium		Approved	[16]
Perphenazine	DMA4MRX	Schizophrenia	6A20	Approved	[17]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[18]
Domperidone	DMBDPY0	Gastrointestinal disease	DE2Z	Approved	[19]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[20]
Quetiapine	DM1N62C	Anorexia nervosa cachexia	6B80	Approved	[21]
Pimozide	DMW83TP	Schizophrenia	6A20	Approved	[22]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[23]
Iloperidone	DM6AUFY	Schizophrenia	6A20	Approved	[24]

Drug(s) Affected By Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[25]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[27]
Fructose	DM43AN2	Vomiting	MD90	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[33]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[34]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 5-lipoxygenase (5-LOX)	TT2J34L	LOX5_HUMAN	Inhibitor	[3]
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Modulator	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)	OT7FOIK2	LOX5_HUMAN	Gene/Protein Processing	[4]

References

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