Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDFRTI)

• Drug Name: Deamido-NAD Drug Info
• Synonyms: Nicotinic acid adenine dinucleotide sodium salt; 104809-30-5; Nicotinic acid adenine dinucleotide sodium salt, &gt
• Cross-matching ID:
  PubChem CID: 165491
  ChEBI ID: CHEBI:18304
  CAS Number: CAS 6450-77-7
  TTD Drug ID: DMDFRTI

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial Nicotinate-nucleotide adenylyltransferase (Bact nadD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DZ9	DM2HLGC	N. A.	N. A.	Patented	[3]
AC1LJNG0	DM9Q0EC	N. A.	N. A.	Patented	[3]
STK696827	DM19GAY	N. A.	N. A.	Patented	[3]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[4]

Drug(s) Affected By Mucin-2 (MUC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[5]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[6]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[8]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[9]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[11]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[12]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[13]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[14]

Drug(s) Affected By Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[6]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[18]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[17]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[19]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[15]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[20]
Nicotinamide mononucleotide	DMW1LKP	N. A.	N. A.	Preclinical	[2]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Nicotinate-nucleotide adenylyltransferase (Bact nadD)	TT1NFO3	NADD_ECOLI	Binder	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Mucin-2 (MUC2)	OT3X4QVX	MUC2_HUMAN	Gene/Protein Processing	[2]
Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1)	OTO3RO36	GALT1_HUMAN	Gene/Protein Processing	[2]

References

• [1] Crystal structures of E. coli nicotinate mononucleotide adenylyltransferase and its complex with deamido-NAD. Structure. 2002 Jan;10(1):69-79.
• [2] Oxyresveratrol stimulates mucin production in an NAD+-dependent manner in human intestinal goblet cells. Food Chem Toxicol. 2018 Aug;118:880-888.
• [3] Targeting NAD biosynthesis in bacterial pathogens. US8785499.
• [4] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [5] Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
• [6] Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
• [7] Induction of differentiation and peroxisome proliferator-activated receptor gamma expression in colon cancer cell lines by troglitazone. J Cancer Res Clin Oncol. 2004 Feb;130(2):73-9. doi: 10.1007/s00432-003-0510-2. Epub 2003 Nov 21.
• [8] Induction of the cytochrome P450 gene CYP26 during mucous cell differentiation of normal human tracheobronchial epithelial cells. Mol Pharmacol. 2000 Sep;58(3):483-90.
• [9] Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
• [10] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [11] Time dependent impact of copper oxide nanomaterials on the expression of genes associated with oxidative stress, metal binding, inflammation and mucus secretion in single and co-culture intestinal in vitro models. Toxicol In Vitro. 2021 Aug;74:105161. doi: 10.1016/j.tiv.2021.105161. Epub 2021 Apr 9.
• [12] Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
• [13] Inorganic arsenic exposure promotes malignant progression by HDAC6-mediated down-regulation of HTRA1. J Appl Toxicol. 2023 Aug;43(8):1214-1224. doi: 10.1002/jat.4457. Epub 2023 Mar 11.
• [14] Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
• [15] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [16] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [17] Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
• [18] Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell. 2004 Mar;15(3):1262-72. doi: 10.1091/mbc.e03-06-0360. Epub 2003 Dec 29.
• [19] Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
• [20] Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.