Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME1LQN)

Drug Name
Streptomycin Drug Info
Synonyms
Agrept; Agrimycin; Gerox; Neodiestreptopab; SRY; Strepcen; Streptomicina; Streptomycine; Streptomycinum; Streptomyzin; Liposomal Streptomycin; Streptomicina [Italian]; Streptomycin A; Streptomycin A sulfate; Streptomycin Sesquisulfate Hydrate; Streptomycin sulfate; Streptomycin sulphate; Streptomyzin [German]; Agrept (TN); Estreptomicina [INN-Spanish]; Hokko-mycin; Plantomycin (TN); Rimosidin (TN); Streptomycin & EEP; Streptomycin & Propolis; Streptomycin (INN); Streptomycin (TN); Streptomycin [INN:BAN]; Streptomycin, Sulfate Salt; AS-50 (TN); STREPTOMYCIN SULFATE (2:3) SALT; Agri-mycin-17 (TN); O-2-Deoxy-2-(methylamino)-.alpha.-L-glucopyranosyl-(1->2)-O-5-deoxy-3-C-formyl-.alpha.-L-lyxofuranosyl-(1->4)-N,N'-bis(aminoiminomethyl)-D-streptamine and Liposome; N,N'''-[(1R,2R,3S,4R,5R,6S)-4-{5-deoxy-2-O-[2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl]-3-C-formyl-alpha-L-lyxofuranosyloxy}-2,5,6-trihydroxycyclohexane-1,3-diyl]diguanidine; N,N'''-[(1R,2R,3S,4R,5R,6S)-4-({5-deoxy-2-O-[2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl]-3-C-formyl-alpha-L-lyxofuranosyl}oxy)-2,5,6-trihydroxycyclohexane-1,3-diyl]diguanidine; 2,4-Diguanidino-3,5,6-trihydroxycyclohexyl 5-deoxy-2-O-(2-deoxy-2-methylamino-alpha-L-glucopyranosyl)-3-C-formyl-beta-L-lyxopentanofuranoside; 2-[(1R,2R,3S,4R,5R,6S)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine; 2-[(1R,2R,3S,4R,5R,6S)-3-(diaminomethylideneamino)-4-[(2S,3S,4S,5R)-3-[(2R,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine; 2-[(1S,2S,3R,4S,5S,6R)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine; 2-[(1S,4S)-5-(diaminomethylideneamino)-2-[(2R,5S)-3-[(2S,5R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy-3,4,6-trihydroxycyclohexyl]guanidine; [2-deoxy-2-(dimethylamino)-alpha-L-glucopyranosyl]-(1->2)-[5-deoxy-3-C-formyl-alpha-L-lyxofuranosyl]-(1->4)-{N',N'''-[(1,3,5/2,4,6)-2,4,5,6-tetrahydroxycyclohexane-1,3-diyl]diguanidine}
Indication
Disease Entry ICD 11 Status REF
Bacterial infection 1A00-1C4Z Approved [1]
Brucellosis Approved [2]
Chancroid Approved [2]
Pulmonary tuberculosis 1B10.Z Approved [2]
Tularemia 1B94 Approved [2]
Plague Investigative [2]
Therapeutic Class
Antibiotics
Cross-matching ID
PubChem CID
19649
ChEBI ID
CHEBI:17076
CAS Number
CAS 57-92-1
TTD Drug ID
DME1LQN

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Staphylococcus 30S ribosomal subunit (Stap-coc pbp2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tetracycline DMZA017 Acne vulgaris ED80 Approved [8]
Framycetin DMF8DNE Acute liver failure DB91 Approved [9]
Netilmicin DMRD1QK Bacterial infection 1A00-1C4Z Approved [10]
Amikacin DM5PDRB Bacteremia 1A73 Approved [11]
Clomocycline DM0ZRMQ Bacterial infection 1A00-1C4Z Approved [12]
Spectinomycin DM0MQ35 Acute gonococcal cervicitis Approved [3]
Paromomycin DM1AGXN Amoebiasis 1A36 Approved [13]
Lymecycline DMOMLHJ Bacterial infection 1A00-1C4Z Approved [14]
Rolitetracycline DMBR5Q7 Acne vulgaris ED80 Approved [15]
Meclocycline DMSFQ8I Bacterial infection 1A00-1C4Z Approved [16]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Aminoglycoside O-phosphotransferase (aphA6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gentamicin DMKINJO Bacteremia 1A73 Approved [4]
Tobramycin DMUI0CH Bacteremia 1A73 Approved [4]
Framycetin DMF8DNE Acute liver failure DB91 Approved [4]
Netilmicin DMRD1QK Bacterial infection 1A00-1C4Z Approved [4]
Amikacin DM5PDRB Bacteremia 1A73 Approved [4]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [4]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Metabolized By Aminoglycoside adenylyltransferase (aadA1a)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Spectinomycin DM0MQ35 Acute gonococcal cervicitis Approved [5]
Drug(s) Metabolized By Endoglucanase Y (EGY)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gentamicin DMKINJO Bacteremia 1A73 Approved [7]
Colistin DMMD9QE Pseudomonas infection 1B92 Approved [7]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [7]
Bacitracin DM5OHYE Blepharoconjunctivitis Approved [7]
Gentamicin DMKINJO Bacteremia 1A73 Approved [7]
Amikacin DM5PDRB Bacteremia 1A73 Approved [7]
Colistin DMMD9QE Pseudomonas infection 1B92 Approved [7]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [7]
⏷ Show the Full List of 8 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) TTQ8KVI F4NA87_STAAU Binder [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Aminoglycoside O-phosphotransferase (aphA6) DEWPAJD KKA6_ACIBA Substrate [4]
Aminoglycoside adenylyltransferase (aadA1a) DEYWTIQ Q6YLD2_SALER Substrate [5]
Phosphotransferase enzyme strB (strB) DEXCHR2 Q57204_ERWAM Substrate [6]
Endoglucanase Y (EGY) DE2M583 A0A256VAC0_LACRE Substrate [7]
Endoglucanase Y (EGY) DE2AZTG A0A256VAC0_LACRE Substrate [7]
Phosphotransferase enzyme strA (strA) DEMVXEA Q79DN3_ERWAM Substrate [6]

References

1 Emerging drugs for chemotherapy-induced mucositis. Expert Opin Emerg Drugs. 2008 Sep;13(3):511-22.
2 Streptomycin FDA Label
3 Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature. 2000 Sep 21;407(6802):340-8.
4 Relationship between antimicrobial resistance and aminoglycoside-modifying enzyme gene expressions in Acinetobacter baumannii. Chin Med J (Engl). 2005 Jan 20;118(2):141-5.
5 Structural mechanism of AadA, a dual-specificity aminoglycoside adenylyltransferase from Salmonella enterica. J Biol Chem. 2018 Jul 20;293(29):11481-11490.
6 Genetic analysis of streptomycin-resistant (Sm(R)) strains of Erwinia amylovora suggests that dissemination of two genotypes is responsible for the current distribution of Sm(R) E. amylovora in Michigan. Phytopathology. 2011 Feb;101(2):182-91.
7 Expression of Clostridium thermocellum endoglucanase gene in Lactobacillus gasseri and Lactobacillus johnsonii and characterization of the genetically modified probiotic lactobacilli. Curr Microbiol. 2000 Apr;40(4):257-63.
8 The glycylcyclines: a comparative review with the tetracyclines. Drugs. 2004;64(1):63-88.
9 Characterization of a 30S ribosomal subunit assembly intermediate found in Escherichia coli cells growing with neomycin or paromomycin. Arch Microbiol. 2008 May;189(5):441-9.
10 Ribosomal resistance in the gentamicin producer organism Micromonospora purpurea. Antimicrob Agents Chemother. 1982 Aug;22(2):231-6.
11 Bacterial resistance to aminoglycosides and beta-lactams: the Tn1331 transposon paradigm. Front Biosci. 2000 Jan 1;5:D20-9.
12 Molecular dynamics simulations of the 30S ribosomal subunit reveal a preferred tetracycline binding site. J Am Chem Soc. 2008 Jan 30;130(4):1114-5.
13 Aminoglycoside association pathways with the 30S ribosomal subunit. J Phys Chem B. 2009 May 21;113(20):7322-30.
14 Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
15 Reversed-phase high-performance liquid chromatography coupled to ultraviolet and electrospray time-of-flight mass spectrometry on-line detection fo... J Chromatogr A. 2008 Jun 27;1195(1-2):107-16.
16 Detection of tetracycline resistance genes by PCR methods. Methods Mol Biol. 2004;268:3-13.