Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEKI1J)

• Drug Name: Carazolol Drug Info
• Synonyms: Carazolol; 57775-29-8; Conducton; Suacron; corazolol; Carazolol [INN:BAN]; 1-((9H-Carbazol-4-yl)oxy)-3-(isopropylamino)propan-2-ol; Carazololum [INN-Latin]; CCRIS 1047; Conducton hydrochloride; 1-(Carbazol-4-yloxy)-3-(isopropylamino)-2-propanol; 1-(9H-carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol; EINECS 260-945-1; BRN 3620576; BM-51052; BM 51052; CHEMBL324665; 1-(9H-carbazol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol; 1-(4-Carbazolyloxy)-3-isopropylamino-2-propanol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 71739
  ChEBI ID: CHEBI:135261
  CAS Number: CAS 57775-29-8
  TTD Drug ID: DMEKI1J

Molecule-Related Drug Atlas

Drug(s) Targeting Adrenergic receptor beta-1 (ADRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[4]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[5]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[6]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[7]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[7]
Metoprolol	DMOJ0V6	Acute coronary syndrome	BA41	Approved	[7]
Timolol	DM3NXRU	High blood pressure	BA00	Approved	[8]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[2]
Betaxolol	DM6EUL5	Hypertension	BA00-BA04	Approved	[9]
Sotalol	DML60TN	Sinus rhythm disorder	BC9Y	Approved	[10]

Drug(s) Targeting Adrenergic receptor beta-3 (ADRB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mirabegron	DMS1GYT	Overactive bladder	GC50.0	Approved	[11]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[12]
Amosulalol	DML8QSZ	Hypertension	BA00-BA04	Approved	[13]
Bopindolol	DMIFYLX	Hypertension	BA00-BA04	Approved	[14]
Mepindolol	DMUDWP9	Angina pectoris	BA40	Approved	[15]
Rimiterol	DMA47C6	Asthma	CA23	Approved	[16]
Bitolterol	DMK6XAV	Chronic obstructive pulmonary disease	CA22	Approved	[17]
Nipradilol	DMA65ER	Angina pectoris	BA40	Approved	[18]
Vibegron	DMFR201	Overactive bladder	GC50.0	Approved	[19]
ONO-2506	DMCA2PJ	Stroke	8B20	Phase 2/3	[20]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[21]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[22]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[23]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[24]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[24]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[26]
Selenium	DM25CGV	N. A.	N. A.	Approved	[27]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[28]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[29]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor beta-1 (ADRB1)	TTR6W5O	ADRB1_HUMAN	Agonist	[2]
Adrenergic receptor beta-3 (ADRB3)	TTMXGCW	ADRB3_HUMAN	Agonist	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Gene/Protein Processing	[3]

References

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• [14] Effect of propranolol, alprenolol, pindolol, and bopindolol on beta 2-adrenoceptor density in human lymphocytes. J Cardiovasc Pharmacol. 1986;8 Suppl 6:S70-3.
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• [19] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
• [20] FR149175, a beta 3-adrenoceptor-selective agonist, is a possible therapeutic agent for non-insulin-dependent diabetes mellitus. Jpn J Pharmacol. 1997 May;74(1):109-12.
• [21] Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
• [22] ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
• [23] Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
• [24] An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
• [25] Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
• [26] (9)-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7-Stimulated Human Coculture. J Pharmacol Exp Ther. 2019 Oct;371(1):191-201. doi: 10.1124/jpet.119.260661. Epub 2019 Aug 5.
• [27] Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
• [28] Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay. Arch Toxicol. 2018 Jun;92(6):2043-2054. doi: 10.1007/s00204-018-2199-7. Epub 2018 Mar 29.
• [29] Spironolactone induces apoptosis in human mononuclear cells. Association between apoptosis and cytokine suppression. Apoptosis. 2006 Apr;11(4):573-9. doi: 10.1007/s10495-006-4919-3.