Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFD9UZ)

• Drug Name: PMID29757691-Compound-4 Drug Info
• Cross-matching ID: TTD Drug ID: DMFD9UZ

Molecule-Related Drug Atlas

Drug(s) Targeting Acetylcholinesterase (AChE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[2]
Donepezil	DMIYG7Z	Advanced cancer	2A00-2F9Z	Approved	[3]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[4]
Galantamine	DMEO794	Alzheimer disease	8A20	Approved	[5]
Huperzine A	DMMAWLU	Alzheimer disease	8A20	Approved	[6]
Neostigmine	DM6T2J3	Myasthenia gravis	8C6Y	Approved	[7]
YM443	DMNZCI1	Functional dyspepsia	DD90.3	Approved	[8]
Ambenonium	DMOP0BL	Myasthenia gravis	8C6Y	Approved	[9]
Demecarium bromide	DMAYEU1	Open-angle glaucoma	9C61	Approved	[10]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[11]

Drug(s) Targeting Monoamine oxidase type B (MAO-B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selegiline Hydrochloride	DM3VR1L	Parkinson disease	8A00.0	Approved	[12]
Phenelzine	DMHIDUE	Depression	6A70-6A7Z	Approved	[13]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[14]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[15]
Safinamide mesylate	DM0J2ZT	Parkinson disease	8A00.0	Approved	[16]
Rasagiline	DM3WKQ4	Parkinson disease	8A00.0	Approved	[17]
Sulphadoxine	DMZI2UF	Malaria	1F40-1F45	Approved	[18]
Pargyline	DMM0HR1	Hypertension	BA00-BA04	Approved	[19]
Indeloxazine	DMWO3N6	Dementia	6D80-6D86	Approved	[8]
Budipine	DMODHQI	Migraine	8A80	Approved	[20]

Drug(s) Targeting Monoamine oxidase type A (MAO-A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Moclobemide	DMNZWL7	Depression	6A70-6A7Z	Approved	[21]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[22]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[23]
Isocarboxazid	DMAF1NB	Depression	6A70-6A7Z	Approved	[24]
TRYPTAMINE	DMAFPHB	N. A.	N. A.	Phase 3	[25]
Psoralen	DMIZJ8M	N. A.	N. A.	Phase 3	[26]
CHF-3381	DMQ2O8V	Neuropathic pain	8E43.0	Phase 2	[27]
Ladostigil	DMJSY3Q	Alzheimer disease	8A20	Phase 2	[28]
CX157	DMS2WB5	Mood disorder	6A60-6E23	Phase 2	[29]
PIPERINE	DMYEAB1	Vitiligo	ED63.0	Phase 1/2	[30]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acetylcholinesterase (AChE)	TT1RS9F	ACES_HUMAN	Inhibitor	[1]
Monoamine oxidase type A (MAO-A)	TT3WG5C	AOFA_HUMAN	Inhibitor	[1]
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[1]

References

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• [22] Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice. Int J Neuropsychopharmacol. 2009 Mar 11:1-11.
• [23] Further investigation into the mechanism of tachykinin NK(2) receptor-triggered serotonin release from guinea-pig proximal colon. J Pharmacol Sci. 2009 May;110(1):122-6.
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